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The map label for this gene is mraW [H]

Identifier: 221229903

GI number: 221229903

Start: 1071630

End: 1072748

Strand: Direct

Name: mraW [H]

Synonym: MLBr_00906

Alternate gene names: 221229903

Gene position: 1071630-1072748 (Clockwise)

Preceding gene: 221229902

Following gene: 221229904

Centisome position: 32.79

GC content: 62.2

Gene sequence:

>1119_bases
GTGCCTTCGGACAGAGACCACGATGCGGGGATATTTGCGTTCTTCGGGGCGGTTCCGAGGAGCGACAGGTGCCGCCAGAC
CCGGGGAGGTGGCGAGGTGGTTGACGGCTCAAGTGTTTTCGGGCATGTGCCCGTCTTTGCGCAACGGTGTGTCACTCTGC
TTGCCCCCGCGTTGACCCGCCATCACGCTGACGGGTCCAATGCGATCCTGGTGGATGCCACTCTCGGTGTTGGTGGGCAC
GCAGAGCGATTCCTGACCGAATTTCCGGGTTTGCGGCTGATTGGACTTGACCGCGACCCGAGCGCCCTGGATATCGCCCG
GACTCGGCTAATGCGATTTGCCGACCGGGTCACGTTAATCCACACGCGTTATGACAACCTCGCTGTAGCACTGAACAAAT
TTGGTTATGCCGCAGTGGAATCGGTCGATGGTGTGCTGTTCGATCTGGGTGTTTCGTCCATGCAGCTGGACTGTGCCGAG
CGGGGTTTTTCCTACGCTCAAGACGTGCCGTTGGACATGCGGATGGACCCGTGGTCACCGGTTAGCGCGGCCGACATCGT
CAATAATTACGACGAGGCCGCATTAGCCGATATCCTTCGCCGGTATGGTGAGGAGCGATTCGCGCGCCGCATCGCTGCGC
ACATCGTCCGCCGGCGTGCCCACACCCCGTTTACTTCGACCGCCGAGCTGGTAGCTCTGTTGTACCAGGCGATTCCAGCA
CCGGCCCGGCGCATCGGAGGCCATCCGGCCAAGCGCACGTTTCAGGCGTTGCGGATCGCGGTCAACGACGAGTTGAACTC
GCTGAGTAACGTCCTTCCCGCTGCGCTGGATGCGCTCACTGTGGCCGGGCGCCTCGTGGTGCTAGCCTATCAGTCGCTCG
AAGACCGGATTGTCAAACGCGTGTTTGCCGACGCGGTCTCCTCCCGCACACCGGCGGGCCTCCCGATCGAACTTCCGGGC
CATGGACCGCGATTCCGGTTGTTGACGCGTGGCGCTGAACACGCAGATGCCGCCGAGATCGAATGTAATCCCCGCAGTGC
CGCCGTGCGATTACGGGCTCTGCAACGAACCCAGCATGGAGTGGAACCGCAGCAGCCAACCAGGAGGGGCGACTCATGA

Upstream 100 bases:

>100_bases
CGCCGCGCTTGCGATCGCCACGAGATCTAAGGCGCATGCTCCCGCATCGTGGTCTCTGTCCGAAGGCACGACCCTGGCGT
ACTTCCCCAACGCCAGGGTC

Downstream 100 bases:

>100_bases
AGGCTCAGCGCGACACGCCGATCCGCCGTGGTGACAGTGGCCGTCCGGGTGGACGCGACGGTGCTGCCCGCAGTGGCAAG
CGCACTGCTAATGAGGCGGG

Product: S-adenosyl-methyltransferase MraW

Products: NA

Alternate protein names: 16S rRNA m(4)C1402 methyltransferase; rRNA (cytosine-N(4)-)-methyltransferase RsmH [H]

Number of amino acids: Translated: 372; Mature: 371

Protein sequence:

>372_residues
MPSDRDHDAGIFAFFGAVPRSDRCRQTRGGGEVVDGSSVFGHVPVFAQRCVTLLAPALTRHHADGSNAILVDATLGVGGH
AERFLTEFPGLRLIGLDRDPSALDIARTRLMRFADRVTLIHTRYDNLAVALNKFGYAAVESVDGVLFDLGVSSMQLDCAE
RGFSYAQDVPLDMRMDPWSPVSAADIVNNYDEAALADILRRYGEERFARRIAAHIVRRRAHTPFTSTAELVALLYQAIPA
PARRIGGHPAKRTFQALRIAVNDELNSLSNVLPAALDALTVAGRLVVLAYQSLEDRIVKRVFADAVSSRTPAGLPIELPG
HGPRFRLLTRGAEHADAAEIECNPRSAAVRLRALQRTQHGVEPQQPTRRGDS

Sequences:

>Translated_372_residues
MPSDRDHDAGIFAFFGAVPRSDRCRQTRGGGEVVDGSSVFGHVPVFAQRCVTLLAPALTRHHADGSNAILVDATLGVGGH
AERFLTEFPGLRLIGLDRDPSALDIARTRLMRFADRVTLIHTRYDNLAVALNKFGYAAVESVDGVLFDLGVSSMQLDCAE
RGFSYAQDVPLDMRMDPWSPVSAADIVNNYDEAALADILRRYGEERFARRIAAHIVRRRAHTPFTSTAELVALLYQAIPA
PARRIGGHPAKRTFQALRIAVNDELNSLSNVLPAALDALTVAGRLVVLAYQSLEDRIVKRVFADAVSSRTPAGLPIELPG
HGPRFRLLTRGAEHADAAEIECNPRSAAVRLRALQRTQHGVEPQQPTRRGDS
>Mature_371_residues
PSDRDHDAGIFAFFGAVPRSDRCRQTRGGGEVVDGSSVFGHVPVFAQRCVTLLAPALTRHHADGSNAILVDATLGVGGHA
ERFLTEFPGLRLIGLDRDPSALDIARTRLMRFADRVTLIHTRYDNLAVALNKFGYAAVESVDGVLFDLGVSSMQLDCAER
GFSYAQDVPLDMRMDPWSPVSAADIVNNYDEAALADILRRYGEERFARRIAAHIVRRRAHTPFTSTAELVALLYQAIPAP
ARRIGGHPAKRTFQALRIAVNDELNSLSNVLPAALDALTVAGRLVVLAYQSLEDRIVKRVFADAVSSRTPAGLPIELPGH
GPRFRLLTRGAEHADAAEIECNPRSAAVRLRALQRTQHGVEPQQPTRRGDS

Specific function: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA [H]

COG id: COG0275

COG function: function code M; Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. RsmH family [H]

Homologues:

Organism=Homo sapiens, GI165377209, Length=272, Percent_Identity=41.9117647058824, Blast_Score=177, Evalue=9e-45,
Organism=Homo sapiens, GI165377202, Length=197, Percent_Identity=40.1015228426396, Blast_Score=128, Evalue=7e-30,
Organism=Escherichia coli, GI1786270, Length=298, Percent_Identity=41.2751677852349, Blast_Score=194, Evalue=7e-51,
Organism=Drosophila melanogaster, GI62472493, Length=339, Percent_Identity=35.9882005899705, Blast_Score=173, Evalue=1e-43,
Organism=Drosophila melanogaster, GI28571637, Length=339, Percent_Identity=35.9882005899705, Blast_Score=173, Evalue=1e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002903 [H]

Pfam domain/function: PF01795 Methyltransf_5 [H]

EC number: NA

Molecular weight: Translated: 40607; Mature: 40475

Theoretical pI: Translated: 8.35; Mature: 8.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSDRDHDAGIFAFFGAVPRSDRCRQTRGGGEVVDGSSVFGHVPVFAQRCVTLLAPALTR
CCCCCCCCCCHHHHCCCCCCCCHHHHCCCCCCEECCCCHHCCHHHHHHHHHHHHHHHHHH
HHADGSNAILVDATLGVGGHAERFLTEFPGLRLIGLDRDPSALDIARTRLMRFADRVTLI
HCCCCCCEEEEEECCCCCCHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHEEE
HTRYDNLAVALNKFGYAAVESVDGVLFDLGVSSMQLDCAERGFSYAQDVPLDMRMDPWSP
EECCCHHHHHHHHHCHHHHHHHCCHHHHCCCCHHHHHHHHCCCCHHHCCCCCCCCCCCCC
VSAADIVNNYDEAALADILRRYGEERFARRIAAHIVRRRAHTPFTSTAELVALLYQAIPA
CHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCC
PARRIGGHPAKRTFQALRIAVNDELNSLSNVLPAALDALTVAGRLVVLAYQSLEDRIVKR
CHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VFADAVSSRTPAGLPIELPGHGPRFRLLTRGAEHADAAEIECNPRSAAVRLRALQRTQHG
HHHHHHHCCCCCCCEEECCCCCCCEEEEECCCCCCCCCEEECCCHHHHHHHHHHHHHHCC
VEPQQPTRRGDS
CCCCCCCCCCCC
>Mature Secondary Structure 
PSDRDHDAGIFAFFGAVPRSDRCRQTRGGGEVVDGSSVFGHVPVFAQRCVTLLAPALTR
CCCCCCCCCHHHHCCCCCCCCHHHHCCCCCCEECCCCHHCCHHHHHHHHHHHHHHHHHH
HHADGSNAILVDATLGVGGHAERFLTEFPGLRLIGLDRDPSALDIARTRLMRFADRVTLI
HCCCCCCEEEEEECCCCCCHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHEEE
HTRYDNLAVALNKFGYAAVESVDGVLFDLGVSSMQLDCAERGFSYAQDVPLDMRMDPWSP
EECCCHHHHHHHHHCHHHHHHHCCHHHHCCCCHHHHHHHHCCCCHHHCCCCCCCCCCCCC
VSAADIVNNYDEAALADILRRYGEERFARRIAAHIVRRRAHTPFTSTAELVALLYQAIPA
CHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCC
PARRIGGHPAKRTFQALRIAVNDELNSLSNVLPAALDALTVAGRLVVLAYQSLEDRIVKR
CHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VFADAVSSRTPAGLPIELPGHGPRFRLLTRGAEHADAAEIECNPRSAAVRLRALQRTQHG
HHHHHHHCCCCCCCEEECCCCCCCEEEEECCCCCCCCCEEECCCHHHHHHHHHHHHHHCC
VEPQQPTRRGDS
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA