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The map label for this gene is crp [H]

Identifier: 220931819

GI number: 220931819

Start: 1063380

End: 1064060

Strand: Direct

Name: crp [H]

Synonym: Hore_09760

Alternate gene names: 220931819

Gene position: 1063380-1064060 (Clockwise)

Preceding gene: 220931818

Following gene: 220931820

Centisome position: 41.25

GC content: 39.94

Gene sequence:

>681_bases
GTGGCCAACGGTAAGGATTTAAGTTTTTTGAGGAAGTTTATTTTATTCTCTGAAATGAGTGATGAAGACCTGAGTACGGT
TGCTTCTTTGCTGCAAACCCGTATTTTTAAAGATGGTACCAATATTTTTTTTGAAGGGGAAGAAGGGGACCGGGTATATT
TCCTGAAAAAAGGAAGGGTAAAGGTCAAAAAAACTTCCCCTGATGGGGGTGAACAGATTCTGGAAATAATAACCCCGGGT
GATGTATTCGGTGAGGTTGTTTTGTTCGGGATAGATAGGTATCCAGCTACTACTGTTGCTATTGGCGAGGTAGTAGTTGA
CTATCTATCCCGTTCAAAATTTAGAAGATACTTTACCAATAACCCGGAAATAGGGTGGGGAATGTTAAAAGTTATGGCCC
GTAAACTGGCCCGCTCCCAGAAACGAATTGAAAATCTGGGGCTCAGGGATACCAAAGGCAGGGTTGCAACCCTTATTATG
GATATGATGAGGGATTTTGGAGAGAAAAATAATCAAGTTGTTAAGCTTCATTTTAATCGTCAGGAACTGGCCAATTTTAT
TGGAACATCCCGGGAAACGGTAAGTCGGACTTTAAGTGAATTTAAAAGTGAGGGGTTAATAGATATTAAAGGGAAGAAGT
TGATTATTAAAGATATAGAGGGTTTAAAGCGGTGGTTATAG

Upstream 100 bases:

>100_bases
TAACAACCCGCATGGTAAATGGAGCCTGTTATGCATATGATTATAACGAAGATAGAATAATAACAGAAGAAGAGAGAATA
CAACGCCTGGGGGGTTAGAT

Downstream 100 bases:

>100_bases
AAATAATATATAAGATTTTAGATAGTTATTGGAGTACTATTTCCGGTTAAGTGGGAGGATAAACATGTCTTTATTATTGC
CATTTATAAGTGGTTTATTT

Product: putative Crp/Fnr family transcriptional regulator

Products: NA

Alternate protein names: cAMP receptor protein; cAMP regulatory protein [H]

Number of amino acids: Translated: 226; Mature: 225

Protein sequence:

>226_residues
MANGKDLSFLRKFILFSEMSDEDLSTVASLLQTRIFKDGTNIFFEGEEGDRVYFLKKGRVKVKKTSPDGGEQILEIITPG
DVFGEVVLFGIDRYPATTVAIGEVVVDYLSRSKFRRYFTNNPEIGWGMLKVMARKLARSQKRIENLGLRDTKGRVATLIM
DMMRDFGEKNNQVVKLHFNRQELANFIGTSRETVSRTLSEFKSEGLIDIKGKKLIIKDIEGLKRWL

Sequences:

>Translated_226_residues
MANGKDLSFLRKFILFSEMSDEDLSTVASLLQTRIFKDGTNIFFEGEEGDRVYFLKKGRVKVKKTSPDGGEQILEIITPG
DVFGEVVLFGIDRYPATTVAIGEVVVDYLSRSKFRRYFTNNPEIGWGMLKVMARKLARSQKRIENLGLRDTKGRVATLIM
DMMRDFGEKNNQVVKLHFNRQELANFIGTSRETVSRTLSEFKSEGLIDIKGKKLIIKDIEGLKRWL
>Mature_225_residues
ANGKDLSFLRKFILFSEMSDEDLSTVASLLQTRIFKDGTNIFFEGEEGDRVYFLKKGRVKVKKTSPDGGEQILEIITPGD
VFGEVVLFGIDRYPATTVAIGEVVVDYLSRSKFRRYFTNNPEIGWGMLKVMARKLARSQKRIENLGLRDTKGRVATLIMD
MMRDFGEKNNQVVKLHFNRQELANFIGTSRETVSRTLSEFKSEGLIDIKGKKLIIKDIEGLKRWL

Specific function: This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons [H]

COG id: COG0664

COG function: function code T; cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH crp-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789756, Length=207, Percent_Identity=28.0193236714976, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1787595, Length=226, Percent_Identity=22.1238938053097, Blast_Score=68, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018490
- InterPro:   IPR018488
- InterPro:   IPR000595
- InterPro:   IPR001808
- InterPro:   IPR012318
- InterPro:   IPR014710
- InterPro:   IPR018335
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00027 cNMP_binding; PF00325 Crp [H]

EC number: NA

Molecular weight: Translated: 25827; Mature: 25696

Theoretical pI: Translated: 10.25; Mature: 10.25

Prosite motif: PS50042 CNMP_BINDING_3 ; PS51063 HTH_CRP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANGKDLSFLRKFILFSEMSDEDLSTVASLLQTRIFKDGTNIFFEGEEGDRVYFLKKGRV
CCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEECCCE
KVKKTSPDGGEQILEIITPGDVFGEVVLFGIDRYPATTVAIGEVVVDYLSRSKFRRYFTN
EEEECCCCHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
NPEIGWGMLKVMARKLARSQKRIENLGLRDTKGRVATLIMDMMRDFGEKNNQVVKLHFNR
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECH
QELANFIGTSRETVSRTLSEFKSEGLIDIKGKKLIIKDIEGLKRWL
HHHHHHHCCCHHHHHHHHHHHHHCCEEEECCCEEHHHHHHHHHHCC
>Mature Secondary Structure 
ANGKDLSFLRKFILFSEMSDEDLSTVASLLQTRIFKDGTNIFFEGEEGDRVYFLKKGRV
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEECCCE
KVKKTSPDGGEQILEIITPGDVFGEVVLFGIDRYPATTVAIGEVVVDYLSRSKFRRYFTN
EEEECCCCHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
NPEIGWGMLKVMARKLARSQKRIENLGLRDTKGRVATLIMDMMRDFGEKNNQVVKLHFNR
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECH
QELANFIGTSRETVSRTLSEFKSEGLIDIKGKKLIIKDIEGLKRWL
HHHHHHHCCCHHHHHHHHHHHHHCCEEEECCCEEHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]