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The map label for this gene is gyaR [H]

Identifier: 220932561

GI number: 220932561

Start: 1841555

End: 1842514

Strand: Reverse

Name: gyaR [H]

Synonym: Hore_17250

Alternate gene names: 220932561

Gene position: 1842514-1841555 (Counterclockwise)

Preceding gene: 220932563

Following gene: 220932559

Centisome position: 71.47

GC content: 40.62

Gene sequence:

>960_bases
GTGAAGGTATTATTGACTTTTGATTTAAAAGATAAGTATATAGAAAAGGTTAAAAGGGAAGTACCGGGTGTTGATATCAT
TAGATGCCCTGATATTGAAGATTACGGGAATAAAGTTCAGGGTTGTGAAGTGATGCTTACTTTCTCTGATATAAACCTGG
AGGTTATAAAAAATAAAGCCACAGACCTGAGGTGGATACAGACTTGGGTAGCCGGGGTAGAGAGTCTTGTGACTCCTCAA
AAAGTAAAGTGGTTCAGGGATAATAATATAATTTTAACCACAATGAGCGGTATTCATGGTGATGTTATTGCTGAACATGT
TACCGGGATGATAATTTCGTTTAGCCGTAAGTTTAAGGATTTTTACCGGCTACAGAAGCAGAAAAAATGGGAGAGGTTAA
CTGTAGACCGTCTAAAAGGGAAAACCCTTCTGGTAGTTGGTCTGGGTAGTATTGGAAGGGAGATAGCGGCCCGGGGTAAA
GCCTTCAAAATGAACGTAACCGGAATAAAACGGGATACCACCCGACCTGTTAATAATGTTGACAGTCTATATACCCCTGA
TGAATTATTAAAAGCCCTGTCAGAGGCAGATTATGTAGTCTTGAGCATGCCCCTGACACAAGAAACAGAGAATATGTTTG
GATATCGAGAGTTTAAAGAGATGAAGACTGATTCATATCTTATAAATATTGCCAGAGGGGGTGTTGTCAGGGAAGATGAC
CTGATCAGGGCGTTGGATGAAGGCCTTATTGCCGGGGCAGGGCTCGATGTATTTACAGAAGAACCTCTACCCCCGGAATC
TCCCCTGTACGAAATGGATAACGTTATTATAACCCCCCATGTGGCCGGTGTTTATCCTGAATATAATGAAGAGGCGATAG
AAATTTTTATAAAAAATCTAAAGAGGTATCAGAAAGGTGAAGATTTAATTAACCGGGTCAATTATAGCCGTGGGTATTGA

Upstream 100 bases:

>100_bases
AAAAAATAATAACCCAGAATTTAAACTCCGGGTCGATTTTTCTTTATGATATTTTCATAAAAAATCTAAGGCTGATTAAA
ATAAAGGGGGATAAAAGACT

Downstream 100 bases:

>100_bases
TATATTAGAAAGTAAACCAGTCTTTCCATTCTTGATAGGGGAAATCATCGGGTAATAGTTTTAATAGATGGTCAGGGTTA
CCGGGTTTTTCAATAAAAAT

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MKVLLTFDLKDKYIEKVKREVPGVDIIRCPDIEDYGNKVQGCEVMLTFSDINLEVIKNKATDLRWIQTWVAGVESLVTPQ
KVKWFRDNNIILTTMSGIHGDVIAEHVTGMIISFSRKFKDFYRLQKQKKWERLTVDRLKGKTLLVVGLGSIGREIAARGK
AFKMNVTGIKRDTTRPVNNVDSLYTPDELLKALSEADYVVLSMPLTQETENMFGYREFKEMKTDSYLINIARGGVVREDD
LIRALDEGLIAGAGLDVFTEEPLPPESPLYEMDNVIITPHVAGVYPEYNEEAIEIFIKNLKRYQKGEDLINRVNYSRGY

Sequences:

>Translated_319_residues
MKVLLTFDLKDKYIEKVKREVPGVDIIRCPDIEDYGNKVQGCEVMLTFSDINLEVIKNKATDLRWIQTWVAGVESLVTPQ
KVKWFRDNNIILTTMSGIHGDVIAEHVTGMIISFSRKFKDFYRLQKQKKWERLTVDRLKGKTLLVVGLGSIGREIAARGK
AFKMNVTGIKRDTTRPVNNVDSLYTPDELLKALSEADYVVLSMPLTQETENMFGYREFKEMKTDSYLINIARGGVVREDD
LIRALDEGLIAGAGLDVFTEEPLPPESPLYEMDNVIITPHVAGVYPEYNEEAIEIFIKNLKRYQKGEDLINRVNYSRGY
>Mature_319_residues
MKVLLTFDLKDKYIEKVKREVPGVDIIRCPDIEDYGNKVQGCEVMLTFSDINLEVIKNKATDLRWIQTWVAGVESLVTPQ
KVKWFRDNNIILTTMSGIHGDVIAEHVTGMIISFSRKFKDFYRLQKQKKWERLTVDRLKGKTLLVVGLGSIGREIAARGK
AFKMNVTGIKRDTTRPVNNVDSLYTPDELLKALSEADYVVLSMPLTQETENMFGYREFKEMKTDSYLINIARGGVVREDD
LIRALDEGLIAGAGLDVFTEEPLPPESPLYEMDNVIITPHVAGVYPEYNEEAIEIFIKNLKRYQKGEDLINRVNYSRGY

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=216, Percent_Identity=35.6481481481481, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI6912396, Length=276, Percent_Identity=26.8115942028986, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI61743967, Length=182, Percent_Identity=34.0659340659341, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI4557497, Length=182, Percent_Identity=34.0659340659341, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI145580578, Length=190, Percent_Identity=34.2105263157895, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI4557499, Length=190, Percent_Identity=34.2105263157895, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI145580575, Length=190, Percent_Identity=34.2105263157895, Blast_Score=92, Evalue=9e-19,
Organism=Escherichia coli, GI87081824, Length=220, Percent_Identity=32.7272727272727, Blast_Score=128, Evalue=4e-31,
Organism=Escherichia coli, GI87082289, Length=232, Percent_Identity=32.3275862068966, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1789279, Length=220, Percent_Identity=32.2727272727273, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1787645, Length=228, Percent_Identity=26.3157894736842, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=268, Percent_Identity=29.4776119402985, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI25147481, Length=151, Percent_Identity=28.476821192053, Blast_Score=71, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6322116, Length=228, Percent_Identity=31.5789473684211, Blast_Score=103, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6320925, Length=228, Percent_Identity=31.140350877193, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6324964, Length=217, Percent_Identity=24.8847926267281, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6325144, Length=149, Percent_Identity=30.8724832214765, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6321253, Length=173, Percent_Identity=27.7456647398844, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324980, Length=165, Percent_Identity=26.0606060606061, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324055, Length=164, Percent_Identity=31.7073170731707, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI45552429, Length=269, Percent_Identity=29.368029739777, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24585514, Length=284, Percent_Identity=28.8732394366197, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI28574282, Length=284, Percent_Identity=28.8732394366197, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI45551003, Length=284, Percent_Identity=28.8732394366197, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI28574284, Length=284, Percent_Identity=28.8732394366197, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24585516, Length=271, Percent_Identity=28.7822878228782, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI28574286, Length=272, Percent_Identity=26.8382352941176, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI28571528, Length=179, Percent_Identity=37.9888268156425, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI19921140, Length=267, Percent_Identity=29.2134831460674, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24646446, Length=153, Percent_Identity=36.6013071895425, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24646448, Length=153, Percent_Identity=36.6013071895425, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24646452, Length=153, Percent_Identity=36.6013071895425, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24646450, Length=153, Percent_Identity=36.6013071895425, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI62472511, Length=153, Percent_Identity=36.6013071895425, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 36481; Mature: 36481

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLLTFDLKDKYIEKVKREVPGVDIIRCPDIEDYGNKVQGCEVMLTFSDINLEVIKNKA
CEEEEEECCCHHHHHHHHHHCCCCEEEECCCCHHHCCCCCCEEEEEEEECCEEEEECCCC
TDLRWIQTWVAGVESLVTPQKVKWFRDNNIILTTMSGIHGDVIAEHVTGMIISFSRKFKD
HHHHHHHHHHHHHHHHCCCHHHEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
FYRLQKQKKWERLTVDRLKGKTLLVVGLGSIGREIAARGKAFKMNVTGIKRDTTRPVNNV
HHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHCCCEEEEEECCCCCCCCCCCCCC
DSLYTPDELLKALSEADYVVLSMPLTQETENMFGYREFKEMKTDSYLINIARGGVVREDD
CCCCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCEECHHH
LIRALDEGLIAGAGLDVFTEEPLPPESPLYEMDNVIITPHVAGVYPEYNEEAIEIFIKNL
HHHHHHHCCEECCCCCCCCCCCCCCCCCCHHCCCEEECCCCCCCCCCCCHHHHHHHHHHH
KRYQKGEDLINRVNYSRGY
HHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKVLLTFDLKDKYIEKVKREVPGVDIIRCPDIEDYGNKVQGCEVMLTFSDINLEVIKNKA
CEEEEEECCCHHHHHHHHHHCCCCEEEECCCCHHHCCCCCCEEEEEEEECCEEEEECCCC
TDLRWIQTWVAGVESLVTPQKVKWFRDNNIILTTMSGIHGDVIAEHVTGMIISFSRKFKD
HHHHHHHHHHHHHHHHCCCHHHEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
FYRLQKQKKWERLTVDRLKGKTLLVVGLGSIGREIAARGKAFKMNVTGIKRDTTRPVNNV
HHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHCCCEEEEEECCCCCCCCCCCCCC
DSLYTPDELLKALSEADYVVLSMPLTQETENMFGYREFKEMKTDSYLINIARGGVVREDD
CCCCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCEECHHH
LIRALDEGLIAGAGLDVFTEEPLPPESPLYEMDNVIITPHVAGVYPEYNEEAIEIFIKNL
HHHHHHHCCEECCCCCCCCCCCCCCCCCCHHCCCEEECCCCCCCCCCCCHHHHHHHHHHH
KRYQKGEDLINRVNYSRGY
HHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA