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The map label for this gene is fba [H]

Identifier: 220932638

GI number: 220932638

Start: 1926196

End: 1927050

Strand: Reverse

Name: fba [H]

Synonym: Hore_18020

Alternate gene names: 220932638

Gene position: 1927050-1926196 (Counterclockwise)

Preceding gene: 220932639

Following gene: 220932637

Centisome position: 74.75

GC content: 40.0

Gene sequence:

>855_bases
ATGAATTTAGTTCCAATGGCAGAGATACTCAAAAAAGCTAACAAAGAAGGCTATGCAGTTGGTGGGTTTAACATTAATAA
TCTGGAATTTTTACAGGGGATCATAGAAGCTGCTGAGGAGATGAATTCCCCACTTATTTTACAGACCAGTGAAGGTGCTA
TTAAATATATTGGTATTGATTATGTTATTGGTATGGTGGAAGCAGCCACCAAAAATACTACTATTCCGGTTGCGCTGCAC
CTGGACCATGGTAGCAGCTTTGAGGTAGTTATGAAGTGTATCAGGCATGGCTATTCTTCAGTTATGATTGATGGCTCTCA
CTATCCCTTTGAAGAAAATGTAAGACTGGTTAAAAAGGTAGTAGAAGCAGCCCATTCAGTCGGAGTTAGTGTTGAAGCTG
AGCTTGGGAAAATAGGTGGAACTGAAGATAATGTATCTGTAGATGAAAAAGATGCTACATATACTGACCCGGATGAGGCT
GTTGAATTTGTGGAAAGAACAGGGGTAGATGCCCTGGCTATAGCTATTGGTACTGCTCATGGGGTATACAAGGGTAAGCC
TGAACTTGATTTTGATCGTTTAACAGATATCAAATCTAAATTAGATATGCCGCTGGTATTACACGGTGCTTCCGGTGTTC
CTACTGAAGATGTAGAAAAGGCTGTAAAGCTGGGAATCAATAAAGTTAATGTAAATACCGATTTCCAGCAGGCCTTTACA
GAAAGAATAAAAGAAATATTTGATGAAAAGCCTGATCTCTATGACCCCCGCAAATATTGTGGGCCGGGTCGTGACGCCAT
TAAAGCTAAAGTTAAAGAGAAGATTAAAATGCTGGGTAGTCAGAATAAAGCCTGA

Upstream 100 bases:

>100_bases
AAAAGCCTGGTAGCTCTAAGGATCCTAAAATAAATATTTAGGGCCAAATTATAATTACAACATAAAATAAAATTATAAAA
ATTATAAGGAGGAAATAAGT

Downstream 100 bases:

>100_bases
CCGGAATTAATGGGTTAACGGGTTATACAGGGTATTCCTGTGAAAGCAGGTATACCCTTTTCCTTATACCCCCTGTTCAA
TTACTGCCACTATTCTCCTT

Product: fructose-1,6-bisphosphate aldolase, class II

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MNLVPMAEILKKANKEGYAVGGFNINNLEFLQGIIEAAEEMNSPLILQTSEGAIKYIGIDYVIGMVEAATKNTTIPVALH
LDHGSSFEVVMKCIRHGYSSVMIDGSHYPFEENVRLVKKVVEAAHSVGVSVEAELGKIGGTEDNVSVDEKDATYTDPDEA
VEFVERTGVDALAIAIGTAHGVYKGKPELDFDRLTDIKSKLDMPLVLHGASGVPTEDVEKAVKLGINKVNVNTDFQQAFT
ERIKEIFDEKPDLYDPRKYCGPGRDAIKAKVKEKIKMLGSQNKA

Sequences:

>Translated_284_residues
MNLVPMAEILKKANKEGYAVGGFNINNLEFLQGIIEAAEEMNSPLILQTSEGAIKYIGIDYVIGMVEAATKNTTIPVALH
LDHGSSFEVVMKCIRHGYSSVMIDGSHYPFEENVRLVKKVVEAAHSVGVSVEAELGKIGGTEDNVSVDEKDATYTDPDEA
VEFVERTGVDALAIAIGTAHGVYKGKPELDFDRLTDIKSKLDMPLVLHGASGVPTEDVEKAVKLGINKVNVNTDFQQAFT
ERIKEIFDEKPDLYDPRKYCGPGRDAIKAKVKEKIKMLGSQNKA
>Mature_284_residues
MNLVPMAEILKKANKEGYAVGGFNINNLEFLQGIIEAAEEMNSPLILQTSEGAIKYIGIDYVIGMVEAATKNTTIPVALH
LDHGSSFEVVMKCIRHGYSSVMIDGSHYPFEENVRLVKKVVEAAHSVGVSVEAELGKIGGTEDNVSVDEKDATYTDPDEA
VEFVERTGVDALAIAIGTAHGVYKGKPELDFDRLTDIKSKLDMPLVLHGASGVPTEDVEKAVKLGINKVNVNTDFQQAFT
ERIKEIFDEKPDLYDPRKYCGPGRDAIKAKVKEKIKMLGSQNKA

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789526, Length=283, Percent_Identity=48.0565371024735, Blast_Score=279, Evalue=2e-76,
Organism=Escherichia coli, GI87082041, Length=284, Percent_Identity=44.0140845070423, Blast_Score=270, Evalue=1e-73,
Organism=Escherichia coli, GI1788072, Length=275, Percent_Identity=42.1818181818182, Blast_Score=218, Evalue=3e-58,
Organism=Escherichia coli, GI1789293, Length=339, Percent_Identity=23.8938053097345, Blast_Score=96, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6322790, Length=336, Percent_Identity=26.1904761904762, Blast_Score=87, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011289
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 31013; Mature: 31013

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00602 ALDOLASE_CLASS_II_1 ; PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLVPMAEILKKANKEGYAVGGFNINNLEFLQGIIEAAEEMNSPLILQTSEGAIKYIGID
CCCCCHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEHHH
YVIGMVEAATKNTTIPVALHLDHGSSFEVVMKCIRHGYSSVMIDGSHYPFEENVRLVKKV
HHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHH
VEAAHSVGVSVEAELGKIGGTEDNVSVDEKDATYTDPDEAVEFVERTGVDALAIAIGTAH
HHHHHHCCCEEEEHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEHHHHHHC
GVYKGKPELDFDRLTDIKSKLDMPLVLHGASGVPTEDVEKAVKLGINKVNVNTDFQQAFT
CCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHCCCEEECCCHHHHHHH
ERIKEIFDEKPDLYDPRKYCGPGRDAIKAKVKEKIKMLGSQNKA
HHHHHHHCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MNLVPMAEILKKANKEGYAVGGFNINNLEFLQGIIEAAEEMNSPLILQTSEGAIKYIGID
CCCCCHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEHHH
YVIGMVEAATKNTTIPVALHLDHGSSFEVVMKCIRHGYSSVMIDGSHYPFEENVRLVKKV
HHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHH
VEAAHSVGVSVEAELGKIGGTEDNVSVDEKDATYTDPDEAVEFVERTGVDALAIAIGTAH
HHHHHHCCCEEEEHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEHHHHHHC
GVYKGKPELDFDRLTDIKSKLDMPLVLHGASGVPTEDVEKAVKLGINKVNVNTDFQQAFT
CCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHCCCEEECCCHHHHHHH
ERIKEIFDEKPDLYDPRKYCGPGRDAIKAKVKEKIKMLGSQNKA
HHHHHHHCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA