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The map label for this gene is mutL

Identifier: 220932003

GI number: 220932003

Start: 1256438

End: 1258372

Strand: Reverse

Name: mutL

Synonym: Hore_11660

Alternate gene names: 220932003

Gene position: 1258372-1256438 (Counterclockwise)

Preceding gene: 220932004

Following gene: 220932002

Centisome position: 48.81

GC content: 33.44

Gene sequence:

>1935_bases
ATGCCTGAGATAAAACGATTACCTGAATCTGTTGCCAATCAAATTTCAGCCGGAGAAGTTGTTGAAAGACCCGCTTCTGT
AGTTAAAGAACTTGTTGAAAATTCATTGGATGCAGGTAGTAATAAGATTTTAATAGAAATTGAAAACGGTGGAAAGGACT
TAATAAGGGTTAAAGATAATGGACATGGTATACCTTCTGATGAGATAGAAATTGCCTTTGACCGGTATGCAACAAGTAAA
ATTACTGATATAAATGATCTTTATTCTTTAAAATCTCTCGGATTCAGGGGAGAAGCCCTGGCCAGTATAGCATCAGTCTC
CATTCTTGATATAATATCCCGGACAAAATCTCAAACAAAAGCTATTAAAATGAGACTTAAAGGGGGTAAAGTGATATCAA
AAGAACCCTGTGGTGCCTCGGTCGGAACAGATATTATAGTAAAAGATTTATTTTTTAATACTCCAGCCCGTTATAAATAC
TTAAAAACAACAAGGAATGAATTTAAACATATAAGTAACATTATAACCAGGGAAGCCCTGGCTTATCCCGGGGTTAATTT
TACCCTTATTCATAATGGACGAATAGTCCTGAAAACACCGGGAACTGGAAAAACCCTGGATTGTATCTATGCGATATATG
GAAAAGAAATGGCACAAAGTCTGGTTAAAATAGATTATGAAGACAGGTATATAAAGGTATCGGGATATATTTCCAGACCT
GATTATTACCGGTATAACCGTAGTTATGAAATATTTTTTGTAAATAAAAGGGCAGTTCATAACTCAATTTTAAACAGGGG
AGTTGAAGAAGCCTATCAGGGGCTCTTACCTCCCGGGGCTTATCCGGTTGTATTTTTAAATTTAAAACTAAACCCGATTC
TGGTTGATGTAAACGTTCATCCCACCAAAAAAGAAGTAAAGTTTAGTAGAGATAAGGTAATAAAAGAAGTAATTCAAAAT
GGAATTAATATTGAGTTATCAAAATTAGATAAATCTCCAAGGCTTAAAAGAAATATTAATCCATTAAATAGGGATGACAA
GACTAAAGATAAAAGTGAGTATCAAAAAATAAAACTACCTGAAGATAAAGAGCAAATTACAAATAAATCTTCCGATGCTG
GTATATTAAAAAATCAAAATCCCTTAGATTCACAGGATTCAATTTTGCTTCCCAGTAAAAAAAATGGGTTTTATAGTAAA
AAAAACTCTCAGGTTAGTCAAAATAAATTTATGGATATTAATAACAAATTAGAAAAAACCGAGATTAACGATAACTACAA
AAAAGATAAACATTATAAAACAGATTCAATAAACATTAAAGATAATAGTATTAAAGAAAATAAAAATAAGATGGACATTC
CGATAAAAAGGGTCCTGGGGCAGATTAAAAACACTTATATTATTGCTGAAGGAAGGGATGGGCTTTATATTATTGACCAG
CATAATGCCCATGAACGTATATTATATCAATCATTTATTGAGAAATATAATAATAGTGAGATTGTCTCACAACCCCTGGT
AGTTCCCGTCAACATTGAAACTACCGCTCCGGAGGCTGAAGTGCTGAAAAGTTATTTGCCCCAGTTAGAAAAAATGGGTT
TTAAACTGGAGGTTTTTGGGATTAATAGTTTTATAGTCAGGGAAGTTCCCTCCCTGATAAAAAAACGTTCAAATAAAAGG
GTTGTTAGGGAAGTAATAGATAAACTCCTGGAACACGATAAAGCTATGAAACCATCAGAATTAATTAATGAGATAATTTC
CTATATGTCGTGCCGTGGGGCAATAAAGGCCGGTGAATATCTGGATAAAAAGGAAGCAGAACAAATTATTGAAGGGTTAT
TTAAAACAGATAACCCTTATCGCTGTCCTCACGGAAGACCGATAATAATACATATAACAGAGGATGATATTAATAAGGGA
ATGGGGCGTAAATGA

Upstream 100 bases:

>100_bases
GAAAAAATAAAAAATAAAGATATTGTTAATATGACCCCCATGGAAGCAATTAATTTTCTCTTTGAAATTCAGAAGGAGCT
TAAGGAAAAGGGGGAAAACT

Downstream 100 bases:

>100_bases
GGAGGTAATTATTTTGATTAAACCCCTGACAAATCATGGAAATAAGAATATATATCCTGATAATTCTACCCTTATCGTTA
TCCTGGGACCTACAGCTGTA

Product: DNA mismatch repair protein MutL

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 644; Mature: 643

Protein sequence:

>644_residues
MPEIKRLPESVANQISAGEVVERPASVVKELVENSLDAGSNKILIEIENGGKDLIRVKDNGHGIPSDEIEIAFDRYATSK
ITDINDLYSLKSLGFRGEALASIASVSILDIISRTKSQTKAIKMRLKGGKVISKEPCGASVGTDIIVKDLFFNTPARYKY
LKTTRNEFKHISNIITREALAYPGVNFTLIHNGRIVLKTPGTGKTLDCIYAIYGKEMAQSLVKIDYEDRYIKVSGYISRP
DYYRYNRSYEIFFVNKRAVHNSILNRGVEEAYQGLLPPGAYPVVFLNLKLNPILVDVNVHPTKKEVKFSRDKVIKEVIQN
GINIELSKLDKSPRLKRNINPLNRDDKTKDKSEYQKIKLPEDKEQITNKSSDAGILKNQNPLDSQDSILLPSKKNGFYSK
KNSQVSQNKFMDINNKLEKTEINDNYKKDKHYKTDSINIKDNSIKENKNKMDIPIKRVLGQIKNTYIIAEGRDGLYIIDQ
HNAHERILYQSFIEKYNNSEIVSQPLVVPVNIETTAPEAEVLKSYLPQLEKMGFKLEVFGINSFIVREVPSLIKKRSNKR
VVREVIDKLLEHDKAMKPSELINEIISYMSCRGAIKAGEYLDKKEAEQIIEGLFKTDNPYRCPHGRPIIIHITEDDINKG
MGRK

Sequences:

>Translated_644_residues
MPEIKRLPESVANQISAGEVVERPASVVKELVENSLDAGSNKILIEIENGGKDLIRVKDNGHGIPSDEIEIAFDRYATSK
ITDINDLYSLKSLGFRGEALASIASVSILDIISRTKSQTKAIKMRLKGGKVISKEPCGASVGTDIIVKDLFFNTPARYKY
LKTTRNEFKHISNIITREALAYPGVNFTLIHNGRIVLKTPGTGKTLDCIYAIYGKEMAQSLVKIDYEDRYIKVSGYISRP
DYYRYNRSYEIFFVNKRAVHNSILNRGVEEAYQGLLPPGAYPVVFLNLKLNPILVDVNVHPTKKEVKFSRDKVIKEVIQN
GINIELSKLDKSPRLKRNINPLNRDDKTKDKSEYQKIKLPEDKEQITNKSSDAGILKNQNPLDSQDSILLPSKKNGFYSK
KNSQVSQNKFMDINNKLEKTEINDNYKKDKHYKTDSINIKDNSIKENKNKMDIPIKRVLGQIKNTYIIAEGRDGLYIIDQ
HNAHERILYQSFIEKYNNSEIVSQPLVVPVNIETTAPEAEVLKSYLPQLEKMGFKLEVFGINSFIVREVPSLIKKRSNKR
VVREVIDKLLEHDKAMKPSELINEIISYMSCRGAIKAGEYLDKKEAEQIIEGLFKTDNPYRCPHGRPIIIHITEDDINKG
MGRK
>Mature_643_residues
PEIKRLPESVANQISAGEVVERPASVVKELVENSLDAGSNKILIEIENGGKDLIRVKDNGHGIPSDEIEIAFDRYATSKI
TDINDLYSLKSLGFRGEALASIASVSILDIISRTKSQTKAIKMRLKGGKVISKEPCGASVGTDIIVKDLFFNTPARYKYL
KTTRNEFKHISNIITREALAYPGVNFTLIHNGRIVLKTPGTGKTLDCIYAIYGKEMAQSLVKIDYEDRYIKVSGYISRPD
YYRYNRSYEIFFVNKRAVHNSILNRGVEEAYQGLLPPGAYPVVFLNLKLNPILVDVNVHPTKKEVKFSRDKVIKEVIQNG
INIELSKLDKSPRLKRNINPLNRDDKTKDKSEYQKIKLPEDKEQITNKSSDAGILKNQNPLDSQDSILLPSKKNGFYSKK
NSQVSQNKFMDINNKLEKTEINDNYKKDKHYKTDSINIKDNSIKENKNKMDIPIKRVLGQIKNTYIIAEGRDGLYIIDQH
NAHERILYQSFIEKYNNSEIVSQPLVVPVNIETTAPEAEVLKSYLPQLEKMGFKLEVFGINSFIVREVPSLIKKRSNKRV
VREVIDKLLEHDKAMKPSELINEIISYMSCRGAIKAGEYLDKKEAEQIIEGLFKTDNPYRCPHGRPIIIHITEDDINKGM
GRK

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=328, Percent_Identity=37.5, Blast_Score=230, Evalue=4e-60,
Organism=Homo sapiens, GI4505911, Length=317, Percent_Identity=29.9684542586751, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI189458898, Length=331, Percent_Identity=29.0030211480363, Blast_Score=146, Evalue=6e-35,
Organism=Homo sapiens, GI4505913, Length=348, Percent_Identity=28.448275862069, Blast_Score=143, Evalue=4e-34,
Organism=Homo sapiens, GI310128478, Length=348, Percent_Identity=28.448275862069, Blast_Score=143, Evalue=5e-34,
Organism=Homo sapiens, GI263191589, Length=234, Percent_Identity=33.7606837606838, Blast_Score=135, Evalue=2e-31,
Organism=Homo sapiens, GI189458896, Length=310, Percent_Identity=30.9677419354839, Blast_Score=134, Evalue=4e-31,
Organism=Homo sapiens, GI91992162, Length=351, Percent_Identity=28.7749287749288, Blast_Score=132, Evalue=8e-31,
Organism=Homo sapiens, GI91992160, Length=351, Percent_Identity=28.7749287749288, Blast_Score=132, Evalue=8e-31,
Organism=Homo sapiens, GI310128480, Length=301, Percent_Identity=26.2458471760797, Blast_Score=110, Evalue=6e-24,
Organism=Homo sapiens, GI263191733, Length=94, Percent_Identity=37.2340425531915, Blast_Score=70, Evalue=7e-12,
Organism=Homo sapiens, GI263191713, Length=94, Percent_Identity=37.2340425531915, Blast_Score=70, Evalue=7e-12,
Organism=Escherichia coli, GI1790612, Length=581, Percent_Identity=32.1858864027539, Blast_Score=270, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI71991825, Length=320, Percent_Identity=34.375, Blast_Score=196, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI17562796, Length=356, Percent_Identity=27.5280898876405, Blast_Score=128, Evalue=9e-30,
Organism=Saccharomyces cerevisiae, GI6323819, Length=341, Percent_Identity=34.3108504398827, Blast_Score=200, Evalue=7e-52,
Organism=Saccharomyces cerevisiae, GI6324247, Length=355, Percent_Identity=28.7323943661972, Blast_Score=138, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6325093, Length=740, Percent_Identity=22.2972972972973, Blast_Score=116, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6323063, Length=364, Percent_Identity=26.0989010989011, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI17136968, Length=523, Percent_Identity=30.2103250478011, Blast_Score=223, Evalue=3e-58,
Organism=Drosophila melanogaster, GI17136970, Length=358, Percent_Identity=28.7709497206704, Blast_Score=136, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_HALOH (B8CX97)

Other databases:

- EMBL:   CP001098
- RefSeq:   YP_002508911.1
- ProteinModelPortal:   B8CX97
- SMR:   B8CX97
- GeneID:   7313864
- GenomeReviews:   CP001098_GR
- KEGG:   hor:Hore_11660
- HOGENOM:   HBG520262
- OMA:   FLFINNR
- ProtClustDB:   CLSK2806384
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 73222; Mature: 73091

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEIKRLPESVANQISAGEVVERPASVVKELVENSLDAGSNKILIEIENGGKDLIRVKDN
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEECCC
GHGIPSDEIEIAFDRYATSKITDINDLYSLKSLGFRGEALASIASVSILDIISRTKSQTK
CCCCCCCCEEEEEHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
AIKMRLKGGKVISKEPCGASVGTDIIVKDLFFNTPARYKYLKTTRNEFKHISNIITREAL
HEEEEECCCEEECCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
AYPGVNFTLIHNGRIVLKTPGTGKTLDCIYAIYGKEMAQSLVKIDYEDRYIKVSGYISRP
HCCCCEEEEEECCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCC
DYYRYNRSYEIFFVNKRAVHNSILNRGVEEAYQGLLPPGAYPVVFLNLKLNPILVDVNVH
CCEEECCEEEEEEEEHHHHHHHHHHCCHHHHHHCCCCCCCCEEEEEEEEECEEEEEEECC
PTKKEVKFSRDKVIKEVIQNGINIELSKLDKSPRLKRNINPLNRDDKTKDKSEYQKIKLP
CCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHCCCCCCCCCCCCCCHHHHHCCCCC
EDKEQITNKSSDAGILKNQNPLDSQDSILLPSKKNGFYSKKNSQVSQNKFMDINNKLEKT
CCHHHHCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCHHHHHCCCCCCCCCCC
EINDNYKKDKHYKTDSINIKDNSIKENKNKMDIPIKRVLGQIKNTYIIAEGRDGLYIIDQ
CCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHCCEEEEEECCCCEEEEEC
HNAHERILYQSFIEKYNNSEIVSQPLVVPVNIETTAPEAEVLKSYLPQLEKMGFKLEVFG
CCCHHHHHHHHHHHHCCCCCHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEEE
INSFIVREVPSLIKKRSNKRVVREVIDKLLEHDKAMKPSELINEIISYMSCRGAIKAGEY
CCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHH
LDKKEAEQIIEGLFKTDNPYRCPHGRPIIIHITEDDINKGMGRK
CCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCHHCCCCCCC
>Mature Secondary Structure 
PEIKRLPESVANQISAGEVVERPASVVKELVENSLDAGSNKILIEIENGGKDLIRVKDN
CHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEECCC
GHGIPSDEIEIAFDRYATSKITDINDLYSLKSLGFRGEALASIASVSILDIISRTKSQTK
CCCCCCCCEEEEEHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
AIKMRLKGGKVISKEPCGASVGTDIIVKDLFFNTPARYKYLKTTRNEFKHISNIITREAL
HEEEEECCCEEECCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
AYPGVNFTLIHNGRIVLKTPGTGKTLDCIYAIYGKEMAQSLVKIDYEDRYIKVSGYISRP
HCCCCEEEEEECCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCC
DYYRYNRSYEIFFVNKRAVHNSILNRGVEEAYQGLLPPGAYPVVFLNLKLNPILVDVNVH
CCEEECCEEEEEEEEHHHHHHHHHHCCHHHHHHCCCCCCCCEEEEEEEEECEEEEEEECC
PTKKEVKFSRDKVIKEVIQNGINIELSKLDKSPRLKRNINPLNRDDKTKDKSEYQKIKLP
CCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHCCCCCCCCCCCCCCHHHHHCCCCC
EDKEQITNKSSDAGILKNQNPLDSQDSILLPSKKNGFYSKKNSQVSQNKFMDINNKLEKT
CCHHHHCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCHHHHHCCCCCCCCCCC
EINDNYKKDKHYKTDSINIKDNSIKENKNKMDIPIKRVLGQIKNTYIIAEGRDGLYIIDQ
CCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHCCEEEEEECCCCEEEEEC
HNAHERILYQSFIEKYNNSEIVSQPLVVPVNIETTAPEAEVLKSYLPQLEKMGFKLEVFG
CCCHHHHHHHHHHHHCCCCCHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEEE
INSFIVREVPSLIKKRSNKRVVREVIDKLLEHDKAMKPSELINEIISYMSCRGAIKAGEY
CCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHH
LDKKEAEQIIEGLFKTDNPYRCPHGRPIIIHITEDDINKGMGRK
CCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA