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The map label for this gene is czcD [H]

Identifier: 221229538

GI number: 221229538

Start: 364932

End: 365738

Strand: Direct

Name: czcD [H]

Synonym: MLBr_00283

Alternate gene names: 221229538

Gene position: 364932-365738 (Clockwise)

Preceding gene: 221229537

Following gene: 221229540

Centisome position: 11.17

GC content: 60.84

Gene sequence:

>807_bases
TTGCAATGCATGCGTAAACACGCATATATTGCACACATGGGCTCTGGGGGTAGTTACACTCCCGCTGAGGCCGCCATATA
TCGGATGATCCGCCGCATGATCGTTGCCGCAGCGATCTTGATGGTGTTCTTTGGTGTGGAGCTGACCATAGCGTTACTGA
TCAACTCGATCACACTGCTCGCCGATGCGGGACACATGCTCACCGACGTAGTTGCCGTGTTCATGGGGCTGGCCGCATTG
GTGCTGGCTAAGCATGGTCACTCAGCACCCAACCGCCCCTACAGCTGGCATCGCGCCGAGGTATTTACCGCAATGGCCAA
CGCCGCGCTGCTGATCGGGGTCGCGACGTTCATCCTATACGAGGCGATCCGACGGTTCAAGGAAGCCCCGTACATCCCGG
GCATGCCGATAGTGGTGGCGGCGCTGGCCGGCCTGGTCACCAATTTCGTGGTAGCGCCGTTGTTGCGCCCGCACGCGGAG
GACAGCCTGGCAATTAAGGGTGCCTATATGGAGGCGGTCGCGGACACCGTAGGCAACATCGGTGTGCTGATCGCCGGTGT
TGTCACCCTAACCACGCACTGGCCCTACGCCGACGTGGTGGTCGCCGTGCTGGTGGCGCTCTGGGTGCTGCCACGGGCAA
TCTCGCTAGCCCGGGCGGCTTGCGGATCTTTTCCTAATTGTCGCCGGCCCACAATCGATGTCGAGGCACTGCGTTCAGCA
CTAGGACGCAGGCGACGTCACCGAAGTGCACGACCTGCACGTGTGAACACTTTCGCTCGGCGAAGATATGTCCCACCGCG
CACCTGA

Upstream 100 bases:

>100_bases
ATCGTGTACTGGCGCTCTTCAACTTGCCTGGTGTGACCCACTGGCTGGTGACCGTGGACAATGCATTTGCCCACTTTAAT
GGAGCCGCTGGTTCTAACGC

Downstream 100 bases:

>100_bases
CCAGCAACAGCAACTCCATCCGGAGGTGGGCCGGCTCTGGAACGGGTCCGATGTTGGCCGAAGTCCTGGGAAAGGCTAGC
CTACGCGACAGTCCAGATCG

Product: putative cation-efflux transporter component

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 268; Mature: 268

Protein sequence:

>268_residues
MQCMRKHAYIAHMGSGGSYTPAEAAIYRMIRRMIVAAAILMVFFGVELTIALLINSITLLADAGHMLTDVVAVFMGLAAL
VLAKHGHSAPNRPYSWHRAEVFTAMANAALLIGVATFILYEAIRRFKEAPYIPGMPIVVAALAGLVTNFVVAPLLRPHAE
DSLAIKGAYMEAVADTVGNIGVLIAGVVTLTTHWPYADVVVAVLVALWVLPRAISLARAACGSFPNCRRPTIDVEALRSA
LGRRRRHRSARPARVNTFARRRYVPPRT

Sequences:

>Translated_268_residues
MQCMRKHAYIAHMGSGGSYTPAEAAIYRMIRRMIVAAAILMVFFGVELTIALLINSITLLADAGHMLTDVVAVFMGLAAL
VLAKHGHSAPNRPYSWHRAEVFTAMANAALLIGVATFILYEAIRRFKEAPYIPGMPIVVAALAGLVTNFVVAPLLRPHAE
DSLAIKGAYMEAVADTVGNIGVLIAGVVTLTTHWPYADVVVAVLVALWVLPRAISLARAACGSFPNCRRPTIDVEALRSA
LGRRRRHRSARPARVNTFARRRYVPPRT
>Mature_268_residues
MQCMRKHAYIAHMGSGGSYTPAEAAIYRMIRRMIVAAAILMVFFGVELTIALLINSITLLADAGHMLTDVVAVFMGLAAL
VLAKHGHSAPNRPYSWHRAEVFTAMANAALLIGVATFILYEAIRRFKEAPYIPGMPIVVAALAGLVTNFVVAPLLRPHAE
DSLAIKGAYMEAVADTVGNIGVLIAGVVTLTTHWPYADVVVAVLVALWVLPRAISLARAACGSFPNCRRPTIDVEALRSA
LGRRRRHRSARPARVNTFARRRYVPPRT

Specific function: Necessary for activation of the czc determinant [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI21359890, Length=207, Percent_Identity=29.4685990338164, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI52352803, Length=130, Percent_Identity=34.6153846153846, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1786966, Length=175, Percent_Identity=32, Blast_Score=70, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI32564488, Length=195, Percent_Identity=25.6410256410256, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6323899, Length=133, Percent_Identity=35.3383458646617, Blast_Score=80, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6324892, Length=121, Percent_Identity=35.5371900826446, Blast_Score=77, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 29105; Mature: 29105

Theoretical pI: Translated: 10.97; Mature: 10.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQCMRKHAYIAHMGSGGSYTPAEAAIYRMIRRMIVAAAILMVFFGVELTIALLINSITLL
CCHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADAGHMLTDVVAVFMGLAALVLAKHGHSAPNRPYSWHRAEVFTAMANAALLIGVATFILY
HHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
EAIRRFKEAPYIPGMPIVVAALAGLVTNFVVAPLLRPHAEDSLAIKGAYMEAVADTVGNI
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
GVLIAGVVTLTTHWPYADVVVAVLVALWVLPRAISLARAACGSFPNCRRPTIDVEALRSA
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
LGRRRRHRSARPARVNTFARRRYVPPRT
HHHHHHHCCCCCHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MQCMRKHAYIAHMGSGGSYTPAEAAIYRMIRRMIVAAAILMVFFGVELTIALLINSITLL
CCHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADAGHMLTDVVAVFMGLAALVLAKHGHSAPNRPYSWHRAEVFTAMANAALLIGVATFILY
HHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
EAIRRFKEAPYIPGMPIVVAALAGLVTNFVVAPLLRPHAEDSLAIKGAYMEAVADTVGNI
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
GVLIAGVVTLTTHWPYADVVVAVLVALWVLPRAISLARAACGSFPNCRRPTIDVEALRSA
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
LGRRRRHRSARPARVNTFARRRYVPPRT
HHHHHHHCCCCCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8829543 [H]