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The map label for this gene is rsmA

Identifier: 220933005

GI number: 220933005

Start: 2364047

End: 2364952

Strand: Reverse

Name: rsmA

Synonym: Hore_21720

Alternate gene names: 220933005

Gene position: 2364952-2364047 (Counterclockwise)

Preceding gene: 220933007

Following gene: 220933004

Centisome position: 91.73

GC content: 38.85

Gene sequence:

>906_bases
ATGGATAAAGTTATAGCAACACCCGGTGGTACAAATGAAATAATAAGGAAATACAACTTAAAACTACATAAAGGGCTGGG
ACAAAATTTTTTAATAGACCAGAACATTGTTGATAAAATAATAAATACAGCTGACCTCAATAATGAGGATATAGTAATTG
AAATTGGACCGGGGATAGGGTCCTTAACCCAGAAAATAGTCCCCCGGTCTGGTCGGGTTTTTGCCTTTGAAAAAGACAAG
AGGCTGGTTAAGGTTTTAAGAGAGCTTTTTAATGGTTACAACCACCTGGAAGTAATTGGTCAGGATGTTCTTGAGGTTGA
CTGGAAACATTTCTTTGACAGTAGAGGTATTTCTGACAGGAGCGTTAAAGTACTGGCCAATTTACCATATTACATCACGA
CCCCGGTTATTATGGGGTTGCTAGAATCTAACATAACATTTTCCTTAATGGTATTGATGGTGCAAAAAGAAGTTGCAGAC
CGGATGGCGGCAGCTCCCGGGAGTAAAGATTATGGGGCTTTAAGTGTAGCGGTTCAGTATTATGGCGAGGTGGAAATCTT
TCATAAGGTTCCACCGACTGTATTTATACCGAGGCCCCGGGTTTATTCCAGCATAATAAAAATTAAACCTCATTCAGAAC
CTGTATACAGGGTTAAAAATGAGGGTTTTTTCTTCAAAATGGTGAGGGCAATATTTCAGCAGAGGAGGAAAACCTTAAAA
AATTCCTTAACCAAATCCTCTGAAATTAAGTTGGATAAGGGTATAGTCACGGAGGCAATAAGAGAGCTTGGGTTAGATCC
CCGGATCAGGGGAGAAAAACTAACTATCAAACAGATGGCTATTTTAAGCAATACCTTATGGTACAAAATTTCTGAAGAAG
ATGGTGAGAATCATGAAATTTACTAG

Upstream 100 bases:

>100_bases
GGAGGCTCTATGTTTATGTAATAATCCCTTTTTTATAATTTTGCGAGTTCTTCTAAATTGTGTTAAAATAAAATAAATAC
AAATAATAGGAGAAATAATA

Downstream 100 bases:

>100_bases
CCCTACCGACGGGACCCTTGATATTAATCAGACCTATCAAACTATTCTGGATTTTATAGAATCTGAGCCAGACAACCAGT
ATAGACTTATTATAGGAACT

Product: dimethyladenosine transferase

Products: NA

Alternate protein names: 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase; 16S rRNA dimethyladenosine transferase; 16S rRNA dimethylase; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MDKVIATPGGTNEIIRKYNLKLHKGLGQNFLIDQNIVDKIINTADLNNEDIVIEIGPGIGSLTQKIVPRSGRVFAFEKDK
RLVKVLRELFNGYNHLEVIGQDVLEVDWKHFFDSRGISDRSVKVLANLPYYITTPVIMGLLESNITFSLMVLMVQKEVAD
RMAAAPGSKDYGALSVAVQYYGEVEIFHKVPPTVFIPRPRVYSSIIKIKPHSEPVYRVKNEGFFFKMVRAIFQQRRKTLK
NSLTKSSEIKLDKGIVTEAIRELGLDPRIRGEKLTIKQMAILSNTLWYKISEEDGENHEIY

Sequences:

>Translated_301_residues
MDKVIATPGGTNEIIRKYNLKLHKGLGQNFLIDQNIVDKIINTADLNNEDIVIEIGPGIGSLTQKIVPRSGRVFAFEKDK
RLVKVLRELFNGYNHLEVIGQDVLEVDWKHFFDSRGISDRSVKVLANLPYYITTPVIMGLLESNITFSLMVLMVQKEVAD
RMAAAPGSKDYGALSVAVQYYGEVEIFHKVPPTVFIPRPRVYSSIIKIKPHSEPVYRVKNEGFFFKMVRAIFQQRRKTLK
NSLTKSSEIKLDKGIVTEAIRELGLDPRIRGEKLTIKQMAILSNTLWYKISEEDGENHEIY
>Mature_301_residues
MDKVIATPGGTNEIIRKYNLKLHKGLGQNFLIDQNIVDKIINTADLNNEDIVIEIGPGIGSLTQKIVPRSGRVFAFEKDK
RLVKVLRELFNGYNHLEVIGQDVLEVDWKHFFDSRGISDRSVKVLANLPYYITTPVIMGLLESNITFSLMVLMVQKEVAD
RMAAAPGSKDYGALSVAVQYYGEVEIFHKVPPTVFIPRPRVYSSIIKIKPHSEPVYRVKNEGFFFKMVRAIFQQRRKTLK
NSLTKSSEIKLDKGIVTEAIRELGLDPRIRGEKLTIKQMAILSNTLWYKISEEDGENHEIY

Specific function: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits

COG id: COG0030

COG function: function code J; Dimethyladenosine transferase (rRNA methylation)

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily

Homologues:

Organism=Homo sapiens, GI7657198, Length=231, Percent_Identity=35.0649350649351, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI156415992, Length=312, Percent_Identity=31.4102564102564, Blast_Score=112, Evalue=4e-25,
Organism=Escherichia coli, GI1786236, Length=274, Percent_Identity=31.7518248175182, Blast_Score=153, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI25146882, Length=226, Percent_Identity=37.1681415929204, Blast_Score=131, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI25141369, Length=292, Percent_Identity=26.7123287671233, Blast_Score=101, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6324989, Length=196, Percent_Identity=31.6326530612245, Blast_Score=94, Evalue=4e-20,
Organism=Drosophila melanogaster, GI21358017, Length=242, Percent_Identity=30.9917355371901, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI21357273, Length=245, Percent_Identity=28.5714285714286, Blast_Score=102, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RSMA_HALOH (B8D0I2)

Other databases:

- EMBL:   CP001098
- RefSeq:   YP_002509913.1
- ProteinModelPortal:   B8D0I2
- SMR:   B8D0I2
- GeneID:   7313720
- GenomeReviews:   CP001098_GR
- KEGG:   hor:Hore_21720
- HOGENOM:   HBG319664
- OMA:   RAENLTP
- GO:   GO:0005737
- HAMAP:   MF_00607
- InterPro:   IPR023165
- InterPro:   IPR020596
- InterPro:   IPR001737
- InterPro:   IPR020598
- InterPro:   IPR011530
- Gene3D:   G3DSA:1.10.8.100
- PANTHER:   PTHR11727
- SMART:   SM00650
- TIGRFAMs:   TIGR00755

Pfam domain/function: PF00398 RrnaAD

EC number: =2.1.1.182

Molecular weight: Translated: 34280; Mature: 34280

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: PS01131 RRNA_A_DIMETH

Important sites: BINDING 29-29 BINDING 31-31 BINDING 56-56 BINDING 77-77 BINDING 102-102 BINDING 127-127

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKVIATPGGTNEIIRKYNLKLHKGLGQNFLIDQNIVDKIINTADLNNEDIVIEIGPGIG
CCCEEECCCCHHHHHHHHCCHHHCCCCCCEEECHHHHHHHHHHCCCCCCEEEEEECCCHH
SLTQKIVPRSGRVFAFEKDKRLVKVLRELFNGYNHLEVIGQDVLEVDWKHFFDSRGISDR
HHHHHHCCCCCCEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
SVKVLANLPYYITTPVIMGLLESNITFSLMVLMVQKEVADRMAAAPGSKDYGALSVAVQY
CEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHEEEEEC
YGEVEIFHKVPPTVFIPRPRVYSSIIKIKPHSEPVYRVKNEGFFFKMVRAIFQQRRKTLK
CCCEEEEECCCCEEECCCCHHHHHHEEECCCCCCCEEECCCCHHHHHHHHHHHHHHHHHH
NSLTKSSEIKLDKGIVTEAIRELGLDPRIRGEKLTIKQMAILSNTLWYKISEEDGENHEI
HHHCCCCCCEEHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHCEEEEEECCCCCCCCC
Y
C
>Mature Secondary Structure
MDKVIATPGGTNEIIRKYNLKLHKGLGQNFLIDQNIVDKIINTADLNNEDIVIEIGPGIG
CCCEEECCCCHHHHHHHHCCHHHCCCCCCEEECHHHHHHHHHHCCCCCCEEEEEECCCHH
SLTQKIVPRSGRVFAFEKDKRLVKVLRELFNGYNHLEVIGQDVLEVDWKHFFDSRGISDR
HHHHHHCCCCCCEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
SVKVLANLPYYITTPVIMGLLESNITFSLMVLMVQKEVADRMAAAPGSKDYGALSVAVQY
CEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHEEEEEC
YGEVEIFHKVPPTVFIPRPRVYSSIIKIKPHSEPVYRVKNEGFFFKMVRAIFQQRRKTLK
CCCEEEEECCCCEEECCCCHHHHHHEEECCCCCCCEEECCCCHHHHHHHHHHHHHHHHHH
NSLTKSSEIKLDKGIVTEAIRELGLDPRIRGEKLTIKQMAILSNTLWYKISEEDGENHEI
HHHCCCCCCEEHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHCEEEEEECCCCCCCCC
Y
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA