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The map label for this gene is fadD10 [H]

Identifier: 221230559

GI number: 221230559

Start: 2381421

End: 2383019

Strand: Direct

Name: fadD10 [H]

Synonym: MLBr_01994

Alternate gene names: 221230559

Gene position: 2381421-2383019 (Clockwise)

Preceding gene: 221230558

Following gene: 221230560

Centisome position: 72.87

GC content: 54.78

Gene sequence:

>1599_bases
ATGTCGCACTTACCGCCTACAGTCCTGGAACGGATACTGAAGCAGGCACACGAGCGTCCGGAGGCAATCGCCTTGCGTCG
CAGCGACGGGACAAGCGAGCTGCGGTACGGTCAGCTTGTTGCCGAAGTCAATGGGCTTGCCGCGCATCTTAGTGCTCAGT
CGGTTTCTCAAAGATCCCGGGTTCTCGTCATTTCGGACAACGGTCCCGAGACATACCTGTCGGTGCTGGCTTGCGCGAAG
CTCGGAGCGATCGCAGTCATGGTGGACGGCAATCTTCCGCCCGCAACCATCAGTCGTTTCAGCGAAATCTGTGACCCCAG
TGCGGTCCTTGTCGCGCGAGAGTGCAGAATAGACTCTTCCTCGCTGCCGGAAATACTACACTCAATACCGGCCATAACGG
TCAATACCACCGCTGATGCAACGTATTCCGCTTGCTCGTTGGATATAGATTATTTAGCCGGTAACCTAAACTACGGCACC
GATGACCCGTTGGCGATGACCTTCACCAGCGGTACAACCGGCGAGCCAAAGGCCGTGCTGCTACCCAATCGCACCTTCTT
TGCTATTCCAGACATTTTACGGGAAAAAGGTCTGGCCTGGATCGATTGGGTCGTCAACGAAACCACCTACTCACCTCTGT
CGGCGACGCATATCGGCGGCCTCTGGTGGATACTCAACTGTTTAATGCATGGAGGGTTATGTATCACCGGCGGTGAGCAC
ACGTCGTCGTTAACGGAGGTTCTTAACGCGAATAAAGTCGCAACAACATGCCTAGTTCCAACCCTTCTTTCGAAACTGGT
TTACGAACTGAAGTTCGGCGATGTGGTGACTCCGCCGTTGCGACTAATTGTTTACGGTGGTTCGCGGGTAATTGCAGCTG
ATGTGCGATTTATTGAAGCTGCGGGTGTGCGCACCGCACAGTTCTACGGTTTGAGCGAAACGGGCTGCACCGCCTTGTGT
TTACCAACCGATAATGGATCAATCTCCAAAATCGAGGCTGGCGCTGTTGGACGTCCATACCCTGGTGTGGAAGTGTATCT
GGCAGATCCAAATGGTGGCGGACCCACTGTCGCAGACACTGCTTCTTCCGCATCCTTCGGCACGCTGTGGATTAAATCAC
CAGCAAACATGTTAGGGTACTGGAATAATCCGGAACGCACCCGAGAAATTCTAGTTGACGGGTGGGTGAACACCGGCGAC
CTTGTGGAGCGACGCGAGGACGGTTTCTTCTATATCAAAGGAAGATCCTCGGAGATGATCGTCTCCGGTGGAGTCAACAT
TGTGCCCGATGAGGTTGATCGCATCGCCGAAAGCGTTTCGGGCGTTGGTGAGGCCGCATGCTACGAAATACCCGATGCGC
ATTTCGGAGCGCTAGTCGGTTTGGCCGTAATCCCATCGGCAGAGCTGAACGAGTCAACAGCGATCGAGCTCAAACGAAGG
ATTGCGGCTCGTTATCGGCGTGAGTCGGAATCGATGGCGCGCCCGTCTAAGATCGTGATCGTTGCGGATATTCCTCGCAC
GCAGTCCGGCAAAGTCATCCGTGCAACACTAGCAGCAGCGCTGAACGGAGAGCAACTCGGAATGGTCGTTCGTGACTGA

Upstream 100 bases:

>100_bases
TCGAATTTTGGGACGATAACGGAGGGTCTGCGATAGGGGAATTCGAGGTCGCGATACTTAACATCCCGTAATTTACTTGT
AGGAGATTCGCTTTACAGCT

Downstream 100 bases:

>100_bases
GACAGCACGGGAAAGGATTCTCACGGCTGTCTGTGAGGTGTTGTACATAGCAGAATCAGATTTGGTTGACGGCGATGAAA
CCGATCTTCGCGACCTCGGG

Product: acyl-CoA synthetase

Products: NA

Alternate protein names: Long-chain acyl-CoA synthetase [H]

Number of amino acids: Translated: 532; Mature: 531

Protein sequence:

>532_residues
MSHLPPTVLERILKQAHERPEAIALRRSDGTSELRYGQLVAEVNGLAAHLSAQSVSQRSRVLVISDNGPETYLSVLACAK
LGAIAVMVDGNLPPATISRFSEICDPSAVLVARECRIDSSSLPEILHSIPAITVNTTADATYSACSLDIDYLAGNLNYGT
DDPLAMTFTSGTTGEPKAVLLPNRTFFAIPDILREKGLAWIDWVVNETTYSPLSATHIGGLWWILNCLMHGGLCITGGEH
TSSLTEVLNANKVATTCLVPTLLSKLVYELKFGDVVTPPLRLIVYGGSRVIAADVRFIEAAGVRTAQFYGLSETGCTALC
LPTDNGSISKIEAGAVGRPYPGVEVYLADPNGGGPTVADTASSASFGTLWIKSPANMLGYWNNPERTREILVDGWVNTGD
LVERREDGFFYIKGRSSEMIVSGGVNIVPDEVDRIAESVSGVGEAACYEIPDAHFGALVGLAVIPSAELNESTAIELKRR
IAARYRRESESMARPSKIVIVADIPRTQSGKVIRATLAAALNGEQLGMVVRD

Sequences:

>Translated_532_residues
MSHLPPTVLERILKQAHERPEAIALRRSDGTSELRYGQLVAEVNGLAAHLSAQSVSQRSRVLVISDNGPETYLSVLACAK
LGAIAVMVDGNLPPATISRFSEICDPSAVLVARECRIDSSSLPEILHSIPAITVNTTADATYSACSLDIDYLAGNLNYGT
DDPLAMTFTSGTTGEPKAVLLPNRTFFAIPDILREKGLAWIDWVVNETTYSPLSATHIGGLWWILNCLMHGGLCITGGEH
TSSLTEVLNANKVATTCLVPTLLSKLVYELKFGDVVTPPLRLIVYGGSRVIAADVRFIEAAGVRTAQFYGLSETGCTALC
LPTDNGSISKIEAGAVGRPYPGVEVYLADPNGGGPTVADTASSASFGTLWIKSPANMLGYWNNPERTREILVDGWVNTGD
LVERREDGFFYIKGRSSEMIVSGGVNIVPDEVDRIAESVSGVGEAACYEIPDAHFGALVGLAVIPSAELNESTAIELKRR
IAARYRRESESMARPSKIVIVADIPRTQSGKVIRATLAAALNGEQLGMVVRD
>Mature_531_residues
SHLPPTVLERILKQAHERPEAIALRRSDGTSELRYGQLVAEVNGLAAHLSAQSVSQRSRVLVISDNGPETYLSVLACAKL
GAIAVMVDGNLPPATISRFSEICDPSAVLVARECRIDSSSLPEILHSIPAITVNTTADATYSACSLDIDYLAGNLNYGTD
DPLAMTFTSGTTGEPKAVLLPNRTFFAIPDILREKGLAWIDWVVNETTYSPLSATHIGGLWWILNCLMHGGLCITGGEHT
SSLTEVLNANKVATTCLVPTLLSKLVYELKFGDVVTPPLRLIVYGGSRVIAADVRFIEAAGVRTAQFYGLSETGCTALCL
PTDNGSISKIEAGAVGRPYPGVEVYLADPNGGGPTVADTASSASFGTLWIKSPANMLGYWNNPERTREILVDGWVNTGDL
VERREDGFFYIKGRSSEMIVSGGVNIVPDEVDRIAESVSGVGEAACYEIPDAHFGALVGLAVIPSAELNESTAIELKRRI
AARYRRESESMARPSKIVIVADIPRTQSGKVIRATLAAALNGEQLGMVVRD

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI187761345, Length=395, Percent_Identity=27.5949367088608, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI187761343, Length=395, Percent_Identity=27.5949367088608, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI156151445, Length=559, Percent_Identity=24.5080500894454, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI38505220, Length=543, Percent_Identity=23.9410681399632, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI42544132, Length=493, Percent_Identity=22.3123732251521, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI115511026, Length=375, Percent_Identity=23.2, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI157311624, Length=487, Percent_Identity=23.4086242299795, Blast_Score=76, Evalue=9e-14,
Organism=Homo sapiens, GI157311622, Length=487, Percent_Identity=23.4086242299795, Blast_Score=76, Evalue=9e-14,
Organism=Homo sapiens, GI58082049, Length=484, Percent_Identity=22.7272727272727, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI122937307, Length=378, Percent_Identity=23.2804232804233, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1788107, Length=380, Percent_Identity=26.5789473684211, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI145693145, Length=519, Percent_Identity=24.2774566473988, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1790505, Length=580, Percent_Identity=22.2413793103448, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI1786810, Length=518, Percent_Identity=22.5868725868726, Blast_Score=76, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI32563687, Length=514, Percent_Identity=24.7081712062257, Blast_Score=149, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI17558820, Length=533, Percent_Identity=25.515947467167, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI71996755, Length=486, Percent_Identity=24.8971193415638, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17559526, Length=369, Percent_Identity=24.6612466124661, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17560308, Length=540, Percent_Identity=25, Blast_Score=95, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17531443, Length=555, Percent_Identity=22.5225225225225, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71985884, Length=371, Percent_Identity=24.2587601078167, Blast_Score=78, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI71994690, Length=309, Percent_Identity=25.2427184466019, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71994694, Length=309, Percent_Identity=25.2427184466019, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71994703, Length=309, Percent_Identity=25.2427184466019, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI115534440, Length=552, Percent_Identity=19.7463768115942, Blast_Score=69, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6319264, Length=555, Percent_Identity=24.6846846846847, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6319699, Length=359, Percent_Identity=24.7910863509749, Blast_Score=77, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6323182, Length=587, Percent_Identity=22.9982964224872, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24653035, Length=490, Percent_Identity=22.2448979591837, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI18859661, Length=516, Percent_Identity=23.2558139534884, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24648253, Length=533, Percent_Identity=22.5140712945591, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24648255, Length=533, Percent_Identity=22.5140712945591, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24648257, Length=537, Percent_Identity=23.463687150838, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI161076582, Length=506, Percent_Identity=21.3438735177866, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24581924, Length=380, Percent_Identity=26.5789473684211, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24648260, Length=520, Percent_Identity=23.0769230769231, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21356947, Length=534, Percent_Identity=23.0337078651685, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI20130357, Length=507, Percent_Identity=22.0907297830375, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI62472339, Length=564, Percent_Identity=22.1631205673759, Blast_Score=76, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24667955, Length=564, Percent_Identity=22.1631205673759, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI281365686, Length=351, Percent_Identity=24.7863247863248, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21355181, Length=221, Percent_Identity=26.6968325791855, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24667959, Length=394, Percent_Identity=24.3654822335025, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020459
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.3 [H]

Molecular weight: Translated: 56886; Mature: 56755

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHLPPTVLERILKQAHERPEAIALRRSDGTSELRYGQLVAEVNGLAAHLSAQSVSQRSR
CCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VLVISDNGPETYLSVLACAKLGAIAVMVDGNLPPATISRFSEICDPSAVLVARECRIDSS
EEEEECCCHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHCCCCCEEEEHCCCCCCC
SLPEILHSIPAITVNTTADATYSACSLDIDYLAGNLNYGTDDPLAMTFTSGTTGEPKAVL
HHHHHHHHCCCEEEECCCCCCCEEEEEEHHHEECCCCCCCCCCEEEEEECCCCCCCCEEE
LPNRTFFAIPDILREKGLAWIDWVVNETTYSPLSATHIGGLWWILNCLMHGGLCITGGEH
ECCCCEEECHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCEEEECCCC
TSSLTEVLNANKVATTCLVPTLLSKLVYELKFGDVVTPPLRLIVYGGSRVIAADVRFIEA
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCEEEEEEEEEEHH
AGVRTAQFYGLSETGCTALCLPTDNGSISKIEAGAVGRPYPGVEVYLADPNGGGPTVADT
CCCEEEEEECCCCCCCEEEEEECCCCCCEEEECCCCCCCCCCEEEEEECCCCCCCCCCCC
ASSASFGTLWIKSPANMLGYWNNPERTREILVDGWVNTGDLVERREDGFFYIKGRSSEMI
CCCCCCCEEEEECCHHHCCCCCCHHHHHHEEEECCCCCCHHHHHCCCCEEEEECCCCCEE
VSGGVNIVPDEVDRIAESVSGVGEAACYEIPDAHFGALVGLAVIPSAELNESTAIELKRR
EECCCEECCHHHHHHHHHHCCCCCHHEEECCCHHHHHHHHHHHCCCCCCCCHHHHHHHHH
IAARYRRESESMARPSKIVIVADIPRTQSGKVIRATLAAALNGEQLGMVVRD
HHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEHHHHCCCCCEEEEECC
>Mature Secondary Structure 
SHLPPTVLERILKQAHERPEAIALRRSDGTSELRYGQLVAEVNGLAAHLSAQSVSQRSR
CCCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VLVISDNGPETYLSVLACAKLGAIAVMVDGNLPPATISRFSEICDPSAVLVARECRIDSS
EEEEECCCHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHCCCCCEEEEHCCCCCCC
SLPEILHSIPAITVNTTADATYSACSLDIDYLAGNLNYGTDDPLAMTFTSGTTGEPKAVL
HHHHHHHHCCCEEEECCCCCCCEEEEEEHHHEECCCCCCCCCCEEEEEECCCCCCCCEEE
LPNRTFFAIPDILREKGLAWIDWVVNETTYSPLSATHIGGLWWILNCLMHGGLCITGGEH
ECCCCEEECHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCEEEECCCC
TSSLTEVLNANKVATTCLVPTLLSKLVYELKFGDVVTPPLRLIVYGGSRVIAADVRFIEA
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCEEEEEEEEEEHH
AGVRTAQFYGLSETGCTALCLPTDNGSISKIEAGAVGRPYPGVEVYLADPNGGGPTVADT
CCCEEEEEECCCCCCCEEEEEECCCCCCEEEECCCCCCCCCCEEEEEECCCCCCCCCCCC
ASSASFGTLWIKSPANMLGYWNNPERTREILVDGWVNTGDLVERREDGFFYIKGRSSEMI
CCCCCCCEEEEECCHHHCCCCCCHHHHHHEEEECCCCCCHHHHHCCCCEEEEECCCCCEE
VSGGVNIVPDEVDRIAESVSGVGEAACYEIPDAHFGALVGLAVIPSAELNESTAIELKRR
EECCCEECCHHHHHHHHHHCCCCCHHEEECCCHHHHHHHHHHHCCCCCCCCHHHHHHHHH
IAARYRRESESMARPSKIVIVADIPRTQSGKVIRATLAAALNGEQLGMVVRD
HHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEHHHHCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]