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The map label for this gene is serS

Identifier: 221229401

GI number: 221229401

Start: 102149

End: 103402

Strand: Direct

Name: serS

Synonym: MLBr_00082

Alternate gene names: 221229401

Gene position: 102149-103402 (Clockwise)

Preceding gene: 221229399

Following gene: 221229402

Centisome position: 3.13

GC content: 61.96

Gene sequence:

>1254_bases
GTGATTGACCTGCAATTGCTCCGGGAAGACCCCGACGTGGTCCGCCGTTCCCAACTTAGCCGTGGCGAAGACCCGGCCTT
GGTGGATGCCCTACTGACAGCCGACACTGCTCGTCGGGCCGCAATTTCGGCTGCAGACTCGCTGCGTGCTGAACAGAAGG
CCACCAGCAAAAGCTTGGGCGCGGCATCTGCCGAGGACCGTCCGGCGTTATTGGAGCGCGCAAAGGACCTCGCCGAGCAG
GTGAAAGCCGCTGAAACCACCCAGGCTGAGACTGCGGCGGCATTCGCTGCAGCGTACATGGCAATTTCCAACGTCGTTCT
GGATGGAGTGCCGACCGGCGGAAAGGACGACTACGCGGTACTGGATATTGTTGGCGATCCACCGCCTTTGAGCAATCCAA
AGGACCACCTGGAACTCGGCGAAGCACTGGGCTTGATCGACATGCAGCGTGGTGCCAAAGTGTCCGGCTCGCGGTTCTAC
TTCCTCACCGGTCGGGGTGCGCTGTTACAACTAGGCCTGTTGCAGCTTGCGTTGCGGCTTGCTGTCGAGAACGACTTTAT
CCCAATGATCCCGCCCGTGCTGGTGCGCCCGGAGGTGATGTCTGGTACCGGATTTTTGGGCGCTCATGCCGAGGAGGTGT
ATAGGGTAGACGATCTGTATCTGGTGGGCACCTCTGAAGTGCCAATGGCCGGCTATCACTCCGACGAAATCCTCGATCTA
TCCGTTGGCCCGCTACGGTACGCGGGTTGGTCGTCGTGTTTCAGGCGCGAGGCCGGCAGCCACGGCAAGGACACTCGTGG
CATCATCCGGGTGCACCAGTTCGACAAGGTGGAGGGGTTTGTCTACTGTGCACCCACCGACGCCGAGGTTGAACACCAAC
GGCTGCTGGGTTGGCAGCGCGAGATGTTGGCGCGCATAGAGGTGCCATATCGGGTAATCGACGTGGCTGCGGGCGATCTC
GGTTCGTCGGCGGCCCGCAAGTTCGATTGCGAGGCGTGGGTACCGACCCAGGGCAGCTACTGCGAGCTGACCTCGACGTC
AAACTGCACCACCTTCCAGGCGCGCCGGCTAGCTACCCGCTACCGAGATGCCAGTGGCAAGCCACAGATCGTTGCCACAC
TAAACGGCACGCTGGGTACCACCCGGTGGCTGGTCGCGATCTTGGAAAACCACCAGCGGCCCGACGGCAGCGTGCGGGTG
CCGCCGGCTTTGGTACCTTTCGTCGGCACAGAGTTGCTAGAGTCGCCCCGCTGA

Upstream 100 bases:

>100_bases
AACAAAGTTCTTGTGACAAACGTTGCAGATGTGCCACCGTCGACCTGTTCGTGCGGGTGCTTCGGCACGTGTGCGTAGCG
TCAAAAGTAGTCTTCAAGCC

Downstream 100 bases:

>100_bases
AGGTGTGATGAACGAAGGGCTGCCTGTCTTCAAGAAACATGCGAGCGTTACGTGCGGTGAAATCCCACGGGGTGTTGTTG
ATGTCTCAGTGATTACTCAG

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MIDLQLLREDPDVVRRSQLSRGEDPALVDALLTADTARRAAISAADSLRAEQKATSKSLGAASAEDRPALLERAKDLAEQ
VKAAETTQAETAAAFAAAYMAISNVVLDGVPTGGKDDYAVLDIVGDPPPLSNPKDHLELGEALGLIDMQRGAKVSGSRFY
FLTGRGALLQLGLLQLALRLAVENDFIPMIPPVLVRPEVMSGTGFLGAHAEEVYRVDDLYLVGTSEVPMAGYHSDEILDL
SVGPLRYAGWSSCFRREAGSHGKDTRGIIRVHQFDKVEGFVYCAPTDAEVEHQRLLGWQREMLARIEVPYRVIDVAAGDL
GSSAARKFDCEAWVPTQGSYCELTSTSNCTTFQARRLATRYRDASGKPQIVATLNGTLGTTRWLVAILENHQRPDGSVRV
PPALVPFVGTELLESPR

Sequences:

>Translated_417_residues
MIDLQLLREDPDVVRRSQLSRGEDPALVDALLTADTARRAAISAADSLRAEQKATSKSLGAASAEDRPALLERAKDLAEQ
VKAAETTQAETAAAFAAAYMAISNVVLDGVPTGGKDDYAVLDIVGDPPPLSNPKDHLELGEALGLIDMQRGAKVSGSRFY
FLTGRGALLQLGLLQLALRLAVENDFIPMIPPVLVRPEVMSGTGFLGAHAEEVYRVDDLYLVGTSEVPMAGYHSDEILDL
SVGPLRYAGWSSCFRREAGSHGKDTRGIIRVHQFDKVEGFVYCAPTDAEVEHQRLLGWQREMLARIEVPYRVIDVAAGDL
GSSAARKFDCEAWVPTQGSYCELTSTSNCTTFQARRLATRYRDASGKPQIVATLNGTLGTTRWLVAILENHQRPDGSVRV
PPALVPFVGTELLESPR
>Mature_417_residues
MIDLQLLREDPDVVRRSQLSRGEDPALVDALLTADTARRAAISAADSLRAEQKATSKSLGAASAEDRPALLERAKDLAEQ
VKAAETTQAETAAAFAAAYMAISNVVLDGVPTGGKDDYAVLDIVGDPPPLSNPKDHLELGEALGLIDMQRGAKVSGSRFY
FLTGRGALLQLGLLQLALRLAVENDFIPMIPPVLVRPEVMSGTGFLGAHAEEVYRVDDLYLVGTSEVPMAGYHSDEILDL
SVGPLRYAGWSSCFRREAGSHGKDTRGIIRVHQFDKVEGFVYCAPTDAEVEHQRLLGWQREMLARIEVPYRVIDVAAGDL
GSSAARKFDCEAWVPTQGSYCELTSTSNCTTFQARRLATRYRDASGKPQIVATLNGTLGTTRWLVAILENHQRPDGSVRV
PPALVPFVGTELLESPR

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=463, Percent_Identity=33.6933045356371, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI8923421, Length=390, Percent_Identity=35.8974358974359, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI225579074, Length=339, Percent_Identity=38.6430678466077, Blast_Score=227, Evalue=2e-59,
Organism=Escherichia coli, GI1787120, Length=425, Percent_Identity=34.8235294117647, Blast_Score=222, Evalue=5e-59,
Organism=Caenorhabditis elegans, GI17539260, Length=459, Percent_Identity=33.9869281045752, Blast_Score=254, Evalue=7e-68,
Organism=Caenorhabditis elegans, GI17542084, Length=301, Percent_Identity=32.2259136212625, Blast_Score=139, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6320226, Length=451, Percent_Identity=32.3725055432373, Blast_Score=237, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6321799, Length=385, Percent_Identity=31.6883116883117, Blast_Score=203, Evalue=4e-53,
Organism=Drosophila melanogaster, GI24581334, Length=465, Percent_Identity=35.2688172043011, Blast_Score=250, Evalue=1e-66,
Organism=Drosophila melanogaster, GI17737985, Length=289, Percent_Identity=35.2941176470588, Blast_Score=166, Evalue=2e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_MYCLB (B8ZTU5)

Other databases:

- EMBL:   FM211192
- RefSeq:   YP_002502817.1
- ProteinModelPortal:   B8ZTU5
- SMR:   B8ZTU5
- EnsemblBacteria:   EBMYCT00000085033
- GeneID:   7325820
- GenomeReviews:   FM211192_GR
- GeneTree:   EBGT00050000016582
- HOGENOM:   HBG629391
- OMA:   PDGETDE
- ProtClustDB:   PRK05431
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 45184; Mature: 45184

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 271-271 BINDING 278-278 BINDING 377-377

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDLQLLREDPDVVRRSQLSRGEDPALVDALLTADTARRAAISAADSLRAEQKATSKSLG
CCCCEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AASAEDRPALLERAKDLAEQVKAAETTQAETAAAFAAAYMAISNVVLDGVPTGGKDDYAV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
LDIVGDPPPLSNPKDHLELGEALGLIDMQRGAKVSGSRFYFLTGRGALLQLGLLQLALRL
EEEECCCCCCCCCHHHHHHHHHHCCEECCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHH
AVENDFIPMIPPVLVRPEVMSGTGFLGAHAEEVYRVDDLYLVGTSEVPMAGYHSDEILDL
HHCCCCCCCCCCHHCCCCCCCCCCCCCCCHHHHEEECCEEEEECCCCCCCCCCCCCEEEE
SVGPLRYAGWSSCFRREAGSHGKDTRGIIRVHQFDKVEGFVYCAPTDAEVEHQRLLGWQR
CCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHH
EMLARIEVPYRVIDVAAGDLGSSAARKFDCEAWVPTQGSYCELTSTSNCTTFQARRLATR
HHHHHHCCCEEEEEEECCCCCCHHHHCCCCCEECCCCCCEEEECCCCCCCHHHHHHHHHH
YRDASGKPQIVATLNGTLGTTRWLVAILENHQRPDGSVRVPPALVPFVGTELLESPR
HCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIDLQLLREDPDVVRRSQLSRGEDPALVDALLTADTARRAAISAADSLRAEQKATSKSLG
CCCCEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AASAEDRPALLERAKDLAEQVKAAETTQAETAAAFAAAYMAISNVVLDGVPTGGKDDYAV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
LDIVGDPPPLSNPKDHLELGEALGLIDMQRGAKVSGSRFYFLTGRGALLQLGLLQLALRL
EEEECCCCCCCCCHHHHHHHHHHCCEECCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHH
AVENDFIPMIPPVLVRPEVMSGTGFLGAHAEEVYRVDDLYLVGTSEVPMAGYHSDEILDL
HHCCCCCCCCCCHHCCCCCCCCCCCCCCCHHHHEEECCEEEEECCCCCCCCCCCCCEEEE
SVGPLRYAGWSSCFRREAGSHGKDTRGIIRVHQFDKVEGFVYCAPTDAEVEHQRLLGWQR
CCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHH
EMLARIEVPYRVIDVAAGDLGSSAARKFDCEAWVPTQGSYCELTSTSNCTTFQARRLATR
HHHHHHCCCEEEEEEECCCCCCHHHHCCCCCEECCCCCCEEEECCCCCCCHHHHHHHHHH
YRDASGKPQIVATLNGTLGTTRWLVAILENHQRPDGSVRVPPALVPFVGTELLESPR
HCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA