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The map label for this gene is PPE [H]

Identifier: 221230556

GI number: 221230556

Start: 2378419

End: 2379825

Strand: Direct

Name: PPE [H]

Synonym: MLBr_01991

Alternate gene names: 221230556

Gene position: 2378419-2379825 (Clockwise)

Preceding gene: 221230552

Following gene: 221230557

Centisome position: 72.78

GC content: 56.57

Gene sequence:

>1407_bases
ATGGCCATACCTCCGGAGGTGCACTCGGTTCTGTTAAGTGCTGGACAGGGGGCTGAATCATTGCTTGTTGCCGCTACTCA
GTGGCAGGAGCTTAGCAAACAATACACTTACGCAGCTGCCGAGCTGACTCGGCTGCTGACTCATGTTCAGGCCACCAGCT
GGCGGGGAACCAGCGCCACACGGTTTGTGGCGGCGCATGGTGCCTATCTGGTCTGGCTCGAACAAACTTCAATCAACAAC
GCAATCACCGCTAAACAGCATGAAATCGCGGCAATCGCTTACAGCAGCGCGCTAGCCGCCATGCCCACGTTGGCAGAACT
TACCGCTAACCGCGCAACTCGTGGTTTCTTGATTGCCACCAACTTCTTCGGCATCAATACCATTCCCATTGCCCTCAACG
AAGCCGACTACGTTCGGATGTGGGTGCAAGCCGCCGACACTATGGCGACCTACCAGGCCATCAGCGAGGCGGTGACGGCA
ACAATACTACCTACCCAAGTAGCGCCACCTATCCTTGCGCCGGGCAGCGCAACCCAAAACGTCCTGCAGTCCGTACCGGA
TTGGATTGTTCAACTACTGACGGACATCTTGGATTTTATCGCAGATCCATACAAATATTTTCTAAGATTTTTCCAACGAT
TGGGATTCAGACCCGCTATTGCTGTTGTCCTTGCCATTATTGCTTTGCAATTGTACGACTTTCTTTGGTATCCCTATTAT
GCCTCGTACGGAATGCTCTTGCTTCCCTTTTTCGCGCCGGCATTGAGCGTCCTGGGTACACTGTCCGTGTTGTGGAACGG
ACAGCTTTCAGCCGGACTGCCTCCCAATCCCGCAGGATCTCACCCAGACAATAACGCTGGCCCACGCATCCACGTTGGAG
TCGCGCCACCTGCCTCGGCTACTTCCAGTGGAAACTCATACACGAGCAACTCCGCACCCAGCACATCCGCATCGGCTACG
ACTGACAACCCCCTATCTTCACCCAGCATCAGATACGCCATACCCGGCTTGTCGCCACCAGAGGTCAGCTCTGGCCCCAA
AGCCGGCACAAAGTCACCTGACACTGCCACCAACACGATCGGGATCACTGCCGCGGCAAGAACAAACTCGCCTTCCGCCC
GGGCGCACCGTAAACGAGGAAACAAGACCAGAGGTGGCGCACGCGGTTACCGTTACGAATTCGTTGAAGGAACCGCCACC
ATGGCCGATACTGTCGACGCCCCCGACCACTCCGAACCCACGTCGCACACAATAAGTAACCACAGCGCCGGCCCCATCGG
CTTTGCCGGCACCGTGCCGACAACCGCCAGCACTCCCACCGGAATGGCTGCCAGTACAAGCAGTAGCGTCCCACTGCTCC
CCACTACCTGGATAACTGGCACCAGCGAAACGGCAGTACACGAATAG

Upstream 100 bases:

>100_bases
ACCAACACCGGGAAGTGACGGCAAAGCCATGCTTTGAGTGCATACAGTCGAGCGCTCTACACCCATGAAAGGAGGTGAAG
CTCTGACAGGCCCGATGTGG

Downstream 100 bases:

>100_bases
AGAAACTTTCACTAGCTTGTCCGACTGCTTACTCTTCGCATGAGCAAAATGCAACCGATTTTTCATCAAGGAGGTATGGA
TCGTGACGGCGAGAGATGCT

Product: PPE-family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MAIPPEVHSVLLSAGQGAESLLVAATQWQELSKQYTYAAAELTRLLTHVQATSWRGTSATRFVAAHGAYLVWLEQTSINN
AITAKQHEIAAIAYSSALAAMPTLAELTANRATRGFLIATNFFGINTIPIALNEADYVRMWVQAADTMATYQAISEAVTA
TILPTQVAPPILAPGSATQNVLQSVPDWIVQLLTDILDFIADPYKYFLRFFQRLGFRPAIAVVLAIIALQLYDFLWYPYY
ASYGMLLLPFFAPALSVLGTLSVLWNGQLSAGLPPNPAGSHPDNNAGPRIHVGVAPPASATSSGNSYTSNSAPSTSASAT
TDNPLSSPSIRYAIPGLSPPEVSSGPKAGTKSPDTATNTIGITAAARTNSPSARAHRKRGNKTRGGARGYRYEFVEGTAT
MADTVDAPDHSEPTSHTISNHSAGPIGFAGTVPTTASTPTGMAASTSSSVPLLPTTWITGTSETAVHE

Sequences:

>Translated_468_residues
MAIPPEVHSVLLSAGQGAESLLVAATQWQELSKQYTYAAAELTRLLTHVQATSWRGTSATRFVAAHGAYLVWLEQTSINN
AITAKQHEIAAIAYSSALAAMPTLAELTANRATRGFLIATNFFGINTIPIALNEADYVRMWVQAADTMATYQAISEAVTA
TILPTQVAPPILAPGSATQNVLQSVPDWIVQLLTDILDFIADPYKYFLRFFQRLGFRPAIAVVLAIIALQLYDFLWYPYY
ASYGMLLLPFFAPALSVLGTLSVLWNGQLSAGLPPNPAGSHPDNNAGPRIHVGVAPPASATSSGNSYTSNSAPSTSASAT
TDNPLSSPSIRYAIPGLSPPEVSSGPKAGTKSPDTATNTIGITAAARTNSPSARAHRKRGNKTRGGARGYRYEFVEGTAT
MADTVDAPDHSEPTSHTISNHSAGPIGFAGTVPTTASTPTGMAASTSSSVPLLPTTWITGTSETAVHE
>Mature_467_residues
AIPPEVHSVLLSAGQGAESLLVAATQWQELSKQYTYAAAELTRLLTHVQATSWRGTSATRFVAAHGAYLVWLEQTSINNA
ITAKQHEIAAIAYSSALAAMPTLAELTANRATRGFLIATNFFGINTIPIALNEADYVRMWVQAADTMATYQAISEAVTAT
ILPTQVAPPILAPGSATQNVLQSVPDWIVQLLTDILDFIADPYKYFLRFFQRLGFRPAIAVVLAIIALQLYDFLWYPYYA
SYGMLLLPFFAPALSVLGTLSVLWNGQLSAGLPPNPAGSHPDNNAGPRIHVGVAPPASATSSGNSYTSNSAPSTSASATT
DNPLSSPSIRYAIPGLSPPEVSSGPKAGTKSPDTATNTIGITAAARTNSPSARAHRKRGNKTRGGARGYRYEFVEGTATM
ADTVDAPDHSEPTSHTISNHSAGPIGFAGTVPTTASTPTGMAASTSSSVPLLPTTWITGTSETAVHE

Specific function: Unknown

COG id: COG5651

COG function: function code N; PPE-repeat proteins

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mycobacterial PPE family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000030 [H]

Pfam domain/function: PF00823 PPE [H]

EC number: NA

Molecular weight: Translated: 49287; Mature: 49156

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIPPEVHSVLLSAGQGAESLLVAATQWQELSKQYTYAAAELTRLLTHVQATSWRGTSAT
CCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
RFVAAHGAYLVWLEQTSINNAITAKQHEIAAIAYSSALAAMPTLAELTANRATRGFLIAT
EEEEECCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
NFFGINTIPIALNEADYVRMWVQAADTMATYQAISEAVTATILPTQVAPPILAPGSATQN
ECCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCHHHH
VLQSVPDWIVQLLTDILDFIADPYKYFLRFFQRLGFRPAIAVVLAIIALQLYDFLWYPYY
HHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
ASYGMLLLPFFAPALSVLGTLSVLWNGQLSAGLPPNPAGSHPDNNAGPRIHVGVAPPASA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCC
TSSGNSYTSNSAPSTSASATTDNPLSSPSIRYAIPGLSPPEVSSGPKAGTKSPDTATNTI
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCEE
GITAAARTNSPSARAHRKRGNKTRGGARGYRYEFVEGTATMADTVDAPDHSEPTSHTISN
EEEEEECCCCCHHHHHHHCCCCCCCCCCCCEEEEECCCHHHHHCCCCCCCCCCCCCCCCC
HSAGPIGFAGTVPTTASTPTGMAASTSSSVPLLPTTWITGTSETAVHE
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCHHCCCC
>Mature Secondary Structure 
AIPPEVHSVLLSAGQGAESLLVAATQWQELSKQYTYAAAELTRLLTHVQATSWRGTSAT
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
RFVAAHGAYLVWLEQTSINNAITAKQHEIAAIAYSSALAAMPTLAELTANRATRGFLIAT
EEEEECCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
NFFGINTIPIALNEADYVRMWVQAADTMATYQAISEAVTATILPTQVAPPILAPGSATQN
ECCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCHHHH
VLQSVPDWIVQLLTDILDFIADPYKYFLRFFQRLGFRPAIAVVLAIIALQLYDFLWYPYY
HHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
ASYGMLLLPFFAPALSVLGTLSVLWNGQLSAGLPPNPAGSHPDNNAGPRIHVGVAPPASA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCC
TSSGNSYTSNSAPSTSASATTDNPLSSPSIRYAIPGLSPPEVSSGPKAGTKSPDTATNTI
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCEE
GITAAARTNSPSARAHRKRGNKTRGGARGYRYEFVEGTATMADTVDAPDHSEPTSHTISN
EEEEEECCCCCHHHHHHHCCCCCCCCCCCCEEEEECCCHHHHHCCCCCCCCCCCCCCCCC
HSAGPIGFAGTVPTTASTPTGMAASTSSSVPLLPTTWITGTSETAVHE
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]