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The map label for this gene is lon2 [H]

Identifier: 220933163

GI number: 220933163

Start: 2550942

End: 2552861

Strand: Reverse

Name: lon2 [H]

Synonym: Hore_23310

Alternate gene names: 220933163

Gene position: 2552861-2550942 (Counterclockwise)

Preceding gene: 220933164

Following gene: 220933160

Centisome position: 99.02

GC content: 42.6

Gene sequence:

>1920_bases
ATGTCCTTCTTGGATGGCCTTTTTAGTAAAGATGATAATAAAATAAAAAAGGCTGATAAAAAAGAAAAAGAACTTAAAGT
ATTGTACAAAAAAGCCAATGATTATTATGGTAAGGAACAGTTCATACTTAAAGCAGGGAAGGTTAATGCCCTGGATTTAA
TAAGTTCCAGTAAATTATTTGATAAACTGACAGCCCTGGAGAGAATAATTTATGAAGACCCTACCATCCAGGTGGGAAAG
GGAAATTTTGAGGAACGAATTTTAAAATTAGAGGATAAGATTGCTGACATGCTGGCCGAGCGCTCCGTTGAAAAGGATAT
TGAAGAACAGATTGCCGAGAGGATGGAGAAGAGGCAGCGTGAATATATTAAGGAGATTAAAAAGGAAATAGTCAATGACG
ATCCTCCAGATAATCCGGAAACATTAAGAAGACTGGCCCGGCTTGAAAAGCTGGATGCCAGGAGTTTAAATAAATCTGTC
ATTGATCTGGTTAGGCCCAAATCACTTGATGAGATAGTGGGTCAGCAGCGGGCTTTAAAGGCCCTTGTTTCCAAAATTGC
TTCTCCCTACCCCCAGCACGTAATCCTATATGGACCCCCGGGGGTGGGTAAAACTACGGCTGCCCGACTGGCCCTGGAAG
AGGCCAAGAAGAGGCAAAATACCCCTTTTTACGGGGATTCAAAATTCGTTGAAGTTGATGGGGCGACCCTGAGGTGGGAC
CCGAGGGAAGTTACCAATCCCTTGCTGGGCTCAGTTCATGACCCCATATACCAGGGTGCCAAAAAAGTTCTGGCCGAGGG
TGGAGTCCCGGAACCCAAGACAGGGCTGGTAACCGAAGCCCATGCTGGTATCCTCTTTATCGATGAAATAGGGGAACTGG
ATCCAATGCTTCAGAACAAACTGTTGAAAGTAATGGAGGATAAAAGGGTTAAGTTTGAATCTTCCTATTATGATAAAAAT
GATGAAAATATCCCCTTATATATTAAAAAGCTCTTTGAAGAAGGGGCTCCGGCTGATTTTATTTTAATCGGAGCTACCAC
CAGAAGTCCCAGTAAAATAAATCCTGCTTTCCGCTCCCGGTGTGCAGAGGTATTCTTTAATCCCCTGTCCCGGGAAGATA
TACAGCAAATTGTTATTAATGCTGTCAAAAAACTCACGGTAAAAATTGAGGATGAAATACCGGAGATAATAAGTGAATAT
ACGACTGAGGGGAGAACAGCTATAAACCTACTGATAGATGCCTACAGCCTTGTCCTCTATGAAAATGAAGGAGCTGACGA
GCAGGAGCTTATAATTACCAGGGATAAGCTCTTTGAAGCTATCCAGAACCGGCGAATGATTCCCCACAACAAGATTAAGT
CCAGTGAAAAATCAGAAATTGGAAAGGTCTTTGGACTGGGGGTCAATGGTTACCTTGGTACAGTTATTGAAATTGAAGCC
GTTGCCTTTACAGCCGAGGAAAAGGGTAATGGTAAGCTGAGATTTAATGAAACCGCCGGTAAAATGGCTAAAGATTCCCT
TTTTAATGCTGCAGCTGTAATCAGAAAAATAACCGGGAAGAAAATGAAGGATTATGACCTCCATGTCAATATTGTCGGGG
GAGGTAATGTAGATGGTCCTTCGGCCGGTATTGCGATGCTGCTGGCTTTAATAAGTGCTATTGAGGAAGTACCCTTAAAA
CAGGATATAGCTGTGACCGGTGAGGTTTCAATCAGGGGTAATATTAAACCGGTCAGTGGTATCAGGGAAAAGATATATGC
CGCCGAACAGGCAGGAATGAGAGAGGTTTTGGTTCCCGCTGAAAATATGATAGATATACAGGAGGACTGGGATATAAAGG
TAACCCCGATATCTACGGTAGAAGAAGCCCTGAAGCGGGTTCTTATTGACCAGGATCAATTAAAGCTATCAATTATTTAA

Upstream 100 bases:

>100_bases
TGGGAACATACCGGGTGCCTGTAAAAATCTTTGAGGATGTAGTAGCAACTTTAAAAATTCAGGTTGTTGAAGCCTAGTTA
AACCCTGGGGAGTGAAAAAA

Downstream 100 bases:

>100_bases
GTTAACAAACCTGCAGGTGTTAAGCCTGCAGGTTTTTATTAATTTAAATGAAATTATACACAGGTGTTTATTGTCGATAA
TTACTGACATCAATAATTAT

Product: Sporulation protease LonC

Products: NA

Alternate protein names: ATP-dependent protease La 2 [H]

Number of amino acids: Translated: 639; Mature: 638

Protein sequence:

>639_residues
MSFLDGLFSKDDNKIKKADKKEKELKVLYKKANDYYGKEQFILKAGKVNALDLISSSKLFDKLTALERIIYEDPTIQVGK
GNFEERILKLEDKIADMLAERSVEKDIEEQIAERMEKRQREYIKEIKKEIVNDDPPDNPETLRRLARLEKLDARSLNKSV
IDLVRPKSLDEIVGQQRALKALVSKIASPYPQHVILYGPPGVGKTTAARLALEEAKKRQNTPFYGDSKFVEVDGATLRWD
PREVTNPLLGSVHDPIYQGAKKVLAEGGVPEPKTGLVTEAHAGILFIDEIGELDPMLQNKLLKVMEDKRVKFESSYYDKN
DENIPLYIKKLFEEGAPADFILIGATTRSPSKINPAFRSRCAEVFFNPLSREDIQQIVINAVKKLTVKIEDEIPEIISEY
TTEGRTAINLLIDAYSLVLYENEGADEQELIITRDKLFEAIQNRRMIPHNKIKSSEKSEIGKVFGLGVNGYLGTVIEIEA
VAFTAEEKGNGKLRFNETAGKMAKDSLFNAAAVIRKITGKKMKDYDLHVNIVGGGNVDGPSAGIAMLLALISAIEEVPLK
QDIAVTGEVSIRGNIKPVSGIREKIYAAEQAGMREVLVPAENMIDIQEDWDIKVTPISTVEEALKRVLIDQDQLKLSII

Sequences:

>Translated_639_residues
MSFLDGLFSKDDNKIKKADKKEKELKVLYKKANDYYGKEQFILKAGKVNALDLISSSKLFDKLTALERIIYEDPTIQVGK
GNFEERILKLEDKIADMLAERSVEKDIEEQIAERMEKRQREYIKEIKKEIVNDDPPDNPETLRRLARLEKLDARSLNKSV
IDLVRPKSLDEIVGQQRALKALVSKIASPYPQHVILYGPPGVGKTTAARLALEEAKKRQNTPFYGDSKFVEVDGATLRWD
PREVTNPLLGSVHDPIYQGAKKVLAEGGVPEPKTGLVTEAHAGILFIDEIGELDPMLQNKLLKVMEDKRVKFESSYYDKN
DENIPLYIKKLFEEGAPADFILIGATTRSPSKINPAFRSRCAEVFFNPLSREDIQQIVINAVKKLTVKIEDEIPEIISEY
TTEGRTAINLLIDAYSLVLYENEGADEQELIITRDKLFEAIQNRRMIPHNKIKSSEKSEIGKVFGLGVNGYLGTVIEIEA
VAFTAEEKGNGKLRFNETAGKMAKDSLFNAAAVIRKITGKKMKDYDLHVNIVGGGNVDGPSAGIAMLLALISAIEEVPLK
QDIAVTGEVSIRGNIKPVSGIREKIYAAEQAGMREVLVPAENMIDIQEDWDIKVTPISTVEEALKRVLIDQDQLKLSII
>Mature_638_residues
SFLDGLFSKDDNKIKKADKKEKELKVLYKKANDYYGKEQFILKAGKVNALDLISSSKLFDKLTALERIIYEDPTIQVGKG
NFEERILKLEDKIADMLAERSVEKDIEEQIAERMEKRQREYIKEIKKEIVNDDPPDNPETLRRLARLEKLDARSLNKSVI
DLVRPKSLDEIVGQQRALKALVSKIASPYPQHVILYGPPGVGKTTAARLALEEAKKRQNTPFYGDSKFVEVDGATLRWDP
REVTNPLLGSVHDPIYQGAKKVLAEGGVPEPKTGLVTEAHAGILFIDEIGELDPMLQNKLLKVMEDKRVKFESSYYDKND
ENIPLYIKKLFEEGAPADFILIGATTRSPSKINPAFRSRCAEVFFNPLSREDIQQIVINAVKKLTVKIEDEIPEIISEYT
TEGRTAINLLIDAYSLVLYENEGADEQELIITRDKLFEAIQNRRMIPHNKIKSSEKSEIGKVFGLGVNGYLGTVIEIEAV
AFTAEEKGNGKLRFNETAGKMAKDSLFNAAAVIRKITGKKMKDYDLHVNIVGGGNVDGPSAGIAMLLALISAIEEVPLKQ
DIAVTGEVSIRGNIKPVSGIREKIYAAEQAGMREVLVPAENMIDIQEDWDIKVTPISTVEEALKRVLIDQDQLKLSII

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG1067

COG function: function code O; Predicted ATP-dependent protease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S16 family [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=183, Percent_Identity=27.8688524590164, Blast_Score=80, Evalue=7e-15,
Organism=Homo sapiens, GI21396489, Length=158, Percent_Identity=32.9113924050633, Blast_Score=76, Evalue=1e-13,
Organism=Escherichia coli, GI1786643, Length=624, Percent_Identity=26.2820512820513, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1790850, Length=92, Percent_Identity=43.4782608695652, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1789233, Length=145, Percent_Identity=33.7931034482759, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17556486, Length=476, Percent_Identity=27.7310924369748, Blast_Score=113, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17505831, Length=480, Percent_Identity=24.375, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI221513036, Length=165, Percent_Identity=32.1212121212121, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24666867, Length=165, Percent_Identity=32.1212121212121, Blast_Score=80, Evalue=4e-15,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR020568
- InterPro:   IPR014251 [H]

Pfam domain/function: PF00004 AAA; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 71550; Mature: 71419

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS50045 SIGMA54_INTERACT_4 ; PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFLDGLFSKDDNKIKKADKKEKELKVLYKKANDYYGKEQFILKAGKVNALDLISSSKLF
CCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHEEEECCCCCHHHHHHHHHHH
DKLTALERIIYEDPTIQVGKGNFEERILKLEDKIADMLAERSVEKDIEEQIAERMEKRQR
HHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EYIKEIKKEIVNDDPPDNPETLRRLARLEKLDARSLNKSVIDLVRPKSLDEIVGQQRALK
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
ALVSKIASPYPQHVILYGPPGVGKTTAARLALEEAKKRQNTPFYGDSKFVEVDGATLRWD
HHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCEEEEC
PREVTNPLLGSVHDPIYQGAKKVLAEGGVPEPKTGLVTEAHAGILFIDEIGELDPMLQNK
HHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCEEEECCCCCCCHHHHHH
LLKVMEDKRVKFESSYYDKNDENIPLYIKKLFEEGAPADFILIGATTRSPSKINPAFRSR
HHHHHHHHCCEECCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHH
CAEVFFNPLSREDIQQIVINAVKKLTVKIEDEIPEIISEYTTEGRTAINLLIDAYSLVLY
HHHHHHCCCCHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHEEEEE
ENEGADEQELIITRDKLFEAIQNRRMIPHNKIKSSEKSEIGKVFGLGVNGYLGTVIEIEA
CCCCCCCHHEEEEHHHHHHHHHCCCCCCCHHCCCCHHHHHHHHEECCCCCHHCCEEEEEE
VAFTAEEKGNGKLRFNETAGKMAKDSLFNAAAVIRKITGKKMKDYDLHVNIVGGGNVDGP
EEEEECCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCC
SAGIAMLLALISAIEEVPLKQDIAVTGEVSIRGNIKPVSGIREKIYAAEQAGMREVLVPA
HHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHCCCHHEECCC
ENMIDIQEDWDIKVTPISTVEEALKRVLIDQDQLKLSII
CCCEECCCCCCEEEECHHHHHHHHHHHHCCCCCEEEECC
>Mature Secondary Structure 
SFLDGLFSKDDNKIKKADKKEKELKVLYKKANDYYGKEQFILKAGKVNALDLISSSKLF
CHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHEEEECCCCCHHHHHHHHHHH
DKLTALERIIYEDPTIQVGKGNFEERILKLEDKIADMLAERSVEKDIEEQIAERMEKRQR
HHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EYIKEIKKEIVNDDPPDNPETLRRLARLEKLDARSLNKSVIDLVRPKSLDEIVGQQRALK
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
ALVSKIASPYPQHVILYGPPGVGKTTAARLALEEAKKRQNTPFYGDSKFVEVDGATLRWD
HHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCEEEEC
PREVTNPLLGSVHDPIYQGAKKVLAEGGVPEPKTGLVTEAHAGILFIDEIGELDPMLQNK
HHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCEEEECCCCCCCHHHHHH
LLKVMEDKRVKFESSYYDKNDENIPLYIKKLFEEGAPADFILIGATTRSPSKINPAFRSR
HHHHHHHHCCEECCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHH
CAEVFFNPLSREDIQQIVINAVKKLTVKIEDEIPEIISEYTTEGRTAINLLIDAYSLVLY
HHHHHHCCCCHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHEEEEE
ENEGADEQELIITRDKLFEAIQNRRMIPHNKIKSSEKSEIGKVFGLGVNGYLGTVIEIEA
CCCCCCCHHEEEEHHHHHHHHHCCCCCCCHHCCCCHHHHHHHHEECCCCCHHCCEEEEEE
VAFTAEEKGNGKLRFNETAGKMAKDSLFNAAAVIRKITGKKMKDYDLHVNIVGGGNVDGP
EEEEECCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCC
SAGIAMLLALISAIEEVPLKQDIAVTGEVSIRGNIKPVSGIREKIYAAEQAGMREVLVPA
HHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHCCCHHEECCC
ENMIDIQEDWDIKVTPISTVEEALKRVLIDQDQLKLSII
CCCEECCCCCCEEEECHHHHHHHHHHHHCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377; 7961402; 11325926 [H]