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The map label for this gene is pyrH [H]

Identifier: 221230312

GI number: 221230312

Start: 1915409

End: 1916248

Strand: Reverse

Name: pyrH [H]

Synonym: MLBr_01591

Alternate gene names: 221230312

Gene position: 1916248-1915409 (Counterclockwise)

Preceding gene: 221230313

Following gene: 221230311

Centisome position: 58.64

GC content: 60.12

Gene sequence:

>840_bases
ATGACGGAGTCCTGGGAGTCTCAAGTCGCCGGCTCGGCGGTTCCCAAGCCACAGCTGATGAGCGCCAATGGTGTGTCGGC
TGCTGCAGCGGGCCGTGGAGAACGGCTCAACCATGCTGGTAACCCGGGGCATCGGTCTAAGTATTCGAGGGTGCTGCTTA
AACTTGGCGGAGAAATGTTCGGTGGAGGCCAGGTAGGGCTGGATCTCGATGTTGTGGCGCAGGTGGCCCGCCAGATCGCC
GAGGTGGTCCGCGGCGGCGTGCAGGTCGCTGTCGTGATCGGCGGTGGCAACTTTTTCCGCGGCGCACAATTGCAACAGCG
TGGGATGGAGCGCACGCGTTCGGATTACATGGGCATGCTCGGTACTGTGATGAACAGCCTTGCACTGCAGGACTTCCTGG
AAAAAGAAGGCATCGCCACCCGAGTTCAAACTGCGATCACCATGGGCCAGGTGGCTGAGCCTTATCTTCCTTTGCGGGCT
GTCCGCCACTTAGAGAAGGGCCGGGTGGTAATTTTCGGTGCAGGCATGGGGCTTCCGTACTTCTCCACTGATACCACGGC
AGCGCAGCGGGCACTGGAGATCGGCGCGGACGTTGTGTTGATGGCCAAGGCGGTCGACGGTGTGTTCGTCGAGGATCCGC
GGGTCAACCCGGAGGCCGAGCTACTCACCGCGATCAGTCACCGCGAAGTAATCGACCGTGGGCTTCGGGTAGCTGATGCC
ACAGCGTTCAGTCTTTGTATGGACAATGGCATGCCGATCCTGGTGTTCAATCTGCTGACCAATGGCAATATCGCCCGTGC
GGTCGCTGGTGAGAAGATCGGGACGTTGGTTACCACTTAA

Upstream 100 bases:

>100_bases
ATAATGCACCCCGTTCATGCTTGAGTGTGGTGATGGGGCAGGATGTCAAATGCCGTTCCGGATGGTGGCCCGGGGTGGCA
ATTGTCATGCGAGGAGTCTG

Downstream 100 bases:

>100_bases
GGCAAAGACGCCGCGCCGGTGACGATGCAGAGCGCAGCGATGAGGAGGAACGGCGCGAATGATCGATGAAGCTCTTTTCG
ATGCAGAAGAGAAAATGGAG

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK [H]

Number of amino acids: Translated: 279; Mature: 278

Protein sequence:

>279_residues
MTESWESQVAGSAVPKPQLMSANGVSAAAAGRGERLNHAGNPGHRSKYSRVLLKLGGEMFGGGQVGLDLDVVAQVARQIA
EVVRGGVQVAVVIGGGNFFRGAQLQQRGMERTRSDYMGMLGTVMNSLALQDFLEKEGIATRVQTAITMGQVAEPYLPLRA
VRHLEKGRVVIFGAGMGLPYFSTDTTAAQRALEIGADVVLMAKAVDGVFVEDPRVNPEAELLTAISHREVIDRGLRVADA
TAFSLCMDNGMPILVFNLLTNGNIARAVAGEKIGTLVTT

Sequences:

>Translated_279_residues
MTESWESQVAGSAVPKPQLMSANGVSAAAAGRGERLNHAGNPGHRSKYSRVLLKLGGEMFGGGQVGLDLDVVAQVARQIA
EVVRGGVQVAVVIGGGNFFRGAQLQQRGMERTRSDYMGMLGTVMNSLALQDFLEKEGIATRVQTAITMGQVAEPYLPLRA
VRHLEKGRVVIFGAGMGLPYFSTDTTAAQRALEIGADVVLMAKAVDGVFVEDPRVNPEAELLTAISHREVIDRGLRVADA
TAFSLCMDNGMPILVFNLLTNGNIARAVAGEKIGTLVTT
>Mature_278_residues
TESWESQVAGSAVPKPQLMSANGVSAAAAGRGERLNHAGNPGHRSKYSRVLLKLGGEMFGGGQVGLDLDVVAQVARQIAE
VVRGGVQVAVVIGGGNFFRGAQLQQRGMERTRSDYMGMLGTVMNSLALQDFLEKEGIATRVQTAITMGQVAEPYLPLRAV
RHLEKGRVVIFGAGMGLPYFSTDTTAAQRALEIGADVVLMAKAVDGVFVEDPRVNPEAELLTAISHREVIDRGLRVADAT
AFSLCMDNGMPILVFNLLTNGNIARAVAGEKIGTLVTT

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP [H]

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786367, Length=232, Percent_Identity=46.1206896551724, Blast_Score=203, Evalue=1e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963 [H]

Pfam domain/function: PF00696 AA_kinase [H]

EC number: =2.7.4.22 [H]

Molecular weight: Translated: 29549; Mature: 29417

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTESWESQVAGSAVPKPQLMSANGVSAAAAGRGERLNHAGNPGHRSKYSRVLLKLGGEMF
CCCCHHHHHCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCC
GGGQVGLDLDVVAQVARQIAEVVRGGVQVAVVIGGGNFFRGAQLQQRGMERTRSDYMGML
CCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
GTVMNSLALQDFLEKEGIATRVQTAITMGQVAEPYLPLRAVRHLEKGRVVIFGAGMGLPY
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEECCCCCCC
FSTDTTAAQRALEIGADVVLMAKAVDGVFVEDPRVNPEAELLTAISHREVIDRGLRVADA
CCCCHHHHHHHHHHCCCCEEEEHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHH
TAFSLCMDNGMPILVFNLLTNGNIARAVAGEKIGTLVTT
HHHHHHHCCCCEEEEEEECCCCCCHHHHHCCHHHHCCCC
>Mature Secondary Structure 
TESWESQVAGSAVPKPQLMSANGVSAAAAGRGERLNHAGNPGHRSKYSRVLLKLGGEMF
CCCHHHHHCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCC
GGGQVGLDLDVVAQVARQIAEVVRGGVQVAVVIGGGNFFRGAQLQQRGMERTRSDYMGML
CCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
GTVMNSLALQDFLEKEGIATRVQTAITMGQVAEPYLPLRAVRHLEKGRVVIFGAGMGLPY
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEECCCCCCC
FSTDTTAAQRALEIGADVVLMAKAVDGVFVEDPRVNPEAELLTAISHREVIDRGLRVADA
CCCCHHHHHHHHHHCCCCEEEEHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHH
TAFSLCMDNGMPILVFNLLTNGNIARAVAGEKIGTLVTT
HHHHHHHCCCCEEEEEEECCCCCCHHHHHCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]