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The map label for this gene is furB [H]

Identifier: 221229840

GI number: 221229840

Start: 977825

End: 978220

Strand: Reverse

Name: furB [H]

Synonym: MLBr_00824

Alternate gene names: 221229840

Gene position: 978220-977825 (Counterclockwise)

Preceding gene: 221229844

Following gene: 221229836

Centisome position: 29.93

GC content: 59.09

Gene sequence:

>396_bases
ATGATGACTGGAGCCAGCGTCCGTTCCACCCGACAACGCGCGGCAATATCAACGCTGTTGGAGACGGTCGATGACTTCCG
CTCAGCCCAGGAGCTTCACAACGAGCTGCGCCGCCGCGGCAATAATATCAGCTTGACCACCGTCTACCGTACCCTGCAAT
CGATGGCAGAGGCGGGAATGGTCGACACGTTGCGCACCAACACCGGTGAATCGGTCTACCGCAGATGTTCCAGGCAGCAT
CACCACCATCTGGTGTGCCGAGGCTGCGGTTCCACTATCGAGGTCGGCGACCACGAAGTCGAGGCATGGGCGGCAGAAGT
GGCCGCCAAGCATGGATTCTCTGACGTTAGCCACACCATCGAAATCTTTGGCACCTGCTCAGAATGTCGGTCCTGA

Upstream 100 bases:

>100_bases
GCCCACGCTGGCGTGGATGCACTGTGACCCGCGCCAGCTACGATGCAGTAGAGGCACCGCTCGCTTGCGAGGGACGACGC
GATGAAGGGAAGCGGCGCAG

Downstream 100 bases:

>100_bases
AACCGCCTCAAGGTGTCGTCGTGATGGTCATTTGGTGGTTATTTTTTGCTGGTTTGGTTTGGGTGGTGGTGTTGTGGTGG
GCTGGTGGGGTGTGGGTGGT

Product: putative ferric uptake regulatory protein

Products: NA

Alternate protein names: Ferric uptake regulator [H]

Number of amino acids: Translated: 131; Mature: 131

Protein sequence:

>131_residues
MMTGASVRSTRQRAAISTLLETVDDFRSAQELHNELRRRGNNISLTTVYRTLQSMAEAGMVDTLRTNTGESVYRRCSRQH
HHHLVCRGCGSTIEVGDHEVEAWAAEVAAKHGFSDVSHTIEIFGTCSECRS

Sequences:

>Translated_131_residues
MMTGASVRSTRQRAAISTLLETVDDFRSAQELHNELRRRGNNISLTTVYRTLQSMAEAGMVDTLRTNTGESVYRRCSRQH
HHHLVCRGCGSTIEVGDHEVEAWAAEVAAKHGFSDVSHTIEIFGTCSECRS
>Mature_131_residues
MMTGASVRSTRQRAAISTLLETVDDFRSAQELHNELRRRGNNISLTTVYRTLQSMAEAGMVDTLRTNTGESVYRRCSRQH
HHHLVCRGCGSTIEVGDHEVEAWAAEVAAKHGFSDVSHTIEIFGTCSECRS

Specific function: Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes. Regulates the expression of several outer-membrane proteins including the iron transport operon [H]

COG id: COG0735

COG function: function code P; Fe2+/Zn2+ uptake regulation proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Fur family [H]

Homologues:

Organism=Escherichia coli, GI1786899, Length=132, Percent_Identity=36.3636363636364, Blast_Score=89, Evalue=9e-20,

Paralogues:

None

Copy number: 3432 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002481
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01475 FUR [H]

EC number: NA

Molecular weight: Translated: 14593; Mature: 14593

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
3.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMTGASVRSTRQRAAISTLLETVDDFRSAQELHNELRRRGNNISLTTVYRTLQSMAEAGM
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCC
VDTLRTNTGESVYRRCSRQHHHHLVCRGCGSTIEVGDHEVEAWAAEVAAKHGFSDVSHTI
HHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHH
EIFGTCSECRS
HHHCCHHHHCC
>Mature Secondary Structure
MMTGASVRSTRQRAAISTLLETVDDFRSAQELHNELRRRGNNISLTTVYRTLQSMAEAGM
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCC
VDTLRTNTGESVYRRCSRQHHHHLVCRGCGSTIEVGDHEVEAWAAEVAAKHGFSDVSHTI
HHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHH
EIFGTCSECRS
HHHCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9055816 [H]