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The map label for this gene is pstP [H]

Identifier: 221229361

GI number: 221229361

Start: 25054

End: 26583

Strand: Reverse

Name: pstP [H]

Synonym: MLBr_00020

Alternate gene names: 221229361

Gene position: 26583-25054 (Counterclockwise)

Preceding gene: 221229362

Following gene: 221229360

Centisome position: 0.81

GC content: 60.92

Gene sequence:

>1530_bases
GTGACCCTGGTCCTCCGATATGCGGCCCGCAGCGATCGCGGCCTGGTGCGCGCCAATAATGAAGACTCGGTTTACGCCGG
TGCACGCCTACTCGCCCTCGCCGACGGCATGGGTGGTCACGCCGCTGGCGAAGTGGCGTCCCAATTGGTGATCGCCGCAC
TGGCCCATCTCGATGACGACGAACCCGGGGGCGACCTGCTTGGCAAGCTCGAGACGGCGGTGCGTGCCGGAAACTTGGCA
ATCGCCGCACAAGTCGAGATGGAACCCGATTTCGAGGGCATGGGAACCACGCTCACCGCAATCCTGTTCGCAGGCAACCG
TCTCGGCCTGGTGCACATCGGTGACTCACGCGGCTACCTACTGCGAGACGGCGAGCTGACCCAGATCACCAAAGACGACA
CCTTTGTCCAAACCCTGGTCGACGAAGGTCGGATCACCGCGGAAGAAGCACACAGCCACCCACAGCGCTCATTGATCATG
CGAGCATTGACCGGCCACGAAGTGGATCCCACTCTCACCATGAGAGAAGCCCGCGCTGGTGATCGTTATCTGCTGTGTTC
GGACGGATTATCCGATCCGGTGAGTGACGAGACCATCCTCGAGGCCCTGCAGATCCCCGACGTCGCCGAGAGTGCCTATC
GGCTTATTGAATTAGCGCTGCGCGGTGGCGGACCCGACAATGTAACGGTTGTAGTCGCTGACGTCATCGACTACGACTAC
GGCCAGACCCAACCGATTCTCGCCGGCGCGGTGTCGGGCGAAGAAAGCCAGCAGATGGCCCTGCCCAACACCGCCGCTAG
CCGCGCCTCAGCTATTGTCCCACGCAAAGAGATAGCCAAAAGTATGGCGCCACAAGTCGATAAAGTACATCAACAGCGGT
GGTCGCAACGCCAAACAGGCATCACACTCACACTGTTAGTGCTACTTGTCCTCGCCGGAGTGGCCATTGGGCGATGGGTC
ATCCGGGACAACTACTACATTGCCGAATACAGTGGCAAGGTGTCCATCGTGCGAGGCATTCAAGGCTCGCTGCTCGGAAT
GCCTTTGCACGAACCCTATTTGGTGGGCTGTCTGAACACCCGCAACGAGCTATCCCTGATTAGTTACGGACAATCCGGAG
GTCACCTCAATTGCCAGGTAATGACTCTGCGGGACTTACGTCCCTCTGGAGGGGCGCAAGTCCAGGCTGGACTGCCCGGA
GGTAACCTAGATCAGGCCGAATCGCAGCTACGAAAATTGTTGGCCGACTCCCTACTACCAACCTGTCCGCCACCCCGCGC
GACATCGCCGCCGGGGCCCTTTACCATGCCCACAGACAGCGGGACACCCCAACCAACTAATACAGCGTCGCCAACGTCCA
CCACACCACCCACGATCACCTCTTCCAGCGGCACCGCACCCACCAACATAAGTCCCACTAGCAGCCCCGCAAGTACCGCG
CCGACAACGCCGGTGGGCACCTCGCAGACGGTCACCATCCTTCCACCACCCCCACCCCAACCGGGCATCGACTGCCGGGC
GGTGGCATGA

Upstream 100 bases:

>100_bases
CCAACGGTACATATCTTGACAGGGCGAAGGTGACAACTGCGGTACGAGTTCCATTAGGAACACCGGTTCGAATCGGCAAA
ACGGCAATCGAGTTGCGCCC

Downstream 100 bases:

>100_bases
CAACGCAACTTCAGCCGGTGGTCACAGTGACACCTCCGTTGCCCACGCGACGTAACGCTGAGCTGCTGCTACTTGGCTTC
GCCGCCGTGATCACCGTCGC

Product: hypothetical protein

Products: NA

Alternate protein names: Mycobacterial Ser/Thr phosphatase; Mstp; Possible serine/threonine phosphatase Ppp [H]

Number of amino acids: Translated: 509; Mature: 508

Protein sequence:

>509_residues
MTLVLRYAARSDRGLVRANNEDSVYAGARLLALADGMGGHAAGEVASQLVIAALAHLDDDEPGGDLLGKLETAVRAGNLA
IAAQVEMEPDFEGMGTTLTAILFAGNRLGLVHIGDSRGYLLRDGELTQITKDDTFVQTLVDEGRITAEEAHSHPQRSLIM
RALTGHEVDPTLTMREARAGDRYLLCSDGLSDPVSDETILEALQIPDVAESAYRLIELALRGGGPDNVTVVVADVIDYDY
GQTQPILAGAVSGEESQQMALPNTAASRASAIVPRKEIAKSMAPQVDKVHQQRWSQRQTGITLTLLVLLVLAGVAIGRWV
IRDNYYIAEYSGKVSIVRGIQGSLLGMPLHEPYLVGCLNTRNELSLISYGQSGGHLNCQVMTLRDLRPSGGAQVQAGLPG
GNLDQAESQLRKLLADSLLPTCPPPRATSPPGPFTMPTDSGTPQPTNTASPTSTTPPTITSSSGTAPTNISPTSSPASTA
PTTPVGTSQTVTILPPPPPQPGIDCRAVA

Sequences:

>Translated_509_residues
MTLVLRYAARSDRGLVRANNEDSVYAGARLLALADGMGGHAAGEVASQLVIAALAHLDDDEPGGDLLGKLETAVRAGNLA
IAAQVEMEPDFEGMGTTLTAILFAGNRLGLVHIGDSRGYLLRDGELTQITKDDTFVQTLVDEGRITAEEAHSHPQRSLIM
RALTGHEVDPTLTMREARAGDRYLLCSDGLSDPVSDETILEALQIPDVAESAYRLIELALRGGGPDNVTVVVADVIDYDY
GQTQPILAGAVSGEESQQMALPNTAASRASAIVPRKEIAKSMAPQVDKVHQQRWSQRQTGITLTLLVLLVLAGVAIGRWV
IRDNYYIAEYSGKVSIVRGIQGSLLGMPLHEPYLVGCLNTRNELSLISYGQSGGHLNCQVMTLRDLRPSGGAQVQAGLPG
GNLDQAESQLRKLLADSLLPTCPPPRATSPPGPFTMPTDSGTPQPTNTASPTSTTPPTITSSSGTAPTNISPTSSPASTA
PTTPVGTSQTVTILPPPPPQPGIDCRAVA
>Mature_508_residues
TLVLRYAARSDRGLVRANNEDSVYAGARLLALADGMGGHAAGEVASQLVIAALAHLDDDEPGGDLLGKLETAVRAGNLAI
AAQVEMEPDFEGMGTTLTAILFAGNRLGLVHIGDSRGYLLRDGELTQITKDDTFVQTLVDEGRITAEEAHSHPQRSLIMR
ALTGHEVDPTLTMREARAGDRYLLCSDGLSDPVSDETILEALQIPDVAESAYRLIELALRGGGPDNVTVVVADVIDYDYG
QTQPILAGAVSGEESQQMALPNTAASRASAIVPRKEIAKSMAPQVDKVHQQRWSQRQTGITLTLLVLLVLAGVAIGRWVI
RDNYYIAEYSGKVSIVRGIQGSLLGMPLHEPYLVGCLNTRNELSLISYGQSGGHLNCQVMTLRDLRPSGGAQVQAGLPGG
NLDQAESQLRKLLADSLLPTCPPPRATSPPGPFTMPTDSGTPQPTNTASPTSTTPPTITSSSGTAPTNISPTSSPASTAP
TTPVGTSQTVTILPPPPPQPGIDCRAVA

Specific function: The only predicted protein phosphatase in M.tuberculosis, it dephosphorylates at least 5 protein kinases (pknA, pknB, pknD, pknE and pknF) and the penicillin-binding protein PBPA [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential). Note=May be localized to the outside of the cell [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PP2C-like domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015655
- InterPro:   IPR001932
- InterPro:   IPR014045 [H]

Pfam domain/function: PF00481 PP2C [H]

EC number: =3.1.3.16 [H]

Molecular weight: Translated: 53577; Mature: 53446

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLVLRYAARSDRGLVRANNEDSVYAGARLLALADGMGGHAAGEVASQLVIAALAHLDDD
CEEEEEECCCCCCCEEEECCCCCCHHCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCC
EPGGDLLGKLETAVRAGNLAIAAQVEMEPDFEGMGTTLTAILFAGNRLGLVHIGDSRGYL
CCCHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCHHHHHHEECCCEEEEEEECCCCCEE
LRDGELTQITKDDTFVQTLVDEGRITAEEAHSHPQRSLIMRALTGHEVDPTLTMREARAG
EECCCEEEEECCHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHCCCCCCCCEEEHHHCCC
DRYLLCSDGLSDPVSDETILEALQIPDVAESAYRLIELALRGGGPDNVTVVVADVIDYDY
CEEEEECCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHCCCC
GQTQPILAGAVSGEESQQMALPNTAASRASAIVPRKEIAKSMAPQVDKVHQQRWSQRQTG
CCCCCEEEEECCCCCCCCEECCCHHHHHHHHCCCHHHHHHHHCHHHHHHHHHHHHHHHCC
ITLTLLVLLVLAGVAIGRWVIRDNYYIAEYSGKVSIVRGIQGSLLGMPLHEPYLVGCLNT
HHHHHHHHHHHHHHHHHEEEEECCEEEEEECCCEEEEECCCCCEECCCCCCCEEEEECCC
RNELSLISYGQSGGHLNCQVMTLRDLRPSGGAQVQAGLPGGNLDQAESQLRKLLADSLLP
CCCEEEEEECCCCCEEEEEEEEEECCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCC
TCPPPRATSPPGPFTMPTDSGTPQPTNTASPTSTTPPTITSSSGTAPTNISPTSSPASTA
CCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCC
PTTPVGTSQTVTILPPPPPQPGIDCRAVA
CCCCCCCCCEEEEECCCCCCCCCCCEECC
>Mature Secondary Structure 
TLVLRYAARSDRGLVRANNEDSVYAGARLLALADGMGGHAAGEVASQLVIAALAHLDDD
EEEEEECCCCCCCEEEECCCCCCHHCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCC
EPGGDLLGKLETAVRAGNLAIAAQVEMEPDFEGMGTTLTAILFAGNRLGLVHIGDSRGYL
CCCHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCHHHHHHEECCCEEEEEEECCCCCEE
LRDGELTQITKDDTFVQTLVDEGRITAEEAHSHPQRSLIMRALTGHEVDPTLTMREARAG
EECCCEEEEECCHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHCCCCCCCCEEEHHHCCC
DRYLLCSDGLSDPVSDETILEALQIPDVAESAYRLIELALRGGGPDNVTVVVADVIDYDY
CEEEEECCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHCCCC
GQTQPILAGAVSGEESQQMALPNTAASRASAIVPRKEIAKSMAPQVDKVHQQRWSQRQTG
CCCCCEEEEECCCCCCCCEECCCHHHHHHHHCCCHHHHHHHHCHHHHHHHHHHHHHHHCC
ITLTLLVLLVLAGVAIGRWVIRDNYYIAEYSGKVSIVRGIQGSLLGMPLHEPYLVGCLNT
HHHHHHHHHHHHHHHHHEEEEECCEEEEEECCCEEEEECCCCCEECCCCCCCEEEEECCC
RNELSLISYGQSGGHLNCQVMTLRDLRPSGGAQVQAGLPGGNLDQAESQLRKLLADSLLP
CCCEEEEEECCCCCEEEEEEEEEECCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCC
TCPPPRATSPPGPFTMPTDSGTPQPTNTASPTSTTPPTITSSSGTAPTNISPTSSPASTA
CCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCC
PTTPVGTSQTVTILPPPPPQPGIDCRAVA
CCCCCCCCCEEEEECCCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]