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The map label for this gene is entC [H]

Identifier: 221229831

GI number: 221229831

Start: 956175

End: 957908

Strand: Reverse

Name: entC [H]

Synonym: MLBr_00808

Alternate gene names: 221229831

Gene position: 957908-956175 (Counterclockwise)

Preceding gene: 221229832

Following gene: 221229829

Centisome position: 29.31

GC content: 61.36

Gene sequence:

>1734_bases
ATGGCGATACGGCGTGGTCGAAATCGGGCCAGCACATTCGGCTGTACCGAGCTGGAGTTGACCGATACCGGCCGAGCACA
GGCCAAGCTAGCTGAGCGGGCCCTAGCGGAACAGAAACTCGTTGATCCGATGATGGCCAGCAACCCACGTCAATGCGACC
TAGTTACTGCCAAGTTGGCCGGACTTACCGTCGACAAAGTATCTCCATTACTAGCTGAATGCACCTACGGCTCCTACGAA
GACCTCACCACCGCAAAGACTCGAGAAGCCGAACCTGCTTGGTTGGCATGGACGCACAGATACCCGAGGGGTGAAAAACG
TCTGGCAAGTCAGCGAACATGCCGACCAGGCCGTCGCTATGGCGTTCGAGCACTTGGAGTCACGGACCATGTAGTCCGTC
AGCCATGGCCACCTCTGCTGGGCGGTGATCACACGCTGGATCGGGCTGCCATTTGTCGAGGGCCGGCGCTTCGGTATGCG
CATCAGCTCGATTGGGATGTGCGGGTTCGAGTACGGGCTACGGCAACTACACACGCTTGGGTCGCCTGGCTAGCCACGAC
CGGTCGCACCCGGGTGAACATCAACAATGACGACGACAAACGCCGCCCAGTGGCGCAGGAGAGAGCCGAACAAATGAGAC
CAAGCGAACCACCGTTCGCACTATGCGGACCACGTGGGACTCTAGTTGCCGACGGGGTGCACACACGCTACGACGATGTG
TATTTAGCGCAAGCTGCACTGCGTTCTGGAGTTACGCCAATACTGTTGGGTGCATTACCTTTCGATGCGGAAAGCCCCGC
CGCACTGATGGCACCTAGTGCTGTGCTGCGCACCGATACACTGCCAAACTGGCAGACCGGCCCGCTACCCACCCTGCGCA
TCACTGCCGCCGTCCCAACGCGTGCCAACTACCGCGTCTGGATAAGCAACGCACGCGAGCAACTCACCGCACCTGGCAAC
TCACTACACAAGGTAGTGCTTGCCCGCGCATTGCAGCTGGTCGCGGACGCTCCACTGGACGGCCGCGCCATCCTGCGCCG
GCTAGTCACAGCCGACCCGACCGCGTACGGATATCTCGTCGACTTGACCGCAGCCGGCGGCCAGTACGCGGGTGTTGCCC
TGGTGGGCGCCAGCCCAGAACTGTTGGTCTCGCGCTTCGGCGACCGTGTAGTCTGCCGGCCGTTTGCCGGTTCGGCCCCA
CGTGCTACCAACCCCGAAGTCGACTCCGCTAACAGCGCCGCGCTGGCCGGCTCGATCAAGAACCGTCACGAACATCAGCT
GGTCATCGACGCGATACGTGCTGCCCTAGAGCCAGTGTGCGACAACTTGACGATCGCGCCCGAGCCGGAATTGAGCCGCA
CCGCGGCAGTCTGGCACCTATGCACACCGATCAGCGGCCGGCTGCGCGACACCTCAATCACAGCAATAGATTTAGCCTTG
ATGCTGCATCCCACTCCAGCGGTCGGTGGGGTACCGGCGGAAGCCGCATCCGAACTTATCGCAGCGCTGGAAGGTGACCG
CGGTTTCTACGCAGGAGCAGTGGGTTGGTGCGATGCCAGGGGGGACGGTCACTGGGTGGTATCCATCCGCTGTGCTCAGC
TATCGGCCGACCGCCGCATCGCCTTCGCCCATGCTGGCGGAGGCATCGTTGCCGAATCCGATCCCGATGACGAAGTTGAT
GAAACCACAGCGAAATTCGCCACGATTCTGAACGCGTTGGGAGTTAAGCAATGA

Upstream 100 bases:

>100_bases
GGCACGTTCTCCTTGATATACCTCAGACGATGGCTCCGGCTCAGGGCGACAACCTATCGTCCGGCATGGGCTTAACACAA
CCACCGTCTGCTGCTACGAC

Downstream 100 bases:

>100_bases
CCTAGCAATCCCATTGTACCAGACTGGAGAACGCCTCAGAAATTACGGCCATGATCCACGCATTTACCGAATTCGAACAT
GTTGACGATCAGTGCACTGT

Product: putative isochorismate synthase

Products: NA

Alternate protein names: Isochorismate mutase [H]

Number of amino acids: Translated: 577; Mature: 576

Protein sequence:

>577_residues
MAIRRGRNRASTFGCTELELTDTGRAQAKLAERALAEQKLVDPMMASNPRQCDLVTAKLAGLTVDKVSPLLAECTYGSYE
DLTTAKTREAEPAWLAWTHRYPRGEKRLASQRTCRPGRRYGVRALGVTDHVVRQPWPPLLGGDHTLDRAAICRGPALRYA
HQLDWDVRVRVRATATTHAWVAWLATTGRTRVNINNDDDKRRPVAQERAEQMRPSEPPFALCGPRGTLVADGVHTRYDDV
YLAQAALRSGVTPILLGALPFDAESPAALMAPSAVLRTDTLPNWQTGPLPTLRITAAVPTRANYRVWISNAREQLTAPGN
SLHKVVLARALQLVADAPLDGRAILRRLVTADPTAYGYLVDLTAAGGQYAGVALVGASPELLVSRFGDRVVCRPFAGSAP
RATNPEVDSANSAALAGSIKNRHEHQLVIDAIRAALEPVCDNLTIAPEPELSRTAAVWHLCTPISGRLRDTSITAIDLAL
MLHPTPAVGGVPAEAASELIAALEGDRGFYAGAVGWCDARGDGHWVVSIRCAQLSADRRIAFAHAGGGIVAESDPDDEVD
ETTAKFATILNALGVKQ

Sequences:

>Translated_577_residues
MAIRRGRNRASTFGCTELELTDTGRAQAKLAERALAEQKLVDPMMASNPRQCDLVTAKLAGLTVDKVSPLLAECTYGSYE
DLTTAKTREAEPAWLAWTHRYPRGEKRLASQRTCRPGRRYGVRALGVTDHVVRQPWPPLLGGDHTLDRAAICRGPALRYA
HQLDWDVRVRVRATATTHAWVAWLATTGRTRVNINNDDDKRRPVAQERAEQMRPSEPPFALCGPRGTLVADGVHTRYDDV
YLAQAALRSGVTPILLGALPFDAESPAALMAPSAVLRTDTLPNWQTGPLPTLRITAAVPTRANYRVWISNAREQLTAPGN
SLHKVVLARALQLVADAPLDGRAILRRLVTADPTAYGYLVDLTAAGGQYAGVALVGASPELLVSRFGDRVVCRPFAGSAP
RATNPEVDSANSAALAGSIKNRHEHQLVIDAIRAALEPVCDNLTIAPEPELSRTAAVWHLCTPISGRLRDTSITAIDLAL
MLHPTPAVGGVPAEAASELIAALEGDRGFYAGAVGWCDARGDGHWVVSIRCAQLSADRRIAFAHAGGGIVAESDPDDEVD
ETTAKFATILNALGVKQ
>Mature_576_residues
AIRRGRNRASTFGCTELELTDTGRAQAKLAERALAEQKLVDPMMASNPRQCDLVTAKLAGLTVDKVSPLLAECTYGSYED
LTTAKTREAEPAWLAWTHRYPRGEKRLASQRTCRPGRRYGVRALGVTDHVVRQPWPPLLGGDHTLDRAAICRGPALRYAH
QLDWDVRVRVRATATTHAWVAWLATTGRTRVNINNDDDKRRPVAQERAEQMRPSEPPFALCGPRGTLVADGVHTRYDDVY
LAQAALRSGVTPILLGALPFDAESPAALMAPSAVLRTDTLPNWQTGPLPTLRITAAVPTRANYRVWISNAREQLTAPGNS
LHKVVLARALQLVADAPLDGRAILRRLVTADPTAYGYLVDLTAAGGQYAGVALVGASPELLVSRFGDRVVCRPFAGSAPR
ATNPEVDSANSAALAGSIKNRHEHQLVIDAIRAALEPVCDNLTIAPEPELSRTAAVWHLCTPISGRLRDTSITAIDLALM
LHPTPAVGGVPAEAASELIAALEGDRGFYAGAVGWCDARGDGHWVVSIRCAQLSADRRIAFAHAGGGIVAESDPDDEVDE
TTAKFATILNALGVKQ

Specific function: Might be involved in the biosynthesis of menaquinone. Converts chorismate to isochorismate [H]

COG id: COG1169

COG function: function code HQ; Isochorismate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isochorismate synthase family [H]

Homologues:

Organism=Escherichia coli, GI1786809, Length=390, Percent_Identity=32.8205128205128, Blast_Score=206, Evalue=4e-54,
Organism=Escherichia coli, GI1788114, Length=210, Percent_Identity=30.952380952381, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1787518, Length=263, Percent_Identity=28.8973384030418, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI87082077, Length=299, Percent_Identity=29.4314381270903, Blast_Score=80, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6320935, Length=238, Percent_Identity=36.5546218487395, Blast_Score=116, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR015890
- InterPro:   IPR004561 [H]

Pfam domain/function: PF00425 Chorismate_bind [H]

EC number: =5.4.4.2 [H]

Molecular weight: Translated: 62107; Mature: 61976

Theoretical pI: Translated: 8.22; Mature: 8.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIRRGRNRASTFGCTELELTDTGRAQAKLAERALAEQKLVDPMMASNPRQCDLVTAKLA
CCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCHHHHCCCCCCEEEEHHHH
GLTVDKVSPLLAECTYGSYEDLTTAKTREAEPAWLAWTHRYPRGEKRLASQRTCRPGRRY
CCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCHHH
GVRALGVTDHVVRQPWPPLLGGDHTLDRAAICRGPALRYAHQLDWDVRVRVRATATTHAW
CEEEECCCHHHHHCCCCCCCCCCCCCCHHHHHCCCHHHHHHHCCCEEEEEEEEECCHHHH
VAWLATTGRTRVNINNDDDKRRPVAQERAEQMRPSEPPFALCGPRGTLVADGVHTRYDDV
HHEEEECCCEEEEECCCCHHHCCHHHHHHHHCCCCCCCEEEECCCCCEEECCCCCCCCHH
YLAQAALRSGVTPILLGALPFDAESPAALMAPSAVLRTDTLPNWQTGPLPTLRITAAVPT
HHHHHHHHCCCCEEEEECCCCCCCCCHHHHCCCHHHCCCCCCCCCCCCCCEEEEEEECCC
RANYRVWISNAREQLTAPGNSLHKVVLARALQLVADAPLDGRAILRRLVTADPTAYGYLV
CCCEEEEECCCHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEEE
DLTAAGGQYAGVALVGASPELLVSRFGDRVVCRPFAGSAPRATNPEVDSANSAALAGSIK
EEEECCCCCCCEEEECCCHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCHHHEHHHH
NRHEHQLVIDAIRAALEPVCDNLTIAPEPELSRTAAVWHLCTPISGRLRDTSITAIDLAL
CCHHHHHHHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEE
MLHPTPAVGGVPAEAASELIAALEGDRGFYAGAVGWCDARGDGHWVVSIRCAQLSADRRI
EECCCCCCCCCCHHHHHHHHHHHCCCCCEEECCEEEEECCCCCEEEEEEEEEEECCCCEE
AFAHAGGGIVAESDPDDEVDETTAKFATILNALGVKQ
EEEECCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AIRRGRNRASTFGCTELELTDTGRAQAKLAERALAEQKLVDPMMASNPRQCDLVTAKLA
CCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCHHHHCCCCCCEEEEHHHH
GLTVDKVSPLLAECTYGSYEDLTTAKTREAEPAWLAWTHRYPRGEKRLASQRTCRPGRRY
CCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCHHH
GVRALGVTDHVVRQPWPPLLGGDHTLDRAAICRGPALRYAHQLDWDVRVRVRATATTHAW
CEEEECCCHHHHHCCCCCCCCCCCCCCHHHHHCCCHHHHHHHCCCEEEEEEEEECCHHHH
VAWLATTGRTRVNINNDDDKRRPVAQERAEQMRPSEPPFALCGPRGTLVADGVHTRYDDV
HHEEEECCCEEEEECCCCHHHCCHHHHHHHHCCCCCCCEEEECCCCCEEECCCCCCCCHH
YLAQAALRSGVTPILLGALPFDAESPAALMAPSAVLRTDTLPNWQTGPLPTLRITAAVPT
HHHHHHHHCCCCEEEEECCCCCCCCCHHHHCCCHHHCCCCCCCCCCCCCCEEEEEEECCC
RANYRVWISNAREQLTAPGNSLHKVVLARALQLVADAPLDGRAILRRLVTADPTAYGYLV
CCCEEEEECCCHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEEE
DLTAAGGQYAGVALVGASPELLVSRFGDRVVCRPFAGSAPRATNPEVDSANSAALAGSIK
EEEECCCCCCCEEEECCCHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCHHHEHHHH
NRHEHQLVIDAIRAALEPVCDNLTIAPEPELSRTAAVWHLCTPISGRLRDTSITAIDLAL
CCHHHHHHHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEE
MLHPTPAVGGVPAEAASELIAALEGDRGFYAGAVGWCDARGDGHWVVSIRCAQLSADRRI
EECCCCCCCCCCHHHHHHHHHHHCCCCCEEECCEEEEECCCCCEEEEEEEEEEECCCCEE
AFAHAGGGIVAESDPDDEVDETTAKFATILNALGVKQ
EEEECCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]