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The map label for this gene is uvrC

Identifier: 221229691

GI number: 221229691

Start: 678879

End: 680822

Strand: Direct

Name: uvrC

Synonym: MLBr_00562

Alternate gene names: 221229691

Gene position: 678879-680822 (Clockwise)

Preceding gene: 221229690

Following gene: 221229692

Centisome position: 20.77

GC content: 58.54

Gene sequence:

>1944_bases
GTGCCAGATCCCGCGACGTATCGCCCCGCGACCGGATCCATCCCGGTCGAGCCTGGTGTGTACCGATTCCGGGATCCGTA
CGGGCGCGTCATTTACGTAGGCAAGGCCAAAAGCCTGCGTAGCCGGCTGGCATCGTATTTTGCCGACGTCGCGAACCTGC
ACCCGCGGACTCGGCAAATGGTGACCATTGCAGCCAAGGTCGAGTGGACAGTGGTCAACACTGAGGTTGAGGCTCTGCAG
TTGGAGTACAATTGGATCAAGGAATTCGATCCGCGCTTCAACATCCGCTACCGCGACGACAAGTCCTATCCGGTATTGGC
CGTCACCCTGGGTGAGGAGTTTCCTCGACTGATGGTCTATCGCGGTCCCCGGCGCAAGGGCGTGCGCTATTTCGGACCGT
ACTCGCACGCGTGGGCCATTCGGGAAACGCTGGATCTGCTCACCCGGGTGTTTCCAGCACGAACCTGTTCACCTGGAGTG
TTCAAGCGGCACAAGCAAATCGATCGTCCATGCCTACTTGGTTACATTGACAAATGTGCGGCGCCGTGTGTGGGCAGGGT
TGGTGCCGAGCAGCATAGTCAAATCGTGGCAGATTTTTGCGACTTCTTGTCCGGCAAGACCGATCGGTATGCCCGTGACT
TGGAACGAAAAATGAGCGCAGCTGCAGAGCAACTCGATTTCGAACGAGCAGCCCGGCTTCGTGACGACCTTTTTGCACTC
AAGCGGGCTATGGAGAAACAGGCGGTGGTGTTCGGCGATGGTACTGACGCTGACGTAGTGGCATTCGCCTACGACGAACT
GGAGGTGGCGGTGCAGGTGTTCCACGTTCGCGGCGGGCGGGTGCGTGGCCAGCGCGGCTGGATTGTTGAAAAGTCCGATG
ACCCTGGTGATACCGGGGAGGAGCAATTGGTGGAGCAATTCCTGGCACAGTTCTATGGCGAACAGGCGGAGTTAGACTTT
GTTGCAGACGAATCCGCTAACCCGGTTCCCCGCGAGGTGTTGGTGCCGTGTTTACCCTCCAACGCCGACGAGTTGGCCAG
TTGGCTGTCCGGTCTGCGTGGATCCCGGGTCGCGCTGCGGGTGCCACGGCGCGGCGACAAACGTGCGCTAGCTGAGACGG
TGCAGCGAAACGCGAAAGAAGAATTGCAGCAACACAAACTGAAGCGTGCCAGTGACTTTAACTCTAGATCCGCTGCGTTG
CAGAATATTCAAGACACACTGGGTTTATCCTATGCACCACTGCGAATTGAATGCGTCGATATAAGCCACGTGCAGGGCAC
CGACGTGGTGGGCTCTCTGGTCGTATTCGAGGACGGTTTGCCGCGCAAGTCGGACTACCGACACTTCGGGATCCGGAAAG
CTGCTGGGAACGGGCGCTCTGATGATGTTGCCTCCATCGCTGAGGTGACTCGACGCCGATTCCTGCAGCATCTTCACGAT
CAGAACGATACGAATCTGCTTTCTCCGGAAGGAAAATCACACCGATTTGCCTATCCGCCTAATCTGTATGTCGTTGACGG
TGGCGCGCCACAAGTCAATGCGGCCAGCACCGTGCTTGAGGAACTCGGTATCATTGATGTGGCTGTGATTGGTCTGGCCA
AGCGGCTCGAAGAGGTGTGGGTGCCGTTCGAGCCGTACCCGGTCATCATGCCGCGCAACAGCGAGGCCCTGTTTCTGCTG
CAGCGGGTTCGTGATGAGGCACATCGATTTGCCATCACCTACCATCGCAGCAAGCGATCCAAGCGAATGACCGCATCGGC
GCTGGATTCGGTGCCGGGGTTGGGAGCGCATCGCCGCAAAGCGCTGGTTACCCACTTCGGATCTATAGCCCGCCTCAAAG
ATGCCACCGTAGAACAGATCACTGCCGTTCCGGGTATCGGCGTGGCAACGGCTACTGCCGTCCTCGAGGCGCTGCGACCG
GATTCATCTGAGGCCTCGGAATGA

Upstream 100 bases:

>100_bases
GAAGGTCCCTGTGAGGAGTGGATAGTTTTCCTTGATCGGACTAGCTCGACGGACACCAGCCTTTCTAGTGGTCCCTGTGA
GCGACCACTAGCCTAGATGC

Downstream 100 bases:

>100_bases
GTGGGAACAACCACCCGGGAGACGCCTCGGCCGAAATCGACGTCGTTCTGGTGACCGGGTTGTCCGGGGCCGGGCGCGGC
ACCGCGGCCAAGGTGCTAGA

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 647; Mature: 646

Protein sequence:

>647_residues
MPDPATYRPATGSIPVEPGVYRFRDPYGRVIYVGKAKSLRSRLASYFADVANLHPRTRQMVTIAAKVEWTVVNTEVEALQ
LEYNWIKEFDPRFNIRYRDDKSYPVLAVTLGEEFPRLMVYRGPRRKGVRYFGPYSHAWAIRETLDLLTRVFPARTCSPGV
FKRHKQIDRPCLLGYIDKCAAPCVGRVGAEQHSQIVADFCDFLSGKTDRYARDLERKMSAAAEQLDFERAARLRDDLFAL
KRAMEKQAVVFGDGTDADVVAFAYDELEVAVQVFHVRGGRVRGQRGWIVEKSDDPGDTGEEQLVEQFLAQFYGEQAELDF
VADESANPVPREVLVPCLPSNADELASWLSGLRGSRVALRVPRRGDKRALAETVQRNAKEELQQHKLKRASDFNSRSAAL
QNIQDTLGLSYAPLRIECVDISHVQGTDVVGSLVVFEDGLPRKSDYRHFGIRKAAGNGRSDDVASIAEVTRRRFLQHLHD
QNDTNLLSPEGKSHRFAYPPNLYVVDGGAPQVNAASTVLEELGIIDVAVIGLAKRLEEVWVPFEPYPVIMPRNSEALFLL
QRVRDEAHRFAITYHRSKRSKRMTASALDSVPGLGAHRRKALVTHFGSIARLKDATVEQITAVPGIGVATATAVLEALRP
DSSEASE

Sequences:

>Translated_647_residues
MPDPATYRPATGSIPVEPGVYRFRDPYGRVIYVGKAKSLRSRLASYFADVANLHPRTRQMVTIAAKVEWTVVNTEVEALQ
LEYNWIKEFDPRFNIRYRDDKSYPVLAVTLGEEFPRLMVYRGPRRKGVRYFGPYSHAWAIRETLDLLTRVFPARTCSPGV
FKRHKQIDRPCLLGYIDKCAAPCVGRVGAEQHSQIVADFCDFLSGKTDRYARDLERKMSAAAEQLDFERAARLRDDLFAL
KRAMEKQAVVFGDGTDADVVAFAYDELEVAVQVFHVRGGRVRGQRGWIVEKSDDPGDTGEEQLVEQFLAQFYGEQAELDF
VADESANPVPREVLVPCLPSNADELASWLSGLRGSRVALRVPRRGDKRALAETVQRNAKEELQQHKLKRASDFNSRSAAL
QNIQDTLGLSYAPLRIECVDISHVQGTDVVGSLVVFEDGLPRKSDYRHFGIRKAAGNGRSDDVASIAEVTRRRFLQHLHD
QNDTNLLSPEGKSHRFAYPPNLYVVDGGAPQVNAASTVLEELGIIDVAVIGLAKRLEEVWVPFEPYPVIMPRNSEALFLL
QRVRDEAHRFAITYHRSKRSKRMTASALDSVPGLGAHRRKALVTHFGSIARLKDATVEQITAVPGIGVATATAVLEALRP
DSSEASE
>Mature_646_residues
PDPATYRPATGSIPVEPGVYRFRDPYGRVIYVGKAKSLRSRLASYFADVANLHPRTRQMVTIAAKVEWTVVNTEVEALQL
EYNWIKEFDPRFNIRYRDDKSYPVLAVTLGEEFPRLMVYRGPRRKGVRYFGPYSHAWAIRETLDLLTRVFPARTCSPGVF
KRHKQIDRPCLLGYIDKCAAPCVGRVGAEQHSQIVADFCDFLSGKTDRYARDLERKMSAAAEQLDFERAARLRDDLFALK
RAMEKQAVVFGDGTDADVVAFAYDELEVAVQVFHVRGGRVRGQRGWIVEKSDDPGDTGEEQLVEQFLAQFYGEQAELDFV
ADESANPVPREVLVPCLPSNADELASWLSGLRGSRVALRVPRRGDKRALAETVQRNAKEELQQHKLKRASDFNSRSAALQ
NIQDTLGLSYAPLRIECVDISHVQGTDVVGSLVVFEDGLPRKSDYRHFGIRKAAGNGRSDDVASIAEVTRRRFLQHLHDQ
NDTNLLSPEGKSHRFAYPPNLYVVDGGAPQVNAASTVLEELGIIDVAVIGLAKRLEEVWVPFEPYPVIMPRNSEALFLLQ
RVRDEAHRFAITYHRSKRSKRMTASALDSVPGLGAHRRKALVTHFGSIARLKDATVEQITAVPGIGVATATAVLEALRPD
SSEASE

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=654, Percent_Identity=35.7798165137615, Blast_Score=360, Evalue=1e-100,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_MYCLB (B8ZUN5)

Other databases:

- EMBL:   FM211192
- RefSeq:   YP_002503107.1
- ProteinModelPortal:   B8ZUN5
- EnsemblBacteria:   EBMYCT00000085623
- GeneID:   7326930
- GenomeReviews:   FM211192_GR
- GeneTree:   EBGT00050000016419
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- ProtClustDB:   PRK00558
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF00633 HHH; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 72387; Mature: 72256

Theoretical pI: Translated: 8.43; Mature: 8.43

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDPATYRPATGSIPVEPGVYRFRDPYGRVIYVGKAKSLRSRLASYFADVANLHPRTRQM
CCCCCCCCCCCCCCCCCCCCEEECCCCCCEEEEECHHHHHHHHHHHHHHHHHCCCCHHEE
VTIAAKVEWTVVNTEVEALQLEYNWIKEFDPRFNIRYRDDKSYPVLAVTLGEEFPRLMVY
EEEEEEEEEEEEECEEEEEEEEHHHHHHCCCCEEEEEECCCCCCEEEEECCCCCCEEEEE
RGPRRKGVRYFGPYSHAWAIRETLDLLTRVFPARTCSPGVFKRHKQIDRPCLLGYIDKCA
ECCCCCCCEEECCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHH
APCVGRVGAEQHSQIVADFCDFLSGKTDRYARDLERKMSAAAEQLDFERAARLRDDLFAL
HHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KRAMEKQAVVFGDGTDADVVAFAYDELEVAVQVFHVRGGRVRGQRGWIVEKSDDPGDTGE
HHHHHHCEEEEECCCCCCEEEEEHHHHHHHHHHHEECCCEEECCCCEEEECCCCCCCCCH
EQLVEQFLAQFYGEQAELDFVADESANPVPREVLVPCLPSNADELASWLSGLRGSRVALR
HHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHCCCCCCCCHHHHHHHHHCCCCCEEEEE
VPRRGDKRALAETVQRNAKEELQQHKLKRASDFNSRSAALQNIQDTLGLSYAPLRIECVD
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEEEEE
ISHVQGTDVVGSLVVFEDGLPRKSDYRHFGIRKAAGNGRSDDVASIAEVTRRRFLQHLHD
CCCCCCCHHHEEEEEEECCCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHCC
QNDTNLLSPEGKSHRFAYPPNLYVVDGGAPQVNAASTVLEELGIIDVAVIGLAKRLEEVW
CCCCCCCCCCCCCCEEECCCCEEEECCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHC
VPFEPYPVIMPRNSEALFLLQRVRDEAHRFAITYHRSKRSKRMTASALDSVPGLGAHRRK
CCCCCEEEEEECCCCHHHHHHHHHHHHHHEEEEEEHHHHHHHHHHHHHHCCCCCCHHHHH
ALVTHFGSIARLKDATVEQITAVPGIGVATATAVLEALRPDSSEASE
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
PDPATYRPATGSIPVEPGVYRFRDPYGRVIYVGKAKSLRSRLASYFADVANLHPRTRQM
CCCCCCCCCCCCCCCCCCCEEECCCCCCEEEEECHHHHHHHHHHHHHHHHHCCCCHHEE
VTIAAKVEWTVVNTEVEALQLEYNWIKEFDPRFNIRYRDDKSYPVLAVTLGEEFPRLMVY
EEEEEEEEEEEEECEEEEEEEEHHHHHHCCCCEEEEEECCCCCCEEEEECCCCCCEEEEE
RGPRRKGVRYFGPYSHAWAIRETLDLLTRVFPARTCSPGVFKRHKQIDRPCLLGYIDKCA
ECCCCCCCEEECCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHH
APCVGRVGAEQHSQIVADFCDFLSGKTDRYARDLERKMSAAAEQLDFERAARLRDDLFAL
HHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KRAMEKQAVVFGDGTDADVVAFAYDELEVAVQVFHVRGGRVRGQRGWIVEKSDDPGDTGE
HHHHHHCEEEEECCCCCCEEEEEHHHHHHHHHHHEECCCEEECCCCEEEECCCCCCCCCH
EQLVEQFLAQFYGEQAELDFVADESANPVPREVLVPCLPSNADELASWLSGLRGSRVALR
HHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHCCCCCCCCHHHHHHHHHCCCCCEEEEE
VPRRGDKRALAETVQRNAKEELQQHKLKRASDFNSRSAALQNIQDTLGLSYAPLRIECVD
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEEEEE
ISHVQGTDVVGSLVVFEDGLPRKSDYRHFGIRKAAGNGRSDDVASIAEVTRRRFLQHLHD
CCCCCCCHHHEEEEEEECCCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHCC
QNDTNLLSPEGKSHRFAYPPNLYVVDGGAPQVNAASTVLEELGIIDVAVIGLAKRLEEVW
CCCCCCCCCCCCCCEEECCCCEEEECCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHC
VPFEPYPVIMPRNSEALFLLQRVRDEAHRFAITYHRSKRSKRMTASALDSVPGLGAHRRK
CCCCCEEEEEECCCCHHHHHHHHHHHHHHEEEEEEHHHHHHHHHHHHHHCCCCCCHHHHH
ALVTHFGSIARLKDATVEQITAVPGIGVATATAVLEALRPDSSEASE
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA