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The map label for this gene is add

Identifier: 221229774

GI number: 221229774

Start: 837688

End: 838776

Strand: Direct

Name: add

Synonym: MLBr_00700

Alternate gene names: 221229774

Gene position: 837688-838776 (Clockwise)

Preceding gene: 221229768

Following gene: 221229779

Centisome position: 25.63

GC content: 60.33

Gene sequence:

>1089_bases
ATGAATACGCCATTGCACCTAGAAAACATCAAGCAAGCGCCGAAGGCCCTGCTGCATGACCACCTTGACGGTGGGCTGCG
CCCAGCGACCGTGTTGGATATTGCCGGCCAGGTCGGCTATGATAGGCTCCCCGCTACCGACGTTGAGTCGCTAGAGACAT
GGTTTCGCACTGCTTCGCACAGCGGCTCGTTGGAGCGCTACCTGGAGCCGTTTTCTCATACCGTGGCCGTGATGCAGACA
CCAGAGGCGTTGCACCGCGTCGCTTATGAGTGCGTGGAAGACCTCGCCGCTGATTCGGTGGTCTACGCCGAAGTCCGGTT
CGCTCCGGAGCTGCACATCGACGAGGGGTTGTCGTTTGATGAGGTCCTCGCAAGCGTGCTGGCGGGTTTTGCTGACGGTG
AAAGGGCTTGTGCCGCCGAGGGCAATGCCATCACAGTGCGCTGCTTGGTCACAGCGATGCGGCACGCGGCAATGTCGCGG
GAGATCGCCGAGCTAGCGATCCGGTTCCGGGACAAAGGAGTCGTCGGATTCGACATCGCTGGTGCTGAGGCTGGGCACCC
TCCGACTCGGCACCTCGACGCTTTTGAGTACATGCGTAGTAATAATGCGCGCTTCACTATTCATGCGGGTGAGGCGTTCG
GGCTGCCATCTATCCACGAGGCGATCGCGTTCTGCGGAGCTGACCGGCTGGGCCACGGGGTGCGGATCGTCGACGACATC
GACGTTGATCCTGGTGGTGGCATCCGGTTGGGTCCCCTGGCCTCGATCCTGCGGGACAAGCGAATACCGCTGGAGCTGTG
CCCCAGCTCGAACCTGCAAACCGGCGCGGTGGCAAGCATCACCGAGCACCCGTTTGATCTGCTGGCCTGGGCACGTTTCC
GGGTGACAGTCAACACCGACAACCGGCTTATGAGCGACACGTCGATGAGCCTGGAGATGCACCGCTTGGTGGAGGCGTTC
GGCTACGGTTGGGGTGATCTCGAACGTTTCACCATCAATGCTATGAAGTCGGCGTTTATTCCGTTCGATCAACGGTTAGC
AATAATCGATGAGGTTATCAAGCCTCGGTTCGCCGTGCTGGTCGGATAG

Upstream 100 bases:

>100_bases
AATACCTCGGCCCAGCAATGGCGTAAAAGCTGTAGCGTGGTTGGAGCGTTGGTGACACACCGCCGGAGCCGTGATCGTTG
ATCATCGATAGAGTCGCCCG

Downstream 100 bases:

>100_bases
CGTTGGGGCAGAACGCTATTGGAGAACCGGAAGCTACGAGGTTTGGGGGCATGAACATTAATTGAATTGCCCTTCCTGGG
ATCGATGTTGCTCACGGGCT

Product: adenosine deaminase

Products: NA

Alternate protein names: Adenosine aminohydrolase

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MNTPLHLENIKQAPKALLHDHLDGGLRPATVLDIAGQVGYDRLPATDVESLETWFRTASHSGSLERYLEPFSHTVAVMQT
PEALHRVAYECVEDLAADSVVYAEVRFAPELHIDEGLSFDEVLASVLAGFADGERACAAEGNAITVRCLVTAMRHAAMSR
EIAELAIRFRDKGVVGFDIAGAEAGHPPTRHLDAFEYMRSNNARFTIHAGEAFGLPSIHEAIAFCGADRLGHGVRIVDDI
DVDPGGGIRLGPLASILRDKRIPLELCPSSNLQTGAVASITEHPFDLLAWARFRVTVNTDNRLMSDTSMSLEMHRLVEAF
GYGWGDLERFTINAMKSAFIPFDQRLAIIDEVIKPRFAVLVG

Sequences:

>Translated_362_residues
MNTPLHLENIKQAPKALLHDHLDGGLRPATVLDIAGQVGYDRLPATDVESLETWFRTASHSGSLERYLEPFSHTVAVMQT
PEALHRVAYECVEDLAADSVVYAEVRFAPELHIDEGLSFDEVLASVLAGFADGERACAAEGNAITVRCLVTAMRHAAMSR
EIAELAIRFRDKGVVGFDIAGAEAGHPPTRHLDAFEYMRSNNARFTIHAGEAFGLPSIHEAIAFCGADRLGHGVRIVDDI
DVDPGGGIRLGPLASILRDKRIPLELCPSSNLQTGAVASITEHPFDLLAWARFRVTVNTDNRLMSDTSMSLEMHRLVEAF
GYGWGDLERFTINAMKSAFIPFDQRLAIIDEVIKPRFAVLVG
>Mature_362_residues
MNTPLHLENIKQAPKALLHDHLDGGLRPATVLDIAGQVGYDRLPATDVESLETWFRTASHSGSLERYLEPFSHTVAVMQT
PEALHRVAYECVEDLAADSVVYAEVRFAPELHIDEGLSFDEVLASVLAGFADGERACAAEGNAITVRCLVTAMRHAAMSR
EIAELAIRFRDKGVVGFDIAGAEAGHPPTRHLDAFEYMRSNNARFTIHAGEAFGLPSIHEAIAFCGADRLGHGVRIVDDI
DVDPGGGIRLGPLASILRDKRIPLELCPSSNLQTGAVASITEHPFDLLAWARFRVTVNTDNRLMSDTSMSLEMHRLVEAF
GYGWGDLERFTINAMKSAFIPFDQRLAIIDEVIKPRFAVLVG

Specific function: Unknown

COG id: COG1816

COG function: function code F; Adenosine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosine and AMP deaminases family

Homologues:

Organism=Homo sapiens, GI47078295, Length=358, Percent_Identity=30.1675977653631, Blast_Score=140, Evalue=1e-33,
Organism=Escherichia coli, GI1787910, Length=340, Percent_Identity=29.4117647058824, Blast_Score=139, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI32565969, Length=347, Percent_Identity=29.6829971181556, Blast_Score=117, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI17538512, Length=347, Percent_Identity=29.6829971181556, Blast_Score=117, Evalue=8e-27,
Organism=Saccharomyces cerevisiae, GI6324188, Length=302, Percent_Identity=23.1788079470199, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24645260, Length=352, Percent_Identity=24.1477272727273, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ADD_MYCLB (B8ZUW8)

Other databases:

- EMBL:   FM211192
- RefSeq:   YP_002503190.1
- ProteinModelPortal:   B8ZUW8
- SMR:   B8ZUW8
- EnsemblBacteria:   EBMYCT00000085305
- GeneID:   7325971
- GenomeReviews:   FM211192_GR
- GeneTree:   EBGT00050000016615
- HOGENOM:   HBG630382
- OMA:   PYYMAMN
- ProtClustDB:   PRK09358
- HAMAP:   MF_00540
- InterPro:   IPR001365
- InterPro:   IPR006330
- PANTHER:   PTHR11409
- TIGRFAMs:   TIGR01430

Pfam domain/function: PF00962 A_deaminase

EC number: =3.5.4.4

Molecular weight: Translated: 39638; Mature: 39638

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00485 A_DEAMINASE

Important sites: ACT_SITE 211-211 BINDING 21-21 BINDING 23-23 BINDING 181-181

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTPLHLENIKQAPKALLHDHLDGGLRPATVLDIAGQVGYDRLPATDVESLETWFRTASH
CCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCC
SGSLERYLEPFSHTVAVMQTPEALHRVAYECVEDLAADSVVYAEVRFAPELHIDEGLSFD
CCCHHHHHHHHHHHHHEEECHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCHH
EVLASVLAGFADGERACAAEGNAITVRCLVTAMRHAAMSREIAELAIRFRDKGVVGFDIA
HHHHHHHHCCCCCCCHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEC
GAEAGHPPTRHLDAFEYMRSNNARFTIHAGEAFGLPSIHEAIAFCGADRLGHGVRIVDDI
CCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHCHHHHCCCEEEEEEC
DVDPGGGIRLGPLASILRDKRIPLELCPSSNLQTGAVASITEHPFDLLAWARFRVTVNTD
CCCCCCCEEHHHHHHHHHCCCCCEEECCCCCCCCCCCHHHHCCCHHHHEEEEEEEEECCC
NRLMSDTSMSLEMHRLVEAFGYGWGDLERFTINAMKSAFIPFDQRLAIIDEVIKPRFAVL
CCEECCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEE
VG
EC
>Mature Secondary Structure
MNTPLHLENIKQAPKALLHDHLDGGLRPATVLDIAGQVGYDRLPATDVESLETWFRTASH
CCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCC
SGSLERYLEPFSHTVAVMQTPEALHRVAYECVEDLAADSVVYAEVRFAPELHIDEGLSFD
CCCHHHHHHHHHHHHHEEECHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCHH
EVLASVLAGFADGERACAAEGNAITVRCLVTAMRHAAMSREIAELAIRFRDKGVVGFDIA
HHHHHHHHCCCCCCCHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEC
GAEAGHPPTRHLDAFEYMRSNNARFTIHAGEAFGLPSIHEAIAFCGADRLGHGVRIVDDI
CCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHCHHHHCCCEEEEEEC
DVDPGGGIRLGPLASILRDKRIPLELCPSSNLQTGAVASITEHPFDLLAWARFRVTVNTD
CCCCCCCEEHHHHHHHHHCCCCCEEECCCCCCCCCCCHHHHCCCHHHHEEEEEEEEECCC
NRLMSDTSMSLEMHRLVEAFGYGWGDLERFTINAMKSAFIPFDQRLAIIDEVIKPRFAVL
CCEECCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEE
VG
EC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA