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The map label for this gene is purM [H]

Identifier: 220933043

GI number: 220933043

Start: 2407616

End: 2408668

Strand: Reverse

Name: purM [H]

Synonym: Hore_22110

Alternate gene names: 220933043

Gene position: 2408668-2407616 (Counterclockwise)

Preceding gene: 220933044

Following gene: 220933042

Centisome position: 93.43

GC content: 44.82

Gene sequence:

>1053_bases
ATGAAAAAGGGCATAACCTATGCTGATTCGGGGGTAAATATTGATAAAGGTAACGAGTTTGTGGATCGCATTAAAGATAA
AGTAAAAGAAACCCACCTTCCCGGGGTTATCGGTGGGGTGGGGGGATTTGGGGGGCTTTTTGCCCCTGATTTTAAACAAT
ACCAAAAACCGGTTCTTGTCTCTGGAACCGATGGGGTTGGTACTAAACTGAAAATTGCCCAGCTTGTTAATAAACATGAT
ATCATCGGGATTGACCTGGTAGCCATGTGTGTTAATGATATCCTGGCCCAGGGGGCAAAACCCCTTTTTTTCCTTGATTA
CATGGCTACCGGGCAACTTGAGCTCGAGACCGGAGAGGAGATTATTACCGGAATTACCAGGGGATGTAAACAGGCCGGTG
TTGCCCTGCTCGGTGGGGAGACAGCGGAGATGCCGGGCTTTTATCAGCAGGGGAGCTATGACCTGGCCGGTTTTGCAGTT
GGGATCGTTGACCGTAAGAATATAATTACCGGTTCGAAAATAAAAGCAGGGGATCAGCTACTGGGCCTTCCTTCATCTGG
GATACATAGTAATGGTTATTCCCTGGTCAGGAAAGTACTTCTTGAAAAAGAGGGGTTGAAAGTAGATGATAGAATAAAAG
AGCTAGACTGTACCCTTGGTGAGGAGCTTTTAAAACCAACCCGTATTTATGTACCTGTGGTTCTTCCGTTGCTAGAAAAA
TATGAAGTAAAGGGAATAGCTCATATTACCGGTGGGGGAATGCCGGAAAATATAGCCCGGATTATTCCTGATGGCCTTCA
GGCCAGGGTAAACAGAGAAAGCTGGTCGTGTCCCCCAGTATTTACCTATATTCAGGCCAAGGGGGATATTGCTACAGTTG
AAATGGAGAGAACCTTCAATATGGGGATCGGTATGGTGCTGGTTGTTTCTCCGGATATATTAGAAAATGTTATGTCAGAT
ATAAAGGCCCGGGGAGAAAAAGTATACCATATTGGAGAAATAAATAGTATCGGTAAAAAAGAGGGTAAGGTGGTTATCTA
CAATGGGCAATAA

Upstream 100 bases:

>100_bases
CCGGAAATGGGAAACTGGCTTTAGAAAAAAACGTCCCTGAGATTAAATCAGGACAATAATCTGATACCGGGCAAGAAATA
TTTAAAAATGGAGGGGTTTA

Downstream 100 bases:

>100_bases
AATTAATCTGGCTGTATTTATTTCCGGGAATGGAACCAATCTTCAGGCAATTATAGATTCTATTAAAGCTGGCAGGGTTG
AGGCTGAATTAAAAATGGTG

Product: phosphoribosylformylglycinamidine cyclo-ligase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MKKGITYADSGVNIDKGNEFVDRIKDKVKETHLPGVIGGVGGFGGLFAPDFKQYQKPVLVSGTDGVGTKLKIAQLVNKHD
IIGIDLVAMCVNDILAQGAKPLFFLDYMATGQLELETGEEIITGITRGCKQAGVALLGGETAEMPGFYQQGSYDLAGFAV
GIVDRKNIITGSKIKAGDQLLGLPSSGIHSNGYSLVRKVLLEKEGLKVDDRIKELDCTLGEELLKPTRIYVPVVLPLLEK
YEVKGIAHITGGGMPENIARIIPDGLQARVNRESWSCPPVFTYIQAKGDIATVEMERTFNMGIGMVLVVSPDILENVMSD
IKARGEKVYHIGEINSIGKKEGKVVIYNGQ

Sequences:

>Translated_350_residues
MKKGITYADSGVNIDKGNEFVDRIKDKVKETHLPGVIGGVGGFGGLFAPDFKQYQKPVLVSGTDGVGTKLKIAQLVNKHD
IIGIDLVAMCVNDILAQGAKPLFFLDYMATGQLELETGEEIITGITRGCKQAGVALLGGETAEMPGFYQQGSYDLAGFAV
GIVDRKNIITGSKIKAGDQLLGLPSSGIHSNGYSLVRKVLLEKEGLKVDDRIKELDCTLGEELLKPTRIYVPVVLPLLEK
YEVKGIAHITGGGMPENIARIIPDGLQARVNRESWSCPPVFTYIQAKGDIATVEMERTFNMGIGMVLVVSPDILENVMSD
IKARGEKVYHIGEINSIGKKEGKVVIYNGQ
>Mature_350_residues
MKKGITYADSGVNIDKGNEFVDRIKDKVKETHLPGVIGGVGGFGGLFAPDFKQYQKPVLVSGTDGVGTKLKIAQLVNKHD
IIGIDLVAMCVNDILAQGAKPLFFLDYMATGQLELETGEEIITGITRGCKQAGVALLGGETAEMPGFYQQGSYDLAGFAV
GIVDRKNIITGSKIKAGDQLLGLPSSGIHSNGYSLVRKVLLEKEGLKVDDRIKELDCTLGEELLKPTRIYVPVVLPLLEK
YEVKGIAHITGGGMPENIARIIPDGLQARVNRESWSCPPVFTYIQAKGDIATVEMERTFNMGIGMVLVVSPDILENVMSD
IKARGEKVYHIGEINSIGKKEGKVVIYNGQ

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=349, Percent_Identity=48.7106017191977, Blast_Score=327, Evalue=7e-90,
Organism=Homo sapiens, GI209869995, Length=349, Percent_Identity=48.7106017191977, Blast_Score=327, Evalue=7e-90,
Organism=Homo sapiens, GI209869993, Length=349, Percent_Identity=48.7106017191977, Blast_Score=327, Evalue=7e-90,
Organism=Escherichia coli, GI1788845, Length=346, Percent_Identity=52.3121387283237, Blast_Score=352, Evalue=2e-98,
Organism=Caenorhabditis elegans, GI17567511, Length=352, Percent_Identity=43.75, Blast_Score=273, Evalue=1e-73,
Organism=Saccharomyces cerevisiae, GI6321203, Length=353, Percent_Identity=48.1586402266289, Blast_Score=320, Evalue=3e-88,
Organism=Drosophila melanogaster, GI24582400, Length=300, Percent_Identity=44.6666666666667, Blast_Score=258, Evalue=4e-69,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 37763; Mature: 37763

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKGITYADSGVNIDKGNEFVDRIKDKVKETHLPGVIGGVGGFGGLFAPDFKQYQKPVLV
CCCCCEECCCCCCCCCCHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCHHHHCCCEEE
SGTDGVGTKLKIAQLVNKHDIIGIDLVAMCVNDILAQGAKPLFFLDYMATGQLELETGEE
ECCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEECCHHH
IITGITRGCKQAGVALLGGETAEMPGFYQQGSYDLAGFAVGIVDRKNIITGSKIKAGDQL
HHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCE
LGLPSSGIHSNGYSLVRKVLLEKEGLKVDDRIKELDCTLGEELLKPTRIYVPVVLPLLEK
ECCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHH
YEVKGIAHITGGGMPENIARIIPDGLQARVNRESWSCPPVFTYIQAKGDIATVEMERTFN
HCCCEEEEECCCCCHHHHHHHCCCHHHHHCCCCCCCCCCEEEEEEECCCEEEEEEEEHHC
MGIGMVLVVSPDILENVMSDIKARGEKVYHIGEINSIGKKEGKVVIYNGQ
CCCCEEEEECHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCEEEEECCC
>Mature Secondary Structure
MKKGITYADSGVNIDKGNEFVDRIKDKVKETHLPGVIGGVGGFGGLFAPDFKQYQKPVLV
CCCCCEECCCCCCCCCCHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCHHHHCCCEEE
SGTDGVGTKLKIAQLVNKHDIIGIDLVAMCVNDILAQGAKPLFFLDYMATGQLELETGEE
ECCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEECCHHH
IITGITRGCKQAGVALLGGETAEMPGFYQQGSYDLAGFAVGIVDRKNIITGSKIKAGDQL
HHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCE
LGLPSSGIHSNGYSLVRKVLLEKEGLKVDDRIKELDCTLGEELLKPTRIYVPVVLPLLEK
ECCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHH
YEVKGIAHITGGGMPENIARIIPDGLQARVNRESWSCPPVFTYIQAKGDIATVEMERTFN
HCCCEEEEECCCCCHHHHHHHCCCHHHHHCCCCCCCCCCEEEEEEECCCEEEEEEEEHHC
MGIGMVLVVSPDILENVMSDIKARGEKVYHIGEINSIGKKEGKVVIYNGQ
CCCCEEEEECHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA