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The map label for this gene is gcp

Identifier: 221229586

GI number: 221229586

Start: 471849

End: 472904

Strand: Direct

Name: gcp

Synonym: MLBr_00379

Alternate gene names: 221229586

Gene position: 471849-472904 (Clockwise)

Preceding gene: 221229585

Following gene: 221229587

Centisome position: 14.44

GC content: 63.54

Gene sequence:

>1056_bases
ATGACGATCTCTGCTGTGCCCGGCACGATTATCTTGGCCATCGAAACCTCTTGCGATGAAACCGGTGTTGGTATTGCCTG
CCTCGATGACTATGGCACCGTGACATTGTTGGCTGACGAGGTGGCTTCCAGCGTCGACGAGCAGGCCCGGTTTGGTGGTG
TGGTGCCCGAGATTGCCTCACGGGCGCATCTAGAGGCTCTTGGCCCCACCATACGCTGCGCGCTTGCTGCTGCCGGCCTG
ACCGGTTCGGCCAAGCCAGATGTTGTAGCCGCCACGATAGGGCCCGGGTTAGCCGGTGCTTTGTTGGTAGGAGTGGCTGC
GGCTAAAGCGTACTCGGCTGCCTGGGGAGTGCCGTTCTACGCCGTGAACCACCTGGGTGGACACCTGGCTGCCGACGTCT
ACGAACATGGACCGTTGCCCGAGTGTGTGGCGCTACTGGTGTCTGGAGGCCATACCCACCTGTTGCAGGTGCGTTCACTT
GGGGCGCCCATTGTCGAGCTGGGCAGTACCGTCGACGACGCCGCCGGTGAAGCTTACGATAAGGTCGCGCGCCTACTGGG
ATTGGGTTATCCAGGCGGTAAAGTGCTAGACGACCTAGCTCGTACCGGCGATCGGGATGCCATTGTGTTCCCACGCGGCA
TGACTGGGCCGGCCGACGACCTAAACGCGTTCAGCTTTTCAGGGCTCAAAACCGCTGTCGCACGATATGTCGAGAGTCAC
CCCGACGCGCTGCCGGCCGATGTCGCCGCTGGGTTTCAGGAGGCTGTCGCCGATGTGTTGACCATGAAGGCGGTGCGTGC
GGCGACCGGGCTCGGCGTTTCCACTTTGTTGATCGTCGGGGGAGTGGCCGCGAATTCGCGGCTGCGCGAGCTAGCCGCGC
AGCGCTGCGCGGCGGCGGGGCTGATGCTGCGGATCCCAGGGCCGCGGTTCTGCACCGACAACGGGGCGATGATCGCCGCG
TTCGCCGCACATCTGCTGGCTGCGGCCGCGCCACCGTCACCGTTGGATGTGCCCAGCGACCCGGGCCTTCCGGTGGTAAA
AAGGCAGATTAATTGA

Upstream 100 bases:

>100_bases
TTGCGTTATACCGCAGTGTGGGATTCGAACGGATCGGTCTACGCCCCCGCTACTACCCAGCCAGCGGTGCCGATGCTTAC
CTCATGCGAAGGGAGGCGCA

Downstream 100 bases:

>100_bases
GCTAGACACGCCAACAGCCAGGAAGCAGCGGGCCGGCCTTGAGTGCTAGCACTCGCGTGTATAGAGTGCTAGATGGCAGT
CGGCCAGACCCCAGTGTCGG

Product: putative DNA-binding/iron metalloprotein/AP endonuclease

Products: NA

Alternate protein names: Glycoprotease

Number of amino acids: Translated: 351; Mature: 350

Protein sequence:

>351_residues
MTISAVPGTIILAIETSCDETGVGIACLDDYGTVTLLADEVASSVDEQARFGGVVPEIASRAHLEALGPTIRCALAAAGL
TGSAKPDVVAATIGPGLAGALLVGVAAAKAYSAAWGVPFYAVNHLGGHLAADVYEHGPLPECVALLVSGGHTHLLQVRSL
GAPIVELGSTVDDAAGEAYDKVARLLGLGYPGGKVLDDLARTGDRDAIVFPRGMTGPADDLNAFSFSGLKTAVARYVESH
PDALPADVAAGFQEAVADVLTMKAVRAATGLGVSTLLIVGGVAANSRLRELAAQRCAAAGLMLRIPGPRFCTDNGAMIAA
FAAHLLAAAAPPSPLDVPSDPGLPVVKRQIN

Sequences:

>Translated_351_residues
MTISAVPGTIILAIETSCDETGVGIACLDDYGTVTLLADEVASSVDEQARFGGVVPEIASRAHLEALGPTIRCALAAAGL
TGSAKPDVVAATIGPGLAGALLVGVAAAKAYSAAWGVPFYAVNHLGGHLAADVYEHGPLPECVALLVSGGHTHLLQVRSL
GAPIVELGSTVDDAAGEAYDKVARLLGLGYPGGKVLDDLARTGDRDAIVFPRGMTGPADDLNAFSFSGLKTAVARYVESH
PDALPADVAAGFQEAVADVLTMKAVRAATGLGVSTLLIVGGVAANSRLRELAAQRCAAAGLMLRIPGPRFCTDNGAMIAA
FAAHLLAAAAPPSPLDVPSDPGLPVVKRQIN
>Mature_350_residues
TISAVPGTIILAIETSCDETGVGIACLDDYGTVTLLADEVASSVDEQARFGGVVPEIASRAHLEALGPTIRCALAAAGLT
GSAKPDVVAATIGPGLAGALLVGVAAAKAYSAAWGVPFYAVNHLGGHLAADVYEHGPLPECVALLVSGGHTHLLQVRSLG
APIVELGSTVDDAAGEAYDKVARLLGLGYPGGKVLDDLARTGDRDAIVFPRGMTGPADDLNAFSFSGLKTAVARYVESHP
DALPADVAAGFQEAVADVLTMKAVRAATGLGVSTLLIVGGVAANSRLRELAAQRCAAAGLMLRIPGPRFCTDNGAMIAAF
AAHLLAAAAPPSPLDVPSDPGLPVVKRQIN

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M22 family

Homologues:

Organism=Homo sapiens, GI116812636, Length=346, Percent_Identity=32.3699421965318, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI8923380, Length=298, Percent_Identity=33.5570469798658, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI1789445, Length=342, Percent_Identity=45.906432748538, Blast_Score=235, Evalue=4e-63,
Organism=Caenorhabditis elegans, GI71995670, Length=333, Percent_Identity=31.5315315315315, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17557464, Length=352, Percent_Identity=30.1136363636364, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320099, Length=371, Percent_Identity=28.3018867924528, Blast_Score=111, Evalue=2e-25,
Organism=Drosophila melanogaster, GI20129063, Length=348, Percent_Identity=31.8965517241379, Blast_Score=118, Evalue=5e-27,
Organism=Drosophila melanogaster, GI21357207, Length=293, Percent_Identity=31.0580204778157, Blast_Score=112, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCP_MYCLE (P37969)

Other databases:

- EMBL:   U00020
- EMBL:   AL583918
- EMBL:   U00015
- PIR:   S72817
- PIR:   S72996
- RefSeq:   NP_301371.1
- ProteinModelPortal:   P37969
- SMR:   P37969
- MEROPS:   M22.001
- EnsemblBacteria:   EBMYCT00000029418
- GeneID:   909071
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML0379
- NMPDR:   fig|272631.1.peg.243
- Leproma:   ML0379
- GeneTree:   EBGT00050000017447
- HOGENOM:   HBG304663
- OMA:   PLYGVNH
- ProtClustDB:   PRK09604
- BioCyc:   MLEP272631:ML0379-MONOMER
- BRENDA:   3.4.24.57
- GO:   GO:0006508
- HAMAP:   MF_01445
- InterPro:   IPR022450
- InterPro:   IPR000905
- InterPro:   IPR017860
- InterPro:   IPR017861
- PANTHER:   PTHR11735
- PRINTS:   PR00789
- TIGRFAMs:   TIGR03723
- TIGRFAMs:   TIGR00329

Pfam domain/function: PF00814 Peptidase_M22

EC number: =3.4.24.57

Molecular weight: Translated: 35406; Mature: 35275

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS01016 GLYCOPROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTISAVPGTIILAIETSCDETGVGIACLDDYGTVTLLADEVASSVDEQARFGGVVPEIAS
CCCCCCCCEEEEEEECCCCCCCCCEEEECCCCCEEEEHHHHHHHHHHHHHHCCCHHHHHH
RAHLEALGPTIRCALAAAGLTGSAKPDVVAATIGPGLAGALLVGVAAAKAYSAAWGVPFY
HHHHHHHCHHHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCHHH
AVNHLGGHLAADVYEHGPLPECVALLVSGGHTHLLQVRSLGAPIVELGSTVDDAAGEAYD
HHHHCCCHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHCCCCHHHHCCCCCHHHHHHHH
KVARLLGLGYPGGKVLDDLARTGDRDAIVFPRGMTGPADDLNAFSFSGLKTAVARYVESH
HHHHHHHCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHC
PDALPADVAAGFQEAVADVLTMKAVRAATGLGVSTLLIVGGVAANSRLRELAAQRCAAAG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHCC
LMLRIPGPRFCTDNGAMIAAFAAHLLAAAAPPSPLDVPSDPGLPVVKRQIN
EEEECCCCCEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCC
>Mature Secondary Structure 
TISAVPGTIILAIETSCDETGVGIACLDDYGTVTLLADEVASSVDEQARFGGVVPEIAS
CCCCCCCEEEEEEECCCCCCCCCEEEECCCCCEEEEHHHHHHHHHHHHHHCCCHHHHHH
RAHLEALGPTIRCALAAAGLTGSAKPDVVAATIGPGLAGALLVGVAAAKAYSAAWGVPFY
HHHHHHHCHHHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCHHH
AVNHLGGHLAADVYEHGPLPECVALLVSGGHTHLLQVRSLGAPIVELGSTVDDAAGEAYD
HHHHCCCHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHCCCCHHHHCCCCCHHHHHHHH
KVARLLGLGYPGGKVLDDLARTGDRDAIVFPRGMTGPADDLNAFSFSGLKTAVARYVESH
HHHHHHHCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHC
PDALPADVAAGFQEAVADVLTMKAVRAATGLGVSTLLIVGGVAANSRLRELAAQRCAAAG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHCC
LMLRIPGPRFCTDNGAMIAAFAAHLLAAAAPPSPLDVPSDPGLPVVKRQIN
EEEECCCCCEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002; 1354834