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The map label for this gene is pyrG [H]

Identifier: 220932642

GI number: 220932642

Start: 1929277

End: 1930884

Strand: Reverse

Name: pyrG [H]

Synonym: Hore_18060

Alternate gene names: 220932642

Gene position: 1930884-1929277 (Counterclockwise)

Preceding gene: 220932643

Following gene: 220932641

Centisome position: 74.89

GC content: 44.71

Gene sequence:

>1608_bases
ATGACAAAATATATTTTTGTTACCGGGGGGGTAGTATCTGCCCTCGGTAAAGGGATAACGGCTGCCTCCCTGGGGAGGTT
ATTGAAGAGCAGGGGTCTAAAAGTCAGTATTCAGAAATTTGATCCTTATATAAATGTGGACCCCGGTACCATGAGTCCAT
ACCAGCATGGAGAGGTTTTTGTTACTGATGATGGTGCAGAAACCGACCTGGACCTGGGCCATTATGAAAGGTTTATCGAT
GTTAACCTGAGTCAGAACAATAATGTAACCACAGGACAGATCTATGGATCGGTTATCCGCAAAGAACGGAAAGGTGAGTA
CCTGGGAGCAACCGTTCAGGTAATCCCCCATATCACCGATGAAATCAAATCAAGAATTACCCGGGTAGGCCGGGAAACCG
ATGCCGATGTAGTTATTACCGAAATCGGGGGAACAGTTGGTGATATCGAAAGTCTACCCTTTATTGAAGCCATCAGGCAA
TTGAAGAGTGATCTCGGCAAGGAGAATGTATTTTACCTTCACTGTACCCTTGTTCCCTATCTGCCAACTGCCGGGGAGTT
AAAGACAAAGCCTACCCAGCACAGTATAAAGGAATTGAGGGGTATCGGTATTCAGCCTGATGCGATAGTATGCCGCTCTG
ACCGTAAGCTTACCCAGGATGTCAAGGATAAAATAGCCCTGTTTGGTGATATTGATAAGAGGGCCGTTATCCAGGCCGTG
GATGCCAAAAATATTTATGAAGTCCCCCTTAAGTTTGAAAAAGAGGGACTGGCCACAATCGTTATTGATAAACTGGGCCT
GGAAAATAAGGTTCATACCCCTGATCTCGAGGACTGGCAGGATATGGTCAACAAGATGAAACACCTTGATAACAGGGTCC
GGATTGCTATAGTTGGTAAATATGTTGAATTACCCGATGCCTATATAAGTATAAATGAGGCTTTCAGGCATGCCGGGGTT
GCCAATAATGCTGAAGTAGAGGTTAAATGGGTTTATGCCGAAGACCTGGAAGGAGATAGTTCCCCTGAAGAATACCTTGA
CGATGTGGATGGAATCCTGGTACCCGGTGGTTTTGGAGACCGGGGAATTGAGGGAAAGATAAAAGCCATTACCTATGCCC
GGGAAAAGGGTATTCCTTTCTTCGGAATCTGTCTGGGTATGCAATGTGCTGTCATCGAGTTTTCCAGAAATGTAGCCGGT
TATAAAGGGGCCAATAGTTCTGAATTTGATCTTGATACCGATCACCCCGTTATCGATCTTATGCCTGAGCAGAAAGAGAT
AGAGGATAAGGGAGGAACTATGCGTCTGGGTATTTACCCCTGTAAGCTTAGCTCCGGTACCAAAAGTTATGAAGCTTATC
AGGATGAAATAATATATGAAAGACATCGCCATCGCTATGAGTTTAACAATGAATATAGAAATGAGTTAATAGAAAAAGGT
CTGATTCTGGCCGGACTTTCCCCTGACGAAAGGCTGGTAGAAATTGTAGAATTACCGGATCATCCCTGGTTTGTTGGTGT
ACAGTTCCACCCTGAATTTAAGAGCAGGCCCAATAGGCCTCATCCGCTTTTTGTAGGATTTATCAGGGCAGCACTGGAAG
AGAAATAA

Upstream 100 bases:

>100_bases
CCCTCCAAATCTGGCAGGGGTTGCAGGAATAATCGGTATATTTCTTGGTTTTACTCTGGTGAAGAATATTTTATAATTCA
GGAGGAGGGAATGAAGAAAT

Downstream 100 bases:

>100_bases
AATTAGACCAGTAAGTGGGGTGATACTATTAAAAGACAGTATTTTTTATTTGACCTGGACGGTACTCTATTACCCATTGA
TTTTGATATATTTTTAAAAA

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase [H]

Number of amino acids: Translated: 535; Mature: 534

Protein sequence:

>535_residues
MTKYIFVTGGVVSALGKGITAASLGRLLKSRGLKVSIQKFDPYINVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFID
VNLSQNNNVTTGQIYGSVIRKERKGEYLGATVQVIPHITDEIKSRITRVGRETDADVVITEIGGTVGDIESLPFIEAIRQ
LKSDLGKENVFYLHCTLVPYLPTAGELKTKPTQHSIKELRGIGIQPDAIVCRSDRKLTQDVKDKIALFGDIDKRAVIQAV
DAKNIYEVPLKFEKEGLATIVIDKLGLENKVHTPDLEDWQDMVNKMKHLDNRVRIAIVGKYVELPDAYISINEAFRHAGV
ANNAEVEVKWVYAEDLEGDSSPEEYLDDVDGILVPGGFGDRGIEGKIKAITYAREKGIPFFGICLGMQCAVIEFSRNVAG
YKGANSSEFDLDTDHPVIDLMPEQKEIEDKGGTMRLGIYPCKLSSGTKSYEAYQDEIIYERHRHRYEFNNEYRNELIEKG
LILAGLSPDERLVEIVELPDHPWFVGVQFHPEFKSRPNRPHPLFVGFIRAALEEK

Sequences:

>Translated_535_residues
MTKYIFVTGGVVSALGKGITAASLGRLLKSRGLKVSIQKFDPYINVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFID
VNLSQNNNVTTGQIYGSVIRKERKGEYLGATVQVIPHITDEIKSRITRVGRETDADVVITEIGGTVGDIESLPFIEAIRQ
LKSDLGKENVFYLHCTLVPYLPTAGELKTKPTQHSIKELRGIGIQPDAIVCRSDRKLTQDVKDKIALFGDIDKRAVIQAV
DAKNIYEVPLKFEKEGLATIVIDKLGLENKVHTPDLEDWQDMVNKMKHLDNRVRIAIVGKYVELPDAYISINEAFRHAGV
ANNAEVEVKWVYAEDLEGDSSPEEYLDDVDGILVPGGFGDRGIEGKIKAITYAREKGIPFFGICLGMQCAVIEFSRNVAG
YKGANSSEFDLDTDHPVIDLMPEQKEIEDKGGTMRLGIYPCKLSSGTKSYEAYQDEIIYERHRHRYEFNNEYRNELIEKG
LILAGLSPDERLVEIVELPDHPWFVGVQFHPEFKSRPNRPHPLFVGFIRAALEEK
>Mature_534_residues
TKYIFVTGGVVSALGKGITAASLGRLLKSRGLKVSIQKFDPYINVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFIDV
NLSQNNNVTTGQIYGSVIRKERKGEYLGATVQVIPHITDEIKSRITRVGRETDADVVITEIGGTVGDIESLPFIEAIRQL
KSDLGKENVFYLHCTLVPYLPTAGELKTKPTQHSIKELRGIGIQPDAIVCRSDRKLTQDVKDKIALFGDIDKRAVIQAVD
AKNIYEVPLKFEKEGLATIVIDKLGLENKVHTPDLEDWQDMVNKMKHLDNRVRIAIVGKYVELPDAYISINEAFRHAGVA
NNAEVEVKWVYAEDLEGDSSPEEYLDDVDGILVPGGFGDRGIEGKIKAITYAREKGIPFFGICLGMQCAVIEFSRNVAGY
KGANSSEFDLDTDHPVIDLMPEQKEIEDKGGTMRLGIYPCKLSSGTKSYEAYQDEIIYERHRHRYEFNNEYRNELIEKGL
ILAGLSPDERLVEIVELPDHPWFVGVQFHPEFKSRPNRPHPLFVGFIRAALEEK

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen [H]

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI148491070, Length=550, Percent_Identity=48.7272727272727, Blast_Score=508, Evalue=1e-144,
Organism=Homo sapiens, GI28559085, Length=547, Percent_Identity=45.1553930530165, Blast_Score=481, Evalue=1e-136,
Organism=Homo sapiens, GI28559083, Length=547, Percent_Identity=45.1553930530165, Blast_Score=481, Evalue=1e-136,
Organism=Homo sapiens, GI221316689, Length=547, Percent_Identity=45.1553930530165, Blast_Score=481, Evalue=1e-136,
Organism=Escherichia coli, GI1789142, Length=542, Percent_Identity=53.1365313653137, Blast_Score=567, Evalue=1e-163,
Organism=Caenorhabditis elegans, GI25148299, Length=604, Percent_Identity=39.7350993377483, Blast_Score=435, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6322563, Length=562, Percent_Identity=43.9501779359431, Blast_Score=465, Evalue=1e-132,
Organism=Saccharomyces cerevisiae, GI6319432, Length=558, Percent_Identity=43.3691756272401, Blast_Score=456, Evalue=1e-129,
Organism=Drosophila melanogaster, GI24664469, Length=549, Percent_Identity=47.3588342440801, Blast_Score=492, Evalue=1e-139,
Organism=Drosophila melanogaster, GI21357815, Length=495, Percent_Identity=45.2525252525253, Blast_Score=417, Evalue=1e-117,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase [H]

EC number: =6.3.4.2 [H]

Molecular weight: Translated: 59928; Mature: 59797

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKYIFVTGGVVSALGKGITAASLGRLLKSRGLKVSIQKFDPYINVDPGTMSPYQHGEVF
CCEEEEEECHHHHHHCCCCHHHHHHHHHHHCCCEEEEEECCCEEECCCCCCCCCCCCEEE
VTDDGAETDLDLGHYERFIDVNLSQNNNVTTGQIYGSVIRKERKGEYLGATVQVIPHITD
EECCCCCCCCCCCCCEEEEEEEECCCCCEEHHHHHHHHHHHHHCCCCCCCHHEEHHHHHH
EIKSRITRVGRETDADVVITEIGGTVGDIESLPFIEAIRQLKSDLGKENVFYLHCTLVPY
HHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEEEEC
LPTAGELKTKPTQHSIKELRGIGIQPDAIVCRSDRKLTQDVKDKIALFGDIDKRAVIQAV
CCCCCCCCCCCHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCHHHHHEEC
DAKNIYEVPLKFEKEGLATIVIDKLGLENKVHTPDLEDWQDMVNKMKHLDNRVRIAIVGK
CCCCEEECCCEECCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEE
YVELPDAYISINEAFRHAGVANNAEVEVKWVYAEDLEGDSSPEEYLDDVDGILVPGGFGD
EEECCCCEEEHHHHHHHCCCCCCCEEEEEEEEEECCCCCCCHHHHHHCCCCEEECCCCCC
RGIEGKIKAITYAREKGIPFFGICLGMQCAVIEFSRNVAGYKGANSSEFDLDTDHPVIDL
CCCCCEEEEEEEHHHCCCCEEEHHHCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEC
MPEQKEIEDKGGTMRLGIYPCKLSSGTKSYEAYQDEIIYERHRHRYEFNNEYRNELIEKG
CCCHHHHHCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCC
LILAGLSPDERLVEIVELPDHPWFVGVQFHPEFKSRPNRPHPLFVGFIRAALEEK
EEEECCCCHHHHHHHEECCCCCEEEEEEECCHHHCCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
TKYIFVTGGVVSALGKGITAASLGRLLKSRGLKVSIQKFDPYINVDPGTMSPYQHGEVF
CEEEEEECHHHHHHCCCCHHHHHHHHHHHCCCEEEEEECCCEEECCCCCCCCCCCCEEE
VTDDGAETDLDLGHYERFIDVNLSQNNNVTTGQIYGSVIRKERKGEYLGATVQVIPHITD
EECCCCCCCCCCCCCEEEEEEEECCCCCEEHHHHHHHHHHHHHCCCCCCCHHEEHHHHHH
EIKSRITRVGRETDADVVITEIGGTVGDIESLPFIEAIRQLKSDLGKENVFYLHCTLVPY
HHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEEEEC
LPTAGELKTKPTQHSIKELRGIGIQPDAIVCRSDRKLTQDVKDKIALFGDIDKRAVIQAV
CCCCCCCCCCCHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCHHHHHEEC
DAKNIYEVPLKFEKEGLATIVIDKLGLENKVHTPDLEDWQDMVNKMKHLDNRVRIAIVGK
CCCCEEECCCEECCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEE
YVELPDAYISINEAFRHAGVANNAEVEVKWVYAEDLEGDSSPEEYLDDVDGILVPGGFGD
EEECCCCEEEHHHHHHHCCCCCCCEEEEEEEEEECCCCCCCHHHHHHCCCCEEECCCCCC
RGIEGKIKAITYAREKGIPFFGICLGMQCAVIEFSRNVAGYKGANSSEFDLDTDHPVIDL
CCCCCEEEEEEEHHHCCCCEEEHHHCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEC
MPEQKEIEDKGGTMRLGIYPCKLSSGTKSYEAYQDEIIYERHRHRYEFNNEYRNELIEKG
CCCHHHHHCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCC
LILAGLSPDERLVEIVELPDHPWFVGVQFHPEFKSRPNRPHPLFVGFIRAALEEK
EEEECCCCHHHHHHHEECCCCCEEEEEEECCHHHCCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA