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The map label for this gene is coaBC [H]

Identifier: 220931826

GI number: 220931826

Start: 1071443

End: 1072627

Strand: Direct

Name: coaBC [H]

Synonym: Hore_09830

Alternate gene names: 220931826

Gene position: 1071443-1072627 (Clockwise)

Preceding gene: 220931825

Following gene: 220931827

Centisome position: 41.56

GC content: 40.08

Gene sequence:

>1185_bases
ATGGATGAAGAAAAAAAACACGTTCTGCTGGGGGTAACTGGTGGAATTGCAGCCTACAAGGCTGTCGATGTGGCCAGCCG
TTTAACTAAAGCAGGGGTATCAACCCATGTGGTAATGACAGAATCAGCCAAAAAGTTTGTAACCCCACTAACCTTCCGGA
GTATTACCCATAATCCGGTAGAAGATGATTTGTTTACTCCTCCGGCCCATTATAATGTAAAACATACTTCCCTGGCCAGC
CTGGTCGATGTCTGCCTGGTGGCCCCGGCAACAGCTAATTTTATTGGCAAAATAGCCAGTGGTATTGCTGATGATCTGTT
GACAACAGTAATTATGGCCACCAATTCACCGGTTTTAATCTCTCCTTCAATGAATGTTAATATGTATAACAACCCTATAG
TTCAGGATAACATTTCATACCTGAAGGATAAGGGATATAAAATAATTGAGCCTTCTTCGGGTTATCTTGCCTGTGGTGAT
ACCGGGAAGGGAAGGTTACCTGAACCTTATCAACTCGTTGAACATGTCTTAAAATATTTATCTGATAAAGATCTGCAAGA
TAGAAATATTTTGATTACGGCAGGACCTACCAGAGAGCCTCTGGATCCGGTCAGGTTTTTATCGAATTATTCCAGTGGGA
AAATGGGTTATGCCCTGGCCCGGGCTGCTTCTTTCAGGGGAGCCAGAGTGACCCTGATCTCTGGACCGGGGAATCTAAAG
CCTCCTGTCGGAGTTAATTTTATTAGAGTAAAGACGGCCAGGGATATGTTTGGTGAAGTAAAAAGTCTGGCAGACGATCA
GGATATTTTTATTCTGGCAGCTGCTGTTTCTGATTACCGACCATCCCATTTTTCCAGACATAAAATTAAGAAAAAAGATA
CAGATATGAAACTGGTTCTGGAACGCAATCCTGATATTGCTGCTTATTTAGGTAAGAATAAAACCTCAAAACAGTTATTA
ATAGGATTTGCGGCTGAATCAGACAGTATTATAGAAAATGCCCGGGAGAAAATGATAAAAAAGAATCTTGATATGATTAT
TGCCAATGATATTACTGGAGAGAATACCGGTTTTGAAAGTGATTATAATAAGGGTTATTTAATTCGAAGAGGGAATGTTG
AAAAATTACCGGAGATGGATAAATATAAACTGGCTAATTTAATTTTAGACCAGATAAACAAATAG

Upstream 100 bases:

>100_bases
AGGAGCCTGGAGGAGATCGCAGCGGGTAAAGTCACCTATGAAATTAAAAGACGTAATTAGTTTTTATAATTCTTTTTAAA
ATTCAGGGAGAGGTTATAAA

Downstream 100 bases:

>100_bases
TTACGGGGTAAAAAAAGGAGCAGGTTTAACCTGCTCCTAATATTATGTGTCCGGGATAAACCCGTCCGGGCCCGGTTACT
ATATTAAAATACTATGTTTA

Product: phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MDEEKKHVLLGVTGGIAAYKAVDVASRLTKAGVSTHVVMTESAKKFVTPLTFRSITHNPVEDDLFTPPAHYNVKHTSLAS
LVDVCLVAPATANFIGKIASGIADDLLTTVIMATNSPVLISPSMNVNMYNNPIVQDNISYLKDKGYKIIEPSSGYLACGD
TGKGRLPEPYQLVEHVLKYLSDKDLQDRNILITAGPTREPLDPVRFLSNYSSGKMGYALARAASFRGARVTLISGPGNLK
PPVGVNFIRVKTARDMFGEVKSLADDQDIFILAAAVSDYRPSHFSRHKIKKKDTDMKLVLERNPDIAAYLGKNKTSKQLL
IGFAAESDSIIENAREKMIKKNLDMIIANDITGENTGFESDYNKGYLIRRGNVEKLPEMDKYKLANLILDQINK

Sequences:

>Translated_394_residues
MDEEKKHVLLGVTGGIAAYKAVDVASRLTKAGVSTHVVMTESAKKFVTPLTFRSITHNPVEDDLFTPPAHYNVKHTSLAS
LVDVCLVAPATANFIGKIASGIADDLLTTVIMATNSPVLISPSMNVNMYNNPIVQDNISYLKDKGYKIIEPSSGYLACGD
TGKGRLPEPYQLVEHVLKYLSDKDLQDRNILITAGPTREPLDPVRFLSNYSSGKMGYALARAASFRGARVTLISGPGNLK
PPVGVNFIRVKTARDMFGEVKSLADDQDIFILAAAVSDYRPSHFSRHKIKKKDTDMKLVLERNPDIAAYLGKNKTSKQLL
IGFAAESDSIIENAREKMIKKNLDMIIANDITGENTGFESDYNKGYLIRRGNVEKLPEMDKYKLANLILDQINK
>Mature_394_residues
MDEEKKHVLLGVTGGIAAYKAVDVASRLTKAGVSTHVVMTESAKKFVTPLTFRSITHNPVEDDLFTPPAHYNVKHTSLAS
LVDVCLVAPATANFIGKIASGIADDLLTTVIMATNSPVLISPSMNVNMYNNPIVQDNISYLKDKGYKIIEPSSGYLACGD
TGKGRLPEPYQLVEHVLKYLSDKDLQDRNILITAGPTREPLDPVRFLSNYSSGKMGYALARAASFRGARVTLISGPGNLK
PPVGVNFIRVKTARDMFGEVKSLADDQDIFILAAAVSDYRPSHFSRHKIKKKDTDMKLVLERNPDIAAYLGKNKTSKQLL
IGFAAESDSIIENAREKMIKKNLDMIIANDITGENTGFESDYNKGYLIRRGNVEKLPEMDKYKLANLILDQINK

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=181, Percent_Identity=37.5690607734807, Blast_Score=105, Evalue=8e-23,
Organism=Escherichia coli, GI87082301, Length=396, Percent_Identity=43.6868686868687, Blast_Score=316, Evalue=2e-87,
Organism=Caenorhabditis elegans, GI17560194, Length=192, Percent_Identity=33.3333333333333, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6322762, Length=198, Percent_Identity=29.7979797979798, Blast_Score=89, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24657262, Length=188, Percent_Identity=32.4468085106383, Blast_Score=92, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 43336; Mature: 43336

Theoretical pI: Translated: 9.35; Mature: 9.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDEEKKHVLLGVTGGIAAYKAVDVASRLTKAGVSTHVVMTESAKKFVTPLTFRSITHNPV
CCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHCCHHHHCCCCCCC
EDDLFTPPAHYNVKHTSLASLVDVCLVAPATANFIGKIASGIADDLLTTVIMATNSPVLI
CCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
SPSMNVNMYNNPIVQDNISYLKDKGYKIIEPSSGYLACGDTGKGRLPEPYQLVEHVLKYL
CCCCCEEECCCCCCCCCHHHHHCCCCEEECCCCCEEEECCCCCCCCCCHHHHHHHHHHHH
SDKDLQDRNILITAGPTREPLDPVRFLSNYSSGKMGYALARAASFRGARVTLISGPGNLK
CCCCCCCCEEEEEECCCCCCCHHHHHHHCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCC
PPVGVNFIRVKTARDMFGEVKSLADDQDIFILAAAVSDYRPSHFSRHKIKKKDTDMKLVL
CCCCCEEEEEEHHHHHHHHHHHHCCCCCEEEEEEEHHCCCCCCHHHHHCCCCCCCEEEEE
ERNPDIAAYLGKNKTSKQLLIGFAAESDSIIENAREKMIKKNLDMIIANDITGENTGFES
ECCCCEEEEECCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCC
DYNKGYLIRRGNVEKLPEMDKYKLANLILDQINK
CCCCCEEEECCCHHHCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDEEKKHVLLGVTGGIAAYKAVDVASRLTKAGVSTHVVMTESAKKFVTPLTFRSITHNPV
CCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHCCHHHHCCCCCCC
EDDLFTPPAHYNVKHTSLASLVDVCLVAPATANFIGKIASGIADDLLTTVIMATNSPVLI
CCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
SPSMNVNMYNNPIVQDNISYLKDKGYKIIEPSSGYLACGDTGKGRLPEPYQLVEHVLKYL
CCCCCEEECCCCCCCCCHHHHHCCCCEEECCCCCEEEECCCCCCCCCCHHHHHHHHHHHH
SDKDLQDRNILITAGPTREPLDPVRFLSNYSSGKMGYALARAASFRGARVTLISGPGNLK
CCCCCCCCEEEEEECCCCCCCHHHHHHHCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCC
PPVGVNFIRVKTARDMFGEVKSLADDQDIFILAAAVSDYRPSHFSRHKIKKKDTDMKLVL
CCCCCEEEEEEHHHHHHHHHHHHCCCCCEEEEEEEHHCCCCCCHHHHHCCCCCCCEEEEE
ERNPDIAAYLGKNKTSKQLLIGFAAESDSIIENAREKMIKKNLDMIIANDITGENTGFES
ECCCCEEEEECCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCC
DYNKGYLIRRGNVEKLPEMDKYKLANLILDQINK
CCCCCEEEECCCHHHCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]