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The map label for this gene is thyX

Identifier: 221230275

GI number: 221230275

Start: 1825568

End: 1826332

Strand: Reverse

Name: thyX

Synonym: MLBr_01514

Alternate gene names: 221230275

Gene position: 1826332-1825568 (Counterclockwise)

Preceding gene: 221230276

Following gene: 221230274

Centisome position: 55.88

GC content: 60.92

Gene sequence:

>765_bases
GTGGCCCAGATCGCGCCGCTACGCGTGCAACTAATTGCCAAGACTGAGTTTCTGGCGCCTCCTGACGTGTCGTGGACTAC
CGACGCCGACGGTGGTTCCGCGCTGGTCGAATTCGCCGGTCGCGCCTGTTATCAGAGCTGGTCGAAGCCCAATCCCCGGA
CCGCGACCAACGCCGCGTACATTAAACACATCATTGACGTCGGGCATGTTGCGGTGCTCGAGCATGCCAGCGTTTCGTTC
TATATCAGCGGCATCTCGCGATCATGCACTCACGAGCTGATCCGACATCGGCATTTCTCCTACTCTCAGCTGTCGCAGCG
CTACGTGCCGGAAAAGGATGCCCAGGTCGTTGTGCCACCGGACATGGAGGATGACGACGAACTTCAACAGATTCTGATTG
CGGCCGTAGAGGCCAGCCGGGCCACCTACACTGAACTGCTGGTCAAGCTGAACGCCAAGTTAATGGCCGGTGAGCTCGGC
GGGAATAGGGCGGTGTTGCGGCGCAAGCAAGCTCGCCAAGCTGCCCACGCGGTGCTGCCCAACGCCAACGAGACCCGGAT
CGTTGTGACCGGGAACTACCGGGCATGGCGGCACTTCATCGCCATGCGGGCCAGCGAGCACGCCGACGTCGAAATCCGGC
GGCTGGCCATTGTCTGCCTGCGCCGGCTCGTCGACGTTGCGCCCGCAGTATTCGCTGATTTCGAGATCACCGCACTTGCT
GATGGTACTGAGGTCGCAACTAGTCCTTTAGCCACCGAAGCTTGA

Upstream 100 bases:

>100_bases
ACGCAAGTTCCGTAGAGAACTTGGCCCGGACCCGGCCTGATTGCCGGGCGTTTCTCGTGTCGCTCTACAGCGTGCATCGC
CCCTGGCTAAGGTGAGTGCT

Downstream 100 bases:

>100_bases
TTCCTAGGGCCGTCGCCAGCGTCCGTGGAGGTACAACTCAGGCGGCGTGTTGCTGGACAAACACGCGCCCTTGCGCGGTT
GCTGAAAGCTTGGCATCGCC

Product: FAD-dependent thymidylate synthase

Products: NA

Alternate protein names: TS; TSase

Number of amino acids: Translated: 254; Mature: 253

Protein sequence:

>254_residues
MAQIAPLRVQLIAKTEFLAPPDVSWTTDADGGSALVEFAGRACYQSWSKPNPRTATNAAYIKHIIDVGHVAVLEHASVSF
YISGISRSCTHELIRHRHFSYSQLSQRYVPEKDAQVVVPPDMEDDDELQQILIAAVEASRATYTELLVKLNAKLMAGELG
GNRAVLRRKQARQAAHAVLPNANETRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIVCLRRLVDVAPAVFADFEITALA
DGTEVATSPLATEA

Sequences:

>Translated_254_residues
MAQIAPLRVQLIAKTEFLAPPDVSWTTDADGGSALVEFAGRACYQSWSKPNPRTATNAAYIKHIIDVGHVAVLEHASVSF
YISGISRSCTHELIRHRHFSYSQLSQRYVPEKDAQVVVPPDMEDDDELQQILIAAVEASRATYTELLVKLNAKLMAGELG
GNRAVLRRKQARQAAHAVLPNANETRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIVCLRRLVDVAPAVFADFEITALA
DGTEVATSPLATEA
>Mature_253_residues
AQIAPLRVQLIAKTEFLAPPDVSWTTDADGGSALVEFAGRACYQSWSKPNPRTATNAAYIKHIIDVGHVAVLEHASVSFY
ISGISRSCTHELIRHRHFSYSQLSQRYVPEKDAQVVVPPDMEDDDELQQILIAAVEASRATYTELLVKLNAKLMAGELGG
NRAVLRRKQARQAAHAVLPNANETRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIVCLRRLVDVAPAVFADFEITALAD
GTEVATSPLATEA

Specific function: Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate

COG id: COG1351

COG function: function code F; Predicted alternative thymidylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thyX (flavin-dependent thymidylate synthase) domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): THYX_MYCLB (B8ZRR4)

Other databases:

- EMBL:   FM211192
- RefSeq:   YP_002503691.1
- ProteinModelPortal:   B8ZRR4
- SMR:   B8ZRR4
- EnsemblBacteria:   EBMYCT00000086337
- GeneID:   7326158
- GenomeReviews:   FM211192_GR
- GeneTree:   EBGT00050000016797
- HOGENOM:   HBG458114
- OMA:   RATEHAD
- ProtClustDB:   PRK00847
- HAMAP:   MF_01408
- InterPro:   IPR003669
- TIGRFAMs:   TIGR02170

Pfam domain/function: PF02511 Thy1; SSF69796 Thy1

EC number: =2.1.1.148

Molecular weight: Translated: 27967; Mature: 27836

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: PS51331 THYX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQIAPLRVQLIAKTEFLAPPDVSWTTDADGGSALVEFAGRACYQSWSKPNPRTATNAAY
CCCCCCHHEEEEEHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHH
IKHIIDVGHVAVLEHASVSFYISGISRSCTHELIRHRHFSYSQLSQRYVPEKDAQVVVPP
HHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHCCCCHHHHHHHCCCCCCCEEEECC
DMEDDDELQQILIAAVEASRATYTELLVKLNAKLMAGELGGNRAVLRRKQARQAAHAVLP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECCCCCHHHHHHHHHHHHHHHHCC
NANETRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIVCLRRLVDVAPAVFADFEITALA
CCCCCEEEEECCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEC
DGTEVATSPLATEA
CCCHHHCCCCCCCC
>Mature Secondary Structure 
AQIAPLRVQLIAKTEFLAPPDVSWTTDADGGSALVEFAGRACYQSWSKPNPRTATNAAY
CCCCCHHEEEEEHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHH
IKHIIDVGHVAVLEHASVSFYISGISRSCTHELIRHRHFSYSQLSQRYVPEKDAQVVVPP
HHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHCCCCHHHHHHHCCCCCCCEEEECC
DMEDDDELQQILIAAVEASRATYTELLVKLNAKLMAGELGGNRAVLRRKQARQAAHAVLP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECCCCCHHHHHHHHHHHHHHHHCC
NANETRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIVCLRRLVDVAPAVFADFEITALA
CCCCCEEEEECCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEC
DGTEVATSPLATEA
CCCHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA