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The map label for this gene is csd1

Identifier: 221229850

GI number: 221229850

Start: 1000594

End: 1001829

Strand: Direct

Name: csd1

Synonym: MLBr_00842

Alternate gene names: 221229850

Gene position: 1000594-1001829 (Clockwise)

Preceding gene: 221229849

Following gene: 221229851

Centisome position: 30.62

GC content: 58.33

Gene sequence:

>1236_bases
ATGGTCGACGTCTTCGATATTCAGGCCGTGCGGGCGGACTTTCCGATTCTGCAGGAGACCGTCAACGGCAAGCCGTTGAT
CTGGTTCGACAATGCCGCGACCACCCAGAAGCCGCAGGTAGTCATCGACCGACTGTCTTACTTCTATGCCCACGAAAACT
CCAACATTCACCGCGCGGCGCATGAACTGGCGGCTCGGGCCACCGATGCTTACGAGGAAGCCCGGGAAACAGCACGGCGT
TTTATCGGTGCAGCCAAGGCCCAAGAGATCATCTTCGTGCGCGGTACTACTGAAGCGATTAACCTGGTTGCCTATGCGTG
GGGGGGTAAGCATTTGCAACCTGGTGACGAGGTAGTCATCACTCATCTCGAACATCACGCTAATATCGTTCCTTGGCAAT
TGCTTTCGTCACAAACTGGGGCAATCCTGAAAGTCGCACCGGTTGACGATGCGGGCAACTTGTTAATGTCGGAATTCGAG
GATCTGCTGGGTCCCAGAACGAAGTTGGTGGCTGCGACTCAGGTGTCGAACGCATTAGGCACGGTTACACAAGGTGAGAA
GATCGTTGAGTTGGGTCATCGCTACGGTGCTCGGGTGCTGATCGACGGCGCACAGTCGATTCCGCATCTGCCGATCAATG
TCTCCGAGCTCGGCGCCGATTTCTTCGTGTTTTCCGGACATAAGATTTACGGCCCCACCGGGATCGGTGTGCTTTACGGG
TGCGAGGATGTGCTGACGGAGATGCCACCGTGGCAGGGCGGTGGCAACATGATCGTCGATGTGACGCTGGAACGGTCGCT
ATATCAGGGGCCGCCCAACAAGTTTGAGGCCGGCACCGGGAATATCGCTGACGCCGTCGGACTGGGGGAGGCGCTGCGTT
ACGTCGAGCGGGTGGGCGTCCAGCGTATTGCGTCCCATGAGCAAGCACTGCTCGACTATGCGACACCTCGGCTGGCCGAC
ATACCCGGTGTTCGCCTGGTGGGCACCGCAACGGAGAAAGCCAGCGTGCTGTCGTTCGTGCTGGCTGGACACGAGCCGCT
AGAGGTGGGCAAGGCACTCAATGCCGAAGGGATTGCGGTGCGTGCTGGTCATCATTGCGCACAGCCAGTTCTGCGGCGCC
TTGGGTTGGAGGCCACGGTTCGCCCATCGTTCGCCTTTTACAACACATACGAAGAGATCGACGTCTTCATCAATGTGGTG
CGTCGGATCGCAGAGGGCGGTACCAATATCGGCTGA

Upstream 100 bases:

>100_bases
GTTTGATGCGGTGCCAGCGGGTGTGCCTGGAGGCGACGAACACAATTACAATTTTCTGATCGCAGCCCCCCAAGTGCCTC
GGTTGGCCGATGAACACGAG

Downstream 100 bases:

>100_bases
TCGGTCGTCCTTTATACTCTACTGCATTTAGGTTGTTGAGCCTTGGGCCTGACGCGGACTTCGGCGAAACAAACGGTAGG
TTCATAGGCTTCGCTAAGCT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 411; Mature: 411

Protein sequence:

>411_residues
MVDVFDIQAVRADFPILQETVNGKPLIWFDNAATTQKPQVVIDRLSYFYAHENSNIHRAAHELAARATDAYEEARETARR
FIGAAKAQEIIFVRGTTEAINLVAYAWGGKHLQPGDEVVITHLEHHANIVPWQLLSSQTGAILKVAPVDDAGNLLMSEFE
DLLGPRTKLVAATQVSNALGTVTQGEKIVELGHRYGARVLIDGAQSIPHLPINVSELGADFFVFSGHKIYGPTGIGVLYG
CEDVLTEMPPWQGGGNMIVDVTLERSLYQGPPNKFEAGTGNIADAVGLGEALRYVERVGVQRIASHEQALLDYATPRLAD
IPGVRLVGTATEKASVLSFVLAGHEPLEVGKALNAEGIAVRAGHHCAQPVLRRLGLEATVRPSFAFYNTYEEIDVFINVV
RRIAEGGTNIG

Sequences:

>Translated_411_residues
MVDVFDIQAVRADFPILQETVNGKPLIWFDNAATTQKPQVVIDRLSYFYAHENSNIHRAAHELAARATDAYEEARETARR
FIGAAKAQEIIFVRGTTEAINLVAYAWGGKHLQPGDEVVITHLEHHANIVPWQLLSSQTGAILKVAPVDDAGNLLMSEFE
DLLGPRTKLVAATQVSNALGTVTQGEKIVELGHRYGARVLIDGAQSIPHLPINVSELGADFFVFSGHKIYGPTGIGVLYG
CEDVLTEMPPWQGGGNMIVDVTLERSLYQGPPNKFEAGTGNIADAVGLGEALRYVERVGVQRIASHEQALLDYATPRLAD
IPGVRLVGTATEKASVLSFVLAGHEPLEVGKALNAEGIAVRAGHHCAQPVLRRLGLEATVRPSFAFYNTYEEIDVFINVV
RRIAEGGTNIG
>Mature_411_residues
MVDVFDIQAVRADFPILQETVNGKPLIWFDNAATTQKPQVVIDRLSYFYAHENSNIHRAAHELAARATDAYEEARETARR
FIGAAKAQEIIFVRGTTEAINLVAYAWGGKHLQPGDEVVITHLEHHANIVPWQLLSSQTGAILKVAPVDDAGNLLMSEFE
DLLGPRTKLVAATQVSNALGTVTQGEKIVELGHRYGARVLIDGAQSIPHLPINVSELGADFFVFSGHKIYGPTGIGVLYG
CEDVLTEMPPWQGGGNMIVDVTLERSLYQGPPNKFEAGTGNIADAVGLGEALRYVERVGVQRIASHEQALLDYATPRLAD
IPGVRLVGTATEKASVLSFVLAGHEPLEVGKALNAEGIAVRAGHHCAQPVLRRLGLEATVRPSFAFYNTYEEIDVFINVV
RRIAEGGTNIG

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily

Homologues:

Organism=Homo sapiens, GI32307132, Length=408, Percent_Identity=25.4901960784314, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI156713448, Length=432, Percent_Identity=26.1574074074074, Blast_Score=73, Evalue=5e-13,
Organism=Escherichia coli, GI1787970, Length=401, Percent_Identity=46.8827930174564, Blast_Score=388, Evalue=1e-109,
Organism=Escherichia coli, GI1789175, Length=404, Percent_Identity=39.1089108910891, Blast_Score=300, Evalue=1e-82,
Organism=Escherichia coli, GI48994898, Length=395, Percent_Identity=27.5949367088608, Blast_Score=111, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI25143064, Length=393, Percent_Identity=26.2086513994911, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI193211090, Length=354, Percent_Identity=25.1412429378531, Blast_Score=75, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6319831, Length=395, Percent_Identity=26.0759493670886, Blast_Score=100, Evalue=4e-22,
Organism=Drosophila melanogaster, GI20129463, Length=406, Percent_Identity=27.5862068965517, Blast_Score=106, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CSD1_MYCLE (O32975)

Other databases:

- EMBL:   Z98741
- EMBL:   AL583920
- PIR:   D87014
- PIR:   T44909
- RefSeq:   NP_301636.1
- ProteinModelPortal:   O32975
- SMR:   O32975
- EnsemblBacteria:   EBMYCT00000028103
- GeneID:   909813
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML0842
- Leproma:   ML0842
- GeneTree:   EBGT00050000015336
- HOGENOM:   HBG635316
- ProtClustDB:   CLSK2460487
- BioCyc:   MLEP272631:ML0842-MONOMER
- BRENDA:   2.8.1.7
- InterPro:   IPR000192
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01979

Pfam domain/function: PF00266 Aminotran_5; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.8.1.7

Molecular weight: Translated: 44538; Mature: 44538

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: ACT_SITE 566-566

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDVFDIQAVRADFPILQETVNGKPLIWFDNAATTQKPQVVIDRLSYFYAHENSNIHRAA
CCCEEEEHHHHCCCHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCHHHHH
HELAARATDAYEEARETARRFIGAAKAQEIIFVRGTTEAINLVAYAWGGKHLQPGDEVVI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHEEEEEEECCCCCCCCCCCEEE
THLEHHANIVPWQLLSSQTGAILKVAPVDDAGNLLMSEFEDLLGPRTKLVAATQVSNALG
EEEHHCCCCCCHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCHHEEEHHHHHHHHC
TVTQGEKIVELGHRYGARVLIDGAQSIPHLPINVSELGADFFVFSGHKIYGPTGIGVLYG
CCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHCCCEEEEECCEEECCCCCHHEEC
CEDVLTEMPPWQGGGNMIVDVTLERSLYQGPPNKFEAGTGNIADAVGLGEALRYVERVGV
CHHHHHCCCCCCCCCCEEEEEEEEHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
QRIASHEQALLDYATPRLADIPGVRLVGTATEKASVLSFVLAGHEPLEVGKALNAEGIAV
HHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCHHHHHCCCCCCCEEE
RAGHHCAQPVLRRLGLEATVRPSFAFYNTYEEIDVFINVVRRIAEGGTNIG
ECCCHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MVDVFDIQAVRADFPILQETVNGKPLIWFDNAATTQKPQVVIDRLSYFYAHENSNIHRAA
CCCEEEEHHHHCCCHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCHHHHH
HELAARATDAYEEARETARRFIGAAKAQEIIFVRGTTEAINLVAYAWGGKHLQPGDEVVI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHEEEEEEECCCCCCCCCCCEEE
THLEHHANIVPWQLLSSQTGAILKVAPVDDAGNLLMSEFEDLLGPRTKLVAATQVSNALG
EEEHHCCCCCCHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCHHEEEHHHHHHHHC
TVTQGEKIVELGHRYGARVLIDGAQSIPHLPINVSELGADFFVFSGHKIYGPTGIGVLYG
CCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHCCCEEEEECCEEECCCCCHHEEC
CEDVLTEMPPWQGGGNMIVDVTLERSLYQGPPNKFEAGTGNIADAVGLGEALRYVERVGV
CHHHHHCCCCCCCCCCEEEEEEEEHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
QRIASHEQALLDYATPRLADIPGVRLVGTATEKASVLSFVLAGHEPLEVGKALNAEGIAV
HHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCHHHHHCCCCCCCEEE
RAGHHCAQPVLRRLGLEATVRPSFAFYNTYEEIDVFINVVRRIAEGGTNIG
ECCCHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002