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The map label for this gene is ribD [H]

Identifier: 220931842

GI number: 220931842

Start: 1090117

End: 1091217

Strand: Direct

Name: ribD [H]

Synonym: Hore_09990

Alternate gene names: 220931842

Gene position: 1090117-1091217 (Clockwise)

Preceding gene: 220931841

Following gene: 220931843

Centisome position: 42.28

GC content: 38.6

Gene sequence:

>1101_bases
ATGGATAAAGATATTTATTACATGGAAAAAGCATTGACCCTGGCCCGAAAGGGGGTCGGTTATACCAGCCCTAATCCAAT
GGTTGGGGCAGTGGTTGTCAGGGATGATAAAATCGTAGGAGAGGGTCACCACAGGTATTACGGCGGGCCCCATGCTGAAG
TATATGCCCTGGAGGAAGCAGGGGAAAAGGCGTTTGGAAGTACCCTTTATGTAAATTTAGAACCATGTAGTCATTATGGT
AAGACACCACCCTGTGTCTTTAAAATTATTGAATCGGGTGTTAAAAGAGTAGTTATTTCTATGGTGGACCCTAATCCCAG
GGTATCGGGCAAGGGTATAGAAATGTTAAAAAAAGCAGGCATTGAAGTAACGGTCGGGGTTTTAGAGGAAAAGGCCCGTA
ATTTAAATGAGGTTTTTATAAAAAATATTACAAACAGGATGCCCTTTGTATATTTGAAGATGGCCCAGACCCTTGATGGC
TATCTGGCTACCTCTTCCGGAGATTCAAGATGGGTTACTGGTAAAAAAGCCCGTCAATATGTACACAGACTGAGACACCG
GGTTGATGCTATTCTGGTTGGTATTGGTACAGTACTTAAAGATGACCCCAGACTTACAACCAGATTATCTGATGGTAAAG
GTAAGGACAGTATAAAAATTGTACTTGATAGTAAATTAAAAATACCTCTGACAGCAAATATTTTAAACCAGGAAAATGAT
GCCCCTGTCATAATTGTCTGTGGTCACAGGGTAGATAGTCATAAGAAAAAGTCCCTTAAGCAACTTAAAAGTGTTGAGGT
TTTAAGTCTTGATTTAAATGAGTATGGCCAGATCCCTATAAAAGAATTATTAATTAACTTAAACAAAAAAGGTATTTCCA
GTTTACTGGTTGAAGGTGGTGGAAGAGTAAACTATTCTTTCCTGAAGGAAGGGTTTGTTGATAAAATGTTATTTTTCATT
GCTCCCAAATTATTGGGGGGGAGTGACGGGGTTTCTGTTTTTGACGGAAAAGGGGCAGAAGTTATGGCAAAAGTAAAGAA
ATTAAAAAAATATAAAATTGAGGAAATAGGAGAAGATATATTGATTACAGGTACTTTATAA

Upstream 100 bases:

>100_bases
CCCTCGTTCTGTGGATAGGGGATAAGGACTTTACTATATTGATGTATTAATAAAAAGTTGACTAAATAGATAAATATACT
TAAAAAAGGAGAGTTACTTA

Downstream 100 bases:

>100_bases
TTTTGAGCAGATTACAAAAAAGGGGGGATATTTTGTTTACAGGTATAATTCAGGAAATAGGTAGCCTTGAAGGAAAAGTA
AGGGGAACAAATAAATACCA

Product: riboflavin biosynthesis protein RibD

Products: NA

Alternate protein names: Diaminohydroxyphosphoribosylaminopyrimidine deaminase; DRAP deaminase; Riboflavin-specific deaminase; 5-amino-6-(5-phosphoribosylamino)uracil reductase; HTP reductase [H]

Number of amino acids: Translated: 366; Mature: 366

Protein sequence:

>366_residues
MDKDIYYMEKALTLARKGVGYTSPNPMVGAVVVRDDKIVGEGHHRYYGGPHAEVYALEEAGEKAFGSTLYVNLEPCSHYG
KTPPCVFKIIESGVKRVVISMVDPNPRVSGKGIEMLKKAGIEVTVGVLEEKARNLNEVFIKNITNRMPFVYLKMAQTLDG
YLATSSGDSRWVTGKKARQYVHRLRHRVDAILVGIGTVLKDDPRLTTRLSDGKGKDSIKIVLDSKLKIPLTANILNQEND
APVIIVCGHRVDSHKKKSLKQLKSVEVLSLDLNEYGQIPIKELLINLNKKGISSLLVEGGGRVNYSFLKEGFVDKMLFFI
APKLLGGSDGVSVFDGKGAEVMAKVKKLKKYKIEEIGEDILITGTL

Sequences:

>Translated_366_residues
MDKDIYYMEKALTLARKGVGYTSPNPMVGAVVVRDDKIVGEGHHRYYGGPHAEVYALEEAGEKAFGSTLYVNLEPCSHYG
KTPPCVFKIIESGVKRVVISMVDPNPRVSGKGIEMLKKAGIEVTVGVLEEKARNLNEVFIKNITNRMPFVYLKMAQTLDG
YLATSSGDSRWVTGKKARQYVHRLRHRVDAILVGIGTVLKDDPRLTTRLSDGKGKDSIKIVLDSKLKIPLTANILNQEND
APVIIVCGHRVDSHKKKSLKQLKSVEVLSLDLNEYGQIPIKELLINLNKKGISSLLVEGGGRVNYSFLKEGFVDKMLFFI
APKLLGGSDGVSVFDGKGAEVMAKVKKLKKYKIEEIGEDILITGTL
>Mature_366_residues
MDKDIYYMEKALTLARKGVGYTSPNPMVGAVVVRDDKIVGEGHHRYYGGPHAEVYALEEAGEKAFGSTLYVNLEPCSHYG
KTPPCVFKIIESGVKRVVISMVDPNPRVSGKGIEMLKKAGIEVTVGVLEEKARNLNEVFIKNITNRMPFVYLKMAQTLDG
YLATSSGDSRWVTGKKARQYVHRLRHRVDAILVGIGTVLKDDPRLTTRLSDGKGKDSIKIVLDSKLKIPLTANILNQEND
APVIIVCGHRVDSHKKKSLKQLKSVEVLSLDLNEYGQIPIKELLINLNKKGISSLLVEGGGRVNYSFLKEGFVDKMLFFI
APKLLGGSDGVSVFDGKGAEVMAKVKKLKKYKIEEIGEDILITGTL

Specific function: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate [H]

COG id: COG0117

COG function: function code H; Pyrimidine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the HTP reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786616, Length=371, Percent_Identity=39.622641509434, Blast_Score=272, Evalue=3e-74,
Organism=Escherichia coli, GI145693172, Length=149, Percent_Identity=31.5436241610738, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319629, Length=191, Percent_Identity=26.7015706806283, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193
- InterPro:   IPR004794
- InterPro:   IPR011549
- InterPro:   IPR002734 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1; PF01872 RibD_C [H]

EC number: =3.5.4.26; =1.1.1.193 [H]

Molecular weight: Translated: 40372; Mature: 40372

Theoretical pI: Translated: 9.85; Mature: 9.85

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKDIYYMEKALTLARKGVGYTSPNPMVGAVVVRDDKIVGEGHHRYYGGPHAEVYALEEA
CCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCEEECCCCCCCCCCCCCEEEEEHHC
GEKAFGSTLYVNLEPCSHYGKTPPCVFKIIESGVKRVVISMVDPNPRVSGKGIEMLKKAG
CCHHCCCEEEEEECCHHCCCCCCHHHHHHHHHHHHEEEEEEECCCCCCCCCHHHHHHHCC
IEVTVGVLEEKARNLNEVFIKNITNRMPFVYLKMAQTLDGYLATSSGDSRWVTGKKARQY
CEEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHCCEEEECCCCCCEECCHHHHHH
VHRLRHRVDAILVGIGTVLKDDPRLTTRLSDGKGKDSIKIVLDSKLKIPLTANILNQEND
HHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEEEECCCCCEEEEHHHCCCCC
APVIIVCGHRVDSHKKKSLKQLKSVEVLSLDLNEYGQIPIKELLINLNKKGISSLLVEGG
CCEEEEECCCCCHHHHHHHHHHHCCEEEEECHHHCCCCCHHHHHHHCCHHHHHHHHHCCC
GRVNYSFLKEGFVDKMLFFIAPKLLGGSDGVSVFDGKGAEVMAKVKKLKKYKIEEIGEDI
CEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHCCCCE
LITGTL
EEEECC
>Mature Secondary Structure
MDKDIYYMEKALTLARKGVGYTSPNPMVGAVVVRDDKIVGEGHHRYYGGPHAEVYALEEA
CCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCEEECCCCCCCCCCCCCEEEEEHHC
GEKAFGSTLYVNLEPCSHYGKTPPCVFKIIESGVKRVVISMVDPNPRVSGKGIEMLKKAG
CCHHCCCEEEEEECCHHCCCCCCHHHHHHHHHHHHEEEEEEECCCCCCCCCHHHHHHHCC
IEVTVGVLEEKARNLNEVFIKNITNRMPFVYLKMAQTLDGYLATSSGDSRWVTGKKARQY
CEEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHCCEEEECCCCCCEECCHHHHHH
VHRLRHRVDAILVGIGTVLKDDPRLTTRLSDGKGKDSIKIVLDSKLKIPLTANILNQEND
HHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEEEECCCCCEEEEHHHCCCCC
APVIIVCGHRVDSHKKKSLKQLKSVEVLSLDLNEYGQIPIKELLINLNKKGISSLLVEGG
CCEEEEECCCCCHHHHHHHHHHHCCEEEEECHHHCCCCCHHHHHHHCCHHHHHHHHHCCC
GRVNYSFLKEGFVDKMLFFIAPKLLGGSDGVSVFDGKGAEVMAKVKKLKKYKIEEIGEDI
CEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHCCCCE
LITGTL
EEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]