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The map label for this gene is 221230563

Identifier: 221230563

GI number: 221230563

Start: 2388202

End: 2390181

Strand: Direct

Name: 221230563

Synonym: MLBr_01998

Alternate gene names: NA

Gene position: 2388202-2390181 (Clockwise)

Preceding gene: 221230561

Following gene: 221230565

Centisome position: 73.08

GC content: 57.63

Gene sequence:

>1980_bases
ATGCAGACTGACGAGCCGACCGGAACAGCGACGTCAGCTATACGGATTCCCCCGCTGATCTCCTTGAGAACCACACTGAT
GGTGGCTGGCCTGCTGGGTAACGTGGTCGCCGTTGCCGCCTACGGACTGTTTTCGCGAACTGAGCGTTATGGCGCTGTCG
GCAATCCGGATCCCGGAAGTTTCATCGGCGTTGCCGAACCCGTGGGGTACTTCGGTGCGTCGCTGTCAAGTGCGCTGTGT
CTTGGAGCATTGATTTACTTCGTGATGATGGTCTGGCCGCAAGCAGACGGCTTGATCGATGCTCAGGCTTTTCGGATTCA
CCTTGCTGAAGAGCGTGTTTCGATCGGCTGGCTGGCGTTTGCACTGACGATGGTGGTGGTTCAGGCTGCTAACGACTCCG
GTGTAACACCGGCTGAGCTTCGAACTGGCGCAGCACTATTCAATGCCATTACAACTTCGGAGACCTCACGGGCTTGGATC
GTTGTGACGATCTGTGCGTTGCTTGTTACGTTGACGCTGCGAGTCATCATCCGATACTCCGACCACTTTGTGCTGCTGAT
CCCCGCAGTGATTGGTGTTATCGCGACCGCGGTGACCGGTAACGCAGGGCAGGGACCGGACCATGACTACGCCACCAGCG
CTGTGATTGTCTTCGCACTCGCCATTGCCGCATTGAGCGGGCTCAAGATTACCGCTGCGCTGACGGAGGTGACGCCAAGC
CGCGCTGTGCTGATTGTGCAAGTTGTGTGTGGGGTGCTCGCGCTAGCGTATGGAGCCGAGCTGGTCTATCTACTTAGCCC
GGGCGCGGCGATGATCGATTCGGACTTCGGTCGGCTCGGTCTGGTGGCCGGAGTGCTGGTGACCTTGGTGTGCTTCTCTG
ACTGCTGGGCGTTGGTCATGGGTCGGCCGCACTCGGATCACCGGACACGTCTTACCGCACTGGCCATGATGGCCGTCACG
GCGGCGACGGCGGCAATGTCTGTTCAAACTGCGCCGCGATTCCTCACCCACAGGTTCACAGCCTGGGACGTTTTTCTGGG
CTACGAGCTGCCGCAGCCACCTAACATTGTTAGGTTTTTCACCGTGTGGCGGTTCGACAGCCTCATTGGAGCTACTGCCA
TCGTCCTCGGGATCGGATATGTAGCGGGCTTTGTCCGTGTGCGGCGTGCCGGCAACACTTGGCCAGTGGGGAGACTGGTG
GCGTGGTTGACTGGGTGTGTCGCACTGGTATTCACCAGTAGCTCAGGCGTGCGAACGTACGGTTCGGCGATGTTCAGCGT
GCACATGGCCGAACATATGACGTTGAATATGTTCATCCCGGTCCTCCTTGTTCTGGGCGGTCCGGTCACCTTGGCGCTTC
GTGCTTTGTCCGCGGCTGGTGATGGACAACAACCCGGACCACGTGAATGGCTAACATGGCTAATGCACTCCTCCGTTACG
GCCTTTCTTTCCCACCCGGTCACAAACTTCATCCTGTTCGTGGGGTCGCCGTACATCGTTTACTTCACACCGCTGTTCGA
TACCCTGGTTCGCTATCACTGGGGACACGAATTCATGGCCATCCACTTCTTGCTGGTAGGATATATCTTCTACTGGGCAA
TAATTGGTATCGATCCAGGGCCCCGACGACTCCCCTATCTGGCACGAATTGGATTGTTGTTTGCAGTGATGCCATTCCAC
GCCTTCTTCGGGATAGCGTTAATGACAATGACATCGGCAATCAGTGCCGAATTCTACCGCTCCGTCAATCTGCCCTGGCT
GGCAAGCATTGACGCTGACCAGCATATAGGTGGAGCGATCGCCTGGAGCGCAACGGAATTACCTGTAATCATCGTCATAG
TGGCGCTGATGGCCCAGTGGGCACGCCAGGACCATAGAGTCGCCGTCCGTGAAGACCGGCATGCGGACAGCACCTACGCC
GATGACGACCTAAATGCATACAACGCGATGCTACGAGAGTTGTCCCGGATGCGTCGATAG

Upstream 100 bases:

>100_bases
CGCTCGGAGGGAGGCATCTGGCTACTGTAGGTTGGCGTTGACCAACCGACGCTTGCCGGCCACCTACGTGGTCTGCTGTT
AGCATCCGTAAGCTCAAGCA

Downstream 100 bases:

>100_bases
ACAAGACCACCCGTTGTCGATGATACGACCTGACGCCCAGGCATGTGGTAGTCATTGTCGAGGATGTGACTGTCCTGGTC
AGGTCCAAGATTGCGGATTA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 659; Mature: 659

Protein sequence:

>659_residues
MQTDEPTGTATSAIRIPPLISLRTTLMVAGLLGNVVAVAAYGLFSRTERYGAVGNPDPGSFIGVAEPVGYFGASLSSALC
LGALIYFVMMVWPQADGLIDAQAFRIHLAEERVSIGWLAFALTMVVVQAANDSGVTPAELRTGAALFNAITTSETSRAWI
VVTICALLVTLTLRVIIRYSDHFVLLIPAVIGVIATAVTGNAGQGPDHDYATSAVIVFALAIAALSGLKITAALTEVTPS
RAVLIVQVVCGVLALAYGAELVYLLSPGAAMIDSDFGRLGLVAGVLVTLVCFSDCWALVMGRPHSDHRTRLTALAMMAVT
AATAAMSVQTAPRFLTHRFTAWDVFLGYELPQPPNIVRFFTVWRFDSLIGATAIVLGIGYVAGFVRVRRAGNTWPVGRLV
AWLTGCVALVFTSSSGVRTYGSAMFSVHMAEHMTLNMFIPVLLVLGGPVTLALRALSAAGDGQQPGPREWLTWLMHSSVT
AFLSHPVTNFILFVGSPYIVYFTPLFDTLVRYHWGHEFMAIHFLLVGYIFYWAIIGIDPGPRRLPYLARIGLLFAVMPFH
AFFGIALMTMTSAISAEFYRSVNLPWLASIDADQHIGGAIAWSATELPVIIVIVALMAQWARQDHRVAVREDRHADSTYA
DDDLNAYNAMLRELSRMRR

Sequences:

>Translated_659_residues
MQTDEPTGTATSAIRIPPLISLRTTLMVAGLLGNVVAVAAYGLFSRTERYGAVGNPDPGSFIGVAEPVGYFGASLSSALC
LGALIYFVMMVWPQADGLIDAQAFRIHLAEERVSIGWLAFALTMVVVQAANDSGVTPAELRTGAALFNAITTSETSRAWI
VVTICALLVTLTLRVIIRYSDHFVLLIPAVIGVIATAVTGNAGQGPDHDYATSAVIVFALAIAALSGLKITAALTEVTPS
RAVLIVQVVCGVLALAYGAELVYLLSPGAAMIDSDFGRLGLVAGVLVTLVCFSDCWALVMGRPHSDHRTRLTALAMMAVT
AATAAMSVQTAPRFLTHRFTAWDVFLGYELPQPPNIVRFFTVWRFDSLIGATAIVLGIGYVAGFVRVRRAGNTWPVGRLV
AWLTGCVALVFTSSSGVRTYGSAMFSVHMAEHMTLNMFIPVLLVLGGPVTLALRALSAAGDGQQPGPREWLTWLMHSSVT
AFLSHPVTNFILFVGSPYIVYFTPLFDTLVRYHWGHEFMAIHFLLVGYIFYWAIIGIDPGPRRLPYLARIGLLFAVMPFH
AFFGIALMTMTSAISAEFYRSVNLPWLASIDADQHIGGAIAWSATELPVIIVIVALMAQWARQDHRVAVREDRHADSTYA
DDDLNAYNAMLRELSRMRR
>Mature_659_residues
MQTDEPTGTATSAIRIPPLISLRTTLMVAGLLGNVVAVAAYGLFSRTERYGAVGNPDPGSFIGVAEPVGYFGASLSSALC
LGALIYFVMMVWPQADGLIDAQAFRIHLAEERVSIGWLAFALTMVVVQAANDSGVTPAELRTGAALFNAITTSETSRAWI
VVTICALLVTLTLRVIIRYSDHFVLLIPAVIGVIATAVTGNAGQGPDHDYATSAVIVFALAIAALSGLKITAALTEVTPS
RAVLIVQVVCGVLALAYGAELVYLLSPGAAMIDSDFGRLGLVAGVLVTLVCFSDCWALVMGRPHSDHRTRLTALAMMAVT
AATAAMSVQTAPRFLTHRFTAWDVFLGYELPQPPNIVRFFTVWRFDSLIGATAIVLGIGYVAGFVRVRRAGNTWPVGRLV
AWLTGCVALVFTSSSGVRTYGSAMFSVHMAEHMTLNMFIPVLLVLGGPVTLALRALSAAGDGQQPGPREWLTWLMHSSVT
AFLSHPVTNFILFVGSPYIVYFTPLFDTLVRYHWGHEFMAIHFLLVGYIFYWAIIGIDPGPRRLPYLARIGLLFAVMPFH
AFFGIALMTMTSAISAEFYRSVNLPWLASIDADQHIGGAIAWSATELPVIIVIVALMAQWARQDHRVAVREDRHADSTYA
DDDLNAYNAMLRELSRMRR

Specific function: Unknown

COG id: COG3336

COG function: function code S; Predicted membrane protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: To M.tuberculosis Rv0102

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y1998_MYCLE (P53525)

Other databases:

- EMBL:   Z46257
- EMBL:   AL583924
- PIR:   S77658
- RefSeq:   NP_302349.1
- ProteinModelPortal:   P53525
- EnsemblBacteria:   EBMYCT00000027912
- GeneID:   909080
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML1998
- NMPDR:   fig|272631.1.peg.1221
- Leproma:   ML1998
- GeneTree:   EBGT00050000017144
- HOGENOM:   HBG579710
- OMA:   AWRWTAI
- ProtClustDB:   CLSK790265
- BioCyc:   MLEP272631:ML1998-MONOMER
- InterPro:   IPR008457
- InterPro:   IPR019108

Pfam domain/function: PF09678 Caa3_CtaG; PF05425 CopD

EC number: NA

Molecular weight: Translated: 71247; Mature: 71247

Theoretical pI: Translated: 7.28; Mature: 7.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x29979108)-; HASH(0x234afb98)-; HASH(0x238924fc)-; HASH(0x228cac6c)-; HASH(0x23208a58)-; HASH(0x2374aadc)-; HASH(0x2374abfc)-; HASH(0x23468fcc)-; HASH(0x22e555ec)-; HASH(0x23654314)-; HASH(0x2308bbf0)-; HASH(0x23ba3acc)-; HASH(0x22904778)-; HASH(0x239227b0)-; HASH(0x2187b194)-; HASH(0x22b3ae1c)-;

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTDEPTGTATSAIRIPPLISLRTTLMVAGLLGNVVAVAAYGLFSRTERYGAVGNPDPGS
CCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
FIGVAEPVGYFGASLSSALCLGALIYFVMMVWPQADGLIDAQAFRIHLAEERVSIGWLAF
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHEEEEHHHHHHHHHHHH
ALTMVVVQAANDSGVTPAELRTGAALFNAITTSETSRAWIVVTICALLVTLTLRVIIRYS
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
DHFVLLIPAVIGVIATAVTGNAGQGPDHDYATSAVIVFALAIAALSGLKITAALTEVTPS
CCCEEHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEHHHHCCCC
RAVLIVQVVCGVLALAYGAELVYLLSPGAAMIDSDFGRLGLVAGVLVTLVCFSDCWALVM
HHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
GRPHSDHRTRLTALAMMAVTAATAAMSVQTAPRFLTHRFTAWDVFLGYELPQPPNIVRFF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCEEHH
TVWRFDSLIGATAIVLGIGYVAGFVRVRRAGNTWPVGRLVAWLTGCVALVFTSSSGVRTY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHH
GSAMFSVHMAEHMTLNMFIPVLLVLGGPVTLALRALSAAGDGQQPGPREWLTWLMHSSVT
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
AFLSHPVTNFILFVGSPYIVYFTPLFDTLVRYHWGHEFMAIHFLLVGYIFYWAIIGIDPG
HHHHCCHHHEEEEECCCEEEEEHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCC
PRRLPYLARIGLLFAVMPFHAFFGIALMTMTSAISAEFYRSVNLPWLASIDADQHIGGAI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCEE
AWSATELPVIIVIVALMAQWARQDHRVAVREDRHADSTYADDDLNAYNAMLRELSRMRR
EECCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCH
>Mature Secondary Structure
MQTDEPTGTATSAIRIPPLISLRTTLMVAGLLGNVVAVAAYGLFSRTERYGAVGNPDPGS
CCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
FIGVAEPVGYFGASLSSALCLGALIYFVMMVWPQADGLIDAQAFRIHLAEERVSIGWLAF
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHEEEEHHHHHHHHHHHH
ALTMVVVQAANDSGVTPAELRTGAALFNAITTSETSRAWIVVTICALLVTLTLRVIIRYS
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
DHFVLLIPAVIGVIATAVTGNAGQGPDHDYATSAVIVFALAIAALSGLKITAALTEVTPS
CCCEEHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEHHHHCCCC
RAVLIVQVVCGVLALAYGAELVYLLSPGAAMIDSDFGRLGLVAGVLVTLVCFSDCWALVM
HHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
GRPHSDHRTRLTALAMMAVTAATAAMSVQTAPRFLTHRFTAWDVFLGYELPQPPNIVRFF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCEEHH
TVWRFDSLIGATAIVLGIGYVAGFVRVRRAGNTWPVGRLVAWLTGCVALVFTSSSGVRTY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHH
GSAMFSVHMAEHMTLNMFIPVLLVLGGPVTLALRALSAAGDGQQPGPREWLTWLMHSSVT
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
AFLSHPVTNFILFVGSPYIVYFTPLFDTLVRYHWGHEFMAIHFLLVGYIFYWAIIGIDPG
HHHHCCHHHEEEEECCCEEEEEHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCC
PRRLPYLARIGLLFAVMPFHAFFGIALMTMTSAISAEFYRSVNLPWLASIDADQHIGGAI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCEE
AWSATELPVIIVIVALMAQWARQDHRVAVREDRHADSTYADDDLNAYNAMLRELSRMRR
EECCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7476188; 11234002