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The map label for this gene is manC [H]

Identifier: 220933118

GI number: 220933118

Start: 2496685

End: 2497761

Strand: Reverse

Name: manC [H]

Synonym: Hore_22860

Alternate gene names: 220933118

Gene position: 2497761-2496685 (Counterclockwise)

Preceding gene: 220933119

Following gene: 220933117

Centisome position: 96.88

GC content: 42.53

Gene sequence:

>1077_bases
ATGGTAACAGCATTGATAATGGCCGGTGGCGAAGGGACCCGTTTCTGGCCCTTAAGCCGGAGCAATAGGCCAAAGCAGTT
TCTAAAACTGACTGATGACCAGAAGACCATGCTCCAGGAGACGGTAGAGCGGATAAAAGAACTGGTGCCACCGGATAAGG
TATTTATAGCTACCAATGAAAGTTATAAAGAGGCCATAAAAAAACAGCTTCCTGAAGTTCCTGAAGAAAACATTATAATA
GAACCATATAAAAGGGATACAGCTGCGTGTATTGGACTGGCTTCATTATATATAGAGAAGAAATTCCCGGGATCCACCAT
GGTTGTGTTACCGGCTGATCATCTTATCAAAAACAAAGAAAGGTTTATAAATATTTTACAAAAAGCGGTAATGACAGCGG
CCGTCGGACCGAATCTTGTTACCATCGGGATAGAGCCGACCCATCCGGAGACAGGATATGGTTATATCCACTTCGGAGAA
CTTCTTCATACCATAGACGAGGACAGGGTTTATCAGGTTAAGGAGTTTACTGAAAAACCCGACCTGGATACAGCCAGAGA
ATTTCTGGAAGAGGGAACCTACCTCTGGAACAGCGGGATGTTTGTCTGGAGGGTGGAGACTATCCAGGATAAGATAGAAA
AACACATGCCCGAACTCAGTAAAGCCATGGAACGAATTAGACAGGCCCTGGGAACAGATCTGGAAGATAAGGTTGTCAGG
GAAGAGTTTAAAGAGCTTGAAGGTATTTCTATCGACTATGGTATTATGGAAAAGGCCAGTGATATTTATGTTATCCCCGG
TGATTTCGGCTGGGATGACCTGGGAAGCTGGCCGGCTTTAGAGAGAGTTAAGAAAGTAGATAAAGATGGTAATGTTGTCC
TGGGAAAACACTATGGTATAGATACCAAAAACTCAATAATTCACAGTGAAGATAAAGTAGTAACCACTATTGGATTGAAG
GATATAGTAATTGTAAATACCAGGGATGCCATTCTTATTTGTGATAAGAAAAGAGCCCAGGAGGTTAAGGAGATAAGGGA
GATATTGCATAGGAATGGTATGGAAGAGTGTCTTTAA

Upstream 100 bases:

>100_bases
ATGGCTATAGCAGGCATTCTGGCATTTATGATAGGTGTATTTGTGGTTTTCTTACGTGAATTTTTAAAGGAAGAAGAAAA
TTAGGAAGGGTGCAAACCAG

Downstream 100 bases:

>100_bases
TACATTATAATTTTATAAATAAGAAAGGCATGGTATAATGAATGGAAGAAGAACTGTTAGATGTAACTAAAAAATCAGGG
GTAGTTTTCATTGGTCGCAT

Product: Mannose-1-phosphate guanylyltransferase (GDP)

Products: NA

Alternate protein names: GDP-mannose pyrophosphorylase; GMP; GMPP [H]

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MVTALIMAGGEGTRFWPLSRSNRPKQFLKLTDDQKTMLQETVERIKELVPPDKVFIATNESYKEAIKKQLPEVPEENIII
EPYKRDTAACIGLASLYIEKKFPGSTMVVLPADHLIKNKERFINILQKAVMTAAVGPNLVTIGIEPTHPETGYGYIHFGE
LLHTIDEDRVYQVKEFTEKPDLDTAREFLEEGTYLWNSGMFVWRVETIQDKIEKHMPELSKAMERIRQALGTDLEDKVVR
EEFKELEGISIDYGIMEKASDIYVIPGDFGWDDLGSWPALERVKKVDKDGNVVLGKHYGIDTKNSIIHSEDKVVTTIGLK
DIVIVNTRDAILICDKKRAQEVKEIREILHRNGMEECL

Sequences:

>Translated_358_residues
MVTALIMAGGEGTRFWPLSRSNRPKQFLKLTDDQKTMLQETVERIKELVPPDKVFIATNESYKEAIKKQLPEVPEENIII
EPYKRDTAACIGLASLYIEKKFPGSTMVVLPADHLIKNKERFINILQKAVMTAAVGPNLVTIGIEPTHPETGYGYIHFGE
LLHTIDEDRVYQVKEFTEKPDLDTAREFLEEGTYLWNSGMFVWRVETIQDKIEKHMPELSKAMERIRQALGTDLEDKVVR
EEFKELEGISIDYGIMEKASDIYVIPGDFGWDDLGSWPALERVKKVDKDGNVVLGKHYGIDTKNSIIHSEDKVVTTIGLK
DIVIVNTRDAILICDKKRAQEVKEIREILHRNGMEECL
>Mature_358_residues
MVTALIMAGGEGTRFWPLSRSNRPKQFLKLTDDQKTMLQETVERIKELVPPDKVFIATNESYKEAIKKQLPEVPEENIII
EPYKRDTAACIGLASLYIEKKFPGSTMVVLPADHLIKNKERFINILQKAVMTAAVGPNLVTIGIEPTHPETGYGYIHFGE
LLHTIDEDRVYQVKEFTEKPDLDTAREFLEEGTYLWNSGMFVWRVETIQDKIEKHMPELSKAMERIRQALGTDLEDKVVR
EEFKELEGISIDYGIMEKASDIYVIPGDFGWDDLGSWPALERVKKVDKDGNVVLGKHYGIDTKNSIIHSEDKVVTTIGLK
DIVIVNTRDAILICDKKRAQEVKEIREILHRNGMEECL

Specific function: Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS O7 antigen [H]

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=357, Percent_Identity=40.0560224089636, Blast_Score=243, Evalue=2e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =2.7.7.13 [H]

Molecular weight: Translated: 40874; Mature: 40874

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTALIMAGGEGTRFWPLSRSNRPKQFLKLTDDQKTMLQETVERIKELVPPDKVFIATNE
CEEEEEEECCCCCEEECCCCCCCCHHHHEECCHHHHHHHHHHHHHHHHCCCCEEEEEECH
SYKEAIKKQLPEVPEENIIIEPYKRDTAACIGLASLYIEKKFPGSTMVVLPADHLIKNKE
HHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHHEECCCCCEEEEECCHHHHHHHH
RFINILQKAVMTAAVGPNLVTIGIEPTHPETGYGYIHFGELLHTIDEDRVYQVKEFTEKP
HHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEHHHHHHHHCCCCEEHHHHHCCCC
DLDTAREFLEEGTYLWNSGMFVWRVETIQDKIEKHMPELSKAMERIRQALGTDLEDKVVR
CHHHHHHHHHCCCEEEECCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
EEFKELEGISIDYGIMEKASDIYVIPGDFGWDDLGSWPALERVKKVDKDGNVVLGKHYGI
HHHHHHCCCEECHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEECCC
DTKNSIIHSEDKVVTTIGLKDIVIVNTRDAILICDKKRAQEVKEIREILHRNGMEECL
CCCCCEEECCCCEEEEECCCEEEEEECCCEEEEECCHHHHHHHHHHHHHHCCCHHHCC
>Mature Secondary Structure
MVTALIMAGGEGTRFWPLSRSNRPKQFLKLTDDQKTMLQETVERIKELVPPDKVFIATNE
CEEEEEEECCCCCEEECCCCCCCCHHHHEECCHHHHHHHHHHHHHHHHCCCCEEEEEECH
SYKEAIKKQLPEVPEENIIIEPYKRDTAACIGLASLYIEKKFPGSTMVVLPADHLIKNKE
HHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHHEECCCCCEEEEECCHHHHHHHH
RFINILQKAVMTAAVGPNLVTIGIEPTHPETGYGYIHFGELLHTIDEDRVYQVKEFTEKP
HHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEHHHHHHHHCCCCEEHHHHHCCCC
DLDTAREFLEEGTYLWNSGMFVWRVETIQDKIEKHMPELSKAMERIRQALGTDLEDKVVR
CHHHHHHHHHCCCEEEECCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
EEFKELEGISIDYGIMEKASDIYVIPGDFGWDDLGSWPALERVKKVDKDGNVVLGKHYGI
HHHHHHCCCEECHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEECCC
DTKNSIIHSEDKVVTTIGLKDIVIVNTRDAILICDKKRAQEVKEIREILHRNGMEECL
CCCCCEEECCCCEEEEECCCEEEEEECCCEEEEECCHHHHHHHHHHHHHHCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7677991 [H]