Click here to switch to the map view.

The map label for this gene is ethR [H]

Identifier: 221229387

GI number: 221229387

Start: 85995

End: 86639

Strand: Reverse

Name: ethR [H]

Synonym: MLBr_00064

Alternate gene names: 221229387

Gene position: 86639-85995 (Counterclockwise)

Preceding gene: 221229389

Following gene: 221229384

Centisome position: 2.65

GC content: 55.81

Gene sequence:

>645_bases
GTGATAAATTCCACTGCCGGACAAACTTCGCAAAGCCGGAGTCGACGCAGCACACGCCCGTCCGGCGACGACCGTGAACT
GGCAATCCTGGCCACCGCTGAGCAACTTCTTGAGGACCGACCGCTTACCGAGATCTCGGTAGATTACTTGGCCAAAAGTG
CCGGGATTTCGCGGCCAACTTTCTACTTCTATTTCGCTTCCAAGGAAGCTGTGCTATTGACACTGCTGGACCGCGTGTTC
AACAAGGCGAACGCTGCCCTCGAAACCCTCATTAAGAATCGAGATAACAAACGCGGCAATAAGTGGCGCACCGGGATCAA
CGTATTCTTCGAAACCTTTGGATCCCATAAAGCAGTGACCTGTGCGGGGCAAGTCACCAGAGACAATACCGAGGTTCGGA
AATTGTGGTCGACCTTCATGCAGAAGTGGATCTCCTACACCGCCGCTGTGATCGATGCCGAACGCAAACGCGGTGTGGCA
CCAGACACCCTGCCCGCCACAGAATTGGCCACCGCGCTCAACCTGATGAACGAGCGGGCGCTGTTTGCCTCATTCACCGC
CGAACAGCCTCACGTCCCGGAGTCCCGGGTGCTCGACACCCTGGTGCACATCTGGGTGAGCAGTATATACAACGAAATTC
GCTAA

Upstream 100 bases:

>100_bases
TCCAGGTACTCGGTCTCAGCCATAACAACCATAATATCAACGCTGTGTCGAAGTCGTCAACGTTGCGTTGAAATTCTCGA
CGTGGGGTAAGCTACCTATC

Downstream 100 bases:

>100_bases
TCCCCCCTCACACCCCATGTGAACACATGTTTCGTGCGGTGTGAAGCATGCATCCTGCATGCGAACCTGGACTTAAATTC
CACACGTCCTTCGAACAGCA

Product: putative transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MINSTAGQTSQSRSRRSTRPSGDDRELAILATAEQLLEDRPLTEISVDYLAKSAGISRPTFYFYFASKEAVLLTLLDRVF
NKANAALETLIKNRDNKRGNKWRTGINVFFETFGSHKAVTCAGQVTRDNTEVRKLWSTFMQKWISYTAAVIDAERKRGVA
PDTLPATELATALNLMNERALFASFTAEQPHVPESRVLDTLVHIWVSSIYNEIR

Sequences:

>Translated_214_residues
MINSTAGQTSQSRSRRSTRPSGDDRELAILATAEQLLEDRPLTEISVDYLAKSAGISRPTFYFYFASKEAVLLTLLDRVF
NKANAALETLIKNRDNKRGNKWRTGINVFFETFGSHKAVTCAGQVTRDNTEVRKLWSTFMQKWISYTAAVIDAERKRGVA
PDTLPATELATALNLMNERALFASFTAEQPHVPESRVLDTLVHIWVSSIYNEIR
>Mature_214_residues
MINSTAGQTSQSRSRRSTRPSGDDRELAILATAEQLLEDRPLTEISVDYLAKSAGISRPTFYFYFASKEAVLLTLLDRVF
NKANAALETLIKNRDNKRGNKWRTGINVFFETFGSHKAVTCAGQVTRDNTEVRKLWSTFMQKWISYTAAVIDAERKRGVA
PDTLPATELATALNLMNERALFASFTAEQPHVPESRVLDTLVHIWVSSIYNEIR

Specific function: Involved in the repression of the monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH) [H]

COG id: COG1309

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR001647 [H]

Pfam domain/function: PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 24105; Mature: 24105

Theoretical pI: Translated: 9.69; Mature: 9.69

Prosite motif: PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINSTAGQTSQSRSRRSTRPSGDDRELAILATAEQLLEDRPLTEISVDYLAKSAGISRPT
CCCCCCCCCHHHHHHHCCCCCCCCCCEEHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCE
FYFYFASKEAVLLTLLDRVFNKANAALETLIKNRDNKRGNKWRTGINVFFETFGSHKAVT
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEE
CAGQVTRDNTEVRKLWSTFMQKWISYTAAVIDAERKRGVAPDTLPATELATALNLMNERA
EECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
LFASFTAEQPHVPESRVLDTLVHIWVSSIYNEIR
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MINSTAGQTSQSRSRRSTRPSGDDRELAILATAEQLLEDRPLTEISVDYLAKSAGISRPT
CCCCCCCCCHHHHHHHCCCCCCCCCCEEHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCE
FYFYFASKEAVLLTLLDRVFNKANAALETLIKNRDNKRGNKWRTGINVFFETFGSHKAVT
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEE
CAGQVTRDNTEVRKLWSTFMQKWISYTAAVIDAERKRGVAPDTLPATELATALNLMNERA
EECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
LFASFTAEQPHVPESRVLDTLVHIWVSSIYNEIR
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]