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The map label for this gene is ahpC [H]

Identifier: 221230579

GI number: 221230579

Start: 2432954

End: 2433541

Strand: Direct

Name: ahpC [H]

Synonym: MLBr_02042

Alternate gene names: 221230579

Gene position: 2432954-2433541 (Clockwise)

Preceding gene: 221230575

Following gene: 221230581

Centisome position: 74.45

GC content: 58.5

Gene sequence:

>588_bases
ATGTCATTGCTATCAATTGGCCAACAGTTCCCCGCCTACCAACTCACCGCGCTGATCGGCGGCGACTTATCAAAGGTTGA
CGCACAGCAGCCTGGTGACTACTTCACCACCGTCTCCAGTGACAGCCACCCAGGCAAGTGGCGCGTAGTGTTCTTCTGGC
CGAAGGACTTCACCTTCATTTGTCCGACCGAAATCGCGGCGTTCGGCAAGCTGAACGAAGAGTTCGAAGGCCGTGGAGCG
CAGATTCTCGGAGTTTCGATCGACAGCGAATTCGTGCACTTCCAGTGGCGTGCACAGCACGAGGACCTCAAGCGGCTTCC
CTTCCCGATGCTCTCGGACATCAAGCGGGAGCTTTCTGCGGCCAGCGGAGCACTCAACGCCGATGGTGTTGCTGACCGTG
TGACGTTCATCGTCGATCCCGACAACGATATCCAGTTCGTCTCGGTCACCGCGGGTTCCGTGGGACGCAACGTGGAAGAG
GTGCTGCGGGTGCTCGATGCCCTACAATCCGACCAACTGTGTGCATGCAACTGGCGCAAGGGCGACCCGACTCTGAACGC
GACTGAATTGCTCAAGACGTCAGCCTGA

Upstream 100 bases:

>100_bases
TATAGTGTGATATATCACCTTTACTTCAGACCAAACTCACGGCAACCTTGAAGGATAGTGTAAAAATCTGATTTTGAATC
AATCCAAACAAGGATCGGAT

Downstream 100 bases:

>100_bases
CCGGGGCAGGCCTGATCTCCAACTTAGATTGGAAGGCATATGAGCATCGAGGACCTCAAGGTCGCGCTGCCGGAGTACAC
CAAGAACTTCAAGCTCATCC

Product: alkyl hydroperoxide reductase

Products: NA

Alternate protein names: MtAhpC; Peroxiredoxin; Thioredoxin peroxidase [H]

Number of amino acids: Translated: 195; Mature: 194

Protein sequence:

>195_residues
MSLLSIGQQFPAYQLTALIGGDLSKVDAQQPGDYFTTVSSDSHPGKWRVVFFWPKDFTFICPTEIAAFGKLNEEFEGRGA
QILGVSIDSEFVHFQWRAQHEDLKRLPFPMLSDIKRELSAASGALNADGVADRVTFIVDPDNDIQFVSVTAGSVGRNVEE
VLRVLDALQSDQLCACNWRKGDPTLNATELLKTSA

Sequences:

>Translated_195_residues
MSLLSIGQQFPAYQLTALIGGDLSKVDAQQPGDYFTTVSSDSHPGKWRVVFFWPKDFTFICPTEIAAFGKLNEEFEGRGA
QILGVSIDSEFVHFQWRAQHEDLKRLPFPMLSDIKRELSAASGALNADGVADRVTFIVDPDNDIQFVSVTAGSVGRNVEE
VLRVLDALQSDQLCACNWRKGDPTLNATELLKTSA
>Mature_194_residues
SLLSIGQQFPAYQLTALIGGDLSKVDAQQPGDYFTTVSSDSHPGKWRVVFFWPKDFTFICPTEIAAFGKLNEEFEGRGAQ
ILGVSIDSEFVHFQWRAQHEDLKRLPFPMLSDIKRELSAASGALNADGVADRVTFIVDPDNDIQFVSVTAGSVGRNVEEV
LRVLDALQSDQLCACNWRKGDPTLNATELLKTSA

Specific function: Together with AhpD, DltA and Lpd constitutes an NADH- dependent peroxidase active against hydrogen and alkyl peroxides as well as serving as a peroxynitrite reductase, thus protecting the bacterium against reactive nitrogen intermediates and oxidative str

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI32189392, Length=189, Percent_Identity=35.978835978836, Blast_Score=119, Evalue=1e-27,
Organism=Homo sapiens, GI5802974, Length=189, Percent_Identity=34.9206349206349, Blast_Score=117, Evalue=5e-27,
Organism=Homo sapiens, GI32483377, Length=194, Percent_Identity=35.0515463917526, Blast_Score=117, Evalue=7e-27,
Organism=Homo sapiens, GI4505591, Length=189, Percent_Identity=34.3915343915344, Blast_Score=114, Evalue=5e-26,
Organism=Homo sapiens, GI32455266, Length=189, Percent_Identity=34.3915343915344, Blast_Score=114, Evalue=5e-26,
Organism=Homo sapiens, GI32455264, Length=189, Percent_Identity=34.3915343915344, Blast_Score=114, Evalue=5e-26,
Organism=Homo sapiens, GI5453549, Length=193, Percent_Identity=31.6062176165803, Blast_Score=101, Evalue=5e-22,
Organism=Homo sapiens, GI4758638, Length=153, Percent_Identity=32.6797385620915, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI33188454, Length=94, Percent_Identity=40.4255319148936, Blast_Score=79, Evalue=3e-15,
Organism=Escherichia coli, GI1786822, Length=167, Percent_Identity=34.1317365269461, Blast_Score=113, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI17554494, Length=196, Percent_Identity=34.6938775510204, Blast_Score=120, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI193204376, Length=194, Percent_Identity=34.5360824742268, Blast_Score=116, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI32565831, Length=194, Percent_Identity=34.5360824742268, Blast_Score=116, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI25153706, Length=155, Percent_Identity=31.6129032258064, Blast_Score=77, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6323613, Length=191, Percent_Identity=35.6020942408377, Blast_Score=112, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6320661, Length=188, Percent_Identity=33.5106382978723, Blast_Score=105, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6319407, Length=152, Percent_Identity=32.8947368421053, Blast_Score=92, Evalue=6e-20,
Organism=Drosophila melanogaster, GI17738015, Length=174, Percent_Identity=36.7816091954023, Blast_Score=118, Evalue=3e-27,
Organism=Drosophila melanogaster, GI21357347, Length=195, Percent_Identity=32.3076923076923, Blast_Score=107, Evalue=5e-24,
Organism=Drosophila melanogaster, GI17157991, Length=185, Percent_Identity=32.4324324324324, Blast_Score=106, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24641739, Length=185, Percent_Identity=32.4324324324324, Blast_Score=106, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24656348, Length=188, Percent_Identity=31.3829787234043, Blast_Score=101, Evalue=4e-22,
Organism=Drosophila melanogaster, GI17864676, Length=188, Percent_Identity=31.3829787234043, Blast_Score=101, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24581278, Length=190, Percent_Identity=28.4210526315789, Blast_Score=81, Evalue=5e-16,
Organism=Drosophila melanogaster, GI17975518, Length=155, Percent_Identity=31.6129032258064, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24652434, Length=155, Percent_Identity=31.6129032258064, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24652436, Length=155, Percent_Identity=31.6129032258064, Blast_Score=79, Evalue=1e-15,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 21497; Mature: 21366

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLLSIGQQFPAYQLTALIGGDLSKVDAQQPGDYFTTVSSDSHPGKWRVVFFWPKDFTFI
CCHHHHCCCCCCEEEEEECCCCCHHCCCCCCCCEEEEECCCCCCCEEEEEEECCCCCEEE
CPTEIAAFGKLNEEFEGRGAQILGVSIDSEFVHFQWRAQHEDLKRLPFPMLSDIKRELSA
CCHHHHHHHCCCHHHCCCCCEEEEEEECCCEEEEEEECCHHHHHHCCCHHHHHHHHHHHH
ASGALNADGVADRVTFIVDPDNDIQFVSVTAGSVGRNVEEVLRVLDALQSDQLCACNWRK
HCCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEECCC
GDPTLNATELLKTSA
CCCCCCHHHHHHCCC
>Mature Secondary Structure 
SLLSIGQQFPAYQLTALIGGDLSKVDAQQPGDYFTTVSSDSHPGKWRVVFFWPKDFTFI
CHHHHCCCCCCEEEEEECCCCCHHCCCCCCCCEEEEECCCCCCCEEEEEEECCCCCEEE
CPTEIAAFGKLNEEFEGRGAQILGVSIDSEFVHFQWRAQHEDLKRLPFPMLSDIKRELSA
CCHHHHHHHCCCHHHCCCCCEEEEEEECCCEEEEEEECCHHHHHHCCCHHHHHHHHHHHH
ASGALNADGVADRVTFIVDPDNDIQFVSVTAGSVGRNVEEVLRVLDALQSDQLCACNWRK
HCCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEECCC
GDPTLNATELLKTSA
CCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7604044; 8596438; 9634230; 12218036 [H]