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The map label for this gene is galK [H]

Identifier: 220932898

GI number: 220932898

Start: 2234999

End: 2236213

Strand: Reverse

Name: galK [H]

Synonym: Hore_20660

Alternate gene names: 220932898

Gene position: 2236213-2234999 (Counterclockwise)

Preceding gene: 220932899

Following gene: 220932897

Centisome position: 86.74

GC content: 44.03

Gene sequence:

>1215_bases
ATGAAAAGCGTAGATGAATTATGGGAGTTCTTTGAGAATAGATATGGTGATAATGGCTTGAAAAAGGGGTCCTATTCAGC
CCCCGGGCGGGTTAATTTAATCGGAGAGCATACTGACTATAATGATGGTTTTGTCCTGCCAATGGCCATTGAAAAAAATG
TCACCATGCTGGGTCAGTTAAGGCATGACCGGAAAATAAAAGTCTATTCTCTTGACTACGATACTGAGTTGTGCTTTAAC
CTGGATAAACTTGAAAAAGATGAGGAACACACCTGGGTTAATTATGTGATGGGGGTTGCCGATGAAATTGAGAAAAAGGG
TCATAAACTAAAGGGGATGAACCTGGTATTTACCGGTAATGTGCCCCAGGGTTCAGGGTTAAGCTCTTCAGCTGCCCTGG
AAGTAGTTACAGCCATGACCATGGCTGATTTAAATGAACTGGATATAGACCCGGTGGAGATGGCTTTGCTCTGCCAGGCT
GCAGAAAACAATTTTGTCGGTGTGGCCTGTGGGATTATGGATCAATATATTTCCCGCCTTGGCCACAGGGACCATGCCCT
CCTGATAGATTGCCGAACCAATGAATATGAACTAATTCCCTTTAAAGATAAAAGGTATCGGATAGTAATCTGTAACTCAA
AAGCCCGGAGGGGGCTAGTTGATTCTGAATATAATACCCGAAGGTCAGAGTGTAACCAGGCTGTTGCCTTTTTTAATGAG
AAGCTGGGCCGTAACATAACTGCCCTGAGGGATGTAAAGCTCAATGAAGTAGGACAATACAGGGGAGAACTCTCTGATTC
AGTATATCGCAGGGCTCATCATGTAGTCAGTGAGAATGAAAGGGTTCTGGCCAGTGTCGAGGCCCTAAAAAATAATGATT
TTGAGAAATTTGGACAGCTAATGATTGAATCACATCAAAGCCTCAGGGACGATTATGAGGTTAGCTGCCGGGAACTGGAT
TGCCTGGTAGACGTGGCCCTTAAACAGGAAGGGGTTCTGGGAGCCAGGATGACCGGGGCCGGTTTTGGTGGTTGTACGGT
TAATCTTGTTGACATCAATTATGTTGAAGTTTTTATAAAAGGGATTAAAGAAGGTTATAAACGGGAAACCGGGATAGAGC
CTGAAATCTATGTAAGTCGACCGGCAGAAGGGGCAAGAAGATTGGAGGTTGATAGAGATGGAGGAAACCCTGGTAAAGAA
GGAAAAAATAGATAA

Upstream 100 bases:

>100_bases
TAAAGCAGCTGTATTGAGGGAAACCAGTCCAGTTTCCTTTGAAGATATGTAGTATCATTTATAACCGGGGTTGATAGATT
TTAAGACAGGGGTGATTGGT

Downstream 100 bases:

>100_bases
GTTGATGAAGGAGAAAGGGCTTGATGGGGTTGTTTTGACCAGTCATAGTAATATTACCTGGTTAACAGGTATCGATAATA
GAATTGTTTTTGCCAGTGAT

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase [H]

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MKSVDELWEFFENRYGDNGLKKGSYSAPGRVNLIGEHTDYNDGFVLPMAIEKNVTMLGQLRHDRKIKVYSLDYDTELCFN
LDKLEKDEEHTWVNYVMGVADEIEKKGHKLKGMNLVFTGNVPQGSGLSSSAALEVVTAMTMADLNELDIDPVEMALLCQA
AENNFVGVACGIMDQYISRLGHRDHALLIDCRTNEYELIPFKDKRYRIVICNSKARRGLVDSEYNTRRSECNQAVAFFNE
KLGRNITALRDVKLNEVGQYRGELSDSVYRRAHHVVSENERVLASVEALKNNDFEKFGQLMIESHQSLRDDYEVSCRELD
CLVDVALKQEGVLGARMTGAGFGGCTVNLVDINYVEVFIKGIKEGYKRETGIEPEIYVSRPAEGARRLEVDRDGGNPGKE
GKNR

Sequences:

>Translated_404_residues
MKSVDELWEFFENRYGDNGLKKGSYSAPGRVNLIGEHTDYNDGFVLPMAIEKNVTMLGQLRHDRKIKVYSLDYDTELCFN
LDKLEKDEEHTWVNYVMGVADEIEKKGHKLKGMNLVFTGNVPQGSGLSSSAALEVVTAMTMADLNELDIDPVEMALLCQA
AENNFVGVACGIMDQYISRLGHRDHALLIDCRTNEYELIPFKDKRYRIVICNSKARRGLVDSEYNTRRSECNQAVAFFNE
KLGRNITALRDVKLNEVGQYRGELSDSVYRRAHHVVSENERVLASVEALKNNDFEKFGQLMIESHQSLRDDYEVSCRELD
CLVDVALKQEGVLGARMTGAGFGGCTVNLVDINYVEVFIKGIKEGYKRETGIEPEIYVSRPAEGARRLEVDRDGGNPGKE
GKNR
>Mature_404_residues
MKSVDELWEFFENRYGDNGLKKGSYSAPGRVNLIGEHTDYNDGFVLPMAIEKNVTMLGQLRHDRKIKVYSLDYDTELCFN
LDKLEKDEEHTWVNYVMGVADEIEKKGHKLKGMNLVFTGNVPQGSGLSSSAALEVVTAMTMADLNELDIDPVEMALLCQA
AENNFVGVACGIMDQYISRLGHRDHALLIDCRTNEYELIPFKDKRYRIVICNSKARRGLVDSEYNTRRSECNQAVAFFNE
KLGRNITALRDVKLNEVGQYRGELSDSVYRRAHHVVSENERVLASVEALKNNDFEKFGQLMIESHQSLRDDYEVSCRELD
CLVDVALKQEGVLGARMTGAGFGGCTVNLVDINYVEVFIKGIKEGYKRETGIEPEIYVSRPAEGARRLEVDRDGGNPGKE
GKNR

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503895, Length=372, Percent_Identity=43.5483870967742, Blast_Score=291, Evalue=1e-78,
Organism=Homo sapiens, GI4503897, Length=454, Percent_Identity=31.7180616740088, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI48527957, Length=454, Percent_Identity=31.7180616740088, Blast_Score=139, Evalue=6e-33,
Organism=Escherichia coli, GI1786972, Length=390, Percent_Identity=42.5641025641026, Blast_Score=310, Evalue=2e-85,
Organism=Caenorhabditis elegans, GI71989053, Length=439, Percent_Identity=30.2961275626424, Blast_Score=129, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6319494, Length=278, Percent_Identity=27.3381294964029, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6320212, Length=271, Percent_Identity=26.5682656826568, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24661292, Length=431, Percent_Identity=28.3062645011601, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI21355577, Length=431, Percent_Identity=28.3062645011601, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24661285, Length=431, Percent_Identity=28.3062645011601, Blast_Score=112, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.6 [H]

Molecular weight: Translated: 45576; Mature: 45576

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS00106 GALACTOKINASE ; PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSVDELWEFFENRYGDNGLKKGSYSAPGRVNLIGEHTDYNDGFVLPMAIEKNVTMLGQL
CCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEEECCCCHHHHHH
RHDRKIKVYSLDYDTELCFNLDKLEKDEEHTWVNYVMGVADEIEKKGHKLKGMNLVFTGN
CCCCEEEEEEECCCCHHHCCHHHHCCCCCHHHHHHHHHHHHHHHHCCCEECCCEEEEECC
VPQGSGLSSSAALEVVTAMTMADLNELDIDPVEMALLCQAAENNFVGVACGIMDQYISRL
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEEEEHHHHHHHHHHH
GHRDHALLIDCRTNEYELIPFKDKRYRIVICNSKARRGLVDSEYNTRRSECNQAVAFFNE
CCCCCEEEEEECCCCEEEEEECCCCEEEEEECCHHHCCCCCCCCCCHHHHHHHHHHHHHH
KLGRNITALRDVKLNEVGQYRGELSDSVYRRAHHVVSENERVLASVEALKNNDFEKFGQL
HHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHH
MIESHQSLRDDYEVSCRELDCLVDVALKQEGVLGARMTGAGFGGCTVNLVDINYVEVFIK
HHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCEEEEEECHHHHHHHH
GIKEGYKRETGIEPEIYVSRPAEGARRLEVDRDGGNPGKEGKNR
HHHHHHHHCCCCCCEEEEECCCCCCCEEEEECCCCCCCCCCCCC
>Mature Secondary Structure
MKSVDELWEFFENRYGDNGLKKGSYSAPGRVNLIGEHTDYNDGFVLPMAIEKNVTMLGQL
CCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEEECCCCHHHHHH
RHDRKIKVYSLDYDTELCFNLDKLEKDEEHTWVNYVMGVADEIEKKGHKLKGMNLVFTGN
CCCCEEEEEEECCCCHHHCCHHHHCCCCCHHHHHHHHHHHHHHHHCCCEECCCEEEEECC
VPQGSGLSSSAALEVVTAMTMADLNELDIDPVEMALLCQAAENNFVGVACGIMDQYISRL
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEEEEHHHHHHHHHHH
GHRDHALLIDCRTNEYELIPFKDKRYRIVICNSKARRGLVDSEYNTRRSECNQAVAFFNE
CCCCCEEEEEECCCCEEEEEECCCCEEEEEECCHHHCCCCCCCCCCHHHHHHHHHHHHHH
KLGRNITALRDVKLNEVGQYRGELSDSVYRRAHHVVSENERVLASVEALKNNDFEKFGQL
HHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHH
MIESHQSLRDDYEVSCRELDCLVDVALKQEGVLGARMTGAGFGGCTVNLVDINYVEVFIK
HHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCEEEEEECHHHHHHHH
GIKEGYKRETGIEPEIYVSRPAEGARRLEVDRDGGNPGKEGKNR
HHHHHHHHCCCCCCEEEEECCCCCCCEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]