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The map label for this gene is atpA

Identifier: 220932774

GI number: 220932774

Start: 2078198

End: 2079970

Strand: Reverse

Name: atpA

Synonym: Hore_19400

Alternate gene names: 220932774

Gene position: 2079970-2078198 (Counterclockwise)

Preceding gene: 220932775

Following gene: 220932773

Centisome position: 80.68

GC content: 46.19

Gene sequence:

>1773_bases
GTGGATAAAAAGGGTGAAATAGTATTTGTCAATGGGCCTGTAGTAAAGGCCGATAAGATGAATGGTTTTATCATGAATGA
GCTTGTTTATGTCGGAAAAGAAAGGCTCATTGGAGAGATAATTGAACTTGAGGGTGACCTGGCCACAATTCAGGTTTATG
AAGAGACAACAGAGATGCAACCGGGTGAGCCGGTTTTTTCTACAGGCAGCCCGTTATCGGTGGAACTGGGACCGGGGATA
ATCGGAAATATATTTGATGGTATTCAAAGGCCTTTACCGGTTATTGCCGAAAAAACAGGTTCCTTTATAAAAAGAGGGAT
TGAGGTTAACCCCCTGGATCGGGACCGGGAATGGACAGTATCTGTTAAGGTAAAACTTGGTGACAGGGTTAAACCTGGCC
AGGTAGTTGCTGAAGTACCGGAAACCAGTATTGTTACTCACCGGGTTATGGTTCCCCCTCATCTGTCAGGAGAGGTGGTT
GAGGTTGTTCCCAATGGTAAATATACTGTGGATCAGGAAATTGTAACTGTAAAAGATGATAAGGGGAATAACCACCAGAT
TCGACTCCATCAGAAATGGCCGGTCAGGCGGCCAAGGCCCTGTGGAGAGCGCTTACCGATCAAAAAACCCCTCCTTACCG
GTCAGAGGGTATTTGATACCTTCTTCCCCCTGGGGATGGGGGGAACAGCTGCTATCCCCGGAGGATTCGGGGCCGGAAAA
ACCATGACCCAGCACCAGCTGGCCAAATGGTCCAGTGCCGATATAATTGTTTATGTGGGGTGTGGGGAACGCGGTAATGA
GATGACGGATGTTCTGGAGGAGTTCCCCAAACTGGAAGACCCTTCAACCGGGAAATCGATGATGGAGAGAACGGTTTTAA
TTGCCAACACTTCCAATATGCCGGTTGCGGCAAGGGAGGCCAGTATTTATACCGGCATTACTATAGCCGAGTTCTACCGG
GATATGGGCTATAATGTGGCCCTGATGGCAGATTCGACATCACGCTGGGCCGAAGCTTTAAGGGAAATATCCGGACGTCT
GGAAGAAATGCCTGCTGAAGAAGGTTTTCCAGCCTATCTTCCAAGCCGGTTAGCCGAGTTTTATGAAAGGGCCGGTTACG
TAAAAACCCTGGGGCAGGACAGGGAGGGTTCTATCTCACTGATCGGGGCTGTTTCTCCACCTGGTGGTGATTTTTCAGAA
CCGGTTACCCAGAATACCAAACGTTATGTTCGCTGTTTCTGGGCTCTGGATAAGAGTCTGGCCAGTGCCCGGCATTTCCC
GGCTGTTAACTGGCTGGAAAGCTATAGTGAATACCTGGAGGATCTTTCAGGCTGGTTGAAGGAAAATATAAACGAGGACT
GGATTAAATTAAGGAATATGGCCATGGAGCTTTTGAAGGAAGAAGACCGGCTCCAGGAGATTGTCAAACTGGTTGGTGAA
GATGTCCTGCCCGATAACCAGCGCCTTATTCTTGAGGTTGCCAGATTGATTAAGATTGGTTTTCTCCAGCAGAATGCCTT
CAGTAAAGTAGACCGGTTCGCCACTCCGGAAAAGCAGTACTGGATGTTAAAAATTATTATGTTCCTATATGAAAAGGCCA
GACCTTTAATTAAAAACAATATTCCGATAAGCCGGGTTAAGAATAATGAACTATTCAGTGAAGTTATAAAAATGAAAGAG
AATATTCCCAATGGTGATTTAGATAAATTCAAGGATTTAATGGCCAGGATTGAAGAATATTACAACAGACTATGGGAAAA
TTATCAGGAGTAG

Upstream 100 bases:

>100_bases
AGTTGAAAATACTTTTGAGACTTGTCTTGAGGAAGTTAAAGAAGACATTGCCGTAGAATTACATTCCAAGGTATTATGAT
TGAAGGCAGGTGATGATATA

Downstream 100 bases:

>100_bases
TGAGGTTGATAGCCATGTTAACAAAAGAGTACCGTGGAGTAGCATCAATAAATGGACCTCTGGTGGTAGTTGATGGTGTT
ACCGATGTAGGGTTTGACGA

Product: V-type ATP synthase subunit A

Products: NA

Alternate protein names: V-ATPase subunit A

Number of amino acids: Translated: 590; Mature: 590

Protein sequence:

>590_residues
MDKKGEIVFVNGPVVKADKMNGFIMNELVYVGKERLIGEIIELEGDLATIQVYEETTEMQPGEPVFSTGSPLSVELGPGI
IGNIFDGIQRPLPVIAEKTGSFIKRGIEVNPLDRDREWTVSVKVKLGDRVKPGQVVAEVPETSIVTHRVMVPPHLSGEVV
EVVPNGKYTVDQEIVTVKDDKGNNHQIRLHQKWPVRRPRPCGERLPIKKPLLTGQRVFDTFFPLGMGGTAAIPGGFGAGK
TMTQHQLAKWSSADIIVYVGCGERGNEMTDVLEEFPKLEDPSTGKSMMERTVLIANTSNMPVAAREASIYTGITIAEFYR
DMGYNVALMADSTSRWAEALREISGRLEEMPAEEGFPAYLPSRLAEFYERAGYVKTLGQDREGSISLIGAVSPPGGDFSE
PVTQNTKRYVRCFWALDKSLASARHFPAVNWLESYSEYLEDLSGWLKENINEDWIKLRNMAMELLKEEDRLQEIVKLVGE
DVLPDNQRLILEVARLIKIGFLQQNAFSKVDRFATPEKQYWMLKIIMFLYEKARPLIKNNIPISRVKNNELFSEVIKMKE
NIPNGDLDKFKDLMARIEEYYNRLWENYQE

Sequences:

>Translated_590_residues
MDKKGEIVFVNGPVVKADKMNGFIMNELVYVGKERLIGEIIELEGDLATIQVYEETTEMQPGEPVFSTGSPLSVELGPGI
IGNIFDGIQRPLPVIAEKTGSFIKRGIEVNPLDRDREWTVSVKVKLGDRVKPGQVVAEVPETSIVTHRVMVPPHLSGEVV
EVVPNGKYTVDQEIVTVKDDKGNNHQIRLHQKWPVRRPRPCGERLPIKKPLLTGQRVFDTFFPLGMGGTAAIPGGFGAGK
TMTQHQLAKWSSADIIVYVGCGERGNEMTDVLEEFPKLEDPSTGKSMMERTVLIANTSNMPVAAREASIYTGITIAEFYR
DMGYNVALMADSTSRWAEALREISGRLEEMPAEEGFPAYLPSRLAEFYERAGYVKTLGQDREGSISLIGAVSPPGGDFSE
PVTQNTKRYVRCFWALDKSLASARHFPAVNWLESYSEYLEDLSGWLKENINEDWIKLRNMAMELLKEEDRLQEIVKLVGE
DVLPDNQRLILEVARLIKIGFLQQNAFSKVDRFATPEKQYWMLKIIMFLYEKARPLIKNNIPISRVKNNELFSEVIKMKE
NIPNGDLDKFKDLMARIEEYYNRLWENYQE
>Mature_590_residues
MDKKGEIVFVNGPVVKADKMNGFIMNELVYVGKERLIGEIIELEGDLATIQVYEETTEMQPGEPVFSTGSPLSVELGPGI
IGNIFDGIQRPLPVIAEKTGSFIKRGIEVNPLDRDREWTVSVKVKLGDRVKPGQVVAEVPETSIVTHRVMVPPHLSGEVV
EVVPNGKYTVDQEIVTVKDDKGNNHQIRLHQKWPVRRPRPCGERLPIKKPLLTGQRVFDTFFPLGMGGTAAIPGGFGAGK
TMTQHQLAKWSSADIIVYVGCGERGNEMTDVLEEFPKLEDPSTGKSMMERTVLIANTSNMPVAAREASIYTGITIAEFYR
DMGYNVALMADSTSRWAEALREISGRLEEMPAEEGFPAYLPSRLAEFYERAGYVKTLGQDREGSISLIGAVSPPGGDFSE
PVTQNTKRYVRCFWALDKSLASARHFPAVNWLESYSEYLEDLSGWLKENINEDWIKLRNMAMELLKEEDRLQEIVKLVGE
DVLPDNQRLILEVARLIKIGFLQQNAFSKVDRFATPEKQYWMLKIIMFLYEKARPLIKNNIPISRVKNNELFSEVIKMKE
NIPNGDLDKFKDLMARIEEYYNRLWENYQE

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit

COG id: COG1155

COG function: function code C; Archaeal/vacuolar-type H+-ATPase subunit A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family

Homologues:

Organism=Homo sapiens, GI19913424, Length=599, Percent_Identity=51.085141903172, Blast_Score=581, Evalue=1e-166,
Organism=Homo sapiens, GI32189394, Length=348, Percent_Identity=25.2873563218391, Blast_Score=107, Evalue=4e-23,
Organism=Homo sapiens, GI19913428, Length=240, Percent_Identity=28.3333333333333, Blast_Score=93, Evalue=7e-19,
Organism=Homo sapiens, GI19913426, Length=241, Percent_Identity=27.8008298755187, Blast_Score=88, Evalue=3e-17,
Organism=Homo sapiens, GI50345984, Length=296, Percent_Identity=24.3243243243243, Blast_Score=66, Evalue=7e-11,
Organism=Homo sapiens, GI4757810, Length=296, Percent_Identity=24.3243243243243, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI1790170, Length=366, Percent_Identity=27.8688524590164, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI1788251, Length=310, Percent_Identity=28.0645161290323, Blast_Score=101, Evalue=2e-22,
Organism=Escherichia coli, GI1790172, Length=354, Percent_Identity=25.7062146892655, Blast_Score=82, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17565854, Length=594, Percent_Identity=51.5151515151515, Blast_Score=588, Evalue=1e-168,
Organism=Caenorhabditis elegans, GI25144756, Length=319, Percent_Identity=26.3322884012539, Blast_Score=106, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17510931, Length=221, Percent_Identity=30.7692307692308, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17570191, Length=240, Percent_Identity=28.75, Blast_Score=94, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71988080, Length=275, Percent_Identity=25.4545454545455, Blast_Score=68, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71988063, Length=275, Percent_Identity=25.4545454545455, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71988074, Length=244, Percent_Identity=25.8196721311475, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320016, Length=314, Percent_Identity=49.0445859872611, Blast_Score=298, Evalue=1e-81,
Organism=Saccharomyces cerevisiae, GI6322581, Length=350, Percent_Identity=26.8571428571429, Blast_Score=109, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6319603, Length=240, Percent_Identity=27.0833333333333, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319370, Length=298, Percent_Identity=24.8322147651007, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24583988, Length=601, Percent_Identity=50.9151414309484, Blast_Score=581, Evalue=1e-166,
Organism=Drosophila melanogaster, GI24583986, Length=601, Percent_Identity=50.9151414309484, Blast_Score=581, Evalue=1e-166,
Organism=Drosophila melanogaster, GI24583984, Length=601, Percent_Identity=50.9151414309484, Blast_Score=581, Evalue=1e-166,
Organism=Drosophila melanogaster, GI20129479, Length=570, Percent_Identity=52.4561403508772, Blast_Score=577, Evalue=1e-164,
Organism=Drosophila melanogaster, GI24583992, Length=599, Percent_Identity=50.5843071786311, Blast_Score=574, Evalue=1e-164,
Organism=Drosophila melanogaster, GI28574560, Length=303, Percent_Identity=30.03300330033, Blast_Score=116, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24638766, Length=298, Percent_Identity=27.5167785234899, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI281361666, Length=240, Percent_Identity=28.75, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24646341, Length=240, Percent_Identity=28.75, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17136796, Length=240, Percent_Identity=28.75, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24658560, Length=297, Percent_Identity=24.2424242424242, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: 10836 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 8,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): VATA_HALOH (B8CZG8)

Other databases:

- EMBL:   CP001098
- RefSeq:   YP_002509682.1
- GeneID:   7312755
- GenomeReviews:   CP001098_GR
- KEGG:   hor:Hore_19400
- HOGENOM:   HBG288114
- OMA:   SMGKISY
- ProtClustDB:   PRK04192
- HAMAP:   MF_00309
- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100
- InterPro:   IPR022878

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N; SSF47917 ATPase_a/b_C; SSF50615 ATPase_a/b_N

EC number: =3.6.3.14

Molecular weight: Translated: 66713; Mature: 66713

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKKGEIVFVNGPVVKADKMNGFIMNELVYVGKERLIGEIIELEGDLATIQVYEETTEMQ
CCCCCCEEEECCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEHHHCCC
PGEPVFSTGSPLSVELGPGIIGNIFDGIQRPLPVIAEKTGSFIKRGIEVNPLDRDREWTV
CCCCCCCCCCCEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEE
SVKVKLGDRVKPGQVVAEVPETSIVTHRVMVPPHLSGEVVEVVPNGKYTVDQEIVTVKDD
EEEEEECCCCCCCCCEECCCCCHHEEEEEECCCCCCCCEEEEECCCCEEECCEEEEEECC
KGNNHQIRLHQKWPVRRPRPCGERLPIKKPLLTGQRVFDTFFPLGMGGTAAIPGGFGAGK
CCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCC
TMTQHQLAKWSSADIIVYVGCGERGNEMTDVLEEFPKLEDPSTGKSMMERTVLIANTSNM
CHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHCCCCCCCCCCHHHHHCEEEEEECCCC
PVAAREASIYTGITIAEFYRDMGYNVALMADSTSRWAEALREISGRLEEMPAEEGFPAYL
CEEECCCHHCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCHHH
PSRLAEFYERAGYVKTLGQDREGSISLIGAVSPPGGDFSEPVTQNTKRYVRCFWALDKSL
HHHHHHHHHHCCHHHHCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
ASARHFPAVNWLESYSEYLEDLSGWLKENINEDWIKLRNMAMELLKEEDRLQEIVKLVGE
HHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DVLPDNQRLILEVARLIKIGFLQQNAFSKVDRFATPEKQYWMLKIIMFLYEKARPLIKNN
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHCC
IPISRVKNNELFSEVIKMKENIPNGDLDKFKDLMARIEEYYNRLWENYQE
CCHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDKKGEIVFVNGPVVKADKMNGFIMNELVYVGKERLIGEIIELEGDLATIQVYEETTEMQ
CCCCCCEEEECCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEHHHCCC
PGEPVFSTGSPLSVELGPGIIGNIFDGIQRPLPVIAEKTGSFIKRGIEVNPLDRDREWTV
CCCCCCCCCCCEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEE
SVKVKLGDRVKPGQVVAEVPETSIVTHRVMVPPHLSGEVVEVVPNGKYTVDQEIVTVKDD
EEEEEECCCCCCCCCEECCCCCHHEEEEEECCCCCCCCEEEEECCCCEEECCEEEEEECC
KGNNHQIRLHQKWPVRRPRPCGERLPIKKPLLTGQRVFDTFFPLGMGGTAAIPGGFGAGK
CCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCC
TMTQHQLAKWSSADIIVYVGCGERGNEMTDVLEEFPKLEDPSTGKSMMERTVLIANTSNM
CHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHCCCCCCCCCCHHHHHCEEEEEECCCC
PVAAREASIYTGITIAEFYRDMGYNVALMADSTSRWAEALREISGRLEEMPAEEGFPAYL
CEEECCCHHCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCHHH
PSRLAEFYERAGYVKTLGQDREGSISLIGAVSPPGGDFSEPVTQNTKRYVRCFWALDKSL
HHHHHHHHHHCCHHHHCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
ASARHFPAVNWLESYSEYLEDLSGWLKENINEDWIKLRNMAMELLKEEDRLQEIVKLVGE
HHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DVLPDNQRLILEVARLIKIGFLQQNAFSKVDRFATPEKQYWMLKIIMFLYEKARPLIKNN
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHCC
IPISRVKNNELFSEVIKMKENIPNGDLDKFKDLMARIEEYYNRLWENYQE
CCHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA