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The map label for this gene is hldE [H]

Identifier: 220932486

GI number: 220932486

Start: 1774084

End: 1774560

Strand: Reverse

Name: hldE [H]

Synonym: Hore_16500

Alternate gene names: 220932486

Gene position: 1774560-1774084 (Counterclockwise)

Preceding gene: 220932487

Following gene: 220932485

Centisome position: 68.83

GC content: 38.36

Gene sequence:

>477_bases
ATGAGAAATAAAATTCAGGATATAAATTCTTTGCAAACGATTGTTCAAACCTTAAAACAGGGAGGGAAAACCCTGGTTTT
TACCAATGGTTGTTTTGACCTCATTCATGTGGGCCACATCCGGTATTTATACAGGGCCAGATCATTTGGTGATATTTTAA
TAGTGGCTGTCAACAGTGATAGTTCGGTCCGTCAGTTAAAGGGAGAAAACCGTCCCATTATAAATGAAAGGGAAAGGGCC
GAGTTACTTTCAGCCCTTGAAATGGTAGATTATGTATTTATATTTGATGAGCTTACCTGCTCTAATGTTATTAAAGAAAT
CAAACCAGATGTTTATGTAAAAGGAGGTGACTATACCCTGGAGACCTTACCCGAATGGCCGGTGGTTAAAGAACTGGGTA
GTCGGGTAGAGCTCGTTAAGGAAGTCAAGGGGAAATCAACAACGGAAATTATAAATAAAATAAAGTCTCATACTTAA

Upstream 100 bases:

>100_bases
GAAGCCATGGATCTGGCCAATACTGCTGCCGGTATTGTGGTCAGGAAATCAGGTGTGGCTACAGTAAAACCAGGAGAGTT
AATGGAAGAAGTGATAAAAA

Downstream 100 bases:

>100_bases
TTTATTTAGATAGTTCTATCAGTCCAAATTCCAACGGCAAATGTTTTATGTTTAATATATGAGGCTGTCGTTTATCTTTT
AAATAATTATGACAAGAGGC

Product: RfaeE domain II

Products: NA

Alternate protein names: D-beta-D-heptose 7-phosphate kinase; D-beta-D-heptose 7-phosphotransferase; D-beta-D-heptose 1-phosphate adenosyltransferase [H]

Number of amino acids: Translated: 158; Mature: 158

Protein sequence:

>158_residues
MRNKIQDINSLQTIVQTLKQGGKTLVFTNGCFDLIHVGHIRYLYRARSFGDILIVAVNSDSSVRQLKGENRPIINERERA
ELLSALEMVDYVFIFDELTCSNVIKEIKPDVYVKGGDYTLETLPEWPVVKELGSRVELVKEVKGKSTTEIINKIKSHT

Sequences:

>Translated_158_residues
MRNKIQDINSLQTIVQTLKQGGKTLVFTNGCFDLIHVGHIRYLYRARSFGDILIVAVNSDSSVRQLKGENRPIINERERA
ELLSALEMVDYVFIFDELTCSNVIKEIKPDVYVKGGDYTLETLPEWPVVKELGSRVELVKEVKGKSTTEIINKIKSHT
>Mature_158_residues
MRNKIQDINSLQTIVQTLKQGGKTLVFTNGCFDLIHVGHIRYLYRARSFGDILIVAVNSDSSVRQLKGENRPIINERERA
ELLSALEMVDYVFIFDELTCSNVIKEIKPDVYVKGGDYTLETLPEWPVVKELGSRVELVKEVKGKSTTEIINKIKSHT

Specific function: Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose [H]

COG id: COG2870

COG function: function code M; ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the cytidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4505651, Length=132, Percent_Identity=31.8181818181818, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI296841136, Length=132, Percent_Identity=31.8181818181818, Blast_Score=69, Evalue=2e-12,
Organism=Escherichia coli, GI1789432, Length=145, Percent_Identity=44.8275862068966, Blast_Score=117, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI193203447, Length=62, Percent_Identity=48.3870967741936, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17509873, Length=62, Percent_Identity=48.3870967741936, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45550974, Length=139, Percent_Identity=30.2158273381295, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI45550973, Length=139, Percent_Identity=30.2158273381295, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI45550975, Length=139, Percent_Identity=30.2158273381295, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI19921220, Length=73, Percent_Identity=42.4657534246575, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023030
- InterPro:   IPR011611
- InterPro:   IPR004821
- InterPro:   IPR004820
- InterPro:   IPR011913
- InterPro:   IPR011914
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01467 CTP_transf_2; PF00294 PfkB [H]

EC number: 2.7.-.-

Molecular weight: Translated: 17967; Mature: 17967

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNKIQDINSLQTIVQTLKQGGKTLVFTNGCFDLIHVGHIRYLYRARSFGDILIVAVNSD
CCCHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
SSVRQLKGENRPIINERERAELLSALEMVDYVFIFDELTCSNVIKEIKPDVYVKGGDYTL
CHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEE
ETLPEWPVVKELGSRVELVKEVKGKSTTEIINKIKSHT
CCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MRNKIQDINSLQTIVQTLKQGGKTLVFTNGCFDLIHVGHIRYLYRARSFGDILIVAVNSD
CCCHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
SSVRQLKGENRPIINERERAELLSALEMVDYVFIFDELTCSNVIKEIKPDVYVKGGDYTL
CHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEE
ETLPEWPVVKELGSRVELVKEVKGKSTTEIINKIKSHT
CCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA