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The map label for this gene is moeA [H]

Identifier: 221229473

GI number: 221229473

Start: 248117

End: 249391

Strand: Direct

Name: moeA [H]

Synonym: MLBr_00183

Alternate gene names: 221229473

Gene position: 248117-249391 (Clockwise)

Preceding gene: 221229472

Following gene: 221229474

Centisome position: 7.59

GC content: 64.31

Gene sequence:

>1275_bases
GTGCGTTCTGTGGAAGAGCAGCAGGCCCGGATATTGGCCGCCGCGGTAGTCCCACGGCCAGTACGTGTCGCCATTGCCGA
GGCACAGGGATTGATGTGCGCCGAAGAAGTGATGACCGAACGGCCACTGCCTGGTTTCGACCAGGCGGCGATTGATGGCT
ACGCGGTACGTAGCGTCGACGTCTCGGGTATCGGTGAGTCGGATGGAGGTGAATCCGGTTCATCCGATGAGGATGGGCGT
TATGTGCTGACCTTGCCGGTGATGGGAACCATCGAGGCTGGTGCGCGCACACCCAGCAGGCTGCTGCCCCACCAGGCTGT
CCGAGTGCAGACTGGGGCACCGCTGCCGGTGCTGGCCGATGCAGTTCTGCCGGTGCGGTGGACCGACGGCGGGATGTCGC
GCGTGCGGATTCTGCGTGGCGCGCCGTCGGGTGCCTATGTACGGCGTGTGGGCGATGATGTGCAGCCCGGGGACGTCGCC
GTGCGTGCCGGAACAATCATCGGGGCTGCCCAGGTGGGGCTGCTAGCGGCGGTCGGCCGCGAACGAGTACTGGTGCACCC
GCGGCCACGGCTGTCAATAATGGCCGTAGGTGGGGAACTGGTCGACATCTCGCGTACTCCAGGCAACGGACAGGTGTACG
ACGTTAACTCCTATGCATTGACCGCGGCCGGCCGTGATGCTGGTGCGGAGGTGAACCGCATCGGCATCGTCAGCAACAAC
CTGAAGGAGTTCGGCGAAGTTGTTGAGGGCCAGATCAGCCGAGCCGAAGTCGTGGTGATCGCCGGAGGAGTCGGGGGGGC
GGCGGCCGAGGCGGTGCGGGCAGTGCTCTCGGAGATAGGCGAGATGGAGGTCGTTCGCGTCGCCATGCATCCTGGCTCCG
TCCAGGGCTTCGGGCAGCTGGGTCGCGAGGGCGTTCCGACATTTCTGCTGCCGGCCAATCCGGTTAGCGCCCTGGTGGTT
TTCGAAGTAATGGTTCGGCCGTTGATCCGGTTGTCGCTGGGCAAGCGCCAGCCGATGCGCCGGATCGTGCAGGCCCGAAC
GCTATCGCCGATCACTTCGGTGGCCGGGCGCAAAGGTTACTTGCGCGGTCAGTTGATGCGGGATCAGGACACCGGTGAAT
ACCTGGTGCAAGCACTTGGTGGCGCTCTTGGTGCGTCGTCGCATTTGCTGGCGACGCTTGCCGAAGCAAACTGTCTGGTA
GTGATTCCCAGTGGCGCCGAGCAGATTCGTACCGGTGAGGTCGTCGACGTTGCTTTCCTTGCTCAGCGCGGCTAA

Upstream 100 bases:

>100_bases
AATCGAGCAGTAGCCTGGCTACCAGACCCCAGTAGCCGGCCATGGCGGGCCCGGCTTGCCCGACATTGTGCCCGGGTAGG
GGGGGCAGAAAGGCGCTTTT

Downstream 100 bases:

>100_bases
GCGATCCGACTGCACGCTTTGGTGACCCTGTTGCGCTTCAACGCCCGGCATCCGGGTTGGCCGTCGAACGTTGGACCGCT
GCGGGTTCCGGCTGGTGTGA

Product: putative molybdopterin biosynthesis protein

Products: NA

Alternate protein names: MPT Mo-transferase 1 [H]

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MRSVEEQQARILAAAVVPRPVRVAIAEAQGLMCAEEVMTERPLPGFDQAAIDGYAVRSVDVSGIGESDGGESGSSDEDGR
YVLTLPVMGTIEAGARTPSRLLPHQAVRVQTGAPLPVLADAVLPVRWTDGGMSRVRILRGAPSGAYVRRVGDDVQPGDVA
VRAGTIIGAAQVGLLAAVGRERVLVHPRPRLSIMAVGGELVDISRTPGNGQVYDVNSYALTAAGRDAGAEVNRIGIVSNN
LKEFGEVVEGQISRAEVVVIAGGVGGAAAEAVRAVLSEIGEMEVVRVAMHPGSVQGFGQLGREGVPTFLLPANPVSALVV
FEVMVRPLIRLSLGKRQPMRRIVQARTLSPITSVAGRKGYLRGQLMRDQDTGEYLVQALGGALGASSHLLATLAEANCLV
VIPSGAEQIRTGEVVDVAFLAQRG

Sequences:

>Translated_424_residues
MRSVEEQQARILAAAVVPRPVRVAIAEAQGLMCAEEVMTERPLPGFDQAAIDGYAVRSVDVSGIGESDGGESGSSDEDGR
YVLTLPVMGTIEAGARTPSRLLPHQAVRVQTGAPLPVLADAVLPVRWTDGGMSRVRILRGAPSGAYVRRVGDDVQPGDVA
VRAGTIIGAAQVGLLAAVGRERVLVHPRPRLSIMAVGGELVDISRTPGNGQVYDVNSYALTAAGRDAGAEVNRIGIVSNN
LKEFGEVVEGQISRAEVVVIAGGVGGAAAEAVRAVLSEIGEMEVVRVAMHPGSVQGFGQLGREGVPTFLLPANPVSALVV
FEVMVRPLIRLSLGKRQPMRRIVQARTLSPITSVAGRKGYLRGQLMRDQDTGEYLVQALGGALGASSHLLATLAEANCLV
VIPSGAEQIRTGEVVDVAFLAQRG
>Mature_424_residues
MRSVEEQQARILAAAVVPRPVRVAIAEAQGLMCAEEVMTERPLPGFDQAAIDGYAVRSVDVSGIGESDGGESGSSDEDGR
YVLTLPVMGTIEAGARTPSRLLPHQAVRVQTGAPLPVLADAVLPVRWTDGGMSRVRILRGAPSGAYVRRVGDDVQPGDVA
VRAGTIIGAAQVGLLAAVGRERVLVHPRPRLSIMAVGGELVDISRTPGNGQVYDVNSYALTAAGRDAGAEVNRIGIVSNN
LKEFGEVVEGQISRAEVVVIAGGVGGAAAEAVRAVLSEIGEMEVVRVAMHPGSVQGFGQLGREGVPTFLLPANPVSALVV
FEVMVRPLIRLSLGKRQPMRRIVQARTLSPITSVAGRKGYLRGQLMRDQDTGEYLVQALGGALGASSHLLATLAEANCLV
VIPSGAEQIRTGEVVDVAFLAQRG

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=409, Percent_Identity=31.5403422982885, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI10880983, Length=409, Percent_Identity=31.2958435207824, Blast_Score=155, Evalue=5e-38,
Organism=Escherichia coli, GI1787049, Length=379, Percent_Identity=30.6068601583113, Blast_Score=153, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI25147659, Length=402, Percent_Identity=26.865671641791, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17562606, Length=366, Percent_Identity=21.8579234972678, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI17136978, Length=373, Percent_Identity=26.5415549597855, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24638841, Length=373, Percent_Identity=26.5415549597855, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 44283; Mature: 44283

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSVEEQQARILAAAVVPRPVRVAIAEAQGLMCAEEVMTERPLPGFDQAAIDGYAVRSVD
CCCHHHHHHHHHHHHHCCCCEEEEEEHHCCCHHHHHHHHCCCCCCCCHHHCCCEEEEEEE
VSGIGESDGGESGSSDEDGRYVLTLPVMGTIEAGARTPSRLLPHQAVRVQTGAPLPVLAD
ECCCCCCCCCCCCCCCCCCEEEEEEECEEEECCCCCCHHHHCCCCEEEEECCCCCCCHHH
AVLPVRWTDGGMSRVRILRGAPSGAYVRRVGDDVQPGDVAVRAGTIIGAAQVGLLAAVGR
CEEEEEECCCCCCEEEEEECCCCCHHHHHCCCCCCCCCEEEEECEEECHHHHHHHHHCCC
ERVLVHPRPRLSIMAVGGELVDISRTPGNGQVYDVNSYALTAAGRDAGAEVNRIGIVSNN
CEEEECCCCCEEEEEECCEEEEEEECCCCCEEEEECCEEEEECCCCCCCCEEEEEEECCC
LKEFGEVVEGQISRAEVVVIAGGVGGAAAEAVRAVLSEIGEMEVVRVAMHPGSVQGFGQL
HHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHC
GREGVPTFLLPANPVSALVVFEVMVRPLIRLSLGKRQPMRRIVQARTLSPITSVAGRKGY
CCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHCCCCC
LRGQLMRDQDTGEYLVQALGGALGASSHLLATLAEANCLVVIPSGAEQIRTGEVVDVAFL
EECEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEEECCCHHHHCCCCEEEEEEE
AQRG
ECCC
>Mature Secondary Structure
MRSVEEQQARILAAAVVPRPVRVAIAEAQGLMCAEEVMTERPLPGFDQAAIDGYAVRSVD
CCCHHHHHHHHHHHHHCCCCEEEEEEHHCCCHHHHHHHHCCCCCCCCHHHCCCEEEEEEE
VSGIGESDGGESGSSDEDGRYVLTLPVMGTIEAGARTPSRLLPHQAVRVQTGAPLPVLAD
ECCCCCCCCCCCCCCCCCCEEEEEEECEEEECCCCCCHHHHCCCCEEEEECCCCCCCHHH
AVLPVRWTDGGMSRVRILRGAPSGAYVRRVGDDVQPGDVAVRAGTIIGAAQVGLLAAVGR
CEEEEEECCCCCCEEEEEECCCCCHHHHHCCCCCCCCCEEEEECEEECHHHHHHHHHCCC
ERVLVHPRPRLSIMAVGGELVDISRTPGNGQVYDVNSYALTAAGRDAGAEVNRIGIVSNN
CEEEECCCCCEEEEEECCEEEEEEECCCCCEEEEECCEEEEECCCCCCCCEEEEEEECCC
LKEFGEVVEGQISRAEVVVIAGGVGGAAAEAVRAVLSEIGEMEVVRVAMHPGSVQGFGQL
HHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHC
GREGVPTFLLPANPVSALVVFEVMVRPLIRLSLGKRQPMRRIVQARTLSPITSVAGRKGY
CCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHCCCCC
LRGQLMRDQDTGEYLVQALGGALGASSHLLATLAEANCLVVIPSGAEQIRTGEVVDVAFL
EECEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEEECCCHHHHCCCCEEEEEEE
AQRG
ECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]