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The map label for this gene is typA [H]

Identifier: 221230266

GI number: 221230266

Start: 1805470

End: 1807356

Strand: Reverse

Name: typA [H]

Synonym: MLBr_01498

Alternate gene names: 221230266

Gene position: 1807356-1805470 (Counterclockwise)

Preceding gene: 221230268

Following gene: 221230265

Centisome position: 55.3

GC content: 61.37

Gene sequence:

>1887_bases
GTGCCATTCCGCAATGTCGCCATTGTCGCGCACGTCGACCACGGCAAAACCACGCTGGTTGACGCGATGCTACGCCAGTC
CGGCGCGCTACACGAACGCGGTCAAGTCCAGGAACGCGTGATGGATACCGGTGACTTGGAACGGGAAAAAGGCATCACAA
TCCTGGCCAAAAACACGGCCGTACATTGTCACAATTCGGACGGTACGGTGACGGTGATCAATGTTATCGACACGCCTGGC
CATGCCGACTTCGGCGGTGAAGTGGAACGCGGGCTGTCTATGGTGGATGGGGTGTTGTTGCTGGTCGATGCCTCCGAAGG
GCCGCTGCCGCAGACGCGGTTCGTGCTGCGCAAGACGCTGGCTGCGCATTTGCCGGTGATTCTGGTAGTTAACAAGACAG
ATCGTCCCGACGCACGCATCGCCGAGGTGGTGGAAGCCAGCCACGACCTGTTGCTTGACGTCGCATCCGATCTTGACGAG
GAAGCGGCTGCGGCCGCCGAGCGTGCGCTGGGTCTGCCGACGTTGTATGCGTCCGGGCGTGCCGGCATCGCCAGCACCGA
GCAGCCTGCTGACGGTGCTGTGCCCACGGGCGACAACCTCGACCCCTTGTTCGACGTGCTGATGGAGCACATCCCGTCGC
CGAAGGGTGACCCCGAAGCGCCGTTGCAGGCGTTGGTGACTAACTTGGACGCCTCGGCCTTCCTCGGTCGGCTTGCTTTG
GTCCGCATCTATAACGGCAAGCTGCGCAAGGGGCAGCAGGTGGCTTGGATGCGTGAAGTGGACGGGCTGCCTGTCACCAC
CGACGCCAAGATCACTGAGTTGCTGGTCACCAAAGGTGTCGAGCGCAGCACTACAGAGGAAGCGACGGCAGGGGATATCG
TAGCCGTAGCGGGACTGCCCGAGATCATGATCGGTGACACGTTGGCCGATCCCGAGCATGCTCATGCACTACCGCGTATC
ACCGTAGACGAGCCGGCTATCTCGGTGACGATCGGCACCAATACCTCGCCCCTGGCGGGCAAGGTGTCGGGCCACAAGTT
GACTGCGCGGATGGTTCGTGGCCGCCTGGACGCTGAGTTGGTCGGCAACATCTCGATCCGTGTGGTGGACATAGGACGGC
CCGATGCGTGGGAGGTGCAGGGCCGAGGTGAGCTTGCGTTGGCAGTGCTTGTTGAGACGATGCGTCGGGAAGGGTTCGAG
CTTACGGTCGGCAAGCCGCAGGTGGTCACCCGTACGATCGATGGCAAACTGCACGAACCATTCGAGGTGATGACGATCGA
CTGTCCCGAGGAGTTCGTCGGCGCGATCACCCAGTTGATGGCCGGCCGTAAGGGCCGCATGGAGGAGATGGCCAACCATG
CTGTGGGCTGGGTGCGAATGGACTTCATCGTGCCCAGCCGTGGCTTGATTGGCTTCCGTACCGACTTCCTCACCCTCACA
CGCGGCACCGGTATTGCTAACGCTGTGTTCGACAGCTATCGGCCGTGGGCCGGTGAGATCCGAGCCAGGGATACGGGGTC
GCTGGTTTCCGACCGGCCGGGTACTATTACGCCGTTTGCTCTGCTCCAACTTGCCGATCGGGGTCAGTTCTTCGTGTCGC
CTGGCCAGGACACTTACCAAGGTATGGTCGTCGGAATCAACCCTCGTCCGGAAGATCTCGATATCAATGTTACTCGTGAG
AAAAAGCTGACCAACATGCGGTCATCGACCGCCAATGTCATCGAGACGTTGACCAAACCGCTCGAGCTGGACCTGGAGCG
GGCGATGGAATTCTGCTCGTTCGACGAATGTGTTGAGGTGACCCCTGAGATTGTGCGGGTGCGCAAGATCGAACTGGAAT
CCAACGCCCGGGCCCGAGGCCGGGCCCGAGCCAAGGTTCGAGGCTAG

Upstream 100 bases:

>100_bases
CTCTGCGCTGGGCGGCGGTGCGGGCCGTCGAGCGGACCGAGGTGGGGTATTTCCGCATGCGGGGGAGAGCCGGCAATCTG
CACCTGCCACAATCACCGAC

Downstream 100 bases:

>100_bases
TGCCAGTGTAGCGCGCTGTGCTAGCACACTGGGTCCGCTGGATCGGTGCTCGATACCCTGAAGGGCGTGCCGAGACGAGC
CCGCCGCGTTGTAACGACGA

Product: putative GTP-binding, protein elongation factor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 628; Mature: 627

Protein sequence:

>628_residues
MPFRNVAIVAHVDHGKTTLVDAMLRQSGALHERGQVQERVMDTGDLEREKGITILAKNTAVHCHNSDGTVTVINVIDTPG
HADFGGEVERGLSMVDGVLLLVDASEGPLPQTRFVLRKTLAAHLPVILVVNKTDRPDARIAEVVEASHDLLLDVASDLDE
EAAAAAERALGLPTLYASGRAGIASTEQPADGAVPTGDNLDPLFDVLMEHIPSPKGDPEAPLQALVTNLDASAFLGRLAL
VRIYNGKLRKGQQVAWMREVDGLPVTTDAKITELLVTKGVERSTTEEATAGDIVAVAGLPEIMIGDTLADPEHAHALPRI
TVDEPAISVTIGTNTSPLAGKVSGHKLTARMVRGRLDAELVGNISIRVVDIGRPDAWEVQGRGELALAVLVETMRREGFE
LTVGKPQVVTRTIDGKLHEPFEVMTIDCPEEFVGAITQLMAGRKGRMEEMANHAVGWVRMDFIVPSRGLIGFRTDFLTLT
RGTGIANAVFDSYRPWAGEIRARDTGSLVSDRPGTITPFALLQLADRGQFFVSPGQDTYQGMVVGINPRPEDLDINVTRE
KKLTNMRSSTANVIETLTKPLELDLERAMEFCSFDECVEVTPEIVRVRKIELESNARARGRARAKVRG

Sequences:

>Translated_628_residues
MPFRNVAIVAHVDHGKTTLVDAMLRQSGALHERGQVQERVMDTGDLEREKGITILAKNTAVHCHNSDGTVTVINVIDTPG
HADFGGEVERGLSMVDGVLLLVDASEGPLPQTRFVLRKTLAAHLPVILVVNKTDRPDARIAEVVEASHDLLLDVASDLDE
EAAAAAERALGLPTLYASGRAGIASTEQPADGAVPTGDNLDPLFDVLMEHIPSPKGDPEAPLQALVTNLDASAFLGRLAL
VRIYNGKLRKGQQVAWMREVDGLPVTTDAKITELLVTKGVERSTTEEATAGDIVAVAGLPEIMIGDTLADPEHAHALPRI
TVDEPAISVTIGTNTSPLAGKVSGHKLTARMVRGRLDAELVGNISIRVVDIGRPDAWEVQGRGELALAVLVETMRREGFE
LTVGKPQVVTRTIDGKLHEPFEVMTIDCPEEFVGAITQLMAGRKGRMEEMANHAVGWVRMDFIVPSRGLIGFRTDFLTLT
RGTGIANAVFDSYRPWAGEIRARDTGSLVSDRPGTITPFALLQLADRGQFFVSPGQDTYQGMVVGINPRPEDLDINVTRE
KKLTNMRSSTANVIETLTKPLELDLERAMEFCSFDECVEVTPEIVRVRKIELESNARARGRARAKVRG
>Mature_627_residues
PFRNVAIVAHVDHGKTTLVDAMLRQSGALHERGQVQERVMDTGDLEREKGITILAKNTAVHCHNSDGTVTVINVIDTPGH
ADFGGEVERGLSMVDGVLLLVDASEGPLPQTRFVLRKTLAAHLPVILVVNKTDRPDARIAEVVEASHDLLLDVASDLDEE
AAAAAERALGLPTLYASGRAGIASTEQPADGAVPTGDNLDPLFDVLMEHIPSPKGDPEAPLQALVTNLDASAFLGRLALV
RIYNGKLRKGQQVAWMREVDGLPVTTDAKITELLVTKGVERSTTEEATAGDIVAVAGLPEIMIGDTLADPEHAHALPRIT
VDEPAISVTIGTNTSPLAGKVSGHKLTARMVRGRLDAELVGNISIRVVDIGRPDAWEVQGRGELALAVLVETMRREGFEL
TVGKPQVVTRTIDGKLHEPFEVMTIDCPEEFVGAITQLMAGRKGRMEEMANHAVGWVRMDFIVPSRGLIGFRTDFLTLTR
GTGIANAVFDSYRPWAGEIRARDTGSLVSDRPGTITPFALLQLADRGQFFVSPGQDTYQGMVVGINPRPEDLDINVTREK
KLTNMRSSTANVIETLTKPLELDLERAMEFCSFDECVEVTPEIVRVRKIELESNARARGRARAKVRG

Specific function: Not known; probably interacts with the ribosomes in a GTP dependent manner [H]

COG id: COG1217

COG function: function code T; Predicted membrane GTPase involved in stress response

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. TypA subfamily [H]

Homologues:

Organism=Homo sapiens, GI157426893, Length=525, Percent_Identity=27.047619047619, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI94966754, Length=133, Percent_Identity=42.1052631578947, Blast_Score=113, Evalue=6e-25,
Organism=Homo sapiens, GI4503483, Length=145, Percent_Identity=37.9310344827586, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI18390331, Length=137, Percent_Identity=39.4160583941606, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI217272894, Length=133, Percent_Identity=33.8345864661654, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI217272892, Length=133, Percent_Identity=33.8345864661654, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI310132016, Length=112, Percent_Identity=39.2857142857143, Blast_Score=87, Evalue=7e-17,
Organism=Homo sapiens, GI310110807, Length=112, Percent_Identity=39.2857142857143, Blast_Score=87, Evalue=7e-17,
Organism=Homo sapiens, GI310123363, Length=112, Percent_Identity=39.2857142857143, Blast_Score=87, Evalue=7e-17,
Organism=Homo sapiens, GI25306283, Length=145, Percent_Identity=40, Blast_Score=83, Evalue=9e-16,
Organism=Homo sapiens, GI19923640, Length=146, Percent_Identity=39.7260273972603, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI25306287, Length=146, Percent_Identity=39.7260273972603, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI34147630, Length=262, Percent_Identity=29.0076335877863, Blast_Score=76, Evalue=9e-14,
Organism=Homo sapiens, GI94966752, Length=80, Percent_Identity=42.5, Blast_Score=70, Evalue=7e-12,
Organism=Homo sapiens, GI53729339, Length=248, Percent_Identity=28.2258064516129, Blast_Score=69, Evalue=2e-11,
Organism=Homo sapiens, GI53729337, Length=248, Percent_Identity=28.2258064516129, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI48994988, Length=620, Percent_Identity=45.3225806451613, Blast_Score=535, Evalue=1e-153,
Organism=Escherichia coli, GI1788922, Length=309, Percent_Identity=34.6278317152104, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI1789738, Length=146, Percent_Identity=38.3561643835616, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1790835, Length=138, Percent_Identity=31.8840579710145, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1790412, Length=134, Percent_Identity=35.8208955223881, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1789737, Length=134, Percent_Identity=35.8208955223881, Blast_Score=67, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17557151, Length=251, Percent_Identity=30.6772908366534, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17556745, Length=146, Percent_Identity=41.0958904109589, Blast_Score=105, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI71988811, Length=133, Percent_Identity=39.0977443609023, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71988819, Length=133, Percent_Identity=39.0977443609023, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17533571, Length=140, Percent_Identity=40.7142857142857, Blast_Score=97, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17552882, Length=133, Percent_Identity=33.8345864661654, Blast_Score=93, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17506493, Length=157, Percent_Identity=36.3057324840764, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17556456, Length=362, Percent_Identity=25.9668508287293, Blast_Score=75, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6323098, Length=505, Percent_Identity=26.3366336633663, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6323320, Length=516, Percent_Identity=25.1937984496124, Blast_Score=124, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6324707, Length=145, Percent_Identity=39.3103448275862, Blast_Score=107, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6320593, Length=145, Percent_Identity=39.3103448275862, Blast_Score=107, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6322359, Length=143, Percent_Identity=36.3636363636364, Blast_Score=84, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6324166, Length=141, Percent_Identity=39.0070921985816, Blast_Score=83, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6324761, Length=300, Percent_Identity=27, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI78706572, Length=531, Percent_Identity=25.0470809792844, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI28574573, Length=136, Percent_Identity=38.9705882352941, Blast_Score=100, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24585711, Length=149, Percent_Identity=36.241610738255, Blast_Score=93, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24585713, Length=149, Percent_Identity=36.241610738255, Blast_Score=93, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24582462, Length=137, Percent_Identity=39.4160583941606, Blast_Score=93, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24585709, Length=149, Percent_Identity=36.241610738255, Blast_Score=93, Evalue=6e-19,
Organism=Drosophila melanogaster, GI21357743, Length=133, Percent_Identity=36.0902255639098, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI19921738, Length=225, Percent_Identity=30.2222222222222, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI221458488, Length=151, Percent_Identity=41.0596026490066, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI281363316, Length=348, Percent_Identity=25.8620689655172, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI17864358, Length=348, Percent_Identity=25.8620689655172, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI28572034, Length=135, Percent_Identity=34.0740740740741, Blast_Score=70, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000640
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR006298 [H]

Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 67996; Mature: 67864

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFRNVAIVAHVDHGKTTLVDAMLRQSGALHERGQVQERVMDTGDLEREKGITILAKNTA
CCCCCEEEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHCCCEEEEECCE
VHCHNSDGTVTVINVIDTPGHADFGGEVERGLSMVDGVLLLVDASEGPLPQTRFVLRKTL
EEEECCCCCEEEEEEEECCCCCCCCCHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHH
AAHLPVILVVNKTDRPDARIAEVVEASHDLLLDVASDLDEEAAAAAERALGLPTLYASGR
HHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEECCCC
AGIASTEQPADGAVPTGDNLDPLFDVLMEHIPSPKGDPEAPLQALVTNLDASAFLGRLAL
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHH
VRIYNGKLRKGQQVAWMREVDGLPVTTDAKITELLVTKGVERSTTEEATAGDIVAVAGLP
EEEECCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCC
EIMIGDTLADPEHAHALPRITVDEPAISVTIGTNTSPLAGKVSGHKLTARMVRGRLDAEL
CEEECCCCCCCHHHHCCCCEEECCCEEEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCEE
VGNISIRVVDIGRPDAWEVQGRGELALAVLVETMRREGFELTVGKPQVVTRTIDGKLHEP
ECCEEEEEEECCCCCCEEECCCCCCHHHHHHHHHHHCCCEEECCCCEEEEEECCCCCCCC
FEVMTIDCPEEFVGAITQLMAGRKGRMEEMANHAVGWVRMDFIVPSRGLIGFRTDFLTLT
EEEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHCCCEEEEEEEECCCCCEEEEECEEEEE
RGTGIANAVFDSYRPWAGEIRARDTGSLVSDRPGTITPFALLQLADRGQFFVSPGQDTYQ
CCCCHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHCCCCEEECCCCCCCC
GMVVGINPRPEDLDINVTREKKLTNMRSSTANVIETLTKPLELDLERAMEFCSFDECVEV
EEEEECCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHC
TPEIVRVRKIELESNARARGRARAKVRG
CHHHEEEEEEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PFRNVAIVAHVDHGKTTLVDAMLRQSGALHERGQVQERVMDTGDLEREKGITILAKNTA
CCCCEEEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHCCCEEEEECCE
VHCHNSDGTVTVINVIDTPGHADFGGEVERGLSMVDGVLLLVDASEGPLPQTRFVLRKTL
EEEECCCCCEEEEEEEECCCCCCCCCHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHH
AAHLPVILVVNKTDRPDARIAEVVEASHDLLLDVASDLDEEAAAAAERALGLPTLYASGR
HHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEECCCC
AGIASTEQPADGAVPTGDNLDPLFDVLMEHIPSPKGDPEAPLQALVTNLDASAFLGRLAL
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHH
VRIYNGKLRKGQQVAWMREVDGLPVTTDAKITELLVTKGVERSTTEEATAGDIVAVAGLP
EEEECCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCC
EIMIGDTLADPEHAHALPRITVDEPAISVTIGTNTSPLAGKVSGHKLTARMVRGRLDAEL
CEEECCCCCCCHHHHCCCCEEECCCEEEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCEE
VGNISIRVVDIGRPDAWEVQGRGELALAVLVETMRREGFELTVGKPQVVTRTIDGKLHEP
ECCEEEEEEECCCCCCEEECCCCCCHHHHHHHHHHHCCCEEECCCCEEEEEECCCCCCCC
FEVMTIDCPEEFVGAITQLMAGRKGRMEEMANHAVGWVRMDFIVPSRGLIGFRTDFLTLT
EEEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHCCCEEEEEEEECCCCCEEEEECEEEEE
RGTGIANAVFDSYRPWAGEIRARDTGSLVSDRPGTITPFALLQLADRGQFFVSPGQDTYQ
CCCCHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHCCCCEEECCCCCCCC
GMVVGINPRPEDLDINVTREKKLTNMRSSTANVIETLTKPLELDLERAMEFCSFDECVEV
EEEEECCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHC
TPEIVRVRKIELESNARARGRARAKVRG
CHHHEEEEEEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]