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The map label for this gene is ilvC [H]

Identifier: 221230378

GI number: 221230378

Start: 2042647

End: 2043648

Strand: Reverse

Name: ilvC [H]

Synonym: MLBr_01694

Alternate gene names: 221230378

Gene position: 2043648-2042647 (Counterclockwise)

Preceding gene: 221230379

Following gene: 221230377

Centisome position: 62.53

GC content: 58.98

Gene sequence:

>1002_bases
TTGTTCTACGACGACAATGCAGATCTGTCGATCATTCAGCGACGCAAAGTCGGCGTGATCGGATACGGCAGCCAGGGGTA
CGCGCACTCGCTGAGTCTGCGCGATTCTGGTGTCCAGGTGCGGGTCGGTCTGCCGGAGGGCTCGAAGTCTCGGCCTAAGG
CCTTCGAGCAGGGCCTGGACGTCGATACCCCTGCCGAGGTCGCCAAGTGGGCCGATGTCATCATGCTGTTGGTGCCTGAC
ACTGCGCAGGCGGACGTCTTTGAAAACGATATCGAGCCCAACCTCCAGCCTGGCGATGCTTTGTTTTTCGGTCATGGACT
CAACATTCACTTCGAACTGGTCAAGCCGTCGGGCGATGTGACCGTCGCGATGGTCGCACCGAAGGGTCCCGGCTACCTGG
TGCGCCGCCAGTTCGTTGATGGCAAGGGTGTGCCCTGCCTGATCGCCGTTAACCAAGACCCGACCGGCACCGGCGAGGCG
CTGGCGTTGTCTTACGCTAAAGCTATCGGCGGCACCCGTGCCGGCGTCATCAAGACTACCTTCAAAGACGAGACAGAAAC
TGATCTTTTCGGTGAGCAGGCCGTATTATGCGGTGGTACAGAGGAATTGGTGAAGGCAGGTTTCGACGTCATGGTCGAAG
CGGGCTACCCTCCCGAGATGGCGTACTTCGAGGTGCTGCACGAACTTAAGCTGATCGTCGATCTGATGTACGAGGGCGGG
ATCGCGCGGATGAACTACTCGGTGTCTGACACCGCTGAGTTTGGTGGGTACCTGTCAGGTCCGCGTGTCATCGATGCTGA
CACCAAGGAGCGGATGCGCGGCATTCTGCGCGACATCCAGGACGGCAGTTTCGTCAAGAAGCTGGTCGCCAACGTTGAGG
GCGGAAACAAGCAACTCGAAGTGCTCCGTAAGGAAAACGCCGAACATCCCATCGAGGTTACCGGCAAAAAGTTGCGCGAC
CTGATGAGCTGGGTTGACCGCCAGAGCACCGAGACCGCATAA

Upstream 100 bases:

>100_bases
GTGGTCTCGTTATCTCGCGGTCCGCGCGGTATCGGCACAGTCAGGTAGCTAACACGAAGGAGATAGTCACGTGGCAGACG
TTTTGGATGAGTCACTATCA

Downstream 100 bases:

>100_bases
CGTAGCGCTCTCTCGGGGTTGAATTGTACTTTGTGTGCATGTTCTGTTGTGGGGGTGGAGTAAAGGGTGGCGGTGTGTTG
CAGTGTTGTGAGTTGATGTG

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase [H]

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MFYDDNADLSIIQRRKVGVIGYGSQGYAHSLSLRDSGVQVRVGLPEGSKSRPKAFEQGLDVDTPAEVAKWADVIMLLVPD
TAQADVFENDIEPNLQPGDALFFGHGLNIHFELVKPSGDVTVAMVAPKGPGYLVRRQFVDGKGVPCLIAVNQDPTGTGEA
LALSYAKAIGGTRAGVIKTTFKDETETDLFGEQAVLCGGTEELVKAGFDVMVEAGYPPEMAYFEVLHELKLIVDLMYEGG
IARMNYSVSDTAEFGGYLSGPRVIDADTKERMRGILRDIQDGSFVKKLVANVEGGNKQLEVLRKENAEHPIEVTGKKLRD
LMSWVDRQSTETA

Sequences:

>Translated_333_residues
MFYDDNADLSIIQRRKVGVIGYGSQGYAHSLSLRDSGVQVRVGLPEGSKSRPKAFEQGLDVDTPAEVAKWADVIMLLVPD
TAQADVFENDIEPNLQPGDALFFGHGLNIHFELVKPSGDVTVAMVAPKGPGYLVRRQFVDGKGVPCLIAVNQDPTGTGEA
LALSYAKAIGGTRAGVIKTTFKDETETDLFGEQAVLCGGTEELVKAGFDVMVEAGYPPEMAYFEVLHELKLIVDLMYEGG
IARMNYSVSDTAEFGGYLSGPRVIDADTKERMRGILRDIQDGSFVKKLVANVEGGNKQLEVLRKENAEHPIEVTGKKLRD
LMSWVDRQSTETA
>Mature_333_residues
MFYDDNADLSIIQRRKVGVIGYGSQGYAHSLSLRDSGVQVRVGLPEGSKSRPKAFEQGLDVDTPAEVAKWADVIMLLVPD
TAQADVFENDIEPNLQPGDALFFGHGLNIHFELVKPSGDVTVAMVAPKGPGYLVRRQFVDGKGVPCLIAVNQDPTGTGEA
LALSYAKAIGGTRAGVIKTTFKDETETDLFGEQAVLCGGTEELVKAGFDVMVEAGYPPEMAYFEVLHELKLIVDLMYEGG
IARMNYSVSDTAEFGGYLSGPRVIDADTKERMRGILRDIQDGSFVKKLVANVEGGNKQLEVLRKENAEHPIEVTGKKLRD
LMSWVDRQSTETA

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family [H]

Homologues:

Organism=Escherichia coli, GI1790210, Length=327, Percent_Identity=35.7798165137615, Blast_Score=153, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6323387, Length=234, Percent_Identity=34.1880341880342, Blast_Score=112, Evalue=8e-26,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116 [H]

Pfam domain/function: PF01450 IlvC; PF07991 IlvN [H]

EC number: =1.1.1.86 [H]

Molecular weight: Translated: 36217; Mature: 36217

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFYDDNADLSIIQRRKVGVIGYGSQGYAHSLSLRDSGVQVRVGLPEGSKSRPKAFEQGLD
CCCCCCCCEEEEEECCCCEEEECCCCCEEEEEEECCCEEEEEECCCCCCCCCHHHHCCCC
VDTPAEVAKWADVIMLLVPDTAQADVFENDIEPNLQPGDALFFGHGLNIHFELVKPSGDV
CCCHHHHHHHHCEEEEEECCCCCCHHHHCCCCCCCCCCCEEEEECCCEEEEEEECCCCCE
TVAMVAPKGPGYLVRRQFVDGKGVPCLIAVNQDPTGTGEALALSYAKAIGGTRAGVIKTT
EEEEECCCCCCEEEEEEECCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCEEEEE
FKDETETDLFGEQAVLCGGTEELVKAGFDVMVEAGYPPEMAYFEVLHELKLIVDLMYEGG
CCCCCCHHHCCCCEEEECCHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCC
IARMNYSVSDTAEFGGYLSGPRVIDADTKERMRGILRDIQDGSFVKKLVANVEGGNKQLE
EEEEECCCCCHHHHCCCCCCCEEECCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHH
VLRKENAEHPIEVTGKKLRDLMSWVDRQSTETA
HHHHCCCCCCHHHCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MFYDDNADLSIIQRRKVGVIGYGSQGYAHSLSLRDSGVQVRVGLPEGSKSRPKAFEQGLD
CCCCCCCCEEEEEECCCCEEEECCCCCEEEEEEECCCEEEEEECCCCCCCCCHHHHCCCC
VDTPAEVAKWADVIMLLVPDTAQADVFENDIEPNLQPGDALFFGHGLNIHFELVKPSGDV
CCCHHHHHHHHCEEEEEECCCCCCHHHHCCCCCCCCCCCEEEEECCCEEEEEEECCCCCE
TVAMVAPKGPGYLVRRQFVDGKGVPCLIAVNQDPTGTGEALALSYAKAIGGTRAGVIKTT
EEEEECCCCCCEEEEEEECCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCEEEEE
FKDETETDLFGEQAVLCGGTEELVKAGFDVMVEAGYPPEMAYFEVLHELKLIVDLMYEGG
CCCCCCHHHCCCCEEEECCHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCC
IARMNYSVSDTAEFGGYLSGPRVIDADTKERMRGILRDIQDGSFVKKLVANVEGGNKQLE
EEEEECCCCCHHHHCCCCCCCEEECCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHH
VLRKENAEHPIEVTGKKLRDLMSWVDRQSTETA
HHHHCCCCCCHHHCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA