Click here to switch to the map view.

The map label for this gene is purC [H]

Identifier: 220933048

GI number: 220933048

Start: 2413468

End: 2414172

Strand: Reverse

Name: purC [H]

Synonym: Hore_22160

Alternate gene names: 220933048

Gene position: 2414172-2413468 (Counterclockwise)

Preceding gene: 220933049

Following gene: 220933047

Centisome position: 93.64

GC content: 38.87

Gene sequence:

>705_bases
ATGTTAACAAAACTGGAAATGCTTTATGAAGGAAAGGCTAAAAAGGTTTATCGGACCGAGGACAAAGACAGGGTTATTAT
TGAGTATAAGGATGATGCTACTGCTTTTAATGGGAAGAAAAAGGGAACTATCCAGGAAAAAGGATTTTATAATGCCCAGA
TAAGTGCAGCTCTATTTAATCTACTCGAGGATAATGGAGTTAAAACCCATTTTATAAAAAAGCTTGGTGACAGAGAGCAG
CTGACAACCTATGTGGATATAATTCCTCTGGAAGTAGTTGTCAGGAATATAGTGGCCGGTAGCCTTTCAAAGCGGCTGGG
TCTTGAAGAAGGTTATGTTCTTGAAGAGCCCATTATTGAATTTTACTATAAGCGGGATGACCTGGGTGATCCTTTACTAA
ACAATTCACACATTAGAGCTCTGAAGCTGGCAGATGAAGAAGAAATTAAGGAAATTACAGCTATGGGTTTTAAAGTTAAC
GATATTTTGAGAAATTATCTTTCAAATAAAGGTATAGAACTGGTTGACTTTAAACTTGAGTTTGGGAAGAATAATGGTAA
TATTTTACTGGCTGATGAAATATCTCCGGATACCTGCCGGTTCTGGGATAAAAGTAGTGGAGAAAAGCTTGATAAAGACC
GCTTCCGTAGGGATTTAGGCGGTGTCGAGAATGCCTACCGGGAAGTCTGGTCCCGGGTTAAATAG

Upstream 100 bases:

>100_bases
GCCAGAAGGATATTCTCTATAATCCGGAGCAGTATACCGGTATTGCCCGGGAAAGGACTGAAGAGATTGTGACTAAAATC
AGGAAGGAGAGGGGTTTGTA

Downstream 100 bases:

>100_bases
AACTGGTTTAGGGATTAGAACTAGTTTAGAGATTTAGGCTCCCATTAAACTAATGTAAACTTTTTATGAAATTTACTGGA
TTAGAAATAAGGAAATAAAT

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MLTKLEMLYEGKAKKVYRTEDKDRVIIEYKDDATAFNGKKKGTIQEKGFYNAQISAALFNLLEDNGVKTHFIKKLGDREQ
LTTYVDIIPLEVVVRNIVAGSLSKRLGLEEGYVLEEPIIEFYYKRDDLGDPLLNNSHIRALKLADEEEIKEITAMGFKVN
DILRNYLSNKGIELVDFKLEFGKNNGNILLADEISPDTCRFWDKSSGEKLDKDRFRRDLGGVENAYREVWSRVK

Sequences:

>Translated_234_residues
MLTKLEMLYEGKAKKVYRTEDKDRVIIEYKDDATAFNGKKKGTIQEKGFYNAQISAALFNLLEDNGVKTHFIKKLGDREQ
LTTYVDIIPLEVVVRNIVAGSLSKRLGLEEGYVLEEPIIEFYYKRDDLGDPLLNNSHIRALKLADEEEIKEITAMGFKVN
DILRNYLSNKGIELVDFKLEFGKNNGNILLADEISPDTCRFWDKSSGEKLDKDRFRRDLGGVENAYREVWSRVK
>Mature_234_residues
MLTKLEMLYEGKAKKVYRTEDKDRVIIEYKDDATAFNGKKKGTIQEKGFYNAQISAALFNLLEDNGVKTHFIKKLGDREQ
LTTYVDIIPLEVVVRNIVAGSLSKRLGLEEGYVLEEPIIEFYYKRDDLGDPLLNNSHIRALKLADEEEIKEITAMGFKVN
DILRNYLSNKGIELVDFKLEFGKNNGNILLADEISPDTCRFWDKSSGEKLDKDRFRRDLGGVENAYREVWSRVK

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Homo sapiens, GI119220557, Length=220, Percent_Identity=32.2727272727273, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI5453539, Length=220, Percent_Identity=32.2727272727273, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI119220559, Length=227, Percent_Identity=31.2775330396476, Blast_Score=104, Evalue=8e-23,
Organism=Escherichia coli, GI1788820, Length=226, Percent_Identity=40.7079646017699, Blast_Score=187, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI17531275, Length=226, Percent_Identity=33.1858407079646, Blast_Score=97, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6319326, Length=257, Percent_Identity=27.2373540856031, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI18860083, Length=223, Percent_Identity=30.4932735426009, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24583917, Length=215, Percent_Identity=32.5581395348837, Blast_Score=93, Evalue=2e-19,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 26953; Mature: 26953

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: PS01057 SAICAR_SYNTHETASE_1 ; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTKLEMLYEGKAKKVYRTEDKDRVIIEYKDDATAFNGKKKGTIQEKGFYNAQISAALFN
CCCHHHHHHCCCCCCEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
LLEDNGVKTHFIKKLGDREQLTTYVDIIPLEVVVRNIVAGSLSKRLGLEEGYVLEEPIIE
HHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
FYYKRDDLGDPLLNNSHIRALKLADEEEIKEITAMGFKVNDILRNYLSNKGIELVDFKLE
HHHCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEEEEE
FGKNNGNILLADEISPDTCRFWDKSSGEKLDKDRFRRDLGGVENAYREVWSRVK
ECCCCCCEEEEECCCCCHHHCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHCC
>Mature Secondary Structure
MLTKLEMLYEGKAKKVYRTEDKDRVIIEYKDDATAFNGKKKGTIQEKGFYNAQISAALFN
CCCHHHHHHCCCCCCEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
LLEDNGVKTHFIKKLGDREQLTTYVDIIPLEVVVRNIVAGSLSKRLGLEEGYVLEEPIIE
HHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
FYYKRDDLGDPLLNNSHIRALKLADEEEIKEITAMGFKVNDILRNYLSNKGIELVDFKLE
HHHCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEEEEE
FGKNNGNILLADEISPDTCRFWDKSSGEKLDKDRFRRDLGGVENAYREVWSRVK
ECCCCCCEEEEECCCCCHHHCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA