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The map label for this gene is obg

Identifier: 220932246

GI number: 220932246

Start: 1498287

End: 1499567

Strand: Reverse

Name: obg

Synonym: Hore_14100

Alternate gene names: 220932246

Gene position: 1499567-1498287 (Counterclockwise)

Preceding gene: 220932247

Following gene: 220932245

Centisome position: 58.16

GC content: 42.0

Gene sequence:

>1281_bases
ATGTTTGTCGATGAAGTAGAAATTAAAGTTAAAGGTGGTCAGGGTGGTAACGGGGTTGTAAGTTTCCGCCGGGAAAAATT
CGAACCAATGGGAGGCCCGGATGGTGGTGATGGTGGTGACGGAGGCAATGTTATATTACGGGTAGATGAAGGTTTAAATA
CCCTGGCTGATTTTAGGTACCAGAGGCATTATGAAGCTGAACGGGGTTATCATGGTTCGGGGAAGAATAAACACGGCAGG
AGTGGGGAAGACCTCGTTCTCAAGGTCCCACCGGGAACTGTAGTATATGATGCGGATACCGATGAGCTACTGGCTGACTT
GACTGAAGATGGAGAAGAGTACATAGTGGCCCATGGTGGAAAAGGGGGCCGTGGGAATGCCAGATTTAAAAAATCAACCA
GAAAAGCCCCCCGCTTTGCTGAAAAAGGGGAACCCGGGGAAGAAAGGTCTATCAGACTGGAACTTAAGCTGGTGGCCGAT
GTGGGACTTATTGGTTTTCCAAATGTCGGGAAATCTACCCTTATTTCAGTGGTTTCTGAAGCCAGGCCAAAGATTGCCAA
CTACCATTTTACAACCCTGAAACCCAATCTGGGAGTTGTGGCCTTGAGTGAATATAAATCTTTTGTTATGGCAGACATCC
CGGGCCTGATAGAAGGAGCCCACCAGGGGGTTGGCCTTGGTGATGAATTTTTGCGACACATTGAGAGAACCAGGTTGTTG
ATTCATATTATTGATATATCCGGGATTGAAGGTCGAGATCCCCTTGAAGATTTTAAAACAATTAACAGGGAATTAGAAAA
ATTTAATGAGAAGTTATCATCAAGACCACAGATTGTTGCTTTAAATAAAATAGATCTTCCAGGTGCCCGGGAAAATGTGG
AACGGGTTCAACCGGTCCTGGAGGAAAAAGGTTATAAGGTTTTTCCTATATCTGCAGCCACTAAAGAAGGAGTAAAAGAG
TTAATCTATTATACCGGTGATTTACTTAAAGAACTTCCAGTTGAAAGGAAAATAGCAAAAGAAGACAGGATAGTCATAAA
ACCTGATTTTGCTGATGAAGAAGAGAATATTGTAGTTGAAAAGAAGAATGGTATTTATGAAGTTTCAGGGAGACTGGTAG
AAAAATATGTTATTAAAACCGATTTTAATAATGATGCAGCAGTTAAGAGATTGCTCAGGGTTCTTCAACATCATGATTTG
AATGAATTGTTGCGTGATAAAGGAGTAAAAAATGGTGATACTGTAAAAATCGGGCCGATGGAATTCGAATATATGGAATA
G

Upstream 100 bases:

>100_bases
AGTACTTGTGACTGGGGGTTTTTTAATTTTTGACTTTAACCCTGAATGGTTAATAATAATTAGTATTGGTTATATTAGGT
AGTGTTAAGAGGGTGATAAA

Downstream 100 bases:

>100_bases
GAGGTGTTTTTTATGTTAACAGGAAAACAGAGGAGTTATCTCAGGAGTGAAGCCAATAACCTTAACCCGGTTATTCATAT
TGGGAAAGATGGGATTACCC

Product: GTP-binding protein Obg/CgtA

Products: NA

Alternate protein names: GTP-binding protein obg

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MFVDEVEIKVKGGQGGNGVVSFRREKFEPMGGPDGGDGGDGGNVILRVDEGLNTLADFRYQRHYEAERGYHGSGKNKHGR
SGEDLVLKVPPGTVVYDADTDELLADLTEDGEEYIVAHGGKGGRGNARFKKSTRKAPRFAEKGEPGEERSIRLELKLVAD
VGLIGFPNVGKSTLISVVSEARPKIANYHFTTLKPNLGVVALSEYKSFVMADIPGLIEGAHQGVGLGDEFLRHIERTRLL
IHIIDISGIEGRDPLEDFKTINRELEKFNEKLSSRPQIVALNKIDLPGARENVERVQPVLEEKGYKVFPISAATKEGVKE
LIYYTGDLLKELPVERKIAKEDRIVIKPDFADEEENIVVEKKNGIYEVSGRLVEKYVIKTDFNNDAAVKRLLRVLQHHDL
NELLRDKGVKNGDTVKIGPMEFEYME

Sequences:

>Translated_426_residues
MFVDEVEIKVKGGQGGNGVVSFRREKFEPMGGPDGGDGGDGGNVILRVDEGLNTLADFRYQRHYEAERGYHGSGKNKHGR
SGEDLVLKVPPGTVVYDADTDELLADLTEDGEEYIVAHGGKGGRGNARFKKSTRKAPRFAEKGEPGEERSIRLELKLVAD
VGLIGFPNVGKSTLISVVSEARPKIANYHFTTLKPNLGVVALSEYKSFVMADIPGLIEGAHQGVGLGDEFLRHIERTRLL
IHIIDISGIEGRDPLEDFKTINRELEKFNEKLSSRPQIVALNKIDLPGARENVERVQPVLEEKGYKVFPISAATKEGVKE
LIYYTGDLLKELPVERKIAKEDRIVIKPDFADEEENIVVEKKNGIYEVSGRLVEKYVIKTDFNNDAAVKRLLRVLQHHDL
NELLRDKGVKNGDTVKIGPMEFEYME
>Mature_426_residues
MFVDEVEIKVKGGQGGNGVVSFRREKFEPMGGPDGGDGGDGGNVILRVDEGLNTLADFRYQRHYEAERGYHGSGKNKHGR
SGEDLVLKVPPGTVVYDADTDELLADLTEDGEEYIVAHGGKGGRGNARFKKSTRKAPRFAEKGEPGEERSIRLELKLVAD
VGLIGFPNVGKSTLISVVSEARPKIANYHFTTLKPNLGVVALSEYKSFVMADIPGLIEGAHQGVGLGDEFLRHIERTRLL
IHIIDISGIEGRDPLEDFKTINRELEKFNEKLSSRPQIVALNKIDLPGARENVERVQPVLEEKGYKVFPISAATKEGVKE
LIYYTGDLLKELPVERKIAKEDRIVIKPDFADEEENIVVEKKNGIYEVSGRLVEKYVIKTDFNNDAAVKRLLRVLQHHDL
NELLRDKGVKNGDTVKIGPMEFEYME

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain

Homologues:

Organism=Homo sapiens, GI24308117, Length=323, Percent_Identity=44.2724458204334, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI111955139, Length=349, Percent_Identity=36.1031518624642, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI111955063, Length=191, Percent_Identity=42.4083769633508, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI58761500, Length=151, Percent_Identity=33.112582781457, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI4758796, Length=160, Percent_Identity=33.75, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI4557537, Length=158, Percent_Identity=32.9113924050633, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1789574, Length=335, Percent_Identity=51.044776119403, Blast_Score=300, Evalue=9e-83,
Organism=Escherichia coli, GI1787454, Length=198, Percent_Identity=28.2828282828283, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1790615, Length=186, Percent_Identity=29.5698924731183, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17508313, Length=321, Percent_Identity=38.9408099688474, Blast_Score=171, Evalue=7e-43,
Organism=Caenorhabditis elegans, GI17552324, Length=302, Percent_Identity=30.1324503311258, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17509631, Length=176, Percent_Identity=31.25, Blast_Score=78, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17555344, Length=120, Percent_Identity=35, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71981008, Length=159, Percent_Identity=30.188679245283, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6321962, Length=192, Percent_Identity=36.9791666666667, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6319281, Length=128, Percent_Identity=36.71875, Blast_Score=70, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6321649, Length=143, Percent_Identity=27.972027972028, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24585318, Length=309, Percent_Identity=40.1294498381877, Blast_Score=195, Evalue=6e-50,
Organism=Drosophila melanogaster, GI20129375, Length=325, Percent_Identity=39.6923076923077, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24640873, Length=128, Percent_Identity=36.71875, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24640877, Length=128, Percent_Identity=36.71875, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24640875, Length=128, Percent_Identity=36.71875, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI21356473, Length=173, Percent_Identity=32.3699421965318, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17981711, Length=160, Percent_Identity=32.5, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OBG_HALOH (B8CXZ0)

Other databases:

- EMBL:   CP001098
- RefSeq:   YP_002509154.1
- GeneID:   7313950
- GenomeReviews:   CP001098_GR
- KEGG:   hor:Hore_14100
- HOGENOM:   HBG716038
- OMA:   HFTTLVP
- ProtClustDB:   CLSK2806443
- GO:   GO:0005737
- HAMAP:   MF_01454
- InterPro:   IPR014100
- InterPro:   IPR015349
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:2.70.210.12
- PANTHER:   PTHR11702:SF3
- PIRSF:   PIRSF002401
- PRINTS:   PR00326
- TIGRFAMs:   TIGR02729
- TIGRFAMs:   TIGR03595
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF09269 DUF1967; PF01018 GTP1_OBG; PF01926 MMR_HSR1; SSF102741 GTP-bd_prot_GTP1/OBG_C; SSF82051 GTP1_OBG_sub

EC number: NA

Molecular weight: Translated: 47389; Mature: 47389

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFVDEVEIKVKGGQGGNGVVSFRREKFEPMGGPDGGDGGDGGNVILRVDEGLNTLADFRY
CCCCEEEEEEECCCCCCCCEEEHHHHCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHH
QRHYEAERGYHGSGKNKHGRSGEDLVLKVPPGTVVYDADTDELLADLTEDGEEYIVAHGG
HHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCEEEECCHHHHHHHHHCCCCEEEEEECC
KGGRGNARFKKSTRKAPRFAEKGEPGEERSIRLELKLVADVGLIGFPNVGKSTLISVVSE
CCCCCCCHHHHHHHCCCCCHHCCCCCCCCEEEEEEEEEEECCEECCCCCCHHHHHHHHHH
ARPKIANYHFTTLKPNLGVVALSEYKSFVMADIPGLIEGAHQGVGLGDEFLRHIERTRLL
HCCCCCCEEEEEECCCCCEEEHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHEEE
IHIIDISGIEGRDPLEDFKTINRELEKFNEKLSSRPQIVALNKIDLPGARENVERVQPVL
EEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHH
EEKGYKVFPISAATKEGVKELIYYTGDLLKELPVERKIAKEDRIVIKPDFADEEENIVVE
HHCCCEEEEECHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCEEECCCCCCCCCCEEEE
KKNGIYEVSGRLVEKYVIKTDFNNDAAVKRLLRVLQHHDLNELLRDKGVKNGDTVKIGPM
CCCCEEEHHHHHEEHEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHCCCCCCCEEEECCC
EFEYME
CCEECC
>Mature Secondary Structure
MFVDEVEIKVKGGQGGNGVVSFRREKFEPMGGPDGGDGGDGGNVILRVDEGLNTLADFRY
CCCCEEEEEEECCCCCCCCEEEHHHHCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHH
QRHYEAERGYHGSGKNKHGRSGEDLVLKVPPGTVVYDADTDELLADLTEDGEEYIVAHGG
HHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCEEEECCHHHHHHHHHCCCCEEEEEECC
KGGRGNARFKKSTRKAPRFAEKGEPGEERSIRLELKLVADVGLIGFPNVGKSTLISVVSE
CCCCCCCHHHHHHHCCCCCHHCCCCCCCCEEEEEEEEEEECCEECCCCCCHHHHHHHHHH
ARPKIANYHFTTLKPNLGVVALSEYKSFVMADIPGLIEGAHQGVGLGDEFLRHIERTRLL
HCCCCCCEEEEEECCCCCEEEHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHEEE
IHIIDISGIEGRDPLEDFKTINRELEKFNEKLSSRPQIVALNKIDLPGARENVERVQPVL
EEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHH
EEKGYKVFPISAATKEGVKELIYYTGDLLKELPVERKIAKEDRIVIKPDFADEEENIVVE
HHCCCEEEEECHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCEEECCCCCCCCCCEEEE
KKNGIYEVSGRLVEKYVIKTDFNNDAAVKRLLRVLQHHDLNELLRDKGVKNGDTVKIGPM
CCCCEEEHHHHHEEHEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHCCCCCCCEEEECCC
EFEYME
CCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA