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The map label for this gene is neuC [H]

Identifier: 220932530

GI number: 220932530

Start: 1812827

End: 1814008

Strand: Reverse

Name: neuC [H]

Synonym: Hore_16940

Alternate gene names: 220932530

Gene position: 1814008-1812827 (Counterclockwise)

Preceding gene: 220932531

Following gene: 220932529

Centisome position: 70.36

GC content: 30.71

Gene sequence:

>1182_bases
ATGATAAAAAAGAAAGTATGTGTTGTTACTGGAACAAGAGCTGAATATGGCCTTTTAAGACCATTAATAAAAAGAATTAA
TGAATCAAATCTGCTTGAATTACAGATAATTGTTACGGGTATGCATTTATCTCCAGAATTTGGACTCACTTATAGATATA
TTGAAGATGATGGTTTTAAAATTGATGAAAAAATAGAAATATTGTTGAGCTCTGACACTCCTGTTGGAGTTTCTAAATCA
ATGGGTTTAACTTTGATTAGTTTTTCGGAGGCATATCAAAGGTTAAACCCTGATTTAATTATAATACTTGGAGATAGATT
TGAGGTTTTTTCTGCTATGGCGGCAGCAACAGTATCTAAAATTCCAGTAGCCCACATTCACGGGGGAGAGCTTACCCAGG
GAGCATTTGATGATTCATTTCGTCATTGTATGACAAAAATGGCTTATTTACATTTTACATCAACAGAAGAATACAGGAAA
AGAGTAATACAGTTAGGTGAAGAGCCGGATAGAGTTTTTAACGTAGGGGCTTTAGGGGTAGAAAACATTTTAAATTTAAA
CTTCTATTCTAAAGAAGATCTGGAAAGAAAACTAAATATTAACCTGCTGGACAAATACTTTTTAGTGGTCTTTCATCCTG
TAACCCTTGAAAAGCAAACAGTTCATAAACAATTCAGTGAATTATTAGATGCTTTAAATTCCTATAATAAAAATCTTGTT
AAAATATTTATTAAGGCAAATTCTGATAATGGAGGAAGAATCATTAATCAGATGATAGATAGTTTTGTTGAGGGACAAGA
AAAGGCCTATTCGTTTACATCTTTACCCGTAAAAACATATTTAAGTTTATTAAGGCATAGCTGGTGTATAGTTGGTAATT
CTTCCAGTGGTATTTTAGAGGCTCCAAGTTTTCAAGTGCCTACGATAAATATTGGTGATAGGCAGAAAGGAAGGGTTAAA
GCTGAATCAGTAATAGATTGTGATCCTGTGAAAAAAAATATAGTTAAATCATTAGATGTAATAAACAGTAGTAGATTTAG
AAAAAAACTTAACAACATTAATAATCCATATGGGGCCGGAAATACATCCAAAAAAATTATTAATATAATTGAGGATTATT
TATCTAATAATAAGATAAATTTAAAGAAAGAATTCTATGACATAGATTTTGATTTAATATAG

Upstream 100 bases:

>100_bases
CAGTTAAGAGACCAGGGAATGGTATAAGTCCCATGTATTGGGATCAAATTATTGGGAAAGTCGCTAAAAGAGATTATAAA
AAGGATGAGTTGATTGAGTT

Downstream 100 bases:

>100_bases
ACAACCTCATCCAGAAGACCCGGGACTTTATACACAAAATATAAGTTGGGTCTTTAATATTATTATCTTAAAACTTAATT
TTTTTGCAGGAATTGGACGA

Product: UDP-N-acetylglucosamine 2-epimerase

Products: UDP-N-acetyl-D-mannosamine [C]

Alternate protein names: NA

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MIKKKVCVVTGTRAEYGLLRPLIKRINESNLLELQIIVTGMHLSPEFGLTYRYIEDDGFKIDEKIEILLSSDTPVGVSKS
MGLTLISFSEAYQRLNPDLIIILGDRFEVFSAMAAATVSKIPVAHIHGGELTQGAFDDSFRHCMTKMAYLHFTSTEEYRK
RVIQLGEEPDRVFNVGALGVENILNLNFYSKEDLERKLNINLLDKYFLVVFHPVTLEKQTVHKQFSELLDALNSYNKNLV
KIFIKANSDNGGRIINQMIDSFVEGQEKAYSFTSLPVKTYLSLLRHSWCIVGNSSSGILEAPSFQVPTINIGDRQKGRVK
AESVIDCDPVKKNIVKSLDVINSSRFRKKLNNINNPYGAGNTSKKIINIIEDYLSNNKINLKKEFYDIDFDLI

Sequences:

>Translated_393_residues
MIKKKVCVVTGTRAEYGLLRPLIKRINESNLLELQIIVTGMHLSPEFGLTYRYIEDDGFKIDEKIEILLSSDTPVGVSKS
MGLTLISFSEAYQRLNPDLIIILGDRFEVFSAMAAATVSKIPVAHIHGGELTQGAFDDSFRHCMTKMAYLHFTSTEEYRK
RVIQLGEEPDRVFNVGALGVENILNLNFYSKEDLERKLNINLLDKYFLVVFHPVTLEKQTVHKQFSELLDALNSYNKNLV
KIFIKANSDNGGRIINQMIDSFVEGQEKAYSFTSLPVKTYLSLLRHSWCIVGNSSSGILEAPSFQVPTINIGDRQKGRVK
AESVIDCDPVKKNIVKSLDVINSSRFRKKLNNINNPYGAGNTSKKIINIIEDYLSNNKINLKKEFYDIDFDLI
>Mature_393_residues
MIKKKVCVVTGTRAEYGLLRPLIKRINESNLLELQIIVTGMHLSPEFGLTYRYIEDDGFKIDEKIEILLSSDTPVGVSKS
MGLTLISFSEAYQRLNPDLIIILGDRFEVFSAMAAATVSKIPVAHIHGGELTQGAFDDSFRHCMTKMAYLHFTSTEEYRK
RVIQLGEEPDRVFNVGALGVENILNLNFYSKEDLERKLNINLLDKYFLVVFHPVTLEKQTVHKQFSELLDALNSYNKNLV
KIFIKANSDNGGRIINQMIDSFVEGQEKAYSFTSLPVKTYLSLLRHSWCIVGNSSSGILEAPSFQVPTINIGDRQKGRVK
AESVIDCDPVKKNIVKSLDVINSSRFRKKLNNINNPYGAGNTSKKIINIIEDYLSNNKINLKKEFYDIDFDLI

Specific function: May be involved in the synthesis of polysialic acid (PSA) [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI298566312, Length=383, Percent_Identity=31.0704960835509, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI4885285, Length=383, Percent_Identity=31.0704960835509, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI190014632, Length=383, Percent_Identity=31.0704960835509, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI298566325, Length=349, Percent_Identity=29.2263610315186, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI298566315, Length=321, Percent_Identity=24.9221183800623, Blast_Score=117, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020004
- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: 5.1.3.14 [C]

Molecular weight: Translated: 44503; Mature: 44503

Theoretical pI: Translated: 8.28; Mature: 8.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKKKVCVVTGTRAEYGLLRPLIKRINESNLLELQIIVTGMHLSPEFGLTYRYIEDDGFK
CCCCEEEEEECCCHHHHHHHHHHHHCCCCCEEEEEEEEEEEEECCCCCEEEEEECCCCCE
IDEKIEILLSSDTPVGVSKSMGLTLISFSEAYQRLNPDLIIILGDRFEVFSAMAAATVSK
ECCEEEEEEECCCCCCCCCCCCEEEEEHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHH
IPVAHIHGGELTQGAFDDSFRHCMTKMAYLHFTSTEEYRKRVIQLGEEPDRVFNVGALGV
CCEEEECCCCCCCCCCHHHHHHHHHHHHHHEECCCHHHHHHHHHCCCCCHHEEEECCCCH
ENILNLNFYSKEDLERKLNINLLDKYFLVVFHPVTLEKQTVHKQFSELLDALNSYNKNLV
HHHHCCCCCCHHHHHHHCCCCHHHHEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCEE
KIFIKANSDNGGRIINQMIDSFVEGQEKAYSFTSLPVKTYLSLLRHSWCIVGNSSSGILE
EEEEEECCCCCHHHHHHHHHHHHCCHHHHEEEECCCHHHHHHHHHCCEEEEECCCCCCEE
APSFQVPTINIGDRQKGRVKAESVIDCDPVKKNIVKSLDVINSSRFRKKLNNINNPYGAG
CCCCCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
NTSKKIINIIEDYLSNNKINLKKEFYDIDFDLI
CCHHHHHHHHHHHHCCCCEEEEEEEEECCEECC
>Mature Secondary Structure
MIKKKVCVVTGTRAEYGLLRPLIKRINESNLLELQIIVTGMHLSPEFGLTYRYIEDDGFK
CCCCEEEEEECCCHHHHHHHHHHHHCCCCCEEEEEEEEEEEEECCCCCEEEEEECCCCCE
IDEKIEILLSSDTPVGVSKSMGLTLISFSEAYQRLNPDLIIILGDRFEVFSAMAAATVSK
ECCEEEEEEECCCCCCCCCCCCEEEEEHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHH
IPVAHIHGGELTQGAFDDSFRHCMTKMAYLHFTSTEEYRKRVIQLGEEPDRVFNVGALGV
CCEEEECCCCCCCCCCHHHHHHHHHHHHHHEECCCHHHHHHHHHCCCCCHHEEEECCCCH
ENILNLNFYSKEDLERKLNINLLDKYFLVVFHPVTLEKQTVHKQFSELLDALNSYNKNLV
HHHHCCCCCCHHHHHHHCCCCHHHHEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCEE
KIFIKANSDNGGRIINQMIDSFVEGQEKAYSFTSLPVKTYLSLLRHSWCIVGNSSSGILE
EEEEEECCCCCHHHHHHHHHHHHCCHHHHEEEECCCHHHHHHHHHCCEEEEECCCCCCEE
APSFQVPTINIGDRQKGRVKAESVIDCDPVKKNIVKSLDVINSSRFRKKLNNINNPYGAG
CCCCCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
NTSKKIINIIEDYLSNNKINLKKEFYDIDFDLI
CCHHHHHHHHHHHHCCCCEEEEEEEEECCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: UDP-N-acetylglucosamine [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.63 {UDP-N-acetylglucosamine}} 1 {UDP-N-acetylmannosamine}} 0.5 {UDP-N-acetylmannosamine}} [C]

Substrates: UDP-N-acetyl-D-glucosamine [C]

Specific reaction: UDP-N-acetyl-D-glucosamine --> UDP-N-acetyl-D-mannosamine [C]

General reaction: Epimerization [C]

Inhibitor: PCMB [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1729218 [H]