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The map label for this gene is dprE1 [H]

Identifier: 221229421

GI number: 221229421

Start: 150155

End: 151537

Strand: Reverse

Name: dprE1 [H]

Synonym: MLBr_00109

Alternate gene names: 221229421

Gene position: 151537-150155 (Counterclockwise)

Preceding gene: 221229422

Following gene: 221229420

Centisome position: 4.64

GC content: 59.07

Gene sequence:

>1383_bases
ATGTTGAACATGGGAGTTTCCACCACCGCAACCCGGCTGACCGGATGGGGGCGTACTGCACCGTCGGTGGCAAACGTGCT
CAGCACCCCTGATGCCGAGCTGATATCCAAGGTAGTGGCCCGGGTCGCCGATGCCGACGGCCGGGGGGTGATAGCCCGCG
GGCTAGGCCGGTCCTACGGCGACAATGCGCAAAACGGTGGTGGGTTAGTGATCGACATGACCCCGCTGAACACCATCCAC
TGCATAAACACCGACACCAAGTTGGCCGACGTCGACGCCGGCGTCAACCTGAACAAGCTGATGAAAGCGGCCCTGCCATT
CGGCCTGTGGATACCGGTGTTGCCGGGAACCCGACAGGTAACCATCGGCGGTGCGATCGCGTGCGACATCCACGGCAAAA
ACCATCACAGCGCGGGCAGCTTCGGCAACTATGTGCGCAGCATGGACTTGCTGACCGCCAGTGGCGAAGTGCGGCGACTC
ACGCCAACAGGCAAGGATTCCGAACTGTTCTGGGCCACCGTCGGTGGGAACGGCCTAACCGGCATCATCATGCGCGCTAC
CATCGAAATGATGCCGACCGAGACAGCCTATTTCATCGCTGACGGCGACATCACCGGTAGCCTCGACGAAACCATCGCAT
TGCATAGCGACGGCAGCGAGGCTGACTACACCTACTCCAGCGCTTGGTTCGACGCCATCAGCGCTTCCCCGAAACTGGGC
CGTGCGGCGGTATCACGCGGCTGCTTAGCCAGGCTGGACCAGTTGCCCGCAAAGCTGCGGCGCAATCCACTGAAATTTCA
TGCACCACAATTACTTACCTTGCCCGATGTTTTTCCGAACGGGTTGGCCAACAAATATACCTTCATGCCGATCGGTGAAC
TCTGGTACCGCAAGTCTGGCACCTACCGAGGCAAGATCCAGAACCTGACACAATTTTACCACCCGTTGGACATGTTCGGC
GAATGGAACCGCGCCTACGGCGCAGCAGGATTCCTACAATACCAGTTCGTGATACCCACCGAAGCGGTCGACAAGGTCAA
GAGGATCATCGGTGACATGCAAGGCAGCGGTCACTATTCATTTCTGAACGTGTTTAAGCTGTTCGGCCCCGGAAACCAGG
CACCGCTGAGTTTCCCGATCCCAGGCTGGAATATCTGCGTGGACTTCCCGATCAAATCCGGACTCAACGAATTTGTCAAC
AAGCTGGACCGCCGGGTCATGGAACTCGGAGGGCGACTCTACACCGCCAAGGACTCCCGTACCACCGCTGACACCTTTCA
CGCCATGTACCCGCGCATCGACGAGTGGATCGCTGTGCGCCGCAAGGTCGACCCCTTGCGGGTTTTCTCCTCCGACATGG
CCCGACGTTTGGAGTTGCTCTAA

Upstream 100 bases:

>100_bases
GTACAACGGGTCGTAATCTTCCGGATCCGCTAAACTAGCCCGGACTACCGGGAAGAAAAATCCCGCATCGTCGCAGAACC
AAGCGGTACTCTCTTTGACG

Downstream 100 bases:

>100_bases
ATATGGTGCTCGACGCCGTAGGACATCCGCAGACAGTGCTGCTGCTCGGGGGGACCTCCGAAATAGGACTGGCCATCTGC
AAGCGCTACCTGCGCAACGC

Product: putative FAD-linked oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MLNMGVSTTATRLTGWGRTAPSVANVLSTPDAELISKVVARVADADGRGVIARGLGRSYGDNAQNGGGLVIDMTPLNTIH
CINTDTKLADVDAGVNLNKLMKAALPFGLWIPVLPGTRQVTIGGAIACDIHGKNHHSAGSFGNYVRSMDLLTASGEVRRL
TPTGKDSELFWATVGGNGLTGIIMRATIEMMPTETAYFIADGDITGSLDETIALHSDGSEADYTYSSAWFDAISASPKLG
RAAVSRGCLARLDQLPAKLRRNPLKFHAPQLLTLPDVFPNGLANKYTFMPIGELWYRKSGTYRGKIQNLTQFYHPLDMFG
EWNRAYGAAGFLQYQFVIPTEAVDKVKRIIGDMQGSGHYSFLNVFKLFGPGNQAPLSFPIPGWNICVDFPIKSGLNEFVN
KLDRRVMELGGRLYTAKDSRTTADTFHAMYPRIDEWIAVRRKVDPLRVFSSDMARRLELL

Sequences:

>Translated_460_residues
MLNMGVSTTATRLTGWGRTAPSVANVLSTPDAELISKVVARVADADGRGVIARGLGRSYGDNAQNGGGLVIDMTPLNTIH
CINTDTKLADVDAGVNLNKLMKAALPFGLWIPVLPGTRQVTIGGAIACDIHGKNHHSAGSFGNYVRSMDLLTASGEVRRL
TPTGKDSELFWATVGGNGLTGIIMRATIEMMPTETAYFIADGDITGSLDETIALHSDGSEADYTYSSAWFDAISASPKLG
RAAVSRGCLARLDQLPAKLRRNPLKFHAPQLLTLPDVFPNGLANKYTFMPIGELWYRKSGTYRGKIQNLTQFYHPLDMFG
EWNRAYGAAGFLQYQFVIPTEAVDKVKRIIGDMQGSGHYSFLNVFKLFGPGNQAPLSFPIPGWNICVDFPIKSGLNEFVN
KLDRRVMELGGRLYTAKDSRTTADTFHAMYPRIDEWIAVRRKVDPLRVFSSDMARRLELL
>Mature_460_residues
MLNMGVSTTATRLTGWGRTAPSVANVLSTPDAELISKVVARVADADGRGVIARGLGRSYGDNAQNGGGLVIDMTPLNTIH
CINTDTKLADVDAGVNLNKLMKAALPFGLWIPVLPGTRQVTIGGAIACDIHGKNHHSAGSFGNYVRSMDLLTASGEVRRL
TPTGKDSELFWATVGGNGLTGIIMRATIEMMPTETAYFIADGDITGSLDETIALHSDGSEADYTYSSAWFDAISASPKLG
RAAVSRGCLARLDQLPAKLRRNPLKFHAPQLLTLPDVFPNGLANKYTFMPIGELWYRKSGTYRGKIQNLTQFYHPLDMFG
EWNRAYGAAGFLQYQFVIPTEAVDKVKRIIGDMQGSGHYSFLNVFKLFGPGNQAPLSFPIPGWNICVDFPIKSGLNEFVN
KLDRRVMELGGRLYTAKDSRTTADTFHAMYPRIDEWIAVRRKVDPLRVFSSDMARRLELL

Specific function: Involved in the epimerization of decaprenylphosphoryl ribose (DPR) to decaprenylphosphoryl arabinose (DPA) a precursor for arabinan synthesis in mycobacterial cell wall biosynthesis. Probably catalyzes the oxidation at C-2 of decaprenylphosphoryl ribose (

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007173
- InterPro:   IPR016166
- InterPro:   IPR016168
- InterPro:   IPR006094 [H]

Pfam domain/function: PF04030 ALO; PF01565 FAD_binding_4 [H]

EC number: NA

Molecular weight: Translated: 50314; Mature: 50314

Theoretical pI: Translated: 9.17; Mature: 9.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNMGVSTTATRLTGWGRTAPSVANVLSTPDAELISKVVARVADADGRGVIARGLGRSYG
CCCCCCCCHHHHHCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEHHCCCCCC
DNAQNGGGLVIDMTPLNTIHCINTDTKLADVDAGVNLNKLMKAALPFGLWIPVLPGTRQV
CCCCCCCEEEEEECCCCEEEEECCCCEEEECCCCCCHHHHHHHHCCCCEEEECCCCCEEE
TIGGAIACDIHGKNHHSAGSFGNYVRSMDLLTASGEVRRLTPTGKDSELFWATVGGNGLT
EECCEEEEEECCCCCCCCCHHHHHHHHHHHEECCCCEEEECCCCCCCEEEEEEECCCCCC
GIIMRATIEMMPTETAYFIADGDITGSLDETIALHSDGSEADYTYSSAWFDAISASPKLG
HHHEEEHHHHCCCCEEEEEECCCCCCCCCCEEEEECCCCCCCEEEHHHHHHHHCCCCCCC
RAAVSRGCLARLDQLPAKLRRNPLKFHAPQLLTLPDVFPNGLANKYTFMPIGELWYRKSG
HHHHHHHHHHHHHHHHHHHCCCCCEECCCCEEECCCCCCCCCCCCEEEEEHHHHHHHCCC
TYRGKIQNLTQFYHPLDMFGEWNRAYGAAGFLQYQFVIPTEAVDKVKRIIGDMQGSGHYS
CCCHHHHHHHHHHCCHHHHCCHHHHCCCCCEEEEEEEECHHHHHHHHHHHHCCCCCCCHH
FLNVFKLFGPGNQAPLSFPIPGWNICVDFPIKSGLNEFVNKLDRRVMELGGRLYTAKDSR
HHHHHHHCCCCCCCCEEECCCCCEEEEECCHHCCHHHHHHHHHHHHHHHCCEEEEECCCC
TTADTFHAMYPRIDEWIAVRRKVDPLRVFSSDMARRLELL
CHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLNMGVSTTATRLTGWGRTAPSVANVLSTPDAELISKVVARVADADGRGVIARGLGRSYG
CCCCCCCCHHHHHCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEHHCCCCCC
DNAQNGGGLVIDMTPLNTIHCINTDTKLADVDAGVNLNKLMKAALPFGLWIPVLPGTRQV
CCCCCCCEEEEEECCCCEEEEECCCCEEEECCCCCCHHHHHHHHCCCCEEEECCCCCEEE
TIGGAIACDIHGKNHHSAGSFGNYVRSMDLLTASGEVRRLTPTGKDSELFWATVGGNGLT
EECCEEEEEECCCCCCCCCHHHHHHHHHHHEECCCCEEEECCCCCCCEEEEEEECCCCCC
GIIMRATIEMMPTETAYFIADGDITGSLDETIALHSDGSEADYTYSSAWFDAISASPKLG
HHHEEEHHHHCCCCEEEEEECCCCCCCCCCEEEEECCCCCCCEEEHHHHHHHHCCCCCCC
RAAVSRGCLARLDQLPAKLRRNPLKFHAPQLLTLPDVFPNGLANKYTFMPIGELWYRKSG
HHHHHHHHHHHHHHHHHHHCCCCCEECCCCEEECCCCCCCCCCCCEEEEEHHHHHHHCCC
TYRGKIQNLTQFYHPLDMFGEWNRAYGAAGFLQYQFVIPTEAVDKVKRIIGDMQGSGHYS
CCCHHHHHHHHHHCCHHHHCCHHHHCCCCCEEEEEEEECHHHHHHHHHHHHCCCCCCCHH
FLNVFKLFGPGNQAPLSFPIPGWNICVDFPIKSGLNEFVNKLDRRVMELGGRLYTAKDSR
HHHHHHHCCCCCCCCEEECCCCCEEEEECCHHCCHHHHHHHHHHHHHHHCCEEEEECCCC
TTADTFHAMYPRIDEWIAVRRKVDPLRVFSSDMARRLELL
CHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]