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The map label for this gene is csd2

Identifier: 221229720

GI number: 221229720

Start: 723263

End: 724519

Strand: Direct

Name: csd2

Synonym: MLBr_00596

Alternate gene names: 221229720

Gene position: 723263-724519 (Clockwise)

Preceding gene: 221229719

Following gene: 221229721

Centisome position: 22.13

GC content: 58.63

Gene sequence:

>1257_bases
ATGACTATCTCGCTGACCCCATTGGATCTCTCGGCGATTCGTGCGGATTTTCCGATCCTAAAGCGCGTCATGCGGGGTGG
AAACCAGTTAGCATATCTGGATTCTGGGGCGACGTCGCAGCGCCCGGTTCAGGTACTCGACGCTGAGCGGGAGTTTCTTG
TTACGTCCAACGGTGCGGTGCATCGTGGTGCGCACCAATTGATGGAAGAGGCCACTGACGCCTACGAGCGGGGGCGCGTC
GACATAGCGGCATTTATCGGTGCTGCCGCCGACGAATTGGTCTTCACTAAGAACGCTACCGAGTCGCTCAATTTAGTGTC
ATATGTCTTCGGCGACAATCGGTTCGAGGGTACGTCCGGTGACGGTGGTGATGTTATTGTCACTACCGAGCTCGAGCACC
ACGCTAACCTGATTCCATGGCAGGAGCTAGCCCGGCGTATTGGTGCGACGTTACGCTGGTACGGAGTCACCGACGACGGG
CAAATCGACTTGGACTCGCTACAGCTCGACGAGCGCGTCAAGGTCGTCGCTTTCAGCCATCACTCCAATGTGACTGGTGC
GGTGGCTCCTGTGCGTGAGCTGGTAGCGAGAGCCAAGGAGGTGGGTGCACTAACAGTTCTGGACGCCTGTCAGTCGGTGC
CGCACCAGCCGGTCGATTTGCATGGTTTGGGTGTTGACTTCGCAGCGTTCTCCGGACATAAAATGTTGGGCCCCAACGGG
ATAGGTGTTCTATATGCGCGGCGTGAGCTGTTATCGGTGATGCCTCCATTTCTTACCGGCGGTTCGATGATCGAGACGGT
TACTATGGAAAGTACGACGTATGCTCCGGCGCCGCAGCGGTTTGAAGCCGGTACCCCGATGACTTCCCAGGTGGTTGGAT
TAGCCGCAGCCGCACGCTATCTCGACGCCATCGGGATGAAAGCCGTCGAAGCCCACGAACGCGAGTTGGTAGCAGCGGCG
GTTGAGGGTCTGTCCAGAATCGATGGTGTACGCATAATCGGGCCGAAGTCGATGGAGAACCGCGGCTCGCCAGTGTCGTT
CGTCGTCGACGGCGTGCACGCGCACGATATCGGTCAGGTGTTAGACGACGACGGCGTCGCCGTGCGGGTCGGGCACCACT
GTGCGTTGCCGCTGCATCGCCGGTTTGCTTTAGCGGCCACTGCGCGGGCGTCGTTTGCCGTGTACAACACCGTCGATGAA
GTCGACCGCTTGGTGGCAGGTGTGTTACGAGCTTTGGATTTCTTTGGGAGAGAATGA

Upstream 100 bases:

>100_bases
GCGGCCGGATCGTCGAATCTGGTGGCTCGGAGCTGGCCGACGAACTTGAGCAGAACGGCTACGTACGTTTCTCCCAACCG
GCGGCAACCGGAGTCTAAGT

Downstream 100 bases:

>100_bases
TATTGCGTCTAGAACAGATCTATCAGGAAGTGATCCTCGATCACTATAAACACCCCCAGCATCGCGGGCTACGTGAGCCG
TTCTGTGCTCAAGTGTACCA

Product: putative aminotransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MTISLTPLDLSAIRADFPILKRVMRGGNQLAYLDSGATSQRPVQVLDAEREFLVTSNGAVHRGAHQLMEEATDAYERGRV
DIAAFIGAAADELVFTKNATESLNLVSYVFGDNRFEGTSGDGGDVIVTTELEHHANLIPWQELARRIGATLRWYGVTDDG
QIDLDSLQLDERVKVVAFSHHSNVTGAVAPVRELVARAKEVGALTVLDACQSVPHQPVDLHGLGVDFAAFSGHKMLGPNG
IGVLYARRELLSVMPPFLTGGSMIETVTMESTTYAPAPQRFEAGTPMTSQVVGLAAAARYLDAIGMKAVEAHERELVAAA
VEGLSRIDGVRIIGPKSMENRGSPVSFVVDGVHAHDIGQVLDDDGVAVRVGHHCALPLHRRFALAATARASFAVYNTVDE
VDRLVAGVLRALDFFGRE

Sequences:

>Translated_418_residues
MTISLTPLDLSAIRADFPILKRVMRGGNQLAYLDSGATSQRPVQVLDAEREFLVTSNGAVHRGAHQLMEEATDAYERGRV
DIAAFIGAAADELVFTKNATESLNLVSYVFGDNRFEGTSGDGGDVIVTTELEHHANLIPWQELARRIGATLRWYGVTDDG
QIDLDSLQLDERVKVVAFSHHSNVTGAVAPVRELVARAKEVGALTVLDACQSVPHQPVDLHGLGVDFAAFSGHKMLGPNG
IGVLYARRELLSVMPPFLTGGSMIETVTMESTTYAPAPQRFEAGTPMTSQVVGLAAAARYLDAIGMKAVEAHERELVAAA
VEGLSRIDGVRIIGPKSMENRGSPVSFVVDGVHAHDIGQVLDDDGVAVRVGHHCALPLHRRFALAATARASFAVYNTVDE
VDRLVAGVLRALDFFGRE
>Mature_417_residues
TISLTPLDLSAIRADFPILKRVMRGGNQLAYLDSGATSQRPVQVLDAEREFLVTSNGAVHRGAHQLMEEATDAYERGRVD
IAAFIGAAADELVFTKNATESLNLVSYVFGDNRFEGTSGDGGDVIVTTELEHHANLIPWQELARRIGATLRWYGVTDDGQ
IDLDSLQLDERVKVVAFSHHSNVTGAVAPVRELVARAKEVGALTVLDACQSVPHQPVDLHGLGVDFAAFSGHKMLGPNGI
GVLYARRELLSVMPPFLTGGSMIETVTMESTTYAPAPQRFEAGTPMTSQVVGLAAAARYLDAIGMKAVEAHERELVAAAV
EGLSRIDGVRIIGPKSMENRGSPVSFVVDGVHAHDIGQVLDDDGVAVRVGHHCALPLHRRFALAATARASFAVYNTVDEV
DRLVAGVLRALDFFGRE

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily

Homologues:

Organism=Homo sapiens, GI32307132, Length=299, Percent_Identity=29.0969899665552, Blast_Score=99, Evalue=9e-21,
Organism=Homo sapiens, GI156713448, Length=312, Percent_Identity=26.6025641025641, Blast_Score=79, Evalue=9e-15,
Organism=Escherichia coli, GI1787970, Length=413, Percent_Identity=43.5835351089588, Blast_Score=345, Evalue=3e-96,
Organism=Escherichia coli, GI1789175, Length=406, Percent_Identity=36.2068965517241, Blast_Score=245, Evalue=5e-66,
Organism=Escherichia coli, GI48994898, Length=273, Percent_Identity=30.7692307692308, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI193211090, Length=399, Percent_Identity=25.5639097744361, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI25143064, Length=306, Percent_Identity=25.8169934640523, Blast_Score=97, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6319831, Length=403, Percent_Identity=27.7915632754342, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI20129463, Length=234, Percent_Identity=33.7606837606838, Blast_Score=109, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CSD2_MYCLE (Q49690)

Other databases:

- EMBL:   U00013
- EMBL:   Z99125
- EMBL:   AL583919
- PIR:   S72761
- RefSeq:   NP_301505.1
- ProteinModelPortal:   Q49690
- SMR:   Q49690
- EnsemblBacteria:   EBMYCT00000029247
- GeneID:   909377
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML0596
- NMPDR:   fig|272631.1.peg.377
- Leproma:   ML0596
- GeneTree:   EBGT00050000015336
- HOGENOM:   HBG635316
- OMA:   AMPPFIT
- ProtClustDB:   CLSK791179
- BioCyc:   MLEP272631:ML0596-MONOMER
- BRENDA:   2.8.1.7
- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01979

Pfam domain/function: PF00266 Aminotran_5; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.8.1.7

Molecular weight: Translated: 44894; Mature: 44763

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: ACT_SITE 374-374

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTISLTPLDLSAIRADFPILKRVMRGGNQLAYLDSGATSQRPVQVLDAEREFLVTSNGAV
CEEEECCCCHHHHHCCHHHHHHHHHCCCEEEEEECCCCCCCCHHEECCCCEEEEECCCCH
HRGAHQLMEEATDAYERGRVDIAAFIGAAADELVFTKNATESLNLVSYVFGDNRFEGTSG
HHHHHHHHHHHHHHHHCCCEEEHHHHCCCHHHEEEECCCCCHHHHHHEEECCCEECCCCC
DGGDVIVTTELEHHANLIPWQELARRIGATLRWYGVTDDGQIDLDSLQLDERVKVVAFSH
CCCCEEEEEEHHHCCCCCCHHHHHHHHCCEEEEEECCCCCCEEHHHHCCCCCEEEEEEEC
HSNVTGAVAPVRELVARAKEVGALTVLDACQSVPHQPVDLHGLGVDFAAFSGHKMLGPNG
CCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEECCCCCEECCCCCEECCCC
IGVLYARRELLSVMPPFLTGGSMIETVTMESTTYAPAPQRFEAGTPMTSQVVGLAAAARY
CCHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
LDAIGMKAVEAHERELVAAAVEGLSRIDGVRIIGPKSMENRGSPVSFVVDGVHAHDIGQV
HHHHCHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCEEEEEECCCHHHHHHH
LDDDGVAVRVGHHCALPLHRRFALAATARASFAVYNTVDEVDRLVAGVLRALDFFGRE
HCCCCCEEEECCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TISLTPLDLSAIRADFPILKRVMRGGNQLAYLDSGATSQRPVQVLDAEREFLVTSNGAV
EEEECCCCHHHHHCCHHHHHHHHHCCCEEEEEECCCCCCCCHHEECCCCEEEEECCCCH
HRGAHQLMEEATDAYERGRVDIAAFIGAAADELVFTKNATESLNLVSYVFGDNRFEGTSG
HHHHHHHHHHHHHHHHCCCEEEHHHHCCCHHHEEEECCCCCHHHHHHEEECCCEECCCCC
DGGDVIVTTELEHHANLIPWQELARRIGATLRWYGVTDDGQIDLDSLQLDERVKVVAFSH
CCCCEEEEEEHHHCCCCCCHHHHHHHHCCEEEEEECCCCCCEEHHHHCCCCCEEEEEEEC
HSNVTGAVAPVRELVARAKEVGALTVLDACQSVPHQPVDLHGLGVDFAAFSGHKMLGPNG
CCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEECCCCCEECCCCCEECCCC
IGVLYARRELLSVMPPFLTGGSMIETVTMESTTYAPAPQRFEAGTPMTSQVVGLAAAARY
CCHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
LDAIGMKAVEAHERELVAAAVEGLSRIDGVRIIGPKSMENRGSPVSFVVDGVHAHDIGQV
HHHHCHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCEEEEEECCCHHHHHHH
LDDDGVAVRVGHHCALPLHRRFALAATARASFAVYNTVDEVDRLVAGVLRALDFFGRE
HCCCCCEEEECCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002