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The map label for this gene is 221229438

Identifier: 221229438

GI number: 221229438

Start: 173197

End: 174453

Strand: Reverse

Name: 221229438

Synonym: MLBr_00129

Alternate gene names: NA

Gene position: 174453-173197 (Counterclockwise)

Preceding gene: 221229439

Following gene: 221229433

Centisome position: 5.34

GC content: 59.67

Gene sequence:

>1257_bases
ATGAGCCCAGATAAGCGTGAGTTCGACATTGTTTTGTACGGCGCTACAGGCTTCTCTGGCAAGTTGACCGCCGAACATCT
CGCACTTAGCGAGTCCACAGCACGGATCGCGCTGGCCGGCCGGTCAAGCGAACGGTTACGGAACGTGCGGGCGCTGTTAG
GCCCAAACGCACAGGACTGGCCGCTGATTGTCGCCGACGCGTCACAACCGTCGACGCTCGAGGCGATGGCGGGTCGAGCC
CAGGTGGTGCTAACGACTGTTGGGCCGTATACGCGCTACGGACTGCCGCTGGTGGCGGCCTGCGCGAGAACTGGAACGGA
CTATGCCGACTTGACCGGCGAACTGATGTTTTGCCGAAACAGTATTGATTTGCACCACAAACAAGCAGCCGCCACTGGCG
CCCGGATAATCTTGGCGTGCGGATTCGATTCGGTCCCTTCAGATCTAAACGTTTACCAGCTGTACCGCCGGGTGATCGAA
GACCGCACCGGTGAACTCTGCGACACCGACCTTGTGCTTCGCTCGTTCTCTCAGCGCTGGGTTTCCGGTGGCTCAGTTGC
GGCATATTCGGAGGCAATGCTGACTACATCCAACGATCCCGAGGCCCTTCGGCTCGTCACCGACCCATATACTCTGACCA
CAGACCGAGACGCCGAACCTGACCTGGGTCCGCAGCCAGACTTTCCCCGGCATCGAGGAAGTGATCTGGCCCCCGAACTT
GCCGGATTCTGGACCGGGGGATTTGTTCAAGCCCAATTCAATACTCGAATTGTTCGGCGTAGCAATGCATTACAGAATTG
GTCCTATGGCCGGCAATTCCGATACTCAGAGACGATGAGTCTGGGCAAGTCGTGGGCGGCACCAGTTGCTTCTGCAGCTG
TCACCAGTGTTGTGGCTGGTGCTGTCGGCTTGGGAAACAAGTATTTCAACCGATTACCCCGGCGGGTAGTGGAACGCGTC
ACACCCAAATCAGGCACTGGTCCAAGCCGAAAAACTCAAGCGCGGGGCCATTACACGTTCGAGACATACACCACGACAAC
CACCGGTGCACGCTATATGGCGACTTTCGCGCACAACGTTGACGCGTACAAGTCGACAGCGGGGCTGCTTGCCGCAAGTG
GTCTGACACTGGCGCTCGATCGCGATCGGCTCTCCGAGCTGCGGGGTGTGCTTACTCCCGCCGCGGCGATGGGCGAGGCG
CTGCTGACGCGGCTCCCCAGCGCAGGCGTGGTCATAGGGACAACCCGGCTGAGCTGA

Upstream 100 bases:

>100_bases
GTCCCGTTACCTGGAGGGCGGGGAGCTGTCATATCGGATGTACTCCTTCGCCAAGGACTGAGGCTGCGTCGATTGCAAGC
ACTCGGGTAGTGTCACCCGG

Downstream 100 bases:

>100_bases
CACTCAATCCGGTCACCGCCAAGGCGCACCGGCTGTGGCAAAAGACGAACCTAGAAGCTAGTCGTGGTCAAGCAAAGTGG
ACCCGGAATCACGACTTTCG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MSPDKREFDIVLYGATGFSGKLTAEHLALSESTARIALAGRSSERLRNVRALLGPNAQDWPLIVADASQPSTLEAMAGRA
QVVLTTVGPYTRYGLPLVAACARTGTDYADLTGELMFCRNSIDLHHKQAAATGARIILACGFDSVPSDLNVYQLYRRVIE
DRTGELCDTDLVLRSFSQRWVSGGSVAAYSEAMLTTSNDPEALRLVTDPYTLTTDRDAEPDLGPQPDFPRHRGSDLAPEL
AGFWTGGFVQAQFNTRIVRRSNALQNWSYGRQFRYSETMSLGKSWAAPVASAAVTSVVAGAVGLGNKYFNRLPRRVVERV
TPKSGTGPSRKTQARGHYTFETYTTTTTGARYMATFAHNVDAYKSTAGLLAASGLTLALDRDRLSELRGVLTPAAAMGEA
LLTRLPSAGVVIGTTRLS

Sequences:

>Translated_418_residues
MSPDKREFDIVLYGATGFSGKLTAEHLALSESTARIALAGRSSERLRNVRALLGPNAQDWPLIVADASQPSTLEAMAGRA
QVVLTTVGPYTRYGLPLVAACARTGTDYADLTGELMFCRNSIDLHHKQAAATGARIILACGFDSVPSDLNVYQLYRRVIE
DRTGELCDTDLVLRSFSQRWVSGGSVAAYSEAMLTTSNDPEALRLVTDPYTLTTDRDAEPDLGPQPDFPRHRGSDLAPEL
AGFWTGGFVQAQFNTRIVRRSNALQNWSYGRQFRYSETMSLGKSWAAPVASAAVTSVVAGAVGLGNKYFNRLPRRVVERV
TPKSGTGPSRKTQARGHYTFETYTTTTTGARYMATFAHNVDAYKSTAGLLAASGLTLALDRDRLSELRGVLTPAAAMGEA
LLTRLPSAGVVIGTTRLS
>Mature_417_residues
SPDKREFDIVLYGATGFSGKLTAEHLALSESTARIALAGRSSERLRNVRALLGPNAQDWPLIVADASQPSTLEAMAGRAQ
VVLTTVGPYTRYGLPLVAACARTGTDYADLTGELMFCRNSIDLHHKQAAATGARIILACGFDSVPSDLNVYQLYRRVIED
RTGELCDTDLVLRSFSQRWVSGGSVAAYSEAMLTTSNDPEALRLVTDPYTLTTDRDAEPDLGPQPDFPRHRGSDLAPELA
GFWTGGFVQAQFNTRIVRRSNALQNWSYGRQFRYSETMSLGKSWAAPVASAAVTSVVAGAVGLGNKYFNRLPRRVVERVT
PKSGTGPSRKTQARGHYTFETYTTTTTGARYMATFAHNVDAYKSTAGLLAASGLTLALDRDRLSELRGVLTPAAAMGEAL
LTRLPSAGVVIGTTRLS

Specific function: Involved in the reduction of the double bond between C-4 and C-5 during phthiocerol dimycocerosates (DIM A) and glycosylated phenolphthiocerol dimycocerosates (PGL) biosynthesis

COG id: COG3268

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the saccharopine dehydrogenase family. Enoyl reductase subfamily

Homologues:

Organism=Homo sapiens, GI55770836, Length=169, Percent_Identity=37.2781065088757, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17560066, Length=150, Percent_Identity=37.3333333333333, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI32567112, Length=150, Percent_Identity=37.3333333333333, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71991033, Length=416, Percent_Identity=25, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24646278, Length=150, Percent_Identity=32, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24644140, Length=156, Percent_Identity=33.3333333333333, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24644142, Length=156, Percent_Identity=33.3333333333333, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21356081, Length=156, Percent_Identity=33.3333333333333, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TAER_MYCLE (Q9CD87)

Other databases:

- EMBL:   AL583917
- PIR:   A86925
- RefSeq:   NP_301223.1
- ProteinModelPortal:   Q9CD87
- EnsemblBacteria:   EBMYCT00000028234
- GeneID:   908431
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML0129
- NMPDR:   fig|272631.1.peg.95
- Leproma:   ML0129
- GeneTree:   EBGT00050000017653
- HOGENOM:   HBG527018
- OMA:   EEMATRA
- ProtClustDB:   CLSK2748649
- BioCyc:   MLEP272631:ML0129-MONOMER
- GO:   GO:0005488
- InterPro:   IPR016040
- InterPro:   IPR005097
- Gene3D:   G3DSA:3.40.50.720

Pfam domain/function: PF03435 Saccharop_dh

EC number: NA

Molecular weight: Translated: 45140; Mature: 45009

Theoretical pI: Translated: 9.20; Mature: 9.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPDKREFDIVLYGATGFSGKLTAEHLALSESTARIALAGRSSERLRNVRALLGPNAQDW
CCCCCCEEEEEEEECCCCCCCCCHHHHHHCCCCEEEEEECCCHHHHHHHHHHHCCCCCCC
PLIVADASQPSTLEAMAGRAQVVLTTVGPYTRYGLPLVAACARTGTDYADLTGELMFCRN
CEEEECCCCCCHHHHHCCCEEEEEEECCCHHHHCCHHHHHHHHCCCCHHHHCCEEEEEEC
SIDLHHKQAAATGARIILACGFDSVPSDLNVYQLYRRVIEDRTGELCDTDLVLRSFSQRW
CCCHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
VSGGSVAAYSEAMLTTSNDPEALRLVTDPYTLTTDRDAEPDLGPQPDFPRHRGSDLAPEL
CCCCCEEEHHHEEEECCCCCCEEEEEECCEEEECCCCCCCCCCCCCCCCCCCCCCCCHHH
AGFWTGGFVQAQFNTRIVRRSNALQNWSYGRQFRYSETMSLGKSWAAPVASAAVTSVVAG
HHHCCCCEEEEECCCEEHHHHCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHH
AVGLGNKYFNRLPRRVVERVTPKSGTGPSRKTQARGHYTFETYTTTTTGARYMATFAHNV
HHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHCC
DAYKSTAGLLAASGLTLALDRDRLSELRGVLTPAAAMGEALLTRLPSAGVVIGTTRLS
HHHHHHHHHHHCCCCEEEECHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEEECC
>Mature Secondary Structure 
SPDKREFDIVLYGATGFSGKLTAEHLALSESTARIALAGRSSERLRNVRALLGPNAQDW
CCCCCEEEEEEEECCCCCCCCCHHHHHHCCCCEEEEEECCCHHHHHHHHHHHCCCCCCC
PLIVADASQPSTLEAMAGRAQVVLTTVGPYTRYGLPLVAACARTGTDYADLTGELMFCRN
CEEEECCCCCCHHHHHCCCEEEEEEECCCHHHHCCHHHHHHHHCCCCHHHHCCEEEEEEC
SIDLHHKQAAATGARIILACGFDSVPSDLNVYQLYRRVIEDRTGELCDTDLVLRSFSQRW
CCCHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
VSGGSVAAYSEAMLTTSNDPEALRLVTDPYTLTTDRDAEPDLGPQPDFPRHRGSDLAPEL
CCCCCEEEHHHEEEECCCCCCEEEEEECCEEEECCCCCCCCCCCCCCCCCCCCCCCCHHH
AGFWTGGFVQAQFNTRIVRRSNALQNWSYGRQFRYSETMSLGKSWAAPVASAAVTSVVAG
HHHCCCCEEEEECCCEEHHHHCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHH
AVGLGNKYFNRLPRRVVERVTPKSGTGPSRKTQARGHYTFETYTTTTTGARYMATFAHNV
HHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHCC
DAYKSTAGLLAASGLTLALDRDRLSELRGVLTPAAAMGEALLTRLPSAGVVIGTTRLS
HHHHHHHHHHHCCCCEEEECHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002