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The map label for this gene is lldD2 [H]

Identifier: 221230582

GI number: 221230582

Start: 2435484

End: 2436728

Strand: Direct

Name: lldD2 [H]

Synonym: MLBr_02046

Alternate gene names: 221230582

Gene position: 2435484-2436728 (Clockwise)

Preceding gene: 221230581

Following gene: 221230583

Centisome position: 74.52

GC content: 60.48

Gene sequence:

>1245_bases
ATGGCAGCCAAACGGCGGATGCCCAGAGTCCACGACCTGGCCCCGCTGATCCAGTTCAAACGGCCCAAATTCGGAGCGAC
CAAACGCCGCCTCGAGGCCGCGCTGACCATTCAGGATCTGCGGTGCATTGCCAAACAGCGCACCCCAAAGGCCGCGTTCG
ACTATACCGATGGCGCCGCCGAGGACGAGCTATCCATTAAACGAGCCCAACAAGCCTTCCGCGACATCGAGTTTCACCCG
GCTATCTTGCGTGATGTCACGAACGTATGCGCCGGATGGGATGTGCTCGGGCATTCGGTCTTGTTGCCGTTCGGAATCGC
GCCAACCGGATTCACTCGGTTGATGCATACCGAGGGTGAGATTGCCGGCGCGCGGGCTGCTGCTGCAGCCGGGATCCCAT
TTTCGTTATCCACTCTCGCCACCTCTGCGATCGAAGATGTAGTGGCCGCCGTTCCGCAGGGCCGCAAATGGTTTCAGCTG
TACATGTGGCGGGATCGTGACCGCTCAATGGCGTTGGTCGAGCGCGCCGCCGACGCAGGGTACGATGCCCTGCTGGTCAC
GGTCGACGTTCCGGTCGCCGGCGCGCGGTTACGTGACACCCGCAACGGCATGTCGATCCCGCCGGCGTTAACACTGCGAA
CTGTGTTCGACGCGCTGCCACACCCGCGCTGGTGGATTGACTTGTTGACTACCGAGCCTCTGGCATTCGCATCGTTAGAT
CGCTGGTCGGGCACTGTCAGCGATTACTTAAACACCATGTTCGACCCCAGCGTCACTTTTGACGATCTGGCGTGGATTAA
AACCCAATGGCCCGGCAAGTTCGTAGTGAAAGGAATCCAGACGCTCGACGACGCTCGCGCCGTCGTTGAGCGCGGTATCG
ACGGTGTCGTGTTGTCCAATCACGGCGGGCGGCAACTTGACCGGGCACCGGTGCCCTTCCATCTACTACCTACGGTGGCG
CGTGAATTCGGCAAGGACACCGAGATACTGTTAGATACCGGTATCATGTCCGGCGCTGACATTGTGGCAGCAATTGCACT
GGGAGCCCGGTGCACACTGGTCGGGCGAGCCTACCTCTACGGGTTGATGGCCGGTGGCGAAGCGGGCGTCAGGCGCGCGA
TCGAAATCCTGGAAAGCGGGGTGATCCGCACGATGCAACTTTTAGGTGTGACCTGTTTAGAGGAACTCTCGCCCAGACAT
GTGACGCAACTACAGCGACTGGGCCCCATTGAACCACCAGCATGA

Upstream 100 bases:

>100_bases
GCTCGGTGGTCGGCGAGGCTCACGGCTGGTAGATCTTGCAACCAACATAGGTTAGATTGCCCAGGCGAGCATGGGTCGAC
CACAGTAAGGATGGGAAACG

Downstream 100 bases:

>100_bases
CGTAACTAACGTGACGCGGGCGCCGCAGTGTTTCTTACCCCGCATCGAAGCAACCAGCCTCAATCATCGCAGAGCTCACT
GGGCTTCGTCTCGTTAGGTT

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 414; Mature: 413

Protein sequence:

>414_residues
MAAKRRMPRVHDLAPLIQFKRPKFGATKRRLEAALTIQDLRCIAKQRTPKAAFDYTDGAAEDELSIKRAQQAFRDIEFHP
AILRDVTNVCAGWDVLGHSVLLPFGIAPTGFTRLMHTEGEIAGARAAAAAGIPFSLSTLATSAIEDVVAAVPQGRKWFQL
YMWRDRDRSMALVERAADAGYDALLVTVDVPVAGARLRDTRNGMSIPPALTLRTVFDALPHPRWWIDLLTTEPLAFASLD
RWSGTVSDYLNTMFDPSVTFDDLAWIKTQWPGKFVVKGIQTLDDARAVVERGIDGVVLSNHGGRQLDRAPVPFHLLPTVA
REFGKDTEILLDTGIMSGADIVAAIALGARCTLVGRAYLYGLMAGGEAGVRRAIEILESGVIRTMQLLGVTCLEELSPRH
VTQLQRLGPIEPPA

Sequences:

>Translated_414_residues
MAAKRRMPRVHDLAPLIQFKRPKFGATKRRLEAALTIQDLRCIAKQRTPKAAFDYTDGAAEDELSIKRAQQAFRDIEFHP
AILRDVTNVCAGWDVLGHSVLLPFGIAPTGFTRLMHTEGEIAGARAAAAAGIPFSLSTLATSAIEDVVAAVPQGRKWFQL
YMWRDRDRSMALVERAADAGYDALLVTVDVPVAGARLRDTRNGMSIPPALTLRTVFDALPHPRWWIDLLTTEPLAFASLD
RWSGTVSDYLNTMFDPSVTFDDLAWIKTQWPGKFVVKGIQTLDDARAVVERGIDGVVLSNHGGRQLDRAPVPFHLLPTVA
REFGKDTEILLDTGIMSGADIVAAIALGARCTLVGRAYLYGLMAGGEAGVRRAIEILESGVIRTMQLLGVTCLEELSPRH
VTQLQRLGPIEPPA
>Mature_413_residues
AAKRRMPRVHDLAPLIQFKRPKFGATKRRLEAALTIQDLRCIAKQRTPKAAFDYTDGAAEDELSIKRAQQAFRDIEFHPA
ILRDVTNVCAGWDVLGHSVLLPFGIAPTGFTRLMHTEGEIAGARAAAAAGIPFSLSTLATSAIEDVVAAVPQGRKWFQLY
MWRDRDRSMALVERAADAGYDALLVTVDVPVAGARLRDTRNGMSIPPALTLRTVFDALPHPRWWIDLLTTEPLAFASLDR
WSGTVSDYLNTMFDPSVTFDDLAWIKTQWPGKFVVKGIQTLDDARAVVERGIDGVVLSNHGGRQLDRAPVPFHLLPTVAR
EFGKDTEILLDTGIMSGADIVAAIALGARCTLVGRAYLYGLMAGGEAGVRRAIEILESGVIRTMQLLGVTCLEELSPRHV
TQLQRLGPIEPPA

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=357, Percent_Identity=34.733893557423, Blast_Score=227, Evalue=1e-59,
Organism=Homo sapiens, GI54234014, Length=374, Percent_Identity=33.4224598930481, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI7705393, Length=374, Percent_Identity=33.4224598930481, Blast_Score=214, Evalue=1e-55,
Organism=Escherichia coli, GI1790033, Length=373, Percent_Identity=37.2654155495979, Blast_Score=240, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI193208036, Length=367, Percent_Identity=35.4223433242507, Blast_Score=220, Evalue=9e-58,
Organism=Caenorhabditis elegans, GI32566217, Length=283, Percent_Identity=35.3356890459364, Blast_Score=169, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6323587, Length=382, Percent_Identity=32.7225130890052, Blast_Score=192, Evalue=1e-49,
Organism=Drosophila melanogaster, GI281363140, Length=380, Percent_Identity=34.4736842105263, Blast_Score=228, Evalue=4e-60,
Organism=Drosophila melanogaster, GI78707190, Length=380, Percent_Identity=34.4736842105263, Blast_Score=228, Evalue=4e-60,
Organism=Drosophila melanogaster, GI78707188, Length=380, Percent_Identity=34.4736842105263, Blast_Score=228, Evalue=4e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 45338; Mature: 45207

Theoretical pI: Translated: 8.01; Mature: 8.01

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKRRMPRVHDLAPLIQFKRPKFGATKRRLEAALTIQDLRCIAKQRTPKAAFDYTDGAA
CCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
EDELSIKRAQQAFRDIEFHPAILRDVTNVCAGWDVLGHSVLLPFGIAPTGFTRLMHTEGE
CHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHEEECCCCCHHHHHHHHCCCC
IAGARAAAAAGIPFSLSTLATSAIEDVVAAVPQGRKWFQLYMWRDRDRSMALVERAADAG
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCHHHHHHHHHCCC
YDALLVTVDVPVAGARLRDTRNGMSIPPALTLRTVFDALPHPRWWIDLLTTEPLAFASLD
CCEEEEEEECCCCCCHHHHCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHH
RWSGTVSDYLNTMFDPSVTFDDLAWIKTQWPGKFVVKGIQTLDDARAVVERGIDGVVLSN
HCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
HGGRQLDRAPVPFHLLPTVAREFGKDTEILLDTGIMSGADIVAAIALGARCTLVGRAYLY
CCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHH
GLMAGGEAGVRRAIEILESGVIRTMQLLGVTCLEELSPRHVTQLQRLGPIEPPA
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
AAKRRMPRVHDLAPLIQFKRPKFGATKRRLEAALTIQDLRCIAKQRTPKAAFDYTDGAA
CCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
EDELSIKRAQQAFRDIEFHPAILRDVTNVCAGWDVLGHSVLLPFGIAPTGFTRLMHTEGE
CHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHEEECCCCCHHHHHHHHCCCC
IAGARAAAAAGIPFSLSTLATSAIEDVVAAVPQGRKWFQLYMWRDRDRSMALVERAADAG
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCHHHHHHHHHCCC
YDALLVTVDVPVAGARLRDTRNGMSIPPALTLRTVFDALPHPRWWIDLLTTEPLAFASLD
CCEEEEEEECCCCCCHHHHCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHH
RWSGTVSDYLNTMFDPSVTFDDLAWIKTQWPGKFVVKGIQTLDDARAVVERGIDGVVLSN
HCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
HGGRQLDRAPVPFHLLPTVAREFGKDTEILLDTGIMSGADIVAAIALGARCTLVGRAYLY
CCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHH
GLMAGGEAGVRRAIEILESGVIRTMQLLGVTCLEELSPRHVTQLQRLGPIEPPA
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]