| Definition | Mycobacterium leprae Br4923 chromosome, complete genome. |
|---|---|
| Accession | NC_011896 |
| Length | 3,268,071 |
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The map label for this gene is lepA
Identifier: 221229728
GI number: 221229728
Start: 742725
End: 744665
Strand: Direct
Name: lepA
Synonym: MLBr_00611
Alternate gene names: 221229728
Gene position: 742725-744665 (Clockwise)
Preceding gene: 221229727
Following gene: 221229729
Centisome position: 22.73
GC content: 57.39
Gene sequence:
>1941_bases GTGTCTTGGTCACTTCGCGTGGATAAGCCGGACACCGGCGAATCGCCGTTCAAACATTCTCTAGTAACTGGAGCCCAGGA GATTCCCATCAGCAGTTTCGCTGACAAGACCTTTACCGCGCCGGCGCAGATTAGGAACTTCTGCATAATCGCTCATATTG ATCACGGCAAATCCACGCTGGCGGACCGGATGCTTCAGCTGACTGGTGTCGTCGATGAGCGGTCGATGCGTGCCCAGTAC CTGGACCGGATGGACATCGAACGTGAGCGCGGAATCACGATTAAAGCGCAGAACGTGCGGCTGTCTTGGAGTGTCACAGC TGGTGGGACGACTGAGAATTATGTGTTGCACTTGATCGACACCCCCGGCCATGTGGACTTCACCTACGAGGTATCGCGAG CATTGGAAGCCTGTGAGGGTGCGGTGCTGCTGGTAGACGCCGTCCAGGGCATCGAAGCTCAGACCTTGGCCAATCTCTAT CTCGCTCTGGAGCGTGACTTGACGATTATTCCGGTGCTAAACAAAATCGACCTGCCGGCTGCCGATCCGGACCGTTACGC CGCTGAGATCGCCCACATCATTGGTTATGAGTCAGGCGATGTGCTTCGGGTGTCCGGCAAAACCGGCGAGGGGGTTTCTG ACCTTCTTGACGAGGTGGTCCGTCGGGTGCCGCATCCGCAAGGTGACCCTGATGCGCCTACCCGCGCGATGATCTTCGAC TCCGTCTACGACATCTACCGAGGCGTGGTCACCTACGTCCGTGTGGTCGACGGCAAGATCAGCCCGCGTGAGCGCATCGC GATGATGTCCACCGGTGCGACGTACGAACTGCTCGAGGTCGGCATCGTGTCGCCTGAACCGAAGGCCAGCGCGGGCCTGG GCGTGGGGGAGGTGGGCTACCTGATTACTGGGGTTAAAGACGTCCGCCAATCCAAAGTCGGCGACACTGTAACGACGGTT CGTTATGGTGCCACTGAACCGTTAACTGGCTACCGAGAACCCAAGCCCATGGTGTACTCCGGGCTGTATCCCGTCGACAG TTCGGACTACCCGAGTTTGCGTGACGCTCTAGGTAAGTTACAGCTCAACGACGCGGCGCTGACCTACGAGCCGGAAACAT CGGTGGCGCTGGGCGTTGGGTACCGGTGCGGCTTCCTCGGTTTGCTGCACATAGATATAACCCGCGAACGCTTAGAGCGC GAGTTCGACCTGGACCTGATCTCCACGTCGCCCAACGTCGTATACCGTGTGGTGACAGAAGATAACACCGAGATTGTGGT GACCAACCCGTCAGACTGGCCGGAGGGCAAGATCCGAACGGTGTACGAGCCAGTGGTGAAGATCACCATCATTGCGCCCA GCGAGTTCATCGGAACGATCATGGAGCTGTGCCAGTCGCGCCGTGGCGAATTAGGTGGCATGGACTATCTTTCACCTGAG CGAGTCGAGTTACGCTACATTATGCCGCTCGGGGAAATCATCTTCGATTTCTTCGATTCGCTGAAGTCACGCACCCGGGG CTACGCTAGCCTCGACTATGAGGAGGCTGGCGAGCAGGAGGCCCAACTGGTCAAGGTTGACATCCTGCTGCAAGGCGAGG CCGTCGACGCATTCAGCGCGATTGTGCACAAGGATTCAGCCTCTGCCTATGGCAACAAGATGACCAACAAGCTCAAAGAA CTGATCCCACGTCAGCAGTTTGAGGTGCCAGTACAGGCGGCTATTGGATCGAAAGTCATTGCGCGCGAAAATATTAGGGC GATACGCAAGGATGTGCTGTCGAAATGTTATGGCGGCGATATCACCCGCAAACGTAAGCTTCTGGAAAAGCAGAAGGAAG GCAAGAAACGGATGAAGACCATTGGGCGGGTCGAGGTGCCGCAGGAAGCGTTTGTCGCCGCGTTGTCCGCCGATGCCGCA GGAGACAAGGACAAGAAATAA
Upstream 100 bases:
>100_bases GTTCTTGGCAAGCCGTTGTAATGTTTTCCACTATGACTGCCAGGCTGACGCCATATTCGCAGTATAGGACCGAAAGGCCC GGCGAGATTGCTGTGCCAGT
Downstream 100 bases:
>100_bases CCTGTTCGACTTTATGTTGACGAACTGAAGCATCAAAAGATTGTTCTGCAAGCACATTCAATATTTAAGCGTGCATACTC TTGGCGCATTCGGGTGCTGT
Product: GTP-binding protein LepA
Products: NA
Alternate protein names: EF-4; Ribosomal back-translocase LepA
Number of amino acids: Translated: 646; Mature: 645
Protein sequence:
>646_residues MSWSLRVDKPDTGESPFKHSLVTGAQEIPISSFADKTFTAPAQIRNFCIIAHIDHGKSTLADRMLQLTGVVDERSMRAQY LDRMDIERERGITIKAQNVRLSWSVTAGGTTENYVLHLIDTPGHVDFTYEVSRALEACEGAVLLVDAVQGIEAQTLANLY LALERDLTIIPVLNKIDLPAADPDRYAAEIAHIIGYESGDVLRVSGKTGEGVSDLLDEVVRRVPHPQGDPDAPTRAMIFD SVYDIYRGVVTYVRVVDGKISPRERIAMMSTGATYELLEVGIVSPEPKASAGLGVGEVGYLITGVKDVRQSKVGDTVTTV RYGATEPLTGYREPKPMVYSGLYPVDSSDYPSLRDALGKLQLNDAALTYEPETSVALGVGYRCGFLGLLHIDITRERLER EFDLDLISTSPNVVYRVVTEDNTEIVVTNPSDWPEGKIRTVYEPVVKITIIAPSEFIGTIMELCQSRRGELGGMDYLSPE RVELRYIMPLGEIIFDFFDSLKSRTRGYASLDYEEAGEQEAQLVKVDILLQGEAVDAFSAIVHKDSASAYGNKMTNKLKE LIPRQQFEVPVQAAIGSKVIARENIRAIRKDVLSKCYGGDITRKRKLLEKQKEGKKRMKTIGRVEVPQEAFVAALSADAA GDKDKK
Sequences:
>Translated_646_residues MSWSLRVDKPDTGESPFKHSLVTGAQEIPISSFADKTFTAPAQIRNFCIIAHIDHGKSTLADRMLQLTGVVDERSMRAQY LDRMDIERERGITIKAQNVRLSWSVTAGGTTENYVLHLIDTPGHVDFTYEVSRALEACEGAVLLVDAVQGIEAQTLANLY LALERDLTIIPVLNKIDLPAADPDRYAAEIAHIIGYESGDVLRVSGKTGEGVSDLLDEVVRRVPHPQGDPDAPTRAMIFD SVYDIYRGVVTYVRVVDGKISPRERIAMMSTGATYELLEVGIVSPEPKASAGLGVGEVGYLITGVKDVRQSKVGDTVTTV RYGATEPLTGYREPKPMVYSGLYPVDSSDYPSLRDALGKLQLNDAALTYEPETSVALGVGYRCGFLGLLHIDITRERLER EFDLDLISTSPNVVYRVVTEDNTEIVVTNPSDWPEGKIRTVYEPVVKITIIAPSEFIGTIMELCQSRRGELGGMDYLSPE RVELRYIMPLGEIIFDFFDSLKSRTRGYASLDYEEAGEQEAQLVKVDILLQGEAVDAFSAIVHKDSASAYGNKMTNKLKE LIPRQQFEVPVQAAIGSKVIARENIRAIRKDVLSKCYGGDITRKRKLLEKQKEGKKRMKTIGRVEVPQEAFVAALSADAA GDKDKK >Mature_645_residues SWSLRVDKPDTGESPFKHSLVTGAQEIPISSFADKTFTAPAQIRNFCIIAHIDHGKSTLADRMLQLTGVVDERSMRAQYL DRMDIERERGITIKAQNVRLSWSVTAGGTTENYVLHLIDTPGHVDFTYEVSRALEACEGAVLLVDAVQGIEAQTLANLYL ALERDLTIIPVLNKIDLPAADPDRYAAEIAHIIGYESGDVLRVSGKTGEGVSDLLDEVVRRVPHPQGDPDAPTRAMIFDS VYDIYRGVVTYVRVVDGKISPRERIAMMSTGATYELLEVGIVSPEPKASAGLGVGEVGYLITGVKDVRQSKVGDTVTTVR YGATEPLTGYREPKPMVYSGLYPVDSSDYPSLRDALGKLQLNDAALTYEPETSVALGVGYRCGFLGLLHIDITRERLERE FDLDLISTSPNVVYRVVTEDNTEIVVTNPSDWPEGKIRTVYEPVVKITIIAPSEFIGTIMELCQSRRGELGGMDYLSPER VELRYIMPLGEIIFDFFDSLKSRTRGYASLDYEEAGEQEAQLVKVDILLQGEAVDAFSAIVHKDSASAYGNKMTNKLKEL IPRQQFEVPVQAAIGSKVIARENIRAIRKDVLSKCYGGDITRKRKLLEKQKEGKKRMKTIGRVEVPQEAFVAALSADAAG DKDKK
Specific function: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- transloc
COG id: COG0481
COG function: function code M; Membrane GTPase LepA
Gene ontology:
Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the GTP-binding elongation factor family. LepA subfamily
Homologues:
Organism=Homo sapiens, GI157426893, Length=607, Percent_Identity=47.9406919275124, Blast_Score=615, Evalue=1e-176, Organism=Homo sapiens, GI94966754, Length=137, Percent_Identity=42.3357664233577, Blast_Score=120, Evalue=5e-27, Organism=Homo sapiens, GI18390331, Length=184, Percent_Identity=33.1521739130435, Blast_Score=101, Evalue=3e-21, Organism=Homo sapiens, GI310132016, Length=114, Percent_Identity=39.4736842105263, Blast_Score=99, Evalue=9e-21, Organism=Homo sapiens, GI310110807, Length=114, Percent_Identity=39.4736842105263, Blast_Score=99, Evalue=9e-21, Organism=Homo sapiens, GI310123363, Length=114, Percent_Identity=39.4736842105263, Blast_Score=99, Evalue=9e-21, Organism=Homo sapiens, GI25306287, Length=153, Percent_Identity=42.483660130719, Blast_Score=99, Evalue=1e-20, Organism=Homo sapiens, GI25306283, Length=153, Percent_Identity=42.483660130719, Blast_Score=99, Evalue=1e-20, Organism=Homo sapiens, GI19923640, Length=153, Percent_Identity=42.483660130719, Blast_Score=99, Evalue=1e-20, Organism=Homo sapiens, GI4503483, Length=145, Percent_Identity=35.8620689655172, Blast_Score=97, Evalue=3e-20, Organism=Homo sapiens, GI217272892, Length=136, Percent_Identity=32.3529411764706, Blast_Score=79, Evalue=1e-14, Organism=Homo sapiens, GI217272894, Length=136, Percent_Identity=32.3529411764706, Blast_Score=79, Evalue=1e-14, Organism=Homo sapiens, GI223555963, Length=278, Percent_Identity=27.6978417266187, Blast_Score=72, Evalue=1e-12, Organism=Homo sapiens, GI5729864, Length=278, Percent_Identity=27.6978417266187, Blast_Score=72, Evalue=1e-12, Organism=Homo sapiens, GI94966752, Length=102, Percent_Identity=40.1960784313725, Blast_Score=70, Evalue=6e-12, Organism=Homo sapiens, GI53729339, Length=272, Percent_Identity=26.4705882352941, Blast_Score=68, Evalue=3e-11, Organism=Homo sapiens, GI53729337, Length=272, Percent_Identity=26.4705882352941, Blast_Score=68, Evalue=3e-11, Organism=Escherichia coli, GI1788922, Length=594, Percent_Identity=54.040404040404, Blast_Score=629, Evalue=0.0, Organism=Escherichia coli, GI48994988, Length=491, Percent_Identity=27.6985743380855, Blast_Score=157, Evalue=3e-39, Organism=Escherichia coli, GI1789738, Length=147, Percent_Identity=39.4557823129252, Blast_Score=92, Evalue=1e-19, Organism=Escherichia coli, GI1790835, Length=149, Percent_Identity=31.5436241610738, Blast_Score=79, Evalue=7e-16, Organism=Escherichia coli, GI1789559, Length=306, Percent_Identity=27.1241830065359, Blast_Score=74, Evalue=3e-14, Organism=Caenorhabditis elegans, GI17557151, Length=618, Percent_Identity=41.2621359223301, Blast_Score=478, Evalue=1e-135, Organism=Caenorhabditis elegans, GI71988811, Length=141, Percent_Identity=39.0070921985816, Blast_Score=102, Evalue=9e-22, Organism=Caenorhabditis elegans, GI71988819, Length=141, Percent_Identity=39.0070921985816, Blast_Score=101, Evalue=1e-21, Organism=Caenorhabditis elegans, GI17533571, Length=148, Percent_Identity=40.5405405405405, Blast_Score=99, Evalue=8e-21, Organism=Caenorhabditis elegans, GI17556745, Length=161, Percent_Identity=33.5403726708075, Blast_Score=94, Evalue=2e-19, Organism=Caenorhabditis elegans, GI17506493, Length=156, Percent_Identity=34.6153846153846, Blast_Score=92, Evalue=7e-19, Organism=Caenorhabditis elegans, GI17552882, Length=152, Percent_Identity=32.8947368421053, Blast_Score=85, Evalue=1e-16, Organism=Saccharomyces cerevisiae, GI6323320, Length=599, Percent_Identity=45.0751252086811, Blast_Score=539, Evalue=1e-154, Organism=Saccharomyces cerevisiae, GI6323098, Length=149, Percent_Identity=39.5973154362416, Blast_Score=105, Evalue=2e-23, Organism=Saccharomyces cerevisiae, GI6324707, Length=144, Percent_Identity=37.5, Blast_Score=102, Evalue=1e-22, Organism=Saccharomyces cerevisiae, GI6320593, Length=144, Percent_Identity=37.5, Blast_Score=102, Evalue=1e-22, Organism=Saccharomyces cerevisiae, GI6322359, Length=120, Percent_Identity=42.5, Blast_Score=97, Evalue=5e-21, Organism=Saccharomyces cerevisiae, GI6324166, Length=144, Percent_Identity=41.6666666666667, Blast_Score=96, Evalue=1e-20, Organism=Drosophila melanogaster, GI78706572, Length=602, Percent_Identity=43.687707641196, Blast_Score=526, Evalue=1e-149, Organism=Drosophila melanogaster, GI28574573, Length=137, Percent_Identity=43.7956204379562, Blast_Score=110, Evalue=3e-24, Organism=Drosophila melanogaster, GI24582462, Length=184, Percent_Identity=34.7826086956522, Blast_Score=101, Evalue=1e-21, Organism=Drosophila melanogaster, GI24585711, Length=148, Percent_Identity=34.4594594594595, Blast_Score=93, Evalue=7e-19, Organism=Drosophila melanogaster, GI24585713, Length=148, Percent_Identity=34.4594594594595, Blast_Score=93, Evalue=7e-19, Organism=Drosophila melanogaster, GI24585709, Length=148, Percent_Identity=34.4594594594595, Blast_Score=92, Evalue=8e-19, Organism=Drosophila melanogaster, GI21357743, Length=149, Percent_Identity=34.8993288590604, Blast_Score=89, Evalue=9e-18, Organism=Drosophila melanogaster, GI221458488, Length=152, Percent_Identity=37.5, Blast_Score=88, Evalue=1e-17,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): LEPA_MYCLB (B8ZUS2)
Other databases:
- EMBL: FM211192 - RefSeq: YP_002503144.1 - ProteinModelPortal: B8ZUS2 - SMR: B8ZUS2 - EnsemblBacteria: EBMYCT00000087588 - GeneID: 7326966 - GenomeReviews: FM211192_GR - GeneTree: EBGT00050000015348 - HOGENOM: HBG286375 - OMA: YDSYRGV - ProtClustDB: PRK05433 - GO: GO:0006412 - HAMAP: MF_00071 - InterPro: IPR009022 - InterPro: IPR006297 - InterPro: IPR013842 - InterPro: IPR000795 - InterPro: IPR005225 - InterPro: IPR000640 - InterPro: IPR009000 - Gene3D: G3DSA:3.30.70.240 - PRINTS: PR00315 - SMART: SM00838 - TIGRFAMs: TIGR01393 - TIGRFAMs: TIGR00231
Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF06421 LepA_C; SSF54980 EFG_III_V; SSF50447 Translat_factor
EC number: NA
Molecular weight: Translated: 71330; Mature: 71199
Theoretical pI: Translated: 5.03; Mature: 5.03
Prosite motif: PS00301 EFACTOR_GTP
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 2.0 %Met (Translated Protein) 2.8 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 1.9 %Met (Mature Protein) 2.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSWSLRVDKPDTGESPFKHSLVTGAQEIPISSFADKTFTAPAQIRNFCIIAHIDHGKSTL CCCEEECCCCCCCCCCHHHHHHCCHHHCCCHHHCCCCCCCHHHHCCEEEEEEECCCHHHH ADRMLQLTGVVDERSMRAQYLDRMDIERERGITIKAQNVRLSWSVTAGGTTENYVLHLID HHHHHHHHCCHHHHHHHHHHHHHHCCHHHCCCEEEEEEEEEEEEEECCCCCCCEEEEEEE TPGHVDFTYEVSRALEACEGAVLLVDAVQGIEAQTLANLYLALERDLTIIPVLNKIDLPA CCCCEEEEHHHHHHHHHHCCCEEEEEHHCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCC ADPDRYAAEIAHIIGYESGDVLRVSGKTGEGVSDLLDEVVRRVPHPQGDPDAPTRAMIFD CCHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHH SVYDIYRGVVTYVRVVDGKISPRERIAMMSTGATYELLEVGIVSPEPKASAGLGVGEVGY HHHHHHHHHHHHHHHHCCCCCHHHHEEEEECCCCEEEHEEECCCCCCCCCCCCCCCHHHH LITGVKDVRQSKVGDTVTTVRYGATEPLTGYREPKPMVYSGLYPVDSSDYPSLRDALGKL HHHCHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCEEECCCCCCCCCCCHHHHHHCCE QLNDAALTYEPETSVALGVGYRCGFLGLLHIDITRERLEREFDLDLISTSPNVVYRVVTE EECCCEEEECCCCCEEEECCCCCCEEEEEEEEEEHHHHHHHCCCEEEECCCCEEEEEEEC DNTEIVVTNPSDWPEGKIRTVYEPVVKITIIAPSEFIGTIMELCQSRRGELGGMDYLSPE CCCEEEEECCCCCCCCCEEEEEECEEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCC RVELRYIMPLGEIIFDFFDSLKSRTRGYASLDYEEAGEQEAQLVKVDILLQGEAVDAFSA CEEEEEECHHHHHHHHHHHHHHHHCCCCEECCHHHCCCCCCEEEEEEEEEECCHHHHHHH IVHKDSASAYGNKMTNKLKELIPRQQFEVPVQAAIGSKVIARENIRAIRKDVLSKCYGGD HHHCCCHHHHHHHHHHHHHHHCCCHHCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCCC ITRKRKLLEKQKEGKKRMKTIGRVEVPQEAFVAALSADAAGDKDKK HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCC >Mature Secondary Structure SWSLRVDKPDTGESPFKHSLVTGAQEIPISSFADKTFTAPAQIRNFCIIAHIDHGKSTL CCEEECCCCCCCCCCHHHHHHCCHHHCCCHHHCCCCCCCHHHHCCEEEEEEECCCHHHH ADRMLQLTGVVDERSMRAQYLDRMDIERERGITIKAQNVRLSWSVTAGGTTENYVLHLID HHHHHHHHCCHHHHHHHHHHHHHHCCHHHCCCEEEEEEEEEEEEEECCCCCCCEEEEEEE TPGHVDFTYEVSRALEACEGAVLLVDAVQGIEAQTLANLYLALERDLTIIPVLNKIDLPA CCCCEEEEHHHHHHHHHHCCCEEEEEHHCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCC ADPDRYAAEIAHIIGYESGDVLRVSGKTGEGVSDLLDEVVRRVPHPQGDPDAPTRAMIFD CCHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHH SVYDIYRGVVTYVRVVDGKISPRERIAMMSTGATYELLEVGIVSPEPKASAGLGVGEVGY HHHHHHHHHHHHHHHHCCCCCHHHHEEEEECCCCEEEHEEECCCCCCCCCCCCCCCHHHH LITGVKDVRQSKVGDTVTTVRYGATEPLTGYREPKPMVYSGLYPVDSSDYPSLRDALGKL HHHCHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCEEECCCCCCCCCCCHHHHHHCCE QLNDAALTYEPETSVALGVGYRCGFLGLLHIDITRERLEREFDLDLISTSPNVVYRVVTE EECCCEEEECCCCCEEEECCCCCCEEEEEEEEEEHHHHHHHCCCEEEECCCCEEEEEEEC DNTEIVVTNPSDWPEGKIRTVYEPVVKITIIAPSEFIGTIMELCQSRRGELGGMDYLSPE CCCEEEEECCCCCCCCCEEEEEECEEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCC RVELRYIMPLGEIIFDFFDSLKSRTRGYASLDYEEAGEQEAQLVKVDILLQGEAVDAFSA CEEEEEECHHHHHHHHHHHHHHHHCCCCEECCHHHCCCCCCEEEEEEEEEECCHHHHHHH IVHKDSASAYGNKMTNKLKELIPRQQFEVPVQAAIGSKVIARENIRAIRKDVLSKCYGGD HHHCCCHHHHHHHHHHHHHHHCCCHHCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCCC ITRKRKLLEKQKEGKKRMKTIGRVEVPQEAFVAALSADAAGDKDKK HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: NA