Definition Mycobacterium leprae Br4923 chromosome, complete genome.
Accession NC_011896
Length 3,268,071

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The map label for this gene is ftsH [H]

Identifier: 221229497

GI number: 221229497

Start: 293708

End: 296080

Strand: Direct

Name: ftsH [H]

Synonym: MLBr_00222

Alternate gene names: 221229497

Gene position: 293708-296080 (Clockwise)

Preceding gene: 221229495

Following gene: 221229498

Centisome position: 8.99

GC content: 62.45

Gene sequence:

>2373_bases
ATGTTATTGATGAACCGAAAAAACGTTATCCGCATGGTTACGGCGATCGCTGTAGTGGTGCTGCTCGGCTGGTCGTTTTT
CTACTTCAGCGACGACACTCGTGGTTACAAGTTCGTCGACACCTCGGTGGCGATGTCCCAGATCAACGGCCACAACGTCA
AGAGCGCGCAAATTGATGACCGGGAACAGCAGCTGCGGTTGACCTTGAAGAAGGGCAACAACGACACCGATGGCTCTGAC
AAGGTCATAACCAAATACCCCACCGGGTACGCGGTCGATTTGTTCAACGCGCTGAGCGCTAAGAACACGAAGGTCACCAC
CGCCGTAAACGAAGGCAGCATCCTGGGCGAGTTGCTCGTTTATGTGCTGCCATTGCTTTTGCTGGTGGGCCTGTTTGTGA
TGTTCTCTCGTATGCAGGGCGGCGCTCGAATGGGCTTTGGATTCGGCAAATCACGCGCTAAGCAACTTTCCAAAGACATG
CCCAAGACCACTTTCGCTGACGTTGCCGGTGTTGACGAGGCGGTCGAGGAGCTCTACGAGATCAAGGACTTCTTGCAAAA
CCCCTGTAGGTACCAGACGCTCGGCGCGAAGATCCCCAAGGGCGTGCTGCTCTACGGGCCGCCGGGCACCGGTAAAACGT
TGCTGGCCCGCGCTGTGGCGGGAGAGGCAGGCGTTCCGTTCTTCACCATCTCCGGATCCGACTTCGTCGAGATGTTCGTT
GGCGTTGGCGCTTCACGCGTAAGGGACCTGTTCGACCAGGCTAAGCAGAACAGCCCGTGCATCATCTTTGTCGATGAGAT
AGACGCGGTGGGCCGCCAGCGCGGCACCGGGCTCGGCGGTGGCCACGACGAGCGCGAGCAAACACTGAACCAGTTGCTGG
TCGAGATGGACGGTTTTGGCGATCGGGCGGGCGTCATCTTGATCGCGGCAACCAACCGGCCTGACATCTTGGACCCCGCG
CTTCTAAGGCCCGGGCGTTTCGACCGGCAGATCCCGGTGTCCAACCCGGACCTGGCAGGTCGTCGCGCGGTGCTGCGCGT
GCATTCGAAGGGCAAGCCGATTGCCGACGATGCTGACCTCGACGGACTGGCCAAACGCACTGTCGGAATGACCGGCGCTG
ACCTTGCCAACGTTGTCAACGAGGCGGCGCTGCTGACCGCCCGAGAGAACGGCCTGGTGATTACCGGACCCGCCTTGGAG
GAGGCGGTGGACCGGGTGATCGGCGGGCCACGTCGCAAGGGCCGGATCATCAGCGAGCAGGAAAAGAAAATCACAGCGTA
TCACGAGGGCGGGCACACCTTGGCGGCTTGGGCTATGCCTGATATCGAGCCTATCTACAAGGTGACGATCCTGGCTCGGG
GACGTACCGGCGGGCACGCGGTGGCGGTGCCCGAGGAAGACAAGGGCTTGAGGACCCGCTCGGAAATGATCGCGCAGCTG
GTGTTCGCGATGGGTGGACGTGCCGCCGAGGAGTTGGTGTTCCGCGAGCCGACGACCGGTGCGGTATCGGATATCGAGAA
GGCCACCAAAATCGCGCGCTCGATGGTTACCGAATTCGGTATGAGCTCCAAACTTGGAGCGGTCAGATATGGTTCCGAGC
ACGGCGACCCGTTCCTCGGCCGGACCATGGGCACCCAGGCGGATTACTCTCATGAGGTCGCCCGCGACATCGATGATGAG
GTTCGCAAGCTTATTGAAGCCGCGCACACCGAGGCGTGGGAGATTCTCACCGAATACCGCGACGTGCTTGACACCCTGGC
CGGCGAGCTGCTGGAAAAAGAAACTCTGCACCGACCAGAGCTGGAGGGGATCTTCGCCAGCGTCGAAAAGCGACCCCGGC
TCACCATGTTCGACGATTTTGGTGGGCGGATCCCGTCGGACAAGCCGCCGATCAAGACACCCGGCGAGCTGGCGATCGAG
CGCGGCGAGCCCTGGCCCCAGCCAGTCCCCGAGCCGGCGTTCAAGGCAGCCATCGCCCGTGCTTCGCAGGCCGCTGAGGC
CTCGCACCAAGCAGCACAATCGGATACCGATGGGCCCCCCGGCCAGGGGGCCAATGGTTCACATGCCGGGGACCGTCAGC
GCCAGCACGGCCCTACTCAACCCGACTATGGCGCTCCGCCGGGTTGGCATGCGCCTGGATGGCCGCCACAACAGCCGCCG
GATTACTGGTATCCGCCTGAACAGCAACCCTCACAGTCGCCCTATTGGCCGCAGCCCGCGCCCAGCTATCCGGGCCAAGC
CCCCCCTCCGTATCCGTCGTACCCGCCTTGTCCTTCTTACCCGCCGCCTGGTCAATCCGCCCCGGACGCGGGTAAGCCCC
CTGCACAGTTGGACGAGGGCGTGAGCCCCTCCAACCCACCGGCGCACGGCTGA

Upstream 100 bases:

>100_bases
CCCGCTGCACCCGGCTCTGCCGAGCTGGCGATCGTCACTGACGGTAGCCTAAACTTTTTTAGCTGCGTGTATCGGGGAAG
GAACCTGGCCGGCACGGCCG

Downstream 100 bases:

>100_bases
CGAAACGGAGAATTCGATGGCCTTACTGGATTTAGGGCTGGAAAGCACCGCGGTCCCGCGCATCCGGGTTTTTGACCAGC
AGCGTGCCGAGGCCGCGATT

Product: putative integral membrane peptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 790; Mature: 790

Protein sequence:

>790_residues
MLLMNRKNVIRMVTAIAVVVLLGWSFFYFSDDTRGYKFVDTSVAMSQINGHNVKSAQIDDREQQLRLTLKKGNNDTDGSD
KVITKYPTGYAVDLFNALSAKNTKVTTAVNEGSILGELLVYVLPLLLLVGLFVMFSRMQGGARMGFGFGKSRAKQLSKDM
PKTTFADVAGVDEAVEELYEIKDFLQNPCRYQTLGAKIPKGVLLYGPPGTGKTLLARAVAGEAGVPFFTISGSDFVEMFV
GVGASRVRDLFDQAKQNSPCIIFVDEIDAVGRQRGTGLGGGHDEREQTLNQLLVEMDGFGDRAGVILIAATNRPDILDPA
LLRPGRFDRQIPVSNPDLAGRRAVLRVHSKGKPIADDADLDGLAKRTVGMTGADLANVVNEAALLTARENGLVITGPALE
EAVDRVIGGPRRKGRIISEQEKKITAYHEGGHTLAAWAMPDIEPIYKVTILARGRTGGHAVAVPEEDKGLRTRSEMIAQL
VFAMGGRAAEELVFREPTTGAVSDIEKATKIARSMVTEFGMSSKLGAVRYGSEHGDPFLGRTMGTQADYSHEVARDIDDE
VRKLIEAAHTEAWEILTEYRDVLDTLAGELLEKETLHRPELEGIFASVEKRPRLTMFDDFGGRIPSDKPPIKTPGELAIE
RGEPWPQPVPEPAFKAAIARASQAAEASHQAAQSDTDGPPGQGANGSHAGDRQRQHGPTQPDYGAPPGWHAPGWPPQQPP
DYWYPPEQQPSQSPYWPQPAPSYPGQAPPPYPSYPPCPSYPPPGQSAPDAGKPPAQLDEGVSPSNPPAHG

Sequences:

>Translated_790_residues
MLLMNRKNVIRMVTAIAVVVLLGWSFFYFSDDTRGYKFVDTSVAMSQINGHNVKSAQIDDREQQLRLTLKKGNNDTDGSD
KVITKYPTGYAVDLFNALSAKNTKVTTAVNEGSILGELLVYVLPLLLLVGLFVMFSRMQGGARMGFGFGKSRAKQLSKDM
PKTTFADVAGVDEAVEELYEIKDFLQNPCRYQTLGAKIPKGVLLYGPPGTGKTLLARAVAGEAGVPFFTISGSDFVEMFV
GVGASRVRDLFDQAKQNSPCIIFVDEIDAVGRQRGTGLGGGHDEREQTLNQLLVEMDGFGDRAGVILIAATNRPDILDPA
LLRPGRFDRQIPVSNPDLAGRRAVLRVHSKGKPIADDADLDGLAKRTVGMTGADLANVVNEAALLTARENGLVITGPALE
EAVDRVIGGPRRKGRIISEQEKKITAYHEGGHTLAAWAMPDIEPIYKVTILARGRTGGHAVAVPEEDKGLRTRSEMIAQL
VFAMGGRAAEELVFREPTTGAVSDIEKATKIARSMVTEFGMSSKLGAVRYGSEHGDPFLGRTMGTQADYSHEVARDIDDE
VRKLIEAAHTEAWEILTEYRDVLDTLAGELLEKETLHRPELEGIFASVEKRPRLTMFDDFGGRIPSDKPPIKTPGELAIE
RGEPWPQPVPEPAFKAAIARASQAAEASHQAAQSDTDGPPGQGANGSHAGDRQRQHGPTQPDYGAPPGWHAPGWPPQQPP
DYWYPPEQQPSQSPYWPQPAPSYPGQAPPPYPSYPPCPSYPPPGQSAPDAGKPPAQLDEGVSPSNPPAHG
>Mature_790_residues
MLLMNRKNVIRMVTAIAVVVLLGWSFFYFSDDTRGYKFVDTSVAMSQINGHNVKSAQIDDREQQLRLTLKKGNNDTDGSD
KVITKYPTGYAVDLFNALSAKNTKVTTAVNEGSILGELLVYVLPLLLLVGLFVMFSRMQGGARMGFGFGKSRAKQLSKDM
PKTTFADVAGVDEAVEELYEIKDFLQNPCRYQTLGAKIPKGVLLYGPPGTGKTLLARAVAGEAGVPFFTISGSDFVEMFV
GVGASRVRDLFDQAKQNSPCIIFVDEIDAVGRQRGTGLGGGHDEREQTLNQLLVEMDGFGDRAGVILIAATNRPDILDPA
LLRPGRFDRQIPVSNPDLAGRRAVLRVHSKGKPIADDADLDGLAKRTVGMTGADLANVVNEAALLTARENGLVITGPALE
EAVDRVIGGPRRKGRIISEQEKKITAYHEGGHTLAAWAMPDIEPIYKVTILARGRTGGHAVAVPEEDKGLRTRSEMIAQL
VFAMGGRAAEELVFREPTTGAVSDIEKATKIARSMVTEFGMSSKLGAVRYGSEHGDPFLGRTMGTQADYSHEVARDIDDE
VRKLIEAAHTEAWEILTEYRDVLDTLAGELLEKETLHRPELEGIFASVEKRPRLTMFDDFGGRIPSDKPPIKTPGELAIE
RGEPWPQPVPEPAFKAAIARASQAAEASHQAAQSDTDGPPGQGANGSHAGDRQRQHGPTQPDYGAPPGWHAPGWPPQQPP
DYWYPPEQQPSQSPYWPQPAPSYPGQAPPPYPSYPPCPSYPPPGQSAPDAGKPPAQLDEGVSPSNPPAHG

Specific function: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins [H]

COG id: COG0465

COG function: function code O; ATP-dependent Zn proteases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein; Cytoplasmic side [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the peptidase M41 family [H]

Homologues:

Organism=Homo sapiens, GI300192933, Length=500, Percent_Identity=46.8, Blast_Score=433, Evalue=1e-121,
Organism=Homo sapiens, GI7657689, Length=522, Percent_Identity=43.1034482758621, Blast_Score=387, Evalue=1e-107,
Organism=Homo sapiens, GI21327685, Length=522, Percent_Identity=43.1034482758621, Blast_Score=387, Evalue=1e-107,
Organism=Homo sapiens, GI4507173, Length=563, Percent_Identity=39.6092362344583, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI4506209, Length=251, Percent_Identity=42.6294820717131, Blast_Score=210, Evalue=5e-54,
Organism=Homo sapiens, GI24430151, Length=248, Percent_Identity=40.3225806451613, Blast_Score=206, Evalue=9e-53,
Organism=Homo sapiens, GI24497435, Length=253, Percent_Identity=41.1067193675889, Blast_Score=200, Evalue=6e-51,
Organism=Homo sapiens, GI6005942, Length=228, Percent_Identity=41.6666666666667, Blast_Score=195, Evalue=1e-49,
Organism=Homo sapiens, GI195539395, Length=255, Percent_Identity=39.2156862745098, Blast_Score=192, Evalue=8e-49,
Organism=Homo sapiens, GI89064750, Length=252, Percent_Identity=39.2857142857143, Blast_Score=191, Evalue=2e-48,
Organism=Homo sapiens, GI21361144, Length=247, Percent_Identity=40.8906882591093, Blast_Score=191, Evalue=3e-48,
Organism=Homo sapiens, GI5729991, Length=252, Percent_Identity=39.2857142857143, Blast_Score=190, Evalue=4e-48,
Organism=Homo sapiens, GI24430155, Length=252, Percent_Identity=39.2857142857143, Blast_Score=189, Evalue=6e-48,
Organism=Homo sapiens, GI157671927, Length=241, Percent_Identity=39.8340248962656, Blast_Score=185, Evalue=2e-46,
Organism=Homo sapiens, GI45643125, Length=278, Percent_Identity=39.568345323741, Blast_Score=183, Evalue=5e-46,
Organism=Homo sapiens, GI45643123, Length=278, Percent_Identity=39.568345323741, Blast_Score=183, Evalue=5e-46,
Organism=Homo sapiens, GI229577436, Length=254, Percent_Identity=39.7637795275591, Blast_Score=172, Evalue=8e-43,
Organism=Homo sapiens, GI40806173, Length=252, Percent_Identity=42.8571428571429, Blast_Score=166, Evalue=7e-41,
Organism=Homo sapiens, GI4505725, Length=215, Percent_Identity=41.3953488372093, Blast_Score=166, Evalue=7e-41,
Organism=Homo sapiens, GI24497618, Length=233, Percent_Identity=40.7725321888412, Blast_Score=162, Evalue=1e-39,
Organism=Homo sapiens, GI153792536, Length=231, Percent_Identity=39.8268398268398, Blast_Score=160, Evalue=5e-39,
Organism=Homo sapiens, GI194018488, Length=272, Percent_Identity=38.2352941176471, Blast_Score=145, Evalue=2e-34,
Organism=Homo sapiens, GI5901990, Length=261, Percent_Identity=36.0153256704981, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI14149767, Length=269, Percent_Identity=34.5724907063197, Blast_Score=139, Evalue=7e-33,
Organism=Homo sapiens, GI62177112, Length=269, Percent_Identity=34.5724907063197, Blast_Score=139, Evalue=7e-33,
Organism=Homo sapiens, GI226371754, Length=239, Percent_Identity=37.2384937238494, Blast_Score=138, Evalue=2e-32,
Organism=Homo sapiens, GI7019569, Length=240, Percent_Identity=35.8333333333333, Blast_Score=134, Evalue=4e-31,
Organism=Homo sapiens, GI17865802, Length=240, Percent_Identity=36.6666666666667, Blast_Score=134, Evalue=4e-31,
Organism=Homo sapiens, GI31377644, Length=236, Percent_Identity=35.5932203389831, Blast_Score=129, Evalue=8e-30,
Organism=Homo sapiens, GI31742536, Length=228, Percent_Identity=32.8947368421053, Blast_Score=128, Evalue=2e-29,
Organism=Homo sapiens, GI112789543, Length=228, Percent_Identity=32.8947368421053, Blast_Score=128, Evalue=2e-29,
Organism=Homo sapiens, GI156564401, Length=274, Percent_Identity=33.2116788321168, Blast_Score=128, Evalue=3e-29,
Organism=Homo sapiens, GI310125282, Length=274, Percent_Identity=32.8467153284672, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI11875211, Length=233, Percent_Identity=38.6266094420601, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI40806170, Length=233, Percent_Identity=38.6266094420601, Blast_Score=125, Evalue=2e-28,
Organism=Homo sapiens, GI310125280, Length=207, Percent_Identity=37.6811594202899, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI64084766, Length=190, Percent_Identity=29.4736842105263, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI75677353, Length=272, Percent_Identity=28.3088235294118, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI116292174, Length=227, Percent_Identity=28.1938325991189, Blast_Score=73, Evalue=1e-12,
Organism=Homo sapiens, GI283436220, Length=238, Percent_Identity=27.3109243697479, Blast_Score=71, Evalue=4e-12,
Organism=Homo sapiens, GI283436222, Length=238, Percent_Identity=27.3109243697479, Blast_Score=71, Evalue=5e-12,
Organism=Homo sapiens, GI283436224, Length=218, Percent_Identity=27.9816513761468, Blast_Score=70, Evalue=7e-12,
Organism=Homo sapiens, GI4757852, Length=158, Percent_Identity=31.6455696202532, Blast_Score=67, Evalue=8e-11,
Organism=Homo sapiens, GI119964730, Length=158, Percent_Identity=31.6455696202532, Blast_Score=67, Evalue=8e-11,
Organism=Escherichia coli, GI1789568, Length=609, Percent_Identity=48.440065681445, Blast_Score=553, Evalue=1e-158,
Organism=Caenorhabditis elegans, GI71994521, Length=469, Percent_Identity=48.1876332622601, Blast_Score=405, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17554264, Length=446, Percent_Identity=47.3094170403587, Blast_Score=374, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI115534323, Length=459, Percent_Identity=41.1764705882353, Blast_Score=334, Evalue=1e-91,
Organism=Caenorhabditis elegans, GI17563248, Length=250, Percent_Identity=44.4, Blast_Score=214, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17554786, Length=265, Percent_Identity=40.377358490566, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI25144278, Length=253, Percent_Identity=41.897233201581, Blast_Score=207, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI25144281, Length=253, Percent_Identity=41.897233201581, Blast_Score=206, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI17532375, Length=249, Percent_Identity=40.5622489959839, Blast_Score=205, Evalue=7e-53,
Organism=Caenorhabditis elegans, GI17563250, Length=248, Percent_Identity=39.5161290322581, Blast_Score=196, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17505546, Length=248, Percent_Identity=41.1290322580645, Blast_Score=193, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI17531535, Length=250, Percent_Identity=41.6, Blast_Score=192, Evalue=7e-49,
Organism=Caenorhabditis elegans, GI71987372, Length=250, Percent_Identity=40, Blast_Score=191, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI71987364, Length=250, Percent_Identity=40, Blast_Score=191, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17508701, Length=255, Percent_Identity=39.2156862745098, Blast_Score=189, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI17554784, Length=248, Percent_Identity=41.5322580645161, Blast_Score=184, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17508053, Length=259, Percent_Identity=39.7683397683398, Blast_Score=178, Evalue=9e-45,
Organism=Caenorhabditis elegans, GI133931034, Length=234, Percent_Identity=42.3076923076923, Blast_Score=164, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI193206114, Length=234, Percent_Identity=42.3076923076923, Blast_Score=164, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI193206116, Length=234, Percent_Identity=42.3076923076923, Blast_Score=164, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17537217, Length=287, Percent_Identity=38.3275261324042, Blast_Score=161, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI25153574, Length=262, Percent_Identity=33.587786259542, Blast_Score=145, Evalue=9e-35,
Organism=Caenorhabditis elegans, GI193209502, Length=260, Percent_Identity=33.4615384615385, Blast_Score=143, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI17562804, Length=232, Percent_Identity=34.9137931034483, Blast_Score=142, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI133901658, Length=289, Percent_Identity=33.2179930795848, Blast_Score=133, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI133901662, Length=209, Percent_Identity=38.2775119617225, Blast_Score=132, Evalue=9e-31,
Organism=Caenorhabditis elegans, GI17570397, Length=165, Percent_Identity=41.8181818181818, Blast_Score=131, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI32566590, Length=165, Percent_Identity=41.8181818181818, Blast_Score=131, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI86561515, Length=234, Percent_Identity=35.042735042735, Blast_Score=130, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17508421, Length=230, Percent_Identity=38.2608695652174, Blast_Score=124, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI32563584, Length=230, Percent_Identity=38.2608695652174, Blast_Score=124, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI25146157, Length=229, Percent_Identity=37.5545851528384, Blast_Score=123, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17541224, Length=242, Percent_Identity=34.297520661157, Blast_Score=117, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17541226, Length=244, Percent_Identity=34.0163934426229, Blast_Score=117, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17560432, Length=231, Percent_Identity=33.7662337662338, Blast_Score=106, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI71990294, Length=199, Percent_Identity=29.6482412060301, Blast_Score=78, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320854, Length=466, Percent_Identity=48.9270386266094, Blast_Score=429, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6323736, Length=525, Percent_Identity=45.1428571428571, Blast_Score=423, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6325281, Length=453, Percent_Identity=45.916114790287, Blast_Score=367, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6322704, Length=256, Percent_Identity=43.359375, Blast_Score=214, Evalue=4e-56,
Organism=Saccharomyces cerevisiae, GI6321390, Length=254, Percent_Identity=41.3385826771654, Blast_Score=209, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6320197, Length=248, Percent_Identity=39.9193548387097, Blast_Score=206, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6320077, Length=233, Percent_Identity=44.206008583691, Blast_Score=201, Evalue=4e-52,
Organism=Saccharomyces cerevisiae, GI6324833, Length=256, Percent_Identity=41.015625, Blast_Score=195, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6320602, Length=244, Percent_Identity=43.0327868852459, Blast_Score=191, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6324691, Length=243, Percent_Identity=41.9753086419753, Blast_Score=188, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6322994, Length=234, Percent_Identity=37.1794871794872, Blast_Score=167, Evalue=5e-42,
Organism=Saccharomyces cerevisiae, GI6323429, Length=242, Percent_Identity=38.4297520661157, Blast_Score=163, Evalue=9e-41,
Organism=Saccharomyces cerevisiae, GI6321709, Length=257, Percent_Identity=37.3540856031128, Blast_Score=162, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6324000, Length=230, Percent_Identity=40, Blast_Score=159, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6322651, Length=246, Percent_Identity=36.5853658536585, Blast_Score=154, Evalue=7e-38,
Organism=Saccharomyces cerevisiae, GI6325431, Length=229, Percent_Identity=39.7379912663755, Blast_Score=142, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6319554, Length=210, Percent_Identity=36.6666666666667, Blast_Score=128, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6321465, Length=236, Percent_Identity=36.4406779661017, Blast_Score=126, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6325183, Length=245, Percent_Identity=33.469387755102, Blast_Score=114, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6320887, Length=246, Percent_Identity=34.1463414634146, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6320583, Length=191, Percent_Identity=31.413612565445, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28574878, Length=612, Percent_Identity=41.5032679738562, Blast_Score=429, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24665814, Length=612, Percent_Identity=41.5032679738562, Blast_Score=427, Evalue=1e-119,
Organism=Drosophila melanogaster, GI24639391, Length=439, Percent_Identity=47.380410022779, Blast_Score=385, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24658770, Length=489, Percent_Identity=43.558282208589, Blast_Score=384, Evalue=1e-106,
Organism=Drosophila melanogaster, GI17137738, Length=251, Percent_Identity=42.2310756972112, Blast_Score=206, Evalue=5e-53,
Organism=Drosophila melanogaster, GI24649446, Length=248, Percent_Identity=40.3225806451613, Blast_Score=202, Evalue=5e-52,
Organism=Drosophila melanogaster, GI17137560, Length=232, Percent_Identity=40.0862068965517, Blast_Score=202, Evalue=1e-51,
Organism=Drosophila melanogaster, GI161076486, Length=232, Percent_Identity=40.0862068965517, Blast_Score=202, Evalue=1e-51,
Organism=Drosophila melanogaster, GI161076488, Length=232, Percent_Identity=40.0862068965517, Blast_Score=202, Evalue=1e-51,
Organism=Drosophila melanogaster, GI45554047, Length=163, Percent_Identity=59.5092024539877, Blast_Score=201, Evalue=2e-51,
Organism=Drosophila melanogaster, GI19920408, Length=253, Percent_Identity=41.1067193675889, Blast_Score=200, Evalue=4e-51,
Organism=Drosophila melanogaster, GI281365776, Length=281, Percent_Identity=40.2135231316726, Blast_Score=197, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24660075, Length=281, Percent_Identity=40.2135231316726, Blast_Score=197, Evalue=2e-50,
Organism=Drosophila melanogaster, GI45552965, Length=281, Percent_Identity=40.2135231316726, Blast_Score=196, Evalue=5e-50,
Organism=Drosophila melanogaster, GI17738151, Length=258, Percent_Identity=39.5348837209302, Blast_Score=196, Evalue=7e-50,
Organism=Drosophila melanogaster, GI24651451, Length=253, Percent_Identity=40.7114624505929, Blast_Score=195, Evalue=9e-50,
Organism=Drosophila melanogaster, GI281361487, Length=242, Percent_Identity=40.495867768595, Blast_Score=190, Evalue=4e-48,
Organism=Drosophila melanogaster, GI18860063, Length=242, Percent_Identity=40.0826446280992, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24640100, Length=245, Percent_Identity=40.4081632653061, Blast_Score=186, Evalue=5e-47,
Organism=Drosophila melanogaster, GI24663015, Length=255, Percent_Identity=37.6470588235294, Blast_Score=182, Evalue=7e-46,
Organism=Drosophila melanogaster, GI24652279, Length=190, Percent_Identity=43.6842105263158, Blast_Score=182, Evalue=8e-46,
Organism=Drosophila melanogaster, GI19921202, Length=237, Percent_Identity=38.3966244725738, Blast_Score=177, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24656820, Length=198, Percent_Identity=43.9393939393939, Blast_Score=167, Evalue=3e-41,
Organism=Drosophila melanogaster, GI24656825, Length=198, Percent_Identity=43.9393939393939, Blast_Score=167, Evalue=4e-41,
Organism=Drosophila melanogaster, GI281363136, Length=237, Percent_Identity=38.3966244725738, Blast_Score=157, Evalue=3e-38,
Organism=Drosophila melanogaster, GI78707192, Length=237, Percent_Identity=38.3966244725738, Blast_Score=157, Evalue=3e-38,
Organism=Drosophila melanogaster, GI21355121, Length=213, Percent_Identity=36.6197183098592, Blast_Score=145, Evalue=1e-34,
Organism=Drosophila melanogaster, GI18859657, Length=235, Percent_Identity=37.8723404255319, Blast_Score=144, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24644145, Length=245, Percent_Identity=36.3265306122449, Blast_Score=140, Evalue=4e-33,
Organism=Drosophila melanogaster, GI20129423, Length=252, Percent_Identity=32.9365079365079, Blast_Score=132, Evalue=9e-31,
Organism=Drosophila melanogaster, GI28571849, Length=237, Percent_Identity=39.2405063291139, Blast_Score=131, Evalue=2e-30,
Organism=Drosophila melanogaster, GI28571847, Length=237, Percent_Identity=39.2405063291139, Blast_Score=131, Evalue=2e-30,
Organism=Drosophila melanogaster, GI17864540, Length=211, Percent_Identity=39.8104265402844, Blast_Score=130, Evalue=4e-30,
Organism=Drosophila melanogaster, GI20129529, Length=233, Percent_Identity=32.618025751073, Blast_Score=129, Evalue=7e-30,
Organism=Drosophila melanogaster, GI28573010, Length=211, Percent_Identity=38.8625592417062, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI281360144, Length=259, Percent_Identity=32.046332046332, Blast_Score=127, Evalue=4e-29,
Organism=Drosophila melanogaster, GI281360140, Length=259, Percent_Identity=32.046332046332, Blast_Score=127, Evalue=4e-29,
Organism=Drosophila melanogaster, GI281360136, Length=259, Percent_Identity=32.046332046332, Blast_Score=127, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24644411, Length=259, Percent_Identity=32.046332046332, Blast_Score=127, Evalue=4e-29,
Organism=Drosophila melanogaster, GI281360146, Length=259, Percent_Identity=32.046332046332, Blast_Score=125, Evalue=8e-29,
Organism=Drosophila melanogaster, GI281360142, Length=259, Percent_Identity=32.046332046332, Blast_Score=125, Evalue=8e-29,
Organism=Drosophila melanogaster, GI281360138, Length=259, Percent_Identity=32.046332046332, Blast_Score=125, Evalue=8e-29,
Organism=Drosophila melanogaster, GI21357333, Length=259, Percent_Identity=32.046332046332, Blast_Score=125, Evalue=8e-29,
Organism=Drosophila melanogaster, GI24581396, Length=235, Percent_Identity=33.6170212765957, Blast_Score=114, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24639486, Length=190, Percent_Identity=34.7368421052632, Blast_Score=99, Evalue=1e-20,
Organism=Drosophila melanogaster, GI20129417, Length=152, Percent_Identity=34.2105263157895, Blast_Score=72, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24583262, Length=152, Percent_Identity=34.2105263157895, Blast_Score=72, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR003960
- InterPro:   IPR005936
- InterPro:   IPR000642 [H]

Pfam domain/function: PF00004 AAA; PF01434 Peptidase_M41 [H]

EC number: 3.4.24.-

Molecular weight: Translated: 85466; Mature: 85466

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS00674 AAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MLLMNRKNVIRMVTAIAVVVLLGWSFFYFSDDTRGYKFVDTSVAMSQINGHNVKSAQIDD
CEECCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCEEEEHHHHHHHCCCCCCCCCCCCC
REQQLRLTLKKGNNDTDGSDKVITKYPTGYAVDLFNALSAKNTKVTTAVNEGSILGELLV
HHHHEEEEEECCCCCCCCCCCEEEECCCCHHHHHHHHHCCCCCEEEEECCCCHHHHHHHH
YVLPLLLLVGLFVMFSRMQGGARMGFGFGKSRAKQLSKDMPKTTFADVAGVDEAVEELYE
HHHHHHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
IKDFLQNPCRYQTLGAKIPKGVLLYGPPGTGKTLLARAVAGEAGVPFFTISGSDFVEMFV
HHHHHHCCCCCHHHCCCCCCCEEEECCCCCCHHHHHHHHHCCCCCCEEEECCHHHHHHHH
GVGASRVRDLFDQAKQNSPCIIFVDEIDAVGRQRGTGLGGGHDEREQTLNQLLVEMDGFG
HCCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCC
DRAGVILIAATNRPDILDPALLRPGRFDRQIPVSNPDLAGRRAVLRVHSKGKPIADDADL
CCCCEEEEEECCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCC
DGLAKRTVGMTGADLANVVNEAALLTARENGLVITGPALEEAVDRVIGGPRRKGRIISEQ
HHHHHHHCCCCCHHHHHHHHHHHHEEECCCCEEEECHHHHHHHHHHHCCCCCCCCCCCCH
EKKITAYHEGGHTLAAWAMPDIEPIYKVTILARGRTGGHAVAVPEEDKGLRTRSEMIAQL
HHEEEEEECCCCEEEEECCCCCCCCEEEEEEEECCCCCCEEECCCCCCCCHHHHHHHHHH
VFAMGGRAAEELVFREPTTGAVSDIEKATKIARSMVTEFGMSSKLGAVRYGSEHGDPFLG
HHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCHH
RTMGTQADYSHEVARDIDDEVRKLIEAAHTEAWEILTEYRDVLDTLAGELLEKETLHRPE
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
LEGIFASVEKRPRLTMFDDFGGRIPSDKPPIKTPGELAIERGEPWPQPVPEPAFKAAIAR
HHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCHHHEEECCCCCCCCCCCHHHHHHHHH
ASQAAEASHQAAQSDTDGPPGQGANGSHAGDRQRQHGPTQPDYGAPPGWHAPGWPPQQPP
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCC
DYWYPPEQQPSQSPYWPQPAPSYPGQAPPPYPSYPPCPSYPPPGQSAPDAGKPPAQLDEG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCC
VSPSNPPAHG
CCCCCCCCCC
>Mature Secondary Structure
MLLMNRKNVIRMVTAIAVVVLLGWSFFYFSDDTRGYKFVDTSVAMSQINGHNVKSAQIDD
CEECCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCEEEEHHHHHHHCCCCCCCCCCCCC
REQQLRLTLKKGNNDTDGSDKVITKYPTGYAVDLFNALSAKNTKVTTAVNEGSILGELLV
HHHHEEEEEECCCCCCCCCCCEEEECCCCHHHHHHHHHCCCCCEEEEECCCCHHHHHHHH
YVLPLLLLVGLFVMFSRMQGGARMGFGFGKSRAKQLSKDMPKTTFADVAGVDEAVEELYE
HHHHHHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
IKDFLQNPCRYQTLGAKIPKGVLLYGPPGTGKTLLARAVAGEAGVPFFTISGSDFVEMFV
HHHHHHCCCCCHHHCCCCCCCEEEECCCCCCHHHHHHHHHCCCCCCEEEECCHHHHHHHH
GVGASRVRDLFDQAKQNSPCIIFVDEIDAVGRQRGTGLGGGHDEREQTLNQLLVEMDGFG
HCCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCC
DRAGVILIAATNRPDILDPALLRPGRFDRQIPVSNPDLAGRRAVLRVHSKGKPIADDADL
CCCCEEEEEECCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCC
DGLAKRTVGMTGADLANVVNEAALLTARENGLVITGPALEEAVDRVIGGPRRKGRIISEQ
HHHHHHHCCCCCHHHHHHHHHHHHEEECCCCEEEECHHHHHHHHHHHCCCCCCCCCCCCH
EKKITAYHEGGHTLAAWAMPDIEPIYKVTILARGRTGGHAVAVPEEDKGLRTRSEMIAQL
HHEEEEEECCCCEEEEECCCCCCCCEEEEEEEECCCCCCEEECCCCCCCCHHHHHHHHHH
VFAMGGRAAEELVFREPTTGAVSDIEKATKIARSMVTEFGMSSKLGAVRYGSEHGDPFLG
HHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCHH
RTMGTQADYSHEVARDIDDEVRKLIEAAHTEAWEILTEYRDVLDTLAGELLEKETLHRPE
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
LEGIFASVEKRPRLTMFDDFGGRIPSDKPPIKTPGELAIERGEPWPQPVPEPAFKAAIAR
HHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCHHHEEECCCCCCCCCCCHHHHHHHHH
ASQAAEASHQAAQSDTDGPPGQGANGSHAGDRQRQHGPTQPDYGAPPGWHAPGWPPQQPP
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCC
DYWYPPEQQPSQSPYWPQPAPSYPGQAPPPYPSYPPCPSYPPPGQSAPDAGKPPAQLDEG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCC
VSPSNPPAHG
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Metalloendopeptidases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]