Definition Mycobacterium leprae Br4923 chromosome, complete genome.
Accession NC_011896
Length 3,268,071

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The map label for this gene is eco57IBM [H]

Identifier: 221229800

GI number: 221229800

Start: 897980

End: 899647

Strand: Reverse

Name: eco57IBM [H]

Synonym: MLBr_00756

Alternate gene names: 221229800

Gene position: 899647-897980 (Counterclockwise)

Preceding gene: 221229801

Following gene: 221229799

Centisome position: 27.53

GC content: 60.37

Gene sequence:

>1668_bases
ATGGTGATCACGTATATCGGTGCTGCCCCCGATACTTGTTCCATGACGACGTTCGCGGGCAAAACGGCCGCCTCTGCCGA
CAAAGTTCGCGGTGGTTATTACACGCCGGCGCCCGTTGCCCGATTTTTGGCCCGTTGGGTTCGCCAGGCGGGGCAAAAGA
TCCTCGAGCCATCCTGCGGCGATGGCCGAATCCTCCGCGAGATCGCTGCACTCACCACCCAGGCGCACGGTGTAGAACTG
CTGGCGCATGAAGCGCGAAAGTCCCGGAAATTCTGCTCGGTCGACACCGAGAACTTCTTCACTTGGTTGAGCAAGACCCA
AGTAGGCAGCTGGGACGGTGTTGCCGGAAACCCGCCCTACATCCGTTTCGGGAACTGGGCAGCCGACCAACGGGATCCGG
CGCTGGAACTGATGAGGCATGTGGGCCTGCGCCCAACGAAATTGACCAATGCTTGGGTCCCGTTCGTCGTGGCAAGCACA
ACGCTGGTGCGCGACGGCGGGCGGGTGGGCCTAGTCGTTCCAGCAGAACTACTCCAAGTCACCTACGCGGCACAGCTGCG
CGAATTTCTGCTGAGCCTCTATCGGGAGATCATCCTCGTGACCTTCGAGCGGTTGGTGTTCGACGGCATCCTGCAAGAAG
TTGTATTGTTCTGCGGTGTCGTCGGTGCAGGCCCAGCGCAAATACGCACCATCAATCTCCGAGATGCAGAATCCCTTAAC
TCTTTAGCAGAGTCGAACCTGGGCGTCGAGTCTGCTCCGGCGCTGCTGCACGAAAAAGAAAAGTGGACCAAATACTTACT
CGACCCCGCGCAAATCCGATTGCTACGAAAACTCAAGCATGCCAACGCGATGACCCGGTTTGGCGAAGTGGCCGATGTGG
ATGTGGGCATTGTTACCGGCCGCAACAGCTTCTTCACCTTCACCGACGCCGATGCGCATGCCCTAAAGCTACGCAAGCAC
TGCGTACCGCTCGTCTCTCGCAGTACCCAGCTGGCCGGCATCGTCTACGACACGAACTGCCGGGCCAACGATATCGCCGC
CAAGCACCGGACTTGGCTGCTCGACGCCCCGCACCACCCGACAGATTCTGCCCTGGTCACACACATCGACGCAGGTAAGC
GCGCCGGCGTGGATAAGGGCTACAAATGCTCCATTCGCAAGCCATGGTGGAGCACACCGTCGCTGTGGATTCCCGACCTG
TTCATGCTGCGCCAAATCCACCTAGCGCCGCGGCTGACCGTCAACGCCGCCGCCGCAACCAGCACCGACACCGTGCATCG
GGTCCGCCTTATCGCCGACGTTGACCCGACCGCTCTTGCCGCAGTGTTCCACAACAGCGCCACCTTCGCCTTTGCCGAGA
TCATGGGGCGCAGTTACGGTGGAGGCATTTTAGAGCTCGAACCCCGGGAAGCCGAGCAGCTGCCCATTCCCCCACCGGCA
TATGCCAGCACCGAACTTGGCCAAGACATCGATCTGCTACTGAAGGCTAACGAGATCGAAAAGGCACTCGACATCGTGGA
TCGCCGGGTGCTGATCGACGGACTAGGCTTGTCGCCGGACCTTGTCGCTCAATGTCGCACGGCTTGGGCATCACTGCGCG
ATCGCAGAACCAAGCGGGGATCCCGGGTGAACATCTCGCGACGACCATTCGACAGTCCGCCATCGTAG

Upstream 100 bases:

>100_bases
GCGGATCGAACGATTCAACACCGACATGTACCACTCGTACCACGCCCGATTCCAGGGCCTCCCACCTCATGCCACCTAAG
TTGTTCGACGCGCCCTATGG

Downstream 100 bases:

>100_bases
TCCTCACCGACTGACAAAGCCTAATCCGGTCCAGGATATCGTGGCTGGATGCGGCACTGGCCTTTATCCACAGTCAACCC
GGCACGTGCCGCCGAGGGTG

Product: putative DNA methylase

Products: NA

Alternate protein names: M.Eco57IB; Adenine-specific methyltransferase Eco57IB [H]

Number of amino acids: Translated: 555; Mature: 555

Protein sequence:

>555_residues
MVITYIGAAPDTCSMTTFAGKTAASADKVRGGYYTPAPVARFLARWVRQAGQKILEPSCGDGRILREIAALTTQAHGVEL
LAHEARKSRKFCSVDTENFFTWLSKTQVGSWDGVAGNPPYIRFGNWAADQRDPALELMRHVGLRPTKLTNAWVPFVVAST
TLVRDGGRVGLVVPAELLQVTYAAQLREFLLSLYREIILVTFERLVFDGILQEVVLFCGVVGAGPAQIRTINLRDAESLN
SLAESNLGVESAPALLHEKEKWTKYLLDPAQIRLLRKLKHANAMTRFGEVADVDVGIVTGRNSFFTFTDADAHALKLRKH
CVPLVSRSTQLAGIVYDTNCRANDIAAKHRTWLLDAPHHPTDSALVTHIDAGKRAGVDKGYKCSIRKPWWSTPSLWIPDL
FMLRQIHLAPRLTVNAAAATSTDTVHRVRLIADVDPTALAAVFHNSATFAFAEIMGRSYGGGILELEPREAEQLPIPPPA
YASTELGQDIDLLLKANEIEKALDIVDRRVLIDGLGLSPDLVAQCRTAWASLRDRRTKRGSRVNISRRPFDSPPS

Sequences:

>Translated_555_residues
MVITYIGAAPDTCSMTTFAGKTAASADKVRGGYYTPAPVARFLARWVRQAGQKILEPSCGDGRILREIAALTTQAHGVEL
LAHEARKSRKFCSVDTENFFTWLSKTQVGSWDGVAGNPPYIRFGNWAADQRDPALELMRHVGLRPTKLTNAWVPFVVAST
TLVRDGGRVGLVVPAELLQVTYAAQLREFLLSLYREIILVTFERLVFDGILQEVVLFCGVVGAGPAQIRTINLRDAESLN
SLAESNLGVESAPALLHEKEKWTKYLLDPAQIRLLRKLKHANAMTRFGEVADVDVGIVTGRNSFFTFTDADAHALKLRKH
CVPLVSRSTQLAGIVYDTNCRANDIAAKHRTWLLDAPHHPTDSALVTHIDAGKRAGVDKGYKCSIRKPWWSTPSLWIPDL
FMLRQIHLAPRLTVNAAAATSTDTVHRVRLIADVDPTALAAVFHNSATFAFAEIMGRSYGGGILELEPREAEQLPIPPPA
YASTELGQDIDLLLKANEIEKALDIVDRRVLIDGLGLSPDLVAQCRTAWASLRDRRTKRGSRVNISRRPFDSPPS
>Mature_555_residues
MVITYIGAAPDTCSMTTFAGKTAASADKVRGGYYTPAPVARFLARWVRQAGQKILEPSCGDGRILREIAALTTQAHGVEL
LAHEARKSRKFCSVDTENFFTWLSKTQVGSWDGVAGNPPYIRFGNWAADQRDPALELMRHVGLRPTKLTNAWVPFVVAST
TLVRDGGRVGLVVPAELLQVTYAAQLREFLLSLYREIILVTFERLVFDGILQEVVLFCGVVGAGPAQIRTINLRDAESLN
SLAESNLGVESAPALLHEKEKWTKYLLDPAQIRLLRKLKHANAMTRFGEVADVDVGIVTGRNSFFTFTDADAHALKLRKH
CVPLVSRSTQLAGIVYDTNCRANDIAAKHRTWLLDAPHHPTDSALVTHIDAGKRAGVDKGYKCSIRKPWWSTPSLWIPDL
FMLRQIHLAPRLTVNAAAATSTDTVHRVRLIADVDPTALAAVFHNSATFAFAEIMGRSYGGGILELEPREAEQLPIPPPA
YASTELGQDIDLLLKANEIEKALDIVDRRVLIDGLGLSPDLVAQCRTAWASLRDRRTKRGSRVNISRRPFDSPPS

Specific function: This methylase recognizes the double-stranded sequence 5'-CTGAAG-3' in one strand and 5'-CTTCAG-3' in the other, causes specific methylation on A-5 on one strand, and protects the DNA from cleavage by the Eco57I endonuclease [H]

COG id: COG0827

COG function: function code L; Adenine-specific DNA methylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the N(4)/N(6)-methyltransferase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003356
- InterPro:   IPR002052
- InterPro:   IPR002296 [H]

Pfam domain/function: PF02384 N6_Mtase [H]

EC number: =2.1.1.72 [H]

Molecular weight: Translated: 61122; Mature: 61122

Theoretical pI: Translated: 9.17; Mature: 9.17

Prosite motif: PS00092 N6_MTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVITYIGAAPDTCSMTTFAGKTAASADKVRGGYYTPAPVARFLARWVRQAGQKILEPSCG
CEEEEECCCCCCCCEEECCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
DGRILREIAALTTQAHGVELLAHEARKSRKFCSVDTENFFTWLSKTQVGSWDGVAGNPPY
CHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCE
IRFGNWAADQRDPALELMRHVGLRPTKLTNAWVPFVVASTTLVRDGGRVGLVVPAELLQV
EEECCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHEEECCCCEEEEECHHHHHH
TYAAQLREFLLSLYREIILVTFERLVFDGILQEVVLFCGVVGAGPAQIRTINLRDAESLN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHH
SLAESNLGVESAPALLHEKEKWTKYLLDPAQIRLLRKLKHANAMTRFGEVADVDVGIVTG
HHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEC
RNSFFTFTDADAHALKLRKHCVPLVSRSTQLAGIVYDTNCRANDIAAKHRTWLLDAPHHP
CCCEEEEECCCHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHCCEEEEECCCCC
TDSALVTHIDAGKRAGVDKGYKCSIRKPWWSTPSLWIPDLFMLRQIHLAPRLTVNAAAAT
CCCCEEEEECCCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCC
STDTVHRVRLIADVDPTALAAVFHNSATFAFAEIMGRSYGGGILELEPREAEQLPIPPPA
CCCHHEEEEEEECCCHHHHHHHHHCCCHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCC
YASTELGQDIDLLLKANEIEKALDIVDRRVLIDGLGLSPDLVAQCRTAWASLRDRRTKRG
CCCHHCCCCCEEEEEHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHCCC
SRVNISRRPFDSPPS
CEEECCCCCCCCCCC
>Mature Secondary Structure
MVITYIGAAPDTCSMTTFAGKTAASADKVRGGYYTPAPVARFLARWVRQAGQKILEPSCG
CEEEEECCCCCCCCEEECCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
DGRILREIAALTTQAHGVELLAHEARKSRKFCSVDTENFFTWLSKTQVGSWDGVAGNPPY
CHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCE
IRFGNWAADQRDPALELMRHVGLRPTKLTNAWVPFVVASTTLVRDGGRVGLVVPAELLQV
EEECCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHEEECCCCEEEEECHHHHHH
TYAAQLREFLLSLYREIILVTFERLVFDGILQEVVLFCGVVGAGPAQIRTINLRDAESLN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHH
SLAESNLGVESAPALLHEKEKWTKYLLDPAQIRLLRKLKHANAMTRFGEVADVDVGIVTG
HHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEC
RNSFFTFTDADAHALKLRKHCVPLVSRSTQLAGIVYDTNCRANDIAAKHRTWLLDAPHHP
CCCEEEEECCCHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHCCEEEEECCCCC
TDSALVTHIDAGKRAGVDKGYKCSIRKPWWSTPSLWIPDLFMLRQIHLAPRLTVNAAAAT
CCCCEEEEECCCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCC
STDTVHRVRLIADVDPTALAAVFHNSATFAFAEIMGRSYGGGILELEPREAEQLPIPPPA
CCCHHEEEEEEECCCHHHHHHHHHCCCHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCC
YASTELGQDIDLLLKANEIEKALDIVDRRVLIDGLGLSPDLVAQCRTAWASLRDRRTKRG
CCCHHCCCCCEEEEEHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHCCC
SRVNISRRPFDSPPS
CEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1334261; 1334260 [H]