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The map label for this gene is mutY [H]

Identifier: 221230508

GI number: 221230508

Start: 2303330

End: 2304223

Strand: Direct

Name: mutY [H]

Synonym: MLBr_01920

Alternate gene names: 221230508

Gene position: 2303330-2304223 (Clockwise)

Preceding gene: 221230505

Following gene: 221230510

Centisome position: 70.48

GC content: 62.42

Gene sequence:

>894_bases
ATGGCACACATTGTGCCTCAGATAAAAATTTCGACCGGCGGGTTGCTCGACTGGTACCGACAATCGTGCCGTGATTTGCC
CTGGCGACAGCCCGGCGTCACCGCATGGCAGATCCTGGTCAGCGAGTTCATGTTGCAGCAGACACCAGTGGCCCGGGTGT
TGTCGATCTGGCCGGATTGGGTGCAGCGCTGGCCCACACCGTCGACTACCGCCGCAGCTAGCGCAGCAGACGTACTACGT
GCCTGGGGCAAGCTGGGCTACCCGAGGCGGGCAAAGCGCTTACACGAGTCCGCTACCATCATCGCACGTGAACACGATGA
TGTGGTTCCTGATGACGTCGATGTCTTGCTGACCATGCCAGGCATCGGCAGCTACACTGCACGAGCCGTCGCGTGCTTCG
CTTACCATCAGCCGGTTCCAGTGGTGGACACCAATGTACGTCGCGTGGTGGCCCGTGCCGTGCATGGCCGAGCGGACGCC
GGCCCGCCATCTGCAACGCGCGACCATGCCGACGTCTCGTCACTGCTGCCGGGCAAGAAAGCTGCGCCGCAATTTTCTAT
GGCGCTGATGGAGTTAGGCGCGATCGTGTGCACGGCCCGGTCGCCGCGATGCGGGTTGTGCCCACTCAACGAATGCGCAT
GGCGGCATGCCGGCTATCCGCCCGCACAAGGGCCAGCGCGGCGCGCGCAACAATACGCAGGAACTGACCGCCAGGTTCGC
GGTCTGTTGCTGGATGTGTTGCGCGCCAAGGATTCTCCAGTTACCGGCACAGAGCTTAACGTGACCTGGTTAACCAACTC
CATCCAACTTGACCGGGCGCTCGATTCGTTGCTTGCCGACGGCCTGGTGACCCGAACAACTGATGGCCGGTTCGCTTTGA
CTGGCGAGGGGTGA

Upstream 100 bases:

>100_bases
ATGCTCGACGCTCTGGCTGGGATGTGCCGGTTGGCCGGCGACAAATCGCTCGTTACCCTCTTTGAGTGCTTTCCAAGCTG
CTATGGGGTTGGTGTTAAAC

Downstream 100 bases:

>100_bases
ATACTTTATCAATCACGCCCAGCGCAGCCCGCTAAGAAAGACACGACAGCCTGCCGATATACCTGCGTCGCTTCATCGTG
AATCAGATGACCGGCTTCGG

Product: putative DNA glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MAHIVPQIKISTGGLLDWYRQSCRDLPWRQPGVTAWQILVSEFMLQQTPVARVLSIWPDWVQRWPTPSTTAAASAADVLR
AWGKLGYPRRAKRLHESATIIAREHDDVVPDDVDVLLTMPGIGSYTARAVACFAYHQPVPVVDTNVRRVVARAVHGRADA
GPPSATRDHADVSSLLPGKKAAPQFSMALMELGAIVCTARSPRCGLCPLNECAWRHAGYPPAQGPARRAQQYAGTDRQVR
GLLLDVLRAKDSPVTGTELNVTWLTNSIQLDRALDSLLADGLVTRTTDGRFALTGEG

Sequences:

>Translated_297_residues
MAHIVPQIKISTGGLLDWYRQSCRDLPWRQPGVTAWQILVSEFMLQQTPVARVLSIWPDWVQRWPTPSTTAAASAADVLR
AWGKLGYPRRAKRLHESATIIAREHDDVVPDDVDVLLTMPGIGSYTARAVACFAYHQPVPVVDTNVRRVVARAVHGRADA
GPPSATRDHADVSSLLPGKKAAPQFSMALMELGAIVCTARSPRCGLCPLNECAWRHAGYPPAQGPARRAQQYAGTDRQVR
GLLLDVLRAKDSPVTGTELNVTWLTNSIQLDRALDSLLADGLVTRTTDGRFALTGEG
>Mature_296_residues
AHIVPQIKISTGGLLDWYRQSCRDLPWRQPGVTAWQILVSEFMLQQTPVARVLSIWPDWVQRWPTPSTTAAASAADVLRA
WGKLGYPRRAKRLHESATIIAREHDDVVPDDVDVLLTMPGIGSYTARAVACFAYHQPVPVVDTNVRRVVARAVHGRADAG
PPSATRDHADVSSLLPGKKAAPQFSMALMELGAIVCTARSPRCGLCPLNECAWRHAGYPPAQGPARRAQQYAGTDRQVRG
LLLDVLRAKDSPVTGTELNVTWLTNSIQLDRALDSLLADGLVTRTTDGRFALTGEG

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HhH domain [H]

Homologues:

Organism=Homo sapiens, GI115298654, Length=217, Percent_Identity=39.1705069124424, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI115298652, Length=217, Percent_Identity=39.1705069124424, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI115298650, Length=217, Percent_Identity=39.1705069124424, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI115298648, Length=217, Percent_Identity=39.1705069124424, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI190358497, Length=217, Percent_Identity=39.1705069124424, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI6912520, Length=217, Percent_Identity=39.1705069124424, Blast_Score=133, Evalue=2e-31,
Organism=Escherichia coli, GI1789331, Length=218, Percent_Identity=33.4862385321101, Blast_Score=124, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 32410; Mature: 32279

Theoretical pI: Translated: 9.05; Mature: 9.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHIVPQIKISTGGLLDWYRQSCRDLPWRQPGVTAWQILVSEFMLQQTPVARVLSIWPDW
CCCCCCEEEECCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCHHH
VQRWPTPSTTAAASAADVLRAWGKLGYPRRAKRLHESATIIAREHDDVVPDDVDVLLTMP
HHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHEEEEECCCCCCCCCCEEEEECC
GIGSYTARAVACFAYHQPVPVVDTNVRRVVARAVHGRADAGPPSATRDHADVSSLLPGKK
CCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCC
AAPQFSMALMELGAIVCTARSPRCGLCPLNECAWRHAGYPPAQGPARRAQQYAGTDRQVR
CCHHHHHHHHHHHHHEEECCCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHH
GLLLDVLRAKDSPVTGTELNVTWLTNSIQLDRALDSLLADGLVTRTTDGRFALTGEG
HHHHHHHHCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCEEECCCCCEEEECCC
>Mature Secondary Structure 
AHIVPQIKISTGGLLDWYRQSCRDLPWRQPGVTAWQILVSEFMLQQTPVARVLSIWPDW
CCCCCEEEECCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCHHH
VQRWPTPSTTAAASAADVLRAWGKLGYPRRAKRLHESATIIAREHDDVVPDDVDVLLTMP
HHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHEEEEECCCCCCCCCCEEEEECC
GIGSYTARAVACFAYHQPVPVVDTNVRRVVARAVHGRADAGPPSATRDHADVSSLLPGKK
CCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCC
AAPQFSMALMELGAIVCTARSPRCGLCPLNECAWRHAGYPPAQGPARRAQQYAGTDRQVR
CCHHHHHHHHHHHHHEEECCCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHH
GLLLDVLRAKDSPVTGTELNVTWLTNSIQLDRALDSLLADGLVTRTTDGRFALTGEG
HHHHHHHHCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCEEECCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]