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The map label for this gene is comE [H]

Identifier: 220932698

GI number: 220932698

Start: 1990847

End: 1992655

Strand: Reverse

Name: comE [H]

Synonym: Hore_18620

Alternate gene names: 220932698

Gene position: 1992655-1990847 (Counterclockwise)

Preceding gene: 220932699

Following gene: 220932697

Centisome position: 77.29

GC content: 41.13

Gene sequence:

>1809_bases
ATGTTCAGAAAGGTGAAGGTGTTTCCGGTGTTTAAGTTAAATAAAAAACAATCAAATTATATTACCCGGGTTTTTGGAGT
AGCCTTAACAGTTTTGTTAATTGTTACATCTACTGTGAGTGCTGAAGAGTTGGTTGATGTGACCGTCAGGGGGGCGGATA
TCAGGGATGTTCTCCTGATGCTTACTGAACAGAGTGGGATAAACCTGGTTCCCGATGAAACAGTTCAGGGGGAGGTTACC
ATAAATTTAAGGGATGTTGACCTCCAGGAAGCCCTAAAGACATTAACCATGGCCTATGGATATCATTTTGAAAAGGTGTC
AGAAAATGTTTATCTGGTAAGTCGGGATAAGTTAGAGGCCCCGGTTGATGTCAGGGTTAAAGATGGGTTTTTGACAGTTC
ACGCCACCAATGCTAATCTAAGAACTCTTTTGAGAGAAATTGCAGATAAAGCCAGTATTAATATTGTTATGGATGATTCA
GTTTCCGGGAAAATTTCTATAGACCTTGAGAATATACCACTGGAAGTGGGGTTAATAAACCTGCTTCATGTTAATGGATT
TTCTCTCAGTAAAAGTAATAGTGTCTACCGAATTTTTAAGGCTGATAATAATACAGGTAATAATCTGGCTATTTCTGTGG
TTGATAACAGGGTAAGTATGGATGTCAGCCAGGCAAATCTTGGTGATGTGTTGCGGACCCTGGCCAGATTAGGAGACCTT
GACATGGTATTATTTGGTGGAGTCAGGGATATAGTTGATTTAAAGCTTGAAGATATATCTCTGGATGAAGCCATTGAAAT
TATTCTGGCCGGAACCCGGTATACTTATCGTAAAGTTGACGGGGTGTATTTAATTGGTGATAAAAATATAAACAGCCCTG
CTTCTGACCTTTTGACCACCAGTGAGCTGATTCCCATGGAATATATAGAGGTGGAAAAAGTCCCGCAGTTATTACCAAAT
AATTTTCCTGCGGCCAATGTGAAGGTTTTGAAGGAAAAAAATGCCCTACTGGTAACTGGAACCCAGTCAGATATTAATAA
GCTAAAAGAGTATATTAAACAAATAGATACCAGGATTCCCCTGATAGTTGTTGAGGCTGTGGTAGTTGAATTGACCCGGA
ACCGCCAGGAAAACCCGGTTATAAAACTGGGAATGGAATATGACGGTGAAGAGGAACTCTTATTTGATACCTCTATGGGA
AAACTTACTTATAAGTCTGTTCTTGATTTACCTGATGACTTTTATTTAAAGATTGAGGCTCTGGTGACTGAAGGGTTACT
TACGGTAAAGGCCCGTCCCAATATAACAACTCTTAACGGCCAGCAGGCTATGATCGACGTGGGTACCGTCCAGTATTATA
AGGTTAAGCAAACTGATGGAGAAGGTAATGAGGAAACCCAGTACCAGAGTATAAATGCCGGAGTATCGTTGACCGTTACC
CCCTGGGTCAGTAGCTCCGGGGAAATCACCCTGAAGTTAAGACCACAGGTAAGTAACATTGGGGCAGCTGCTGCAGAGGG
CCCCCCACAGGTCAGCAGACGTGAAGTGGATACTACTGTAAGGGTAAAAGACGGCCAGACCGTGGTTATCGGGGGGTTGA
TTCAGGATGTGGGGACAAATACAACTTCAAAAGTACCATTTCTGGCCAACATACCCCTGATTGGAAAATTATTTAAATCA
CGTAATAATAATGTTAACCAGACAGAGTTAATTATCTTTATAACCCCAAGGGTCTTAAAAGTTAATGAGGAGGAAGTTAA
GAGCAAAATGAAAAAGATGCTTGAAAAGTCCAGAGAACAGTTACAGTAA

Upstream 100 bases:

>100_bases
TATCTGGTTCAGGCACTCAGTATAAAAGGTGATGTCAGTACCAGCTTTCTTACTTTTAATCTTGTAATTCAGGTTATATT
TTTTGAAGATGGGATAGAAA

Downstream 100 bases:

>100_bases
AAATATATAAAGGAAGTTGAGTAACACCCCCGGGTTTGTCCCGGGGTGTTTTTATGTAAAATGGAGAAAAATGGAGGTAA
ATGTCAGAAAAAATAGTAAA

Product: type II and III secretion system protein

Products: NA

Alternate protein names: DNA transformation protein ComE [H]

Number of amino acids: Translated: 602; Mature: 602

Protein sequence:

>602_residues
MFRKVKVFPVFKLNKKQSNYITRVFGVALTVLLIVTSTVSAEELVDVTVRGADIRDVLLMLTEQSGINLVPDETVQGEVT
INLRDVDLQEALKTLTMAYGYHFEKVSENVYLVSRDKLEAPVDVRVKDGFLTVHATNANLRTLLREIADKASINIVMDDS
VSGKISIDLENIPLEVGLINLLHVNGFSLSKSNSVYRIFKADNNTGNNLAISVVDNRVSMDVSQANLGDVLRTLARLGDL
DMVLFGGVRDIVDLKLEDISLDEAIEIILAGTRYTYRKVDGVYLIGDKNINSPASDLLTTSELIPMEYIEVEKVPQLLPN
NFPAANVKVLKEKNALLVTGTQSDINKLKEYIKQIDTRIPLIVVEAVVVELTRNRQENPVIKLGMEYDGEEELLFDTSMG
KLTYKSVLDLPDDFYLKIEALVTEGLLTVKARPNITTLNGQQAMIDVGTVQYYKVKQTDGEGNEETQYQSINAGVSLTVT
PWVSSSGEITLKLRPQVSNIGAAAAEGPPQVSRREVDTTVRVKDGQTVVIGGLIQDVGTNTTSKVPFLANIPLIGKLFKS
RNNNVNQTELIIFITPRVLKVNEEEVKSKMKKMLEKSREQLQ

Sequences:

>Translated_602_residues
MFRKVKVFPVFKLNKKQSNYITRVFGVALTVLLIVTSTVSAEELVDVTVRGADIRDVLLMLTEQSGINLVPDETVQGEVT
INLRDVDLQEALKTLTMAYGYHFEKVSENVYLVSRDKLEAPVDVRVKDGFLTVHATNANLRTLLREIADKASINIVMDDS
VSGKISIDLENIPLEVGLINLLHVNGFSLSKSNSVYRIFKADNNTGNNLAISVVDNRVSMDVSQANLGDVLRTLARLGDL
DMVLFGGVRDIVDLKLEDISLDEAIEIILAGTRYTYRKVDGVYLIGDKNINSPASDLLTTSELIPMEYIEVEKVPQLLPN
NFPAANVKVLKEKNALLVTGTQSDINKLKEYIKQIDTRIPLIVVEAVVVELTRNRQENPVIKLGMEYDGEEELLFDTSMG
KLTYKSVLDLPDDFYLKIEALVTEGLLTVKARPNITTLNGQQAMIDVGTVQYYKVKQTDGEGNEETQYQSINAGVSLTVT
PWVSSSGEITLKLRPQVSNIGAAAAEGPPQVSRREVDTTVRVKDGQTVVIGGLIQDVGTNTTSKVPFLANIPLIGKLFKS
RNNNVNQTELIIFITPRVLKVNEEEVKSKMKKMLEKSREQLQ
>Mature_602_residues
MFRKVKVFPVFKLNKKQSNYITRVFGVALTVLLIVTSTVSAEELVDVTVRGADIRDVLLMLTEQSGINLVPDETVQGEVT
INLRDVDLQEALKTLTMAYGYHFEKVSENVYLVSRDKLEAPVDVRVKDGFLTVHATNANLRTLLREIADKASINIVMDDS
VSGKISIDLENIPLEVGLINLLHVNGFSLSKSNSVYRIFKADNNTGNNLAISVVDNRVSMDVSQANLGDVLRTLARLGDL
DMVLFGGVRDIVDLKLEDISLDEAIEIILAGTRYTYRKVDGVYLIGDKNINSPASDLLTTSELIPMEYIEVEKVPQLLPN
NFPAANVKVLKEKNALLVTGTQSDINKLKEYIKQIDTRIPLIVVEAVVVELTRNRQENPVIKLGMEYDGEEELLFDTSMG
KLTYKSVLDLPDDFYLKIEALVTEGLLTVKARPNITTLNGQQAMIDVGTVQYYKVKQTDGEGNEETQYQSINAGVSLTVT
PWVSSSGEITLKLRPQVSNIGAAAAEGPPQVSRREVDTTVRVKDGQTVVIGGLIQDVGTNTTSKVPFLANIPLIGKLFKS
RNNNVNQTELIIFITPRVLKVNEEEVKSKMKKMLEKSREQLQ

Specific function: Involved in transformation (competence for DNA uptake) [H]

COG id: COG4796

COG function: function code U; Type II secretory pathway, component HofQ

Gene ontology:

Cell location: Cell outer membrane (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GSP D family [H]

Homologues:

Organism=Escherichia coli, GI87082242, Length=305, Percent_Identity=26.2295081967213, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI1789793, Length=395, Percent_Identity=23.2911392405063, Blast_Score=77, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001775
- InterPro:   IPR005644
- InterPro:   IPR013355
- InterPro:   IPR004846
- InterPro:   IPR004845
- InterPro:   IPR001814 [H]

Pfam domain/function: PF00263 Secretin; PF03958 Secretin_N [H]

EC number: NA

Molecular weight: Translated: 66726; Mature: 66726

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00875 T2SP_D

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRKVKVFPVFKLNKKQSNYITRVFGVALTVLLIVTSTVSAEELVDVTVRGADIRDVLLM
CCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCHHHEEEEEECCCCHHHHHHE
LTEQSGINLVPDETVQGEVTINLRDVDLQEALKTLTMAYGYHFEKVSENVYLVSRDKLEA
EECCCCCEECCCCCCCEEEEEEEECCCHHHHHHHHHHHHCCCHHHHCCCEEEEECCCCCC
PVDVRVKDGFLTVHATNANLRTLLREIADKASINIVMDDSVSGKISIDLENIPLEVGLIN
CEEEEEECCEEEEEECCCHHHHHHHHHHCCCEEEEEEECCCCCEEEEEEECCCEEEEEEE
LLHVNGFSLSKSNSVYRIFKADNNTGNNLAISVVDNRVSMDVSQANLGDVLRTLARLGDL
EEEECCEEECCCCCEEEEEECCCCCCCEEEEEEECCCEEEEECCCCHHHHHHHHHHHCCC
DMVLFGGVRDIVDLKLEDISLDEAIEIILAGTRYTYRKVDGVYLIGDKNINSPASDLLTT
EEEEECCCCHHHEEEEECCCHHHEEEEEEECCCEEEEECCEEEEEECCCCCCCHHHHHHH
SELIPMEYIEVEKVPQLLPNNFPAANVKVLKEKNALLVTGTQSDINKLKEYIKQIDTRIP
HCCCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCEEEEECCHHHHHHHHHHHHHHCCCCC
LIVVEAVVVELTRNRQENPVIKLGMEYDGEEELLFDTSMGKLTYKSVLDLPDDFYLKIEA
HHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCEEEECCCCCEEHHHHHCCCCCCEEEEEE
LVTEGLLTVKARPNITTLNGQQAMIDVGTVQYYKVKQTDGEGNEETQYQSINAGVSLTVT
EEECCEEEEEECCCEEEECCCEEEEEECCEEEEEEEECCCCCCCCCCEEEECCCEEEEEE
PWVSSSGEITLKLRPQVSNIGAAAAEGPPQVSRREVDTTVRVKDGQTVVIGGLIQDVGTN
ECCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCEEEEEEEHHHCCCC
TTSKVPFLANIPLIGKLFKSRNNNVNQTELIIFITPRVLKVNEEEVKSKMKKMLEKSREQ
CCCCCCEEECCCHHHHHHHHCCCCCCCEEEEEEECCCEEECCHHHHHHHHHHHHHHHHHH
LQ
CC
>Mature Secondary Structure
MFRKVKVFPVFKLNKKQSNYITRVFGVALTVLLIVTSTVSAEELVDVTVRGADIRDVLLM
CCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCHHHEEEEEECCCCHHHHHHE
LTEQSGINLVPDETVQGEVTINLRDVDLQEALKTLTMAYGYHFEKVSENVYLVSRDKLEA
EECCCCCEECCCCCCCEEEEEEEECCCHHHHHHHHHHHHCCCHHHHCCCEEEEECCCCCC
PVDVRVKDGFLTVHATNANLRTLLREIADKASINIVMDDSVSGKISIDLENIPLEVGLIN
CEEEEEECCEEEEEECCCHHHHHHHHHHCCCEEEEEEECCCCCEEEEEEECCCEEEEEEE
LLHVNGFSLSKSNSVYRIFKADNNTGNNLAISVVDNRVSMDVSQANLGDVLRTLARLGDL
EEEECCEEECCCCCEEEEEECCCCCCCEEEEEEECCCEEEEECCCCHHHHHHHHHHHCCC
DMVLFGGVRDIVDLKLEDISLDEAIEIILAGTRYTYRKVDGVYLIGDKNINSPASDLLTT
EEEEECCCCHHHEEEEECCCHHHEEEEEEECCCEEEEECCEEEEEECCCCCCCHHHHHHH
SELIPMEYIEVEKVPQLLPNNFPAANVKVLKEKNALLVTGTQSDINKLKEYIKQIDTRIP
HCCCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCEEEEECCHHHHHHHHHHHHHHCCCCC
LIVVEAVVVELTRNRQENPVIKLGMEYDGEEELLFDTSMGKLTYKSVLDLPDDFYLKIEA
HHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCEEEECCCCCEEHHHHHCCCCCCEEEEEE
LVTEGLLTVKARPNITTLNGQQAMIDVGTVQYYKVKQTDGEGNEETQYQSINAGVSLTVT
EEECCEEEEEECCCEEEECCCEEEEEECCEEEEEEEECCCCCCCCCCEEEECCCEEEEEE
PWVSSSGEITLKLRPQVSNIGAAAAEGPPQVSRREVDTTVRVKDGQTVVIGGLIQDVGTN
ECCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCEEEEEEEHHHCCCC
TTSKVPFLANIPLIGKLFKSRNNNVNQTELIIFITPRVLKVNEEEVKSKMKKMLEKSREQ
CCCCCCEEECCCHHHHHHHHCCCCCCCEEEEEEECCCEEECCHHHHHHHHHHHHHHHHHH
LQ
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1916268; 7542800; 1856167 [H]