Click here to switch to the map view.

The map label for this gene is fgd1 [H]

Identifier: 221229530

GI number: 221229530

Start: 353023

End: 354033

Strand: Reverse

Name: fgd1 [H]

Synonym: MLBr_00269

Alternate gene names: 221229530

Gene position: 354033-353023 (Counterclockwise)

Preceding gene: 221229532

Following gene: 221229523

Centisome position: 10.83

GC content: 59.45

Gene sequence:

>1011_bases
ATGGCTGAATTGAGACTTGGATACAAGGCGTCAGCTGAACAATTCGCACCGCGTGAACTAGTCGAACTCGGGGTTGCCGC
CGAAGCTCACGGGATGGACAGCGCTACCGTCAGCGATCATTTCCAGCCGTGGCGTCACCAGGGCGGGCACGCGTCATTCT
CACTGTCGTGGATGACTGCAGTTGGTGAACGCACTAACCGGATTCTGCTGGGTACCTCGGTACTTACCCCGACGTTTCGC
TACAACCCTGCTGTCATAGGGCAGGCCTTCGCCACCATGGGCTGCCTCTATCCGAACCGGGTCTTTCTCGGAGTTGGCAC
TGGTGAGGCGCTTAACGAGGTTGCCACCGGGTATCAGGGTGCCTGGCCGGAGTTCAAGGAGCGGTTCGCCCGGCTGCGTG
AATCTGTGCGGCTAATGCGGGAGCTGTGGCGCGGTGATCGTGTCGACTTCGATGGCGACTATTACCAGCTCAAAGGTGCG
TCGATTTACGACGTACCCGAAGGCGGTGTGCCAATCTACATTGCCGCAGGTGGCCCGGAGGTGGCCAAATATGCCGGTCG
CGCCGGCGAAGGCTTCGTCTGCACCTCTGGCAAGGGGGAGGAACTATACACTGAAAAGCTTATTCCTGCCGTCCTAGAAG
GGGCAGCAGTGGCTGGCAGAGATGCTGACGACATCGACAAGATGATCGAAATCAAGATGTCCTACGACCCCGATCCCGAG
CAGGCTCTGTCCAACATCCGGTTCTGGGCGCCGCTATCGCTGGCCGCCGAGCAGAAGCACAGCATTGACGACCCGATCGA
GATGGAGAAGGTCGCCGACGCACTGCCGATCGAGCAGGTTGCCAAGCGCTGGATCGTGGTGTCGGATCCTGATGAAGCCG
TAGCAAGGGTTGGTCAATATGTGACGTGGGGCCTCAATCATCTGGTGTTTCATGCTCCCGGTCATAACCAGCGCCGCTTC
CTCGAGTTGTTTGAGAAAGATCTGGCGCCCCGGCTGCGGCGGCTGGGCTGA

Upstream 100 bases:

>100_bases
TCGCCGCTGCCATGTCGGAGAGTCTAAGTCTGATGTGTGGAGACCTGCTGCGCCCGGCTCAGCTGCGCTTGCAATCGGCC
ACGAGGAGTAGAAAGAACTA

Downstream 100 bases:

>100_bases
AGGCAGGCTGCCGCCGAATCCGGCGACCTCGATTGCCGCGCCTGAATCGGCGTCCGGCAAGGTGACGATCGCACTGGACA
TCCCGAGATCGGTACCCCTT

Product: putative F420-dependent glucose-6-phosphate dehydrogenase

Products: NA

Alternate protein names: F420_G6P_DH [H]

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MAELRLGYKASAEQFAPRELVELGVAAEAHGMDSATVSDHFQPWRHQGGHASFSLSWMTAVGERTNRILLGTSVLTPTFR
YNPAVIGQAFATMGCLYPNRVFLGVGTGEALNEVATGYQGAWPEFKERFARLRESVRLMRELWRGDRVDFDGDYYQLKGA
SIYDVPEGGVPIYIAAGGPEVAKYAGRAGEGFVCTSGKGEELYTEKLIPAVLEGAAVAGRDADDIDKMIEIKMSYDPDPE
QALSNIRFWAPLSLAAEQKHSIDDPIEMEKVADALPIEQVAKRWIVVSDPDEAVARVGQYVTWGLNHLVFHAPGHNQRRF
LELFEKDLAPRLRRLG

Sequences:

>Translated_336_residues
MAELRLGYKASAEQFAPRELVELGVAAEAHGMDSATVSDHFQPWRHQGGHASFSLSWMTAVGERTNRILLGTSVLTPTFR
YNPAVIGQAFATMGCLYPNRVFLGVGTGEALNEVATGYQGAWPEFKERFARLRESVRLMRELWRGDRVDFDGDYYQLKGA
SIYDVPEGGVPIYIAAGGPEVAKYAGRAGEGFVCTSGKGEELYTEKLIPAVLEGAAVAGRDADDIDKMIEIKMSYDPDPE
QALSNIRFWAPLSLAAEQKHSIDDPIEMEKVADALPIEQVAKRWIVVSDPDEAVARVGQYVTWGLNHLVFHAPGHNQRRF
LELFEKDLAPRLRRLG
>Mature_335_residues
AELRLGYKASAEQFAPRELVELGVAAEAHGMDSATVSDHFQPWRHQGGHASFSLSWMTAVGERTNRILLGTSVLTPTFRY
NPAVIGQAFATMGCLYPNRVFLGVGTGEALNEVATGYQGAWPEFKERFARLRESVRLMRELWRGDRVDFDGDYYQLKGAS
IYDVPEGGVPIYIAAGGPEVAKYAGRAGEGFVCTSGKGEELYTEKLIPAVLEGAAVAGRDADDIDKMIEIKMSYDPDPEQ
ALSNIRFWAPLSLAAEQKHSIDDPIEMEKVADALPIEQVAKRWIVVSDPDEAVARVGQYVTWGLNHLVFHAPGHNQRRFL
ELFEKDLAPRLRRLG

Specific function: Involved in the bioreductive activation of the prodrug PA-824 (nitroimidazo-oxazine) developed for anti-tuberculosis therapy against both replicating and persistent bacteria. It does not interact directly with PA-824 but, rather, provides reduced F420 to

COG id: COG2141

COG function: function code C; Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the F420-dependent glucose-6-phosphate dehydrogenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019945
- InterPro:   IPR019944
- InterPro:   IPR011251
- InterPro:   IPR016048 [H]

Pfam domain/function: PF00296 Bac_luciferase [H]

EC number: =1.1.99.34 [H]

Molecular weight: Translated: 37200; Mature: 37068

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAELRLGYKASAEQFAPRELVELGVAAEAHGMDSATVSDHFQPWRHQGGHASFSLSWMTA
CCCCCCCCCCCHHHCCHHHHHHHCCHHHHCCCCCCHHHHHCCHHHCCCCCCEEEEHHHHH
VGERTNRILLGTSVLTPTFRYNPAVIGQAFATMGCLYPNRVFLGVGTGEALNEVATGYQG
HCCCCCEEEEECHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHCCCCC
AWPEFKERFARLRESVRLMRELWRGDRVDFDGDYYQLKGASIYDVPEGGVPIYIAAGGPE
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCEEEECCCCCEEEEEECCCHH
VAKYAGRAGEGFVCTSGKGEELYTEKLIPAVLEGAAVAGRDADDIDKMIEIKMSYDPDPE
HHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHCCCHHCCCCHHHHHHHEEEEECCCCCHH
QALSNIRFWAPLSLAAEQKHSIDDPIEMEKVADALPIEQVAKRWIVVSDPDEAVARVGQY
HHHHCCEEECCHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHCEEEECCCHHHHHHHHHH
VTWGLNHLVFHAPGHNQRRFLELFEKDLAPRLRRLG
HHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AELRLGYKASAEQFAPRELVELGVAAEAHGMDSATVSDHFQPWRHQGGHASFSLSWMTA
CCCCCCCCCCHHHCCHHHHHHHCCHHHHCCCCCCHHHHHCCHHHCCCCCCEEEEHHHHH
VGERTNRILLGTSVLTPTFRYNPAVIGQAFATMGCLYPNRVFLGVGTGEALNEVATGYQG
HCCCCCEEEEECHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHCCCCC
AWPEFKERFARLRESVRLMRELWRGDRVDFDGDYYQLKGASIYDVPEGGVPIYIAAGGPE
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCEEEECCCCCEEEEEECCCHH
VAKYAGRAGEGFVCTSGKGEELYTEKLIPAVLEGAAVAGRDADDIDKMIEIKMSYDPDPE
HHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHCCCHHCCCCHHHHHHHEEEEECCCCCHH
QALSNIRFWAPLSLAAEQKHSIDDPIEMEKVADALPIEQVAKRWIVVSDPDEAVARVGQY
HHHHCCEEECCHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHCEEEECCCHHHHHHHHHH
VTWGLNHLVFHAPGHNQRRFLELFEKDLAPRLRRLG
HHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]