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The map label for this gene is tkt [H]

Identifier: 220932277

GI number: 220932277

Start: 1528431

End: 1530413

Strand: Reverse

Name: tkt [H]

Synonym: Hore_14410

Alternate gene names: 220932277

Gene position: 1530413-1528431 (Counterclockwise)

Preceding gene: 220932278

Following gene: 220932276

Centisome position: 59.36

GC content: 46.29

Gene sequence:

>1983_bases
ATGAAATTGTTAAAAAAAGTTGCCAATACTGTCAGAGGATTATCAGCAGATGCAGTAGAAAAAGCAAACTCTGGTCATCC
GGGTCTTCCCATCGGATGTGCTGATATAGGAGCTTTGCTCTATGGGAAGGTTATGAAATATGATCCGACTCAGCCGGAGT
GGCCTGACCGGGATCGGTTTATCCTTTCAGCAGGCCATGGCTCCATGCTTGTATATTCATTACTCCATTTAGCCGGTTTT
GAAGTTAGTCTCGATGACCTTAAATCATTCCGTCAGTTAGGTTCCAAAACCCCGGGACATCCCGAATATGGAGAAACCCC
CGGTGTTGAAACCACAACCGGCCCTCTGGGTCAGGGCTTTGCCAATGCTGTAGGAATGGCTATTGCCGAAAGAATGCTGG
CCCAGCGCTTTAACACCGAAGGACATACCATAGTTGATCACTATACATATACCCTCCTCGGAGATGGTTGTATGATGGAA
GGAATTTCATCTGAAGCCGCTTCCCTGGCCGGACACCTTGGCCTGGGTAAACTGATTGCTATCTATGATGACAATGAAAT
CTCCATCGGGGGTAGTACCGATATAACCTTTACCGAATCAGTAGCTGATAGATTTAAGGCCTATAACTGGCATGTCATTG
AAGGGGTAGACGGCCATGACCTTAAGGCTCTGGAAGAGGCCGTTAAAGAAGCTAAGGAGGTAAATGATAAACCCAGTTTA
ATAATTGCTAAAACTAAAATTGCTTTCGGGGCTCCTACCAAAGAAGGGAGCAGTTCGGCCCACGGGGCTCCACTGGGTGA
AGAAGAGATAAGGGGATTAAAGAAAAATATTGGTTTCCCTGAAGATAAGGAATTCTATATCCCGGATGAGGTAAAAGAAT
TCTTTAAGGACCATACCGAAAAGCTCAAAAAAGAACGTGAAGAATGGGAAAAAGCCTTTACTGAATGGGCTGAAGAAAAC
CCTGACCTGAAAGAAGAATGGGATAAGGCCCATAATCTCGAGCTTCCCGGAGACTTAGAAGAAATAATCAATAATCTTGA
GATAAAAACCCCCGTGGCTACCAGGAAGGCTTCAGGGGAGACTTTAAGAAAAATTGCCGATGAAATACCATACCTGGTCG
GCGGTTCAGCAGACCTGGCCCCATCCAATAAGACCTATTTAGATAAATATGGAGAGATACAGAAAGACAGCTTTGATGGG
CGTAACTTCCGCTTCGGTGTCAGGGAGCATGCTATGGGAGCCATAGTAAACGGGTTATCCCTCCACAAAGGGGTAAGGCC
CTTCTGTGCTACCTTTTTAGTCTTCTCAGATTACATGAGGCCTGCTATCAGAATGGCTGCCTTAATGAAACAGCCTGTAA
TCTATGTCTTTACCCATGACTCTGTATATGTAGGAGAAGATGGTCCTACCCACCAGCCTATCGAACATGTTGAAGCCCTG
AGAGTGATACCGAATCTCAAAGTTTTAAGGCCGGCTGATGCCGAAGAGACCAAAGCAGCCTGGCTTGAGGCTGTAAAGAG
GACCGATGGACCTACAGCCCTGGTACTGACAAGACAGGGATTGCCCCATATTGAAAAAGAAGAGGGGATCGTAGGATTCA
AACGTGGTGGTTATATTGTCCACAAGGAAAAAGGAGATAGAACCGATGCTGTCCTTATGGCCAGTGGTAGTGAGGTTTCC
CTGGCTGTAGAGGTAGCTAAACTGCTTGAGGAAAAAGGTAAAGAGGTCAGGGTAGTATCTGTACCTGAGCGGCGGGAATT
TGTAAACCAGGGTACAGAATATATAGAAGAAGTCCTCGGTAAGGATACTTTCAGGGTAGTCCTGGAGGCTGGAGTCGGAA
ATGGCTGGTACCGTCTATTAGGTCATAAATGCCATGTGGTAAGCCTTGAGGATTTCGGTATGAGTGGTCCCGGGGAGGAA
GTGGCCCGTGAGCTTGGATTTGATGCTGAAAAGATTGCTTCTGATATCCTGGCCAGAATGTAA

Upstream 100 bases:

>100_bases
GATTTACTGGACAAATAAAATGAAAACATATACAATATTTAAGGATAAAAAAATATCTTAAGTATCTTAAGTTTTTATTA
ATTAAATTATCAGGGAGGTA

Downstream 100 bases:

>100_bases
TAACCAGATTTATCCTGTTATTATGTATTGAGAATAGATAAACTGAAGGCCGCCGGTATTTCCGGCGGTTTTATTATATG
CAGAGAATTTTTAACTGGAG

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 660; Mature: 660

Protein sequence:

>660_residues
MKLLKKVANTVRGLSADAVEKANSGHPGLPIGCADIGALLYGKVMKYDPTQPEWPDRDRFILSAGHGSMLVYSLLHLAGF
EVSLDDLKSFRQLGSKTPGHPEYGETPGVETTTGPLGQGFANAVGMAIAERMLAQRFNTEGHTIVDHYTYTLLGDGCMME
GISSEAASLAGHLGLGKLIAIYDDNEISIGGSTDITFTESVADRFKAYNWHVIEGVDGHDLKALEEAVKEAKEVNDKPSL
IIAKTKIAFGAPTKEGSSSAHGAPLGEEEIRGLKKNIGFPEDKEFYIPDEVKEFFKDHTEKLKKEREEWEKAFTEWAEEN
PDLKEEWDKAHNLELPGDLEEIINNLEIKTPVATRKASGETLRKIADEIPYLVGGSADLAPSNKTYLDKYGEIQKDSFDG
RNFRFGVREHAMGAIVNGLSLHKGVRPFCATFLVFSDYMRPAIRMAALMKQPVIYVFTHDSVYVGEDGPTHQPIEHVEAL
RVIPNLKVLRPADAEETKAAWLEAVKRTDGPTALVLTRQGLPHIEKEEGIVGFKRGGYIVHKEKGDRTDAVLMASGSEVS
LAVEVAKLLEEKGKEVRVVSVPERREFVNQGTEYIEEVLGKDTFRVVLEAGVGNGWYRLLGHKCHVVSLEDFGMSGPGEE
VARELGFDAEKIASDILARM

Sequences:

>Translated_660_residues
MKLLKKVANTVRGLSADAVEKANSGHPGLPIGCADIGALLYGKVMKYDPTQPEWPDRDRFILSAGHGSMLVYSLLHLAGF
EVSLDDLKSFRQLGSKTPGHPEYGETPGVETTTGPLGQGFANAVGMAIAERMLAQRFNTEGHTIVDHYTYTLLGDGCMME
GISSEAASLAGHLGLGKLIAIYDDNEISIGGSTDITFTESVADRFKAYNWHVIEGVDGHDLKALEEAVKEAKEVNDKPSL
IIAKTKIAFGAPTKEGSSSAHGAPLGEEEIRGLKKNIGFPEDKEFYIPDEVKEFFKDHTEKLKKEREEWEKAFTEWAEEN
PDLKEEWDKAHNLELPGDLEEIINNLEIKTPVATRKASGETLRKIADEIPYLVGGSADLAPSNKTYLDKYGEIQKDSFDG
RNFRFGVREHAMGAIVNGLSLHKGVRPFCATFLVFSDYMRPAIRMAALMKQPVIYVFTHDSVYVGEDGPTHQPIEHVEAL
RVIPNLKVLRPADAEETKAAWLEAVKRTDGPTALVLTRQGLPHIEKEEGIVGFKRGGYIVHKEKGDRTDAVLMASGSEVS
LAVEVAKLLEEKGKEVRVVSVPERREFVNQGTEYIEEVLGKDTFRVVLEAGVGNGWYRLLGHKCHVVSLEDFGMSGPGEE
VARELGFDAEKIASDILARM
>Mature_660_residues
MKLLKKVANTVRGLSADAVEKANSGHPGLPIGCADIGALLYGKVMKYDPTQPEWPDRDRFILSAGHGSMLVYSLLHLAGF
EVSLDDLKSFRQLGSKTPGHPEYGETPGVETTTGPLGQGFANAVGMAIAERMLAQRFNTEGHTIVDHYTYTLLGDGCMME
GISSEAASLAGHLGLGKLIAIYDDNEISIGGSTDITFTESVADRFKAYNWHVIEGVDGHDLKALEEAVKEAKEVNDKPSL
IIAKTKIAFGAPTKEGSSSAHGAPLGEEEIRGLKKNIGFPEDKEFYIPDEVKEFFKDHTEKLKKEREEWEKAFTEWAEEN
PDLKEEWDKAHNLELPGDLEEIINNLEIKTPVATRKASGETLRKIADEIPYLVGGSADLAPSNKTYLDKYGEIQKDSFDG
RNFRFGVREHAMGAIVNGLSLHKGVRPFCATFLVFSDYMRPAIRMAALMKQPVIYVFTHDSVYVGEDGPTHQPIEHVEAL
RVIPNLKVLRPADAEETKAAWLEAVKRTDGPTALVLTRQGLPHIEKEEGIVGFKRGGYIVHKEKGDRTDAVLMASGSEVS
LAVEVAKLLEEKGKEVRVVSVPERREFVNQGTEYIEEVLGKDTFRVVLEAGVGNGWYRLLGHKCHVVSLEDFGMSGPGEE
VARELGFDAEKIASDILARM

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=585, Percent_Identity=28.3760683760684, Blast_Score=182, Evalue=1e-45,
Organism=Homo sapiens, GI4507521, Length=585, Percent_Identity=28.3760683760684, Blast_Score=182, Evalue=1e-45,
Organism=Homo sapiens, GI133778974, Length=592, Percent_Identity=27.3648648648649, Blast_Score=160, Evalue=4e-39,
Organism=Homo sapiens, GI225637459, Length=524, Percent_Identity=23.0916030534351, Blast_Score=118, Evalue=2e-26,
Organism=Homo sapiens, GI225637461, Length=490, Percent_Identity=23.0612244897959, Blast_Score=105, Evalue=2e-22,
Organism=Homo sapiens, GI225637463, Length=487, Percent_Identity=22.7926078028747, Blast_Score=104, Evalue=3e-22,
Organism=Escherichia coli, GI1788808, Length=657, Percent_Identity=49.923896499239, Blast_Score=629, Evalue=0.0,
Organism=Escherichia coli, GI48994911, Length=661, Percent_Identity=48.8653555219365, Blast_Score=625, Evalue=1e-180,
Organism=Caenorhabditis elegans, GI17539652, Length=582, Percent_Identity=27.8350515463918, Blast_Score=169, Evalue=5e-42,
Organism=Saccharomyces cerevisiae, GI6325331, Length=659, Percent_Identity=45.2200303490137, Blast_Score=547, Evalue=1e-156,
Organism=Saccharomyces cerevisiae, GI6319593, Length=664, Percent_Identity=42.6204819277108, Blast_Score=510, Evalue=1e-145,
Organism=Drosophila melanogaster, GI45551847, Length=589, Percent_Identity=27.3344651952462, Blast_Score=173, Evalue=3e-43,
Organism=Drosophila melanogaster, GI45550715, Length=589, Percent_Identity=27.3344651952462, Blast_Score=173, Evalue=3e-43,
Organism=Drosophila melanogaster, GI24666278, Length=593, Percent_Identity=26.9814502529511, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24645119, Length=555, Percent_Identity=26.8468468468468, Blast_Score=155, Evalue=6e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 72614; Mature: 72614

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00801 TRANSKETOLASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLKKVANTVRGLSADAVEKANSGHPGLPIGCADIGALLYGKVMKYDPTQPEWPDRDRF
CHHHHHHHHHHHCCCHHHHHHCCCCCCCCEECHHHHHHHHHHHHHCCCCCCCCCCCCCCE
ILSAGHGSMLVYSLLHLAGFEVSLDDLKSFRQLGSKTPGHPEYGETPGVETTTGPLGQGF
EEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHH
ANAVGMAIAERMLAQRFNTEGHTIVDHYTYTLLGDGCMMEGISSEAASLAGHLGLGKLIA
HHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCHHHHCCCHHHHHHHHHCCCCCEEE
IYDDNEISIGGSTDITFTESVADRFKAYNWHVIEGVDGHDLKALEEAVKEAKEVNDKPSL
EEECCEEEECCCCCCEEHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCE
IIAKTKIAFGAPTKEGSSSAHGAPLGEEEIRGLKKNIGFPEDKEFYIPDEVKEFFKDHTE
EEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEECCHHHHHHHHHHHH
KLKKEREEWEKAFTEWAEENPDLKEEWDKAHNLELPGDLEEIINNLEIKTPVATRKASGE
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHCCEECCCCHHCCCCHH
TLRKIADEIPYLVGGSADLAPSNKTYLDKYGEIQKDSFDGRNFRFGVREHAMGAIVNGLS
HHHHHHHHCCEEECCCCCCCCCCCHHHHHCCCCCCCCCCCCCEECCHHHHHHHHHHHHHH
LHKGVRPFCATFLVFSDYMRPAIRMAALMKQPVIYVFTHDSVYVGEDGPTHQPIEHVEAL
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCEEEECCCCCCCCHHHHHHHH
RVIPNLKVLRPADAEETKAAWLEAVKRTDGPTALVLTRQGLPHIEKEEGIVGFKRGGYIV
HHCCCCEEECCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCEEEECCCEEE
HKEKGDRTDAVLMASGSEVSLAVEVAKLLEEKGKEVRVVSVPERREFVNQGTEYIEEVLG
ECCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHC
KDTFRVVLEAGVGNGWYRLLGHKCHVVSLEDFGMSGPGEEVARELGFDAEKIASDILARM
CCCEEHHEECCCCCHHHHHHCCEEEEEEHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHCC
>Mature Secondary Structure
MKLLKKVANTVRGLSADAVEKANSGHPGLPIGCADIGALLYGKVMKYDPTQPEWPDRDRF
CHHHHHHHHHHHCCCHHHHHHCCCCCCCCEECHHHHHHHHHHHHHCCCCCCCCCCCCCCE
ILSAGHGSMLVYSLLHLAGFEVSLDDLKSFRQLGSKTPGHPEYGETPGVETTTGPLGQGF
EEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHH
ANAVGMAIAERMLAQRFNTEGHTIVDHYTYTLLGDGCMMEGISSEAASLAGHLGLGKLIA
HHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCHHHHCCCHHHHHHHHHCCCCCEEE
IYDDNEISIGGSTDITFTESVADRFKAYNWHVIEGVDGHDLKALEEAVKEAKEVNDKPSL
EEECCEEEECCCCCCEEHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCE
IIAKTKIAFGAPTKEGSSSAHGAPLGEEEIRGLKKNIGFPEDKEFYIPDEVKEFFKDHTE
EEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEECCHHHHHHHHHHHH
KLKKEREEWEKAFTEWAEENPDLKEEWDKAHNLELPGDLEEIINNLEIKTPVATRKASGE
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHCCEECCCCHHCCCCHH
TLRKIADEIPYLVGGSADLAPSNKTYLDKYGEIQKDSFDGRNFRFGVREHAMGAIVNGLS
HHHHHHHHCCEEECCCCCCCCCCCHHHHHCCCCCCCCCCCCCEECCHHHHHHHHHHHHHH
LHKGVRPFCATFLVFSDYMRPAIRMAALMKQPVIYVFTHDSVYVGEDGPTHQPIEHVEAL
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCEEEECCCCCCCCHHHHHHHH
RVIPNLKVLRPADAEETKAAWLEAVKRTDGPTALVLTRQGLPHIEKEEGIVGFKRGGYIV
HHCCCCEEECCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCEEEECCCEEE
HKEKGDRTDAVLMASGSEVSLAVEVAKLLEEKGKEVRVVSVPERREFVNQGTEYIEEVLG
ECCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHC
KDTFRVVLEAGVGNGWYRLLGHKCHVVSLEDFGMSGPGEEVARELGFDAEKIASDILARM
CCCEEHHEECCCCCHHHHHHCCEEEEEEHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]