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The map label for this gene is espR [H]

Identifier: 221229392

GI number: 221229392

Start: 90548

End: 90946

Strand: Reverse

Name: espR [H]

Synonym: MLBr_00069

Alternate gene names: 221229392

Gene position: 90946-90548 (Counterclockwise)

Preceding gene: 221229393

Following gene: 221229391

Centisome position: 2.78

GC content: 59.4

Gene sequence:

>399_bases
ATGAGCACGACATTCGCTGCCCGCCTAAACCGCCTGTTCGACACGGTGTATCCACCCGGGCGCGGGCCGCACACCTCTGC
CGAGGTAATCGCAGCGCTCAAGGCGGAGGGCATCACCATGTCGGCTCCTTACCTGTCACAGCTCCGCTCCGGTAATCGCA
CGAACCCTTCGTCAGCCACGATATCCGCCCTTGCCAACTTCTTCCGCATCAAACCGGCCTATTTCACCAACGACGAGTAT
TACGAAAAACTCGATCAAGAATTGGCATGGCTGGCCACCATGCGTGATGAAGGCGTGCGCCGGATCGCGATGCGGACCAT
CGGGTTGTCTGCCCAAGCTCAGCAGGACATCGTGGATCGAGTCGACGAACTACGGCGTGCGGAGCATCTTGACGTGTAG

Upstream 100 bases:

>100_bases
TGTCACTGCCCACTTGAAACACCATTACAGAATCTATTTGGGTTTGCACTTATACTTATTGACAACCGGTCGTTCTTTCA
GCTCGTTGGAGGTCATATCG

Downstream 100 bases:

>100_bases
GTCACCTTGGCAGACGGCGCAGCACTCGCCTCCGGTAGCTCACCTAACGGCCTGTTCTTACTTGCTGTCCTTCGTTCCAG
CGCGACAGGGCAGCCTGACA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 132; Mature: 131

Protein sequence:

>132_residues
MSTTFAARLNRLFDTVYPPGRGPHTSAEVIAALKAEGITMSAPYLSQLRSGNRTNPSSATISALANFFRIKPAYFTNDEY
YEKLDQELAWLATMRDEGVRRIAMRTIGLSAQAQQDIVDRVDELRRAEHLDV

Sequences:

>Translated_132_residues
MSTTFAARLNRLFDTVYPPGRGPHTSAEVIAALKAEGITMSAPYLSQLRSGNRTNPSSATISALANFFRIKPAYFTNDEY
YEKLDQELAWLATMRDEGVRRIAMRTIGLSAQAQQDIVDRVDELRRAEHLDV
>Mature_131_residues
STTFAARLNRLFDTVYPPGRGPHTSAEVIAALKAEGITMSAPYLSQLRSGNRTNPSSATISALANFFRIKPAYFTNDEYY
EKLDQELAWLATMRDEGVRRIAMRTIGLSAQAQQDIVDRVDELRRAEHLDV

Specific function: Required for secretion and virulence in mice. Activates transcription of an operon that includes espA, espC and espD genes, which are ESX-1 components. Acts by binding directly to the promoter region [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted. Note=Probably secreted via the ESX-1 / type VII secretion system (T7SS) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 14808; Mature: 14677

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTFAARLNRLFDTVYPPGRGPHTSAEVIAALKAEGITMSAPYLSQLRSGNRTNPSSAT
CCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCEECCHHHHHHHCCCCCCCHHHH
ISALANFFRIKPAYFTNDEYYEKLDQELAWLATMRDEGVRRIAMRTIGLSAQAQQDIVDR
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
VDELRRAEHLDV
HHHHHHHHCCCC
>Mature Secondary Structure 
STTFAARLNRLFDTVYPPGRGPHTSAEVIAALKAEGITMSAPYLSQLRSGNRTNPSSAT
CCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCEECCHHHHHHHCCCCCCCHHHH
ISALANFFRIKPAYFTNDEYYEKLDQELAWLATMRDEGVRRIAMRTIGLSAQAQQDIVDR
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
VDELRRAEHLDV
HHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]