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The map label for this gene is patA [H]

Identifier: 220932558

GI number: 220932558

Start: 1837346

End: 1838734

Strand: Reverse

Name: patA [H]

Synonym: Hore_17220

Alternate gene names: 220932558

Gene position: 1838734-1837346 (Counterclockwise)

Preceding gene: 220932559

Following gene: 220932557

Centisome position: 71.32

GC content: 40.32

Gene sequence:

>1389_bases
ATGAGTTATGACCTTATTAATGTTGAGACTGCTATGAAGATAACAAAAGAGGAAGTGGTTGATAACTATAAGAAATATAT
TAACCCTTCCCTGGCCAAAATGCTGGGGTTATTAAATTTTGATAAACAGTTTGTAAAAGCTAATGGAGTCCGTGTCTGGG
ATAGTGAGGGTAATGAATACCTTGATTTTCTGGGGGGATATGGTGCCCTTAACCTGGGGCATAACCCACCTGAAGTCCAT
GAGGCCCTGGAAAAGGTTAAAGAGATGCCCAATCTTTTGCAGGCTTCAATGGGAACCATGGCCAGTGTGGCTGCCCGTAA
TCTGAGTAAACTTACCCCTGGCAAGTTGACCCATACATTTTTCAGTAATAGTGGAACTGAGGCAGTAGAAGGTGCGATTA
AACTGGCCCGGATTGCTTCAGGGAAGAAAAAAATAATCTACTGTAAAAATTCATTTCATGGCAAATCCATGGGATCCCTA
TCCATTACAGGGAGGGAAAAATATCAGAAATTATTTAAACCACTGGTTCCGGAAACTGAAAGTGTCCCCTTCGGTGATGT
TAAAAGCCTTGAAGAAAAATTTAAAGAAGGGGATATTGCTGGCTTTATTGTTGAGCCAATTCAGGGGGAAGGTGGCATAA
ATTTACCACCTGATGGGTATTTTAAAAAGGTTAGAGAATTATGTGATGAATATGGTGTTTACTTAATTTTAGATGAAATT
CAAACCGGTTTTGGCCGGACCGGAAAAATTTTCGCCTGTGAACATGAAGGGATTGTTCCTGACATTATGTGTCTGGCAAA
ATCCCTTGGTGGAGGGGTTATGCCCATAGGGGCCTATACAACTACTGAAGAAATCTGGTCTAAAGCTTATGGAAGTATGG
ATAAAGCCCTGCTCCATACCTCTACCTTCGGAGGGAATACCCTGGCTACTGCAGCTGCTATAGCGGCTATGGAACAGATT
GTAGAACAAAAATTAAGCCAGCAGGCTGCTGAAAAAGGGGAGTATTTTATAAATCGACTTAAGGAACTGGCTGATAAATA
TGATTTGATAAAAGAAGTCAGGGGTCGTGGTTTAATGATAGGAATCGAGTTTAAACAACCAGAATCGGGTCTTCTGGACA
AAATCTCCCAGGGTATGGTAAGTAAATTCTCTCATGAGTATCTGGGATCAATGGTAGCAGGTGCCCTGTATAATGATTAC
AGGATTATTACCGCCTATACCCTGAATAACCCCAATGTAATTAGAATGGAACCACCTTTGATTGTAACCAGAGAAGAAAT
TGACACCGTAATCGGGGCTCTGGAAGATATTTTCAGTAAAAATAAAGGACTATTCGGTTTTACTGTAAACAGTGCTAAAA
AGGTTTTATCAGGATTTTTCAAAAAATAA

Upstream 100 bases:

>100_bases
GGTATATGAATTATACATCTGTTTTTAAAACTAAAACTATCAGGAACAATAAGGATAATGAAAATGATATGAAAGAATAT
GAAAGGATGGTGCTTTAAAA

Downstream 100 bases:

>100_bases
CTTTTAAAATCTTTGAATTGTGGTATAATGTTTCATGGGAAACATTTTCTGACAATAAGGGGAATGCCTGCAAAATAAAG
AATAAACACCATCCGGAGTT

Product: ornithine aminotransferase

Products: NA

Alternate protein names: Putrescine--2-oxoglutaric acid transaminase; PAT; PATase [H]

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MSYDLINVETAMKITKEEVVDNYKKYINPSLAKMLGLLNFDKQFVKANGVRVWDSEGNEYLDFLGGYGALNLGHNPPEVH
EALEKVKEMPNLLQASMGTMASVAARNLSKLTPGKLTHTFFSNSGTEAVEGAIKLARIASGKKKIIYCKNSFHGKSMGSL
SITGREKYQKLFKPLVPETESVPFGDVKSLEEKFKEGDIAGFIVEPIQGEGGINLPPDGYFKKVRELCDEYGVYLILDEI
QTGFGRTGKIFACEHEGIVPDIMCLAKSLGGGVMPIGAYTTTEEIWSKAYGSMDKALLHTSTFGGNTLATAAAIAAMEQI
VEQKLSQQAAEKGEYFINRLKELADKYDLIKEVRGRGLMIGIEFKQPESGLLDKISQGMVSKFSHEYLGSMVAGALYNDY
RIITAYTLNNPNVIRMEPPLIVTREEIDTVIGALEDIFSKNKGLFGFTVNSAKKVLSGFFKK

Sequences:

>Translated_462_residues
MSYDLINVETAMKITKEEVVDNYKKYINPSLAKMLGLLNFDKQFVKANGVRVWDSEGNEYLDFLGGYGALNLGHNPPEVH
EALEKVKEMPNLLQASMGTMASVAARNLSKLTPGKLTHTFFSNSGTEAVEGAIKLARIASGKKKIIYCKNSFHGKSMGSL
SITGREKYQKLFKPLVPETESVPFGDVKSLEEKFKEGDIAGFIVEPIQGEGGINLPPDGYFKKVRELCDEYGVYLILDEI
QTGFGRTGKIFACEHEGIVPDIMCLAKSLGGGVMPIGAYTTTEEIWSKAYGSMDKALLHTSTFGGNTLATAAAIAAMEQI
VEQKLSQQAAEKGEYFINRLKELADKYDLIKEVRGRGLMIGIEFKQPESGLLDKISQGMVSKFSHEYLGSMVAGALYNDY
RIITAYTLNNPNVIRMEPPLIVTREEIDTVIGALEDIFSKNKGLFGFTVNSAKKVLSGFFKK
>Mature_461_residues
SYDLINVETAMKITKEEVVDNYKKYINPSLAKMLGLLNFDKQFVKANGVRVWDSEGNEYLDFLGGYGALNLGHNPPEVHE
ALEKVKEMPNLLQASMGTMASVAARNLSKLTPGKLTHTFFSNSGTEAVEGAIKLARIASGKKKIIYCKNSFHGKSMGSLS
ITGREKYQKLFKPLVPETESVPFGDVKSLEEKFKEGDIAGFIVEPIQGEGGINLPPDGYFKKVRELCDEYGVYLILDEIQ
TGFGRTGKIFACEHEGIVPDIMCLAKSLGGGVMPIGAYTTTEEIWSKAYGSMDKALLHTSTFGGNTLATAAAIAAMEQIV
EQKLSQQAAEKGEYFINRLKELADKYDLIKEVRGRGLMIGIEFKQPESGLLDKISQGMVSKFSHEYLGSMVAGALYNDYR
IITAYTLNNPNVIRMEPPLIVTREEIDTVIGALEDIFSKNKGLFGFTVNSAKKVLSGFFKK

Specific function: Catalyzes the aminotransferase reaction from putrescine to 2-oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneously cyclizes to form 1-pyrroline. Is also able to transaminate cadaverine and, in lower extent, spermidine, but not ornithi

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. Putrescine aminotransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=396, Percent_Identity=31.8181818181818, Blast_Score=198, Evalue=7e-51,
Organism=Homo sapiens, GI13994255, Length=476, Percent_Identity=29.6218487394958, Blast_Score=172, Evalue=8e-43,
Organism=Homo sapiens, GI284507298, Length=318, Percent_Identity=32.7044025157233, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI37574042, Length=450, Percent_Identity=28.8888888888889, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI226442705, Length=450, Percent_Identity=28.6666666666667, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI226442709, Length=393, Percent_Identity=29.7709923664122, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI24119277, Length=426, Percent_Identity=25.8215962441315, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI188536080, Length=405, Percent_Identity=24.4444444444444, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI38679950, Length=405, Percent_Identity=24.4444444444444, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI38679946, Length=405, Percent_Identity=24.4444444444444, Blast_Score=91, Evalue=3e-18,
Organism=Escherichia coli, GI145693181, Length=443, Percent_Identity=42.4379232505643, Blast_Score=350, Evalue=1e-97,
Organism=Escherichia coli, GI1788044, Length=392, Percent_Identity=34.6938775510204, Blast_Score=219, Evalue=3e-58,
Organism=Escherichia coli, GI1789759, Length=392, Percent_Identity=36.734693877551, Blast_Score=216, Evalue=3e-57,
Organism=Escherichia coli, GI1789016, Length=394, Percent_Identity=32.2335025380711, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI1787560, Length=429, Percent_Identity=32.1678321678322, Blast_Score=182, Evalue=3e-47,
Organism=Escherichia coli, GI1786991, Length=346, Percent_Identity=30.9248554913295, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI1786349, Length=333, Percent_Identity=30.6306306306306, Blast_Score=143, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI25144271, Length=455, Percent_Identity=31.8681318681319, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI25144274, Length=438, Percent_Identity=29.2237442922374, Blast_Score=188, Evalue=7e-48,
Organism=Caenorhabditis elegans, GI32564660, Length=438, Percent_Identity=31.0502283105023, Blast_Score=167, Evalue=8e-42,
Organism=Caenorhabditis elegans, GI71992977, Length=461, Percent_Identity=25.1626898047722, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17541228, Length=410, Percent_Identity=26.5853658536585, Blast_Score=105, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI71981843, Length=196, Percent_Identity=30.1020408163265, Blast_Score=77, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6323470, Length=423, Percent_Identity=36.4066193853428, Blast_Score=219, Evalue=5e-58,
Organism=Saccharomyces cerevisiae, GI6324432, Length=377, Percent_Identity=32.8912466843501, Blast_Score=172, Evalue=9e-44,
Organism=Saccharomyces cerevisiae, GI6324386, Length=326, Percent_Identity=27.9141104294479, Blast_Score=117, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6321456, Length=391, Percent_Identity=25.3196930946292, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21357415, Length=363, Percent_Identity=35.8126721763085, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI161085790, Length=470, Percent_Identity=30.6382978723404, Blast_Score=188, Evalue=6e-48,
Organism=Drosophila melanogaster, GI28574759, Length=392, Percent_Identity=32.9081632653061, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI21356575, Length=457, Percent_Identity=28.0087527352298, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI281366494, Length=384, Percent_Identity=23.6979166666667, Blast_Score=89, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24667139, Length=384, Percent_Identity=23.6979166666667, Blast_Score=89, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24667143, Length=384, Percent_Identity=23.6979166666667, Blast_Score=89, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR010164
- InterPro:   IPR017747
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.82 [H]

Molecular weight: Translated: 50866; Mature: 50735

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYDLINVETAMKITKEEVVDNYKKYINPSLAKMLGLLNFDKQFVKANGVRVWDSEGNEY
CCCCEEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCEEEECCCCCHH
LDFLGGYGALNLGHNPPEVHEALEKVKEMPNLLQASMGTMASVAARNLSKLTPGKLTHTF
HHHHCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
FSNSGTEAVEGAIKLARIASGKKKIIYCKNSFHGKSMGSLSITGREKYQKLFKPLVPETE
HCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEECCHHHHHHHHHHCCCCCC
SVPFGDVKSLEEKFKEGDIAGFIVEPIQGEGGINLPPDGYFKKVRELCDEYGVYLILDEI
CCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEEHH
QTGFGRTGKIFACEHEGIVPDIMCLAKSLGGGVMPIGAYTTTEEIWSKAYGSMDKALLHT
HCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHCCHHHHHHHH
STFGGNTLATAAAIAAMEQIVEQKLSQQAAEKGEYFINRLKELADKYDLIKEVRGRGLMI
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
GIEFKQPESGLLDKISQGMVSKFSHEYLGSMVAGALYNDYRIITAYTLNNPNVIRMEPPL
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCEEEECCCE
IVTREEIDTVIGALEDIFSKNKGLFGFTVNSAKKVLSGFFKK
EEEHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHCC
>Mature Secondary Structure 
SYDLINVETAMKITKEEVVDNYKKYINPSLAKMLGLLNFDKQFVKANGVRVWDSEGNEY
CCCEEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCEEEECCCCCHH
LDFLGGYGALNLGHNPPEVHEALEKVKEMPNLLQASMGTMASVAARNLSKLTPGKLTHTF
HHHHCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
FSNSGTEAVEGAIKLARIASGKKKIIYCKNSFHGKSMGSLSITGREKYQKLFKPLVPETE
HCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEECCHHHHHHHHHHCCCCCC
SVPFGDVKSLEEKFKEGDIAGFIVEPIQGEGGINLPPDGYFKKVRELCDEYGVYLILDEI
CCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEEHH
QTGFGRTGKIFACEHEGIVPDIMCLAKSLGGGVMPIGAYTTTEEIWSKAYGSMDKALLHT
HCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHCCHHHHHHHH
STFGGNTLATAAAIAAMEQIVEQKLSQQAAEKGEYFINRLKELADKYDLIKEVRGRGLMI
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
GIEFKQPESGLLDKISQGMVSKFSHEYLGSMVAGALYNDYRIITAYTLNNPNVIRMEPPL
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCEEEECCCE
IVTREEIDTVIGALEDIFSKNKGLFGFTVNSAKKVLSGFFKK
EEEHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA